Prevention and treatment of radiotherapy-induced side effects

Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of patients. The precision with which the radiation dose can be delivered is rapidly improving. This precision allows the more accurate targeting of radiation dose to the tumor and reduces the amount of surrounding normal tissue exposed. Although this often reduces the unwanted side effects of radiotherapy, we still need to further improve patients' quality of life and to escalate radiation doses to tumors when necessary. High-precision radiotherapy forces one to choose which organ or functional organ substructures should be spared. To be able to make such choices, we urgently need to better understand the molecular and physiological mechanisms of normal tissue responses to radiotherapy. Currently, oversimplified approaches using constraints on mean doses, and irradiated volumes of normal tissues are used to plan treatments with minimized risk of radiation side effects. In this review, we discuss the responses of three different normal tissues to radiotherapy: the salivary glands, cardiopulmonary system, and brain. We show that although they may share very similar local cellular processes, they respond very differently through organ-specific, nonlocal mechanisms. We also discuss how a better knowledge of these mechanisms can be used to treat or to prevent the effects of radiotherapy on normal tissue and to optimize radiotherapy delivery

Quiver Structure of Heterotic Moduli

We analyse the vector bundle moduli arising from generic heterotic compactifications from the point of view of quiver representations. Phenomena such as stability walls, crossing between chambers of supersymmetry, splitting of non-Abelian bundles and dynamic generation of D-terms are succinctly encoded into finite quivers. By studying the Poincar\'e polynomial of the quiver moduli space using the Reineke formula, we can learn about such useful concepts as Donaldson-Thomas invariants, instanton transitions and supersymmetry breaking.Comment: 38 pages, 5 figures, 1 tabl

Wrist-Ankle Acupuncture for the Treatment of Pain Symptoms: A systematic Review and Meta-analysis

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Quantitative trait loci analysis for chlorophyll content of cucumber (Cucumis sativus L.) seedlings under low-light stress

An increase in chlorophyll content is an adaptive response to low-light stress and can be used to evaluate low-light tolerance. The effects of low-light stress (100 ìmol·m-2.s-1) on the chlorophyll content of cucumber (Cucumis sativus L.) were investigated in a set of 123 F2:3 lines in the seedling stage in the autumn of 2008 and spring of 2009. Quantitative trait loci (QTL) analysis was undertaken on the basis of a genetic linkage map of the corresponding F2 population that was constructed using composite interval mapping. F2:3-based QTL analysis of the chlorophyll-a (chl.a), chlorophyll-b (chl.b) and chlorophyll-a+b (chl.a+b) content in the 2 environments revealed 21 QTLs located on the linkage groups 1, 2, 3, 4, 6 and 7, which accounted for 4.8 - 17.3% of the phenotypic variation. In the spring of 2009, the total phenotypic variation among the F2:3 lines accounted for by the QTLs for chl.a, chl.b and chl.a+b were 44.5, 29.4 and39.0%, respectively. In the autumn of 2008, 11 QTLs were identified, which accounted for 4.8 - 14.9% of the observed phenotypic variation and an additive effect of -8.10 to 20.85. Four major-effect QTLs (chla2.1, chlb2.2, chlb3.1 and chla+b2.2) were detected under both conditions. The QTL information presented in this research, together with the data from our previous study on heredity of low-light tolerant traits, will facilitate the breeding of low-light-stress-resistant cucumbers

High volumetric energy density capacitors based on new electrode material lanthanum nitride

This is the author accepted manuscript. The final version is available from the American Chemical Society via the DOI in this recordLaN is synthesized via calcining La2O3 in NH3 and studied as capacitive material for energy storage. A volumetric capacitance of 951.3 F cm-3 was found in 1 mol dm-3 Na2SO4 using a current density of 1 Ag-1, with less than 1% loss of capacitance being experienced after 5000 cycles. In addition, 87.3% of the initial capacitance remained at a current density of 10 A g-1. LaN exhibits high capacitance that is attributed to subsurface space charge accumulation with a possible electric double-layer capacitor component. A reversible electrode process ensures long cycle life and favorable electrical charge transfer. The assembled LaN symmetrical capacitor showed high volumetric energy densities, facilitating high-duty applications.National Natural Science Foundation of ChinaFoundation for Innovation Groups of Basic Research in Gansu Provinc

Effects of hydrogen bond and solvent polarity on the C=O strectching of bis(2-thienyl)ketone in solution

The optimized structural parameters, the absorption and the resonance Raman spectra have been investigated for the bis(2-thienyl)ketone in gas phase, in cyclohexane, methanol, and acetonitrile solvents by means of time dependent density functional theory calculations, the solvent electronic polarization effect on the solvation shift is examined and in well accordance with the calculation. The effect of increasing the polarity of the solvent is well represented by the polarizable continuum model, both for the absorption spectra and resonance Raman intensities. The Raman spectra of the C=O stretching mode, which is sensitive to the intermolecular interaction for bis(2-thienyl)ketone dissolved in solvents, were systematically studied. It was found that the hydrogen bond effect plays an important role in reducing the carbonyl stretching wavenumbers. The results of Raman shifts were interpreted through the dilution effect, solvation effects, and hydrogen bond-forming effects. Furthermore, the excitation profiles of several important Raman bands of bis(2-thienyl)ketone molecule in different solvents have been critically analyzed. The solvent effects on structural and symmetry properties of the molecule in S2 electronic state as well as the short-time photo relaxation dynamics have been discussed.published_or_final_versio

Two Years versus One Year of Tianjiu Therapy in Sanfu Days for Chronic Asthma: A Clinical Efficacy Observation Trial

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Tellurium quantum dots: Preparation and optical properties

Herein, we report an effective and simple method for producing Tellurium Quantum dots (TeQDs), zero-dimensional nanomaterials with great prospects for biomedical applications. Their preparation is based on the ultrasonic exfoliation of Te powder dispersed in 1-methyl-2-pyrrolidone. Sonication causes the van der Waals forces between the structural hexagons of Te to break so that the relatively coarse powder breaks down into nanoscale particles. The TeQDs have an average size of about 4 nm. UV-Vis absorption spectra of the TeQDs showed an absorption peak at 288 nm. Photoluminescence excitation (PLE) and photoluminescence (PL) are used to study the optical properties of TeQDs. Both the PLE and PL peaks revealed a linear relationship against the emission and excitation energies, respectively. TeQDs have important potential applications in biological imaging and catalysis as well as optoelectronics

Spectra of supernovae in the nebular phase

When supernovae enter the nebular phase after a few months, they reveal spectral fingerprints of their deep interiors, glowing by radioactivity produced in the explosion. We are given a unique opportunity to see what an exploded star looks like inside. The line profiles and luminosities encode information about physical conditions, explosive and hydrostatic nucleosynthesis, and ejecta morphology, which link to the progenitor properties and the explosion mechanism. Here, the fundamental properties of spectral formation of supernovae in the nebular phase are reviewed. The formalism between ejecta morphology and line profile shapes is derived, including effects of scattering and absorption. Line luminosity expressions are derived in various physical limits, with examples of applications from the literature. The physical processes at work in the supernova ejecta, including gamma-ray deposition, non-thermal electron degradation, ionization and excitation, and radiative transfer are described and linked to the computation and application of advanced spectral models. Some of the results derived so far from nebular-phase supernova analysis are discussed.Comment: Book chapter for 'Handbook of Supernovae,' edited by Alsabti and Murdin, Springer. 51 pages, 14 figure

Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B

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