La représentation des devoirs à domicile selon parents, enseignants et élèves

Ce travail de mémoire a comme but de comparer la représentation des devoirs à domicile selon parents, enseignants et élèves. L’objectif principal étant de comprendre comment les devoirs sont représentés par les différents acteurs et pourquoi il en est ainsi. C’est pourquoi, je me suis également intéressée à l’éventuelle influence de divers facteurs comme le niveau de formation, le nombre d’années d’expérience ou encore le profil de l’élève qui seraient susceptibles de jouer un rôle dans la construction des différentes opinions. Les résultats indiquent que les devoirs sont une réalité scolaire, puis que la majorité des acteurs y étant liée y est favorable. Néanmoins, il existe certains malentendus entre parents, enseignants et élèves sur certains aspects de ces derniers. Pour tenter d’éviter ce genre de divergences qui peuvent donner lieu à des conflits mais aussi brouiller les rôles de chaque acteur, comme le souligne Rayou (2009), il convient que chacun exprime ses attentes et ses besoins en matière de devoirs

Insights into German polar research during POLARSTUNDE

Polar research is an interdisciplinary and multi-faceted field of research ranging from history to geology and geophysics to social sciences and education. Thus, several different universities and institutions within Germany participate in polar research. The seminar series POLARSTUNDE, organized by the German Society for Polar Research (Deutsche Gesellschaft für Polarforschung) and the German National Committee of the Association of Polar Early Career Scientists (APECS Germany) regularly features different topics of German polar research. Although initially a "pandemic solution", the seminar series has established itself as a valuable and highly successful part of the German polar research landscape. The seminar series was held in German and was aimed at both scientists and the general public. This article addresses the first season of POLARSTUNDE and provides (1) comprehensive summaries of the talks and (2) insight into the planning and execution from an organizational point of view

Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk

Aims High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular outcome remains unknown. Methods and results We examined the association of SAA and HDL-C with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study, which included 3310 patients undergoing coronary angiography. To validate our findings, we analysed 1255 participants of the German Diabetes and Dialysis study (4D) and 4027 participants of the Cooperative Health Research in the Region of Augsburg (KORA) S4 study. In LURIC, SAA concentrations predicted all-cause and cardiovascular mortality. In patients with low SAA, higher HDL-C was associated with lower all-cause and cardiovascular mortality. In contrast, in patients with high SAA, higher HDL-C was associated with increased all-cause and cardiovascular mortality, indicating that SAA indeed modifies the beneficial properties of HDL. We complemented these clinical observations by in vitro experiments, in which SAA impaired vascular functions of HDL. We further derived a formula for the simple calculation of the amount of biologically ‘effective' HDL-C based on measured HDL-C and SAA from the LURIC study. In 4D and KORA S4 studies, we found that measured HDL-C was not associated with clinical outcomes, whereas calculated ‘effective' HDL-C significantly predicted better outcome. Conclusion The acute-phase protein SAA modifies the biological effects of HDL-C in several clinical conditions. The concomitant measurement of SAA is a simple, useful, and clinically applicable surrogate for the vascular functionality of HD

Unravelling the evolution of the Allatostatin-Type A, KISS and Galanin Peptide-Receptor gene families in Bilaterians: insights from Anopheles Mosquitoes

Allatostatin type A receptors (AST-ARs) are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A) peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects. The present study provides a comprehensive analysis of the origin and comparative evolution of the AST-A system. To determine how evolution and feeding modified the function of AST-AR the duplicate receptors in Anopheles mosquitoes, were characterised. Phylogeny and gene synteny suggested that invertebrate AST-A receptors and peptide genes shared a common evolutionary origin with KISS/GAL receptors and ligands. AST-ARs and KISSR emerged from a common gene ancestor after the divergence of GALRs in the bilaterian genome. In arthropods, the AST-A system evolved through lineage-specific events and the maintenance of two receptors in the flies and mosquitoes (Diptera) was the result of a gene duplication event. Speciation of Anophelesmosquitoes affected receptor gene organisation and characterisation of AST-AR duplicates (GPRALS1 and 2) revealed that in common with other insects, the mosquito receptors were activated by insect AST-A peptides and the iCa(2+)-signalling pathway was stimulated. GPRALS1 and 2 were expressed mainly in mosquito midgut and ovaries and transcript abundance of both receptors was modified by feeding. A blood meal strongly up-regulated expression of both GPRALS in the midgut (p < 0.05) compared to glucose fed females. Based on the results we hypothesise that the AST-A system in insects shared a common origin with the vertebrate KISS system and may also share a common function as an integrator of metabolism and reproduction. Highlights: AST-A and KISS/GAL receptors and ligands shared common ancestry prior to the protostome-deuterostome divergence. Phylogeny and gene synteny revealed that AST-AR and KISSR emerged after GALR gene divergence. AST-AR genes were present in the hemichordates but were lost from the chordates. In protostomes, AST-ARs persisted and evolved through lineage-specific events and duplicated in the arthropod radiation. Diptera acquired and maintained functionally divergent duplicate AST-AR genes.Foundation for Science and Technology, Portugal (FCT) [PTDC/BIA-BCM/114395/2009]; European Regional Development Fund (ERDF) COMPETE - Operational Competitiveness Programme; Portuguese funds through FCT Foundation for Science and Technology [PEst-C/MAR/LA0015/2013, UID/Multi/04326/2013, PEst-OE/SAU/LA0018/2013]; FCT [SFRH/BPD/89811/2012, SFRH/BPD/80447/2011, SFRH/BPD/66742/2009]; auxiliary research contract FCT Pluriannual funds [PEst-C/MAR/LA0015/2013, UID/Multi/04326/2013]info:eu-repo/semantics/publishedVersio

Impactanalyse der Energiewende

Bei der Energiewende handelt es sich um einen komplexen Transformationsprozess, der nicht allein aus der nationalen Perspektive betrachtet werden kann. Er ist nicht vollständig unabhängig, sondern in einen Mehr-Ebenen-Prozess eingebunden. Es gilt entsprechend sowohl lokale als auch regionale, nationale, europäische und auch die internationalen Energiewendeprozesse und zugehörigen Rahmenbedingungen zu diskutieren und zu beachten. Es gilt aber auch, über den eigentlichen Energiebereich hinausgehende Trends in ihren Wechselwirkungen mit dem Energiesystem zu identifizieren und zu analysieren. Mit der Energiewende wird zudem eine Zielvielfalt angesprochen. Es geht über das Erreichen von Klimaschutzzielen hinaus um eine größere Vielfalt von gesellschaftlich-politischen Zielen. Der Transformationsprozess hat keine eindimensionale Zielorientierung, sondern muss in einer mehrdimensionalen Betrachtung analysiert werden

gyrB Multiplex PCR To Differentiate between Acinetobacter calcoaceticus and Acinetobacter Genomic Species 3 ▿

A previously established multiplex PCR that identifies to the species level Acinetobacter baumannii and Acinetobacter genomic species 13TU (GS13TU) was expanded to include Acinetobacter calcoaceticus and Acinetobacter genomic species 3

OXA-143, a Novel Carbapenem-Hydrolyzing Class D β-Lactamase in Acinetobacter baumannii▿

A carbapenem-resistant Acinetobacter baumannii strain was isolated in Brazil in 2004 in which no known carbapenemase gene was detected by PCR. Cloning experiments, followed by expression in Escherichia coli, gave an E. coli recombinant strain expressing a novel carbapenem-hydrolyzing class D β-lactamase (CHDL). OXA-143 showed 88% amino acid sequence identity with OXA-40, 63% identity with OXA-23, and 52% identity with OXA-58. It hydrolyzed penicillins, oxacillin, meropenem, and imipenem but not expanded-spectrum cephalosporins. The blaOXA-143 gene was located on a ca. 30-kb plasmid. After transformation into reference strain A. baumannii ATCC 19606, it conferred resistance to carbapenems. Analysis of the genetic environment of blaOXA-143 revealed that it was associated with neither insertion sequences nor integron structures. However, it was bracketed by similar replicase-encoding genes at both ends, suggesting acquisition through a homologous recombination process. This study identified a novel class D β-lactamase involved in carbapenem resistance in A. baumannii. This enzyme is the first member of a novel subgroup of CHDLs whose prevalence remains to be determined

Design options for the new international market mechanism under article 6.4 of the Paris agreement

In this project commissioned by the German Environment Agency, important aspects of the mechanism under Article 6.4 of the Paris Agreement were examined in more detail. This mechanism is to succeed the CDM under the Kyoto Protocol from 2021 onwards, but it will contain decisive improvements, especially with regard to a robust accounting of emission reductions and better integration into the national climate policy of the host country. The report is addressed to the international experts, in particular to the delegates to the climate conference and observers, and is therefore written in English. A German summary is included. The following topics are covered: How does the mechanism achieve an overall reduction of global emissions? Are there opportunities to use benchmarks to establish baselines? Can contributions to increasing ambition be made by using Art. 6.4? What contribution can the voluntary market make to increasing ambition in the future? Introduction of incentives for the participation of private companies under Art. 6.4 of the PA. The role of the Art. 6.4 mechanism on the way to a net zero emission world. The project provides a contribution to the general discussion in the EU as well as to the Article 6 - Negotiations under the UNFCCC. It is a contribution that presents backgrounds and interrelationships for individual questions concerning the design of the new market mechanisms under Article 6 and can thus contribute to a more informed decision-making process.Since there are, however, several different ways of designing a mechanism that can avoid double counting and provide incentives for increasing ambition, this project is only one of several current contributions to the international discussion