9 research outputs found
Automatization of Individual Anti-thermal Protection of Rescuers in the Initial Period of Fire Suppression
- Author
- Publication venue
- PC TECHNOLOGY CENTER
- Publication date
- 01/01/2017
- Field of study
The problem of protection of rescuers from thermal injuries at the initial stage of fire suppression was explored.The authors substantiated structural components of the autonomous device for individual protection of rescuers from thermal injuries at the initial stage of emergency elimination, mainly during the site reconnaissance, when means of fire suppression and thermal protection of rescuers are not deployed yet. The automatic autonomous thermoprotective device, the structural system of which contains hydraulic and automatic parts, was proposed. The hydraulic part includes: the tank, pipelines for feeding a cooling agent, the atomizer, and the shutter of the electromagnetic valve. The tank is filled with the cooling agent under pressure. The shutter of the valve is located on the neck of the tank and in the initial state overlaps the pipeline. The atomizer is fixed on a rescuer's helmet. The automatic part of the device consists of the control unit with the autonomous battery, located in the under-clothing space, the temperature sensor and the driving part of the electromagnetic valve.The model and the model sample of the autonomous thermoprotective device were tested under laboratory conditions. Testing results demonstrated workability of the proposed technical solution and possibility of operation in automatic mode. Effectiveness of cooling the rescuer's body by periodic sprinkling of the surface of special protective clothing was proved. The device timely reacted to the temperature change in the under-clothing space and automatically cooled down the surface of special firefighter clothing within five seconds. Pulse mode of device operation provides economical consumption of a cooling agent and an increase in the duration of rescuer's protection from thermal injuries.External sprinkling for the purpose of cooling helps counteract thermal destruction of fabric of the special clothes for firefighters and increase their operation ter
Highly Flexible Molecule âChameleonâ: Reversible Thermochromism and Phase Transitions in Solid Copper(II) Diiminate Cu[CF<sub>3</sub>î¸C(NH)î¸CFîťC(NH)î¸CF<sub>3</sub>]<sub>2</sub>
- Author
- Publication venue
- Publication date
- Field of study
Three thermochromic phases (ι, green; β,
red; Îł,
yellow) and six polymorphic modifications (Îą<sub>1</sub>, monoclinic, <i>P</i>2<sub>1</sub>/<i>n</i>, <i>Z</i> =
2; β<sub>1</sub>, monoclinic, <i>P</i>2<sub>1</sub>/<i>c</i>, <i>Z</i> = 4; β<sub>2</sub>,
triclinic, <i>P</i>1Ě
, <i>Z</i> = 4; β<sub>3</sub>, monoclinic, <i>P</i>2<sub>1</sub>/<i>n</i>, <i>Z</i> = 4; γ<sub>1</sub> and γ<sub>2</sub>, tetragonal, <i>P</i>4<sub>2</sub>/<i>n</i>, <i>Z</i> = 4) have been found and structurally characterized for
copperÂ(II) diiminate CuÂ[CF<sub>3</sub>î¸CÂ(NH)î¸CFîťCÂ(NH)î¸CF<sub>3</sub>]<sub>2</sub> (<b>1</b>). The Îą phase is stable
under normal conditions, whereas the high-temperature β and
Îł phases are metastable at room temperature and transform slowly
into the more stable Îą phase over several days or even weeks.
X-ray diffraction study revealed that the title molecules adopt different
conformations in the ι, β, and γ phases, namely,
staircase-like, twisted, and planar, respectively. The investigation
of the ι, β, and γ phases by differential scanning
calorimetry showed that the three endothermic peaks in the range 283,
360, and 438 K are present on their thermograms upon heating/cooling.
The two peaks at 283 and 360 K correspond to the solidâsolid
phase transitions, and the high-temperature peak at 438 K belongs
to the melting process of <b>1</b>. The temperature and thermal
effect of all the observed transitions depend on the prehistory of
the crystalline sample obtained. A reversible thermochromic single-crystal-to-single-crystal
Îą<sub>1</sub>âβ<sub>1</sub> phase transition occurring
within a temperature interval of 353â358 K can be directly
observed using a CCD video camera of the X-ray diffractometer. A series
of other solidâsolid Îą<sub>1</sub>âÎł<sub>1</sub>, β<sub>2</sub>âÎł<sub>1</sub>, β<sub>3</sub>âÎł<sub>1</sub>, and Îł<sub>1</sub>âÎł<sub>2</sub> phase transitions can be triggered in <b>1</b> by temperature.
It has been suggested that, under equilibrium conditions, the Îą<sub>1</sub>âÎł<sub>1</sub> and β<sub>2</sub>âÎł<sub>1</sub> phase transitions should proceed stepwise through the Îą<sub>1</sub>âβ<sub>1</sub>âβ<sub>2</sub>âβ<sub>3</sub>âÎł<sub>1</sub> and β<sub>2</sub>âβ<sub>3</sub>âÎł<sub>1</sub> stages, respectively. The mechanism
of the phase transitions is discussed on the basis of experimental
and theoretical data
The 1983 Nuclear Crisis â Lessons for Deterrence Theory and Practice
- Author
- Adamsky Dima
- Akhromeev S. F.
- Aleksandrov-Agentov A. M.
- Andrew Christopher
- Andropov I. V.
- Arbatov Georgii
- Bakatin Vadim
- Bar Shmuel
- Barrass Gordon
- Batanov Aleksei
- Berkutov S. N.
- Blackwell James
- Bunn Elaine
- Chazov Evgenii
- Cherkashin Victor
- Cherniakova E.
- Cimbala Stephen
- Danilov Aleksei
- Danilov Aleksei
- Department of Defense
- Department of Defense
- Dhzemal Okhranâ
- DiCicco M. Jonathan
- Dmitry Dima Adamsky
- Dobrynin Anatolii
- Drogovoz Igorâ
- Edelman Eric
- Editorial
- Editorial
- Editorial
- Fischer Benjamin
- Freedman Lawrence
- Garthoff L. Raymond
- George Alexander
- George Alexander
- Grinevskii Oleg
- Grinevskii Oleg
- Gromyko Anatolii
- Guthe Kurth
- Haines K. Gerald
- Hines G. John
- Hoffman David
- Ischenko Sergei
- Ivanov Sergei
- Ivasutin Petr
- Ivliev N. I.
- Ivliev S. N.
- Jervis Robert
- Karpenko A. V.
- Kir'ian M. M.
- Kireev Iu.K.
- Kirpichenko Vadim
- Knopf W. Jeffrey
- Kocher Karel
- Kokoshin Andrei
- Koniukhov S. N.
- Kopeischikov Pavel
- Korneluk Natalia
- Kornienko Georgii
- Korochanskii I. F.
- Kostenko Korochanskii
- Kravchenko V. P.
- Kriuchkov V. A.
- Kuzichkin Vladimir
- Lantis Jeffrey
- Larkin P. Sean
- Lekarev Stanisalv
- Lekarev Stanislav
- Leonidov L. V.
- Leonov N. S.
- Leshenko Iurii
- Lupovici Amir
- Lupovici Amir
- Mahnken Thomas
- Malevannyi Vladimir
- Malevannyi Vladimir
- Malevannyi Vladimir
- Malinovskii G. G.
- Manchanda Arnav
- Mastny Vojtech
- Medvedev Roi
- Mlechin Leonid
- Montaigne Fen
- Morgan Patrick
- Morozov Vladimir
- Nervov Mikhail
- Nikolaev Aleksandr
- Nuti Leopoldo
- Odom E. William
- Ogarkov N.
- Ogarkov N. V.
- Ogarkov N. V.
- Palazhchenko Pavel
- Panio Ekaterina
- Paul T. V.
- Payne Keith
- Petrov I.
- Petrov N. F.
- Petrov N. F.
- Podvig Pavel
- Podvig Pavel
- Podvig Pavel
- Potopov V.Ia.
- Press Daryl
- Primakov Evgenii
- Rebrov Mikhail
- Rid Thomas
- Rovner Joshua
- Savel'ev Aleksandr
- Schelling Thomas
- Scott Len
- Shebarshin Leonid
- Shirokorad Aleksandr
- Shironin V
- Shvets B. Yuri
- Starodubov V. P.
- Starodubov Viktor
- Strugovetc Vitalii
- Tsygichko V. N.
- Ushakov V. S.
- Usol'tcev Vladimir
- Ustinov D. F.
- Ustinov Dmitry
- Varennikov Valentin
- Vasilchenko M. V.
- Vasiliev Iurii
- Votintcev Iu. V.
- Weiss Gus
- Wilner Alex
- Wilner Alex
- Wohlforth C. William
- Wolf Markus
- Yarynich Valery
- Zolotarev V. A.
- Zubok Vladislav
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure.
- Author
- Abhyankar A
- Accini J
- Adamson P
- Adelberger V
- Agarwal D K
- Ageev F
- Aggarwal R
- Aguilera M
- AhlstrĂśm P
- Ahmad W
- Ahmed F
- Akimov A
- Akinboboye O
- Aktoz M
- Akyea-Djamson A
- Al-Zoebi A
- Albisu J
- Albornoz F
- Alegre R
- Alexeeva-Kovalchuk A
- Almanzar A
- Almeida F
- Alvarez M
- Alvarisqueta A
- Amin A
- Amkieh A
- Amos A
- Amuchastegui M
- Anand I
- Anastasio L
- Andersen H
- Andersen K
- Andor M
- Andrade A
- Andrade C
- Andrassy G
- Andreka P
- Anonuevo J
- AntalĂk L
- Apostolakis S
- Arango J L
- Arango Juan Luis
- Arenas J
- Arias-CastaĂąo J C
- Arnold J Malcolm
- Arnold M
- Aronson D
- Arriola J
- Astesiano A
- Atilano A
- AvendaĂąo A
- AvendaĂąo P
- Averkov O
- Avila E
- AvilĂŠs E
- Awasty V
- AzaĂąero R
- Baben L
- Badat A
- Baek S H
- Bagirath R
- Bakai J
- Baldin M G
- Ballyuzek M
- Banerjee P
- Banish D
- Bank A
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- Bargout R
- Barnard D
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- Basarab G
- Basart D
- Basavanagowdappa H
- Bassan R
- Basson D
- Bastian A
- Bauer F
- Beacom M
- Bebenek W
- Behrens S
- Bellersen L
- Belohlavek J
- Beloscar J
- Ben Gal T
- Benov H
- Berdague P
- Berg I
- Bergeron S
- Berk M
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- Bouvier J-M
- Boyarkin M
- Boytsov Sergey
- Bozkurt B
- Braga J
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- Pronk A
- Proskynitopoulus N
- Ptacin M
- Purvis J
- Puschita M
- PĂĄlka J
- Quinlan E
- Quinn T
- Rabelo A
- Radvan M
- Raev D
- Rafalsky V
- RaidRihani R
- Rajda M
- Rama B
- Ramanathan K
- Ramires F
- Ramshev K
- Rancane G
- Ranjith N
- Rassi S
- Rawitscher D
- Rebrov A
- Reddy N
- Refsgaard J
- Regner S
- Reimer D
- Reis G
- Reis H
- RemiĹĄovĂĄ S
- Reyes A
- Reynales H
- Reznik I
- Richter M
- Rickers H
- Riha V
- Rizkala Adel R
- Robinson S
- Rodriguez A
- Rodriguez I
- Rodriguez M
- Rodriguez T
- RodrĂguez D
- RodrĂguez M
- Roeder S
- Rogelio G
- Rojas C
- Roldan Y
- Romano A
- Ronchi E
- Ronner E
- Rosado J
- Rosenthal A
- Rosenthal S
- Rosita R
- Rossi P
- Rouleau J
- Ruales A
- Ruda M
- Rummel R
- Rupka D
- Ryding A
- Saaiman J
- Saba P S
- Sabatier R
- Sabe-Affaki G
- Sabl P
- Saifutdinov R
- Salamon C
- Salbach P
- Salcido E
- Salvatierra Ruiz A
- Samal A
- Sanchez A
- Sanguanwong S
- SanmartĂn M
- Saporito W
- Sarjanovich R
- Sarma P
- Sarries A
- Sayganov S
- Schaefer S
- Schaum T
- Schenkenberger I
- Schiavi L
- SchichorovĂĄ J
- Schindler A
- Schmalfuss C
- Schmidt A
- Schmidt E
- Schnabel A
- Schneider R
- Schneider W
- Schreckenberg A
- SchreibmĂźller F
- Schreiner M
- SchrĂśder T
- Schumacher M
- Schwartz S
- Schäfer T
- Sciborski R
- Seals A
- Sebopa B
- Segner A
- Seibert H
- Selektor Y
- Senni M
- Sepulveda P
- Sessa H
- Sestier F
- Seto T
- Shah P
- Shah S
- Shamsudden K
- Shanes J
- Sharma K
- Sheppard R
- Shi Victor C
- Shin J-H
- Shochat M
- Shpagina L
- Shustov S
- Shutemova E
- Shvarts Y
- Siao G
- Siao K
- Sibulo A S
- Sibulo Antonio S
- Sicuro M
- Sigurdsson A
- Silva E
- Silva-Cardoso JosĂŠ
- Silvestre I
- Silvestri F
- Sime I
- Simoes M
- Sims J
- Singh S
- Sinha S
- Sirakova V
- Sitnikova M
- Sizova J
- Slaby J
- Slapikas R
- Smik R
- Smith D
- Smolders W
- Smolenskaya O
- Soares R
- Sobkowicz B
- Sobolewska J
- Sohn H-Y
- SokolovĂĄ B
- Solache G
- Soler J
- Solomon S
- Solovieva A
- Soo L
- Sooudi S
- Sotolongo R
- Sotomayor A
- Souza W
- Spagnuolo V
- Sprovieri M
- Squire I
- Srinivasa Rao M
- Srinivasa Rao N
- Staneva A
- Starling R
- Staroverov I
- Steffensen F
- Stockins B
- Strain D
- Struk R
- StĂśhring R
- Suiter D
- Sun N L
- Sunderam S
- Svejda J
- Svistov A
- Swart H
- Swedberg K
- Szocs A
- Szpajer M
- SzĂĄntai G
- Taddei S
- Tangerding G
- Tarasov N
- Tarlovskaya E
- Taubert G
- Taurio J
- Tayob M
- Teerlink J
- Telekes P
- Tereschenko S
- Terhorst A
- Terrosu P
- Tesch C
- Tespili M
- Thadani U
- Thakkar B
- Thanvi S
- Theron H
- Thomas M
- Thongsri T
- Thorgeirsson G
- ThorsĂŠn C
- Thrasher J
- Tisheva-Gospodinova S
- Tjeerdsma G
- Todorov G
- Tokmakova M
- TomcsĂĄnyi J
- Tomescu M
- Torres F
- Torres P
- Toth D
- Toursarkissian N
- Tran N-T To
- Trelawny J
- Trevelyan J
- Trichon B
- Trivedi P
- Trofimov N
- Tsao H M
- Tse H F
- Tudoran M
- Tyler K
- Tyminski M
- Tzekova M
- Tzeng B H
- Uebel P
- Ulman J
- Ural D
- Uriarte A S
- Uriarte J
- Urina M
- Urquiaga J
- Uspensky Y
- Valchanova P
- Vally T
- van der Merwe N
- van Eck J
- van Zyl L
- Vandekerckhove H
- Vanhaecke J
- VarjĂş I
- Vasilieva E
- Velasco R
- Velasquez J
- Velasquez L
- Venter T
- Veress G
- Vergara G
- Vergoni W
- Vertes A
- Vesga B
- Vezikova N
- Vico M
- Vicuna R
- Vida M
- Vijan V
- Vilas Boas F
- Vilela G
- Vincent M
- Vinereanu D
- Vishnevsky A
- ViĹanskĂĄ D
- Volkov D
- Volterrani M
- Vomacka Z
- Vranian R
- VĂŠlez S
- Wallach S
- Ward N
- Watkin R
- Weglarz P
- Weinstein D
- Wellmann H
- Wells T
- Weyland K
- Weytjens C
- Wickemeyer W
- Wight J
- Wilke A
- Willems F
- Williams C
- Witherow F
- Wojciechowska C
- Woldman S
- Wollaert B
- Wong R
- Wronska D
- Wu L
- Wyss F
- Xu G
- Yakhontov D
- Yakovlev A
- Yan B
- Yang K
- Yannick N
- Yao L
- Yavdosyuk A
- Yavuzgil O
- Yenigun M
- Yeo D
- Yigit Z
- Yilmaz A
- Yilmaz M B
- Yip G
- Yokusoglu M
- Yoo B-S
- Yotov Y
- Yousef Z
- Yovaniniz P
- Yuan Z Y
- Yugandhar B
- Zaidman C
- Zannad F
- Zateyshchikova A
- Zebrack J
- Zeh W
- Zemek S
- Zemmrich C
- Zethson-HalldĂŠn M
- Zhang J
- Zhao R P
- Zharkov O
- Zhelev V
- Zhilyaev E
- Zilahi Z
- Zile M
- Zo J-H
- Zotov D
- Zotz R
- Zrazhevsky K
- Zuraw B
- ZĂĄmolyi K
- Ădes I
- Ĺ uch S
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 06/01/2015
- Field of study
Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo
- Author
- Abid Mohamed
- Accini Jose Luis
- AcuĂąa Silvia
- Adawi Faiad
- Adenuga Babafemi
- Adina Pop-Moldovan
- Ageev Fail
- Aguilar David
- Aguilar-Orozco Raul
- Ahmad Zia
- Aimaretti Gianluca
- Aizenberg Diego
- Akahori Hiroshi
- Akhmedzhanov Nadir
- Akinboboye Olakunle
- Akright Laura
- Al Mahmeed Wael
- Alanko Juha
- Alappat Paul
- Alawad Mohamad
- Alfonso Teresa
- Alimard Ramin
- Allen Peter
- Alvarez Carlos
- Alvarisqueta Andres
- Alzohaili Opada
- Ambos Anu
- Amerena John
- Amolina Ildze
- Andjelic Jelic Marina
- Andrade Miguel
- Andrews Robert
- Antorrena Isabel
- Araneda Guillermo
- Arango Juan
- Ariani Mehrdad
- Arnold Susan
- Arora Chander
- Arteaga Juan Manuel
- Assaad Samir
- Atar Shaul
- Avram Rodica Ioana
- Azad Nasrin
- Azzam Samir
- Baccaro Claudia
- Bailey Gordon
- Bain Stephen
- Barbarash Olga
- Barbarich Vladimir
- Barkoudah Ebrahim
- Bartolacci Ines
- Bascil Tutuncu Neslihan
- Basu Ambar
- Bayram Edmundo
- Bednarski Janusz
- Belousov Yury
- Ben Abdallah Nejib
- Benjamin Sabrina
- Bentley-Lewis Rhonda
- Berns Svetlana
- Berra Cesare
- Bertrand Olivier
- Bhargava Rakesh
- Bhatnagar Deepak
- Bickerton Alex
- Bijata-Bronisz Renata
- Block Bradley
- Boberg Gunnar
- Bodi Vicent
- Bokarev Igor
- Bolshakova Olga
- Bordonava Anselmo
- Borzadek Eliza
- Botelho Roberto Vieira
- Botella Marta
- Botero Rodrigo
- Boyarkin Mikhail
- Bragança Nuno
- Brahimi Abdel
- Breisblatt Warren
- Bright Tamis
- Bronnum-Schou Jens
- Browne Duncan
- Bryniarski Leszek
- Bunster Lia
- Burgess Lesley
- Burton Jeffrey
- Bustamante Labarta Miguel
- Busz-Papiez Benita
- Byrd Leroy
- Caccavo Alberto
- Calderon Jorge
- Calella Pedro
- Campeau Jean
- Camsari Ahmet
- Cantero Maria
- Cardosa-Torres Francisco
- Cariou Bertrand
- Carranza-Madrigal Jaime
- Castillo Gilberto
- Castro Eholo
- Castro Maria Guadalupe
- Catargi Bogdan
- Cerqueira Maria Jose
- Chacra Antonio
- Charytan David
- Chaturvedi Nishi
- Chavez Carlos
- Chen Li
- Chiang Chern-En
- Chiou Choyen
- Chiu Yu-Wei
- Chochinov Ronald
- Chopda Manoj
- Chopra Vijay
- Christensen Tom
- Christofides Elena
- Chumakova Galina
- Chumburidze Vakhtang
- Chung Choon Hee
- Chung Wook Jin
- Ciardullo Anna Vittoria
- Cif Adriana
- Claggett Brian
- Cobos Leonardo
- Codutti Renzo
- Coetzee Kathleen
- Cohen Ohad
- Cohen Robert
- Commendatore Victor
- Consoli Agostino
- Contzen Christel
- Cooper John
- CorbalĂĄn RamĂłn
- Cornel Jan Hein
- Coronel Julian
- Correa Flores Roger Martin
- Costamagna Osvaldo
- Creteanu Gabriela
- Cucinotta Domenico
- Cuello Jose
- Cure Carlos
- Czajkowska-Kaczmarek Eugenia
- Danilova Larisa
- Dans Antonio
- Dawood Gamil
- Dawood Saleem
- De La Fuente Javier
- De Souza Jose
- Dekkers Paulus
- Del Prato Stefano
- Delchev Alexy
- Delgado ElĂas
- Delibasi Tuncay
- Delport Eluned
- DeMets David
- Dempsey Michael
- Deshpande Neeta
- Di Marco Sandra
- Diaz Rafael
- Dickstein Kenneth
- Dinccag Nevin
- Dmitry Platonov
- Dong Yugang
- Dos Santos Fabio
- Dragomir Dinu
- Drzewiecka Anna
- Du Jianling
- Duarte JoĂŁo
- Duarte-Vera Yan
- Ducena Kristine
- Ducloux Roxane
- Dulak Elzbieta
- Dumas Richard
- Duran Garcia Santiago
- Dussaillant Gaston
- Dutta R.
- Dwivedi Sudhanshu
- Eagerton Donald
- East Cara
- Ebrahim I.
- Efrati Shai
- Eggers German
- Eki Yutaka
- Elder Charles
- Ellis Graham
- Elorza Jose
- Enciso Fidel
- Escalante Miguel
- Farfan Julio
- Fasching Peter
- Feitosa Gilson
- Ferariu Ioana Emilia
- Fernandez Alberto
- Fernando Ronald
- Filteau Pierre
- Finn Peter
- Fischer Hermann
- Fitilev Sergey
- Florenzano Fernando
- Flynn Aiden
- Fogelfeld Leon
- Forti Adriana
- Foucauld Jean
- Frederiks J.
- French William
- Frohnauer Mary
- Fujii Kenshi
- Gaffney Mary
- Galeana Cielmar
- Galyavich Albert
- Gandhi Pramod
- Gangopadhyay Subroto
- Garcia Duran Ruben
- Garcia Henry
- Garcia Luis
- Garcia-Castillo Armando
- Garcia-Hernandez Pedro
- Garcia-Soria Martin
- Garza Jose
- Gaztambide Sonia
- Gerstein Hertzel C.
- Gibson Martin
- Giorda Carlo
- Giordano Carla
- Glezer Maria
- Glonti Salome
- Godoy Gonzalo
- Gogia Harinder
- Golbert Milton
- Gomez Vilamajo Oscar
- Gomez Claudia
- Gomez Maria Honolina
- Gonzalez Castillo Baldomero
- Gonzalez Elis
- Gonzalez Jose Gerardo
- Gonzalez Ronaldo
- Gorban De Lapertosa Silvia
- Gorska Maria
- Gosmanov Aidar
- Granados Arnoldo
- Granger Christopher
- Greenberg Craig
- Greenway Frank
- Grinfeld Diego
- Guo Xiaohui
- Gupta Jugal Bihari
- Gupta Sandeep Kumar
- Gupta Sunil
- Hadjadj Samy
- Hagenow Andreas
- Halpern Alfredo
- Hamankiewicz Maciej
- Hammond Peter
- Han Ping
- Hanna Edward
- Hanna Fahmy
- Haouala Habib
- Hargrove Joe
- Harris Anthony
- Harris Bill
- Hart Terence
- Hartley L. Howard
- Hata Yoshiki
- Hatterjee Sanjay
- Helda Renate
- Henderson Galen
- Hermans Wrm
- Hermida Sonia
- Hernandez Triana Eric
- Hernandez Hector
- Hernandez-MuĂąuzuri Jesus
- Herrera Milton
- Herrington David
- Hewitt Mitzie
- Himeno Hideo
- Himpel-BĂśnninghoff Agnes
- Hirayama Atsushi
- Hiregouder Narendra
- Hissa Miguel
- Howard David
- Hu Taohong
- Huang Tsuei-Yuan
- Huidobro Laura Andrea
- Iancu Adrian-Corneliu
- Ismail Siddique
- Issa Basil
- Istratoaie Octavian
- Ivanica Gabriel
- Ivanov Valentin
- Ivanova Luidmila
- Izuora Kenneth
- Jaap Alan
- Jakovlev Ulle
- Jang Hakchul
- Janik Krzysztof
- Jendle Johan
- Jetty Preetham
- Jha Sujeet
- Jiang Bin
- Jimenez Silvia
- Johnston Peter
- Joseph Franklin
- Joseph Jacob
- Joshi Abhijeet
- Jude Edward
- JĂśrneskog Gun
- Kaddaha Ghaida Mohamad
- Kaiser Nielsen Peter
- Kakariekiene Vaida
- Kalashnikov Victor
- Kalashnikova Marina
- Kaplan Allen
- Kapoor Anoop
- Karnieli Eddy
- Karpenko Oleksandr
- Karpov Yuri
- Kasper Joseph F.
- Kavaliauskiene Roma
- Ke Yuannan
- Kelbe Dudley
- Kelehan Shaun
- Kelly Chris
- Kelly Richard
- Kereiakes Dean
- Kerlan Veronique
- Khaira Ajit
- Khaisheva Larisa
- Khalimov Yuri
- Khan Atir
- Khan Misal
- Khan Noor
- Khan Salman
- Kihm Lars
- Killat Holger
- Kim Chong-Jin
- Kim Jaetaek
- Kim Kyehun
- Kim Ung
- Kincel Krzysztof
- Kishimoto Ichiro
- Klainman Eliezer
- Kleinertz Klaus
- Klyuchkova Neli
- Kobalava Zhanna
- Kobayashi Youichi
- Kocic Radivoj
- Komnenovic Snezana
- Konieczny Marek
- Konrade Ilze
- Korban Elie
- Korpachev Vadym
- Korsoff Pirkko
- Kosch Christine
- Kosiborod Mikhail
- Koski Anna-Mari
- Kosmachova Elena
- Kostenko Victor
- Koval Olena
- Koziolova Natalya
- Kreutzmann Kristin
- Kulibaba Elena
- Kultursay Hakan
- Kumbla Mukund
- Kyoleyan Michael
- Køber Lars V.
- Lagrutta Mariana
- Laguerre Jacques
- Lahsen Rodolfo
- Lahtela Jorma
- Lalic Katarina
- Lalic Nebojsa
- Lanas Fernando
- LappegĂĽrd Knut Tore
- Lappo Mariola
- Lara Susano
- Larenas Gladys
- Larocque James
- Latif Kashif
- Lawson Francesca
- Lee Nae Hee
- Leon De La Fuente Ricardo
- Lesnov Victor
- Lester Frank
- Levin Philip
- Levine Steven
- Levterov Georgi
- Lewis Eldrin F.
- Li Charles
- Li Zhanquan
- Libov Igor
- Licheri Alberto
- Lichiardopol Radu
- Lieberman Phil
- Lisboa Hugo
- Llamas Guillermo
- Lok Dirk
- Lominadze Zaza
- Lonso Elena
- Lopez Rosas Enrique
- Lopez Gabriel Arturo
- Lopez Monica
- Lopez Patricio
- Lovell Charles
- Lu Chieh-Hsiang
- Lu Juming
- Lu Libia
- Lubi Maire
- Lubinski Andrzej
- Lucheva Mariya
- Luciardi Hector
- Lujan Jesus
- Lupovitch Steven
- Luque Edith
- Lyamina Nadezhda
- Ma Changsheng
- Mackinnon Ignacio
- Madu Ivy-Joan
- Maffei Laura
- Magdum Mohan
- Maggioni Aldo P.
- Mahabadi Vahid
- Mahmood Asif
- Malecot Jean-Marc
- Malik Rayaz
- Mannucci Edoardo
- Manrique Helard
- Manriquez Leopoldo
- Manzur Fernando
- Maragos Stavros
- Marck Cornelia
- Mariash Cary
- Marin Francisco
- Marino Javier
- Markov Valentin
- Marmol Alvear Ricardo
- Martin Paul
- Martin Victoria
- Maslyanko Vitaliy
- Mathew James
- Mathew John
- Mathiesen Ulrik
- Mathieu Chantal
- Mauricio Didac
- May Michael
- Mayfield Ronald
- McCall Anthony
- Mcdaniel Clayton
- Mcgrew Frank
- Mckenzie Marcus
- McMurray John J. V.
- Medina Marcelo
- Meeder Joan
- Mefford Ivan
- Mehta Arvind
- Mertes Bernardo
- Micic Dragan
- Mikdadi Ghiath
- Mikhail Magdy
- Militaru Constantin
- Minescu Bogdan
- Minuchin Oscar
- Mitkovskaya Natalya
- Miyaoka Hiroaki
- Moccetti Tiziano
- Mogrovejo Walter
- Moiseev Valentin
- Molchanova Olga
- Molina Dora
- Monchamp Travis
- MontaĂąa Oscar
- Monteiro Pedro
- Montenegro Pablo
- Moore Charles
- Moraes Joao
- Moran Michael
- Morrar Nidal
- Mosenzon Ofri
- Mosley Jonathan
- Mukhopadhyay Babu
- Mulford Mim
- Munoz Ricardo
- Murray John
- Murthy Keshava
- Märtsin Kaja
- Naidoo Visvakuren
- Nakhle Samer
- Nallasivan Mani
- Nedrebø Bjørn Gunnar
- Nelimarkka Lassi
- Nery Max
- Nielsen Henrik
- Nierop Peter
- Nieto Ortega Ruben
- Niiya Tetsuji
- Nishi Yutaro
- Novaretto Leonardo
- Nozaki Akira
- Ntsekhe Mpiko
- Nunohiro Tatsuya
- O'Kane M.
- O'Reilly Eileen
- Odio Alberto
- Odutayo Kayode
- Oh Charles
- Olelewe Sarah
- Oleynikov Valentin
- Olszanecka-Glinianowicz Magdalena
- Onaca Adriana
- Orio Silvia
- Orlandini Andres
- Orlikova Olga
- Orsi Emanuela
- Otasevic Petar
- Oto Ali
- Oviedo Alejandra
- Palchick Bryce
- Paliwal Yogesh
- Palma Juan Carlos
- Panelo Araceli
- Panov Alexey
- Papademetriou Vasilios
- Parikh Naresh
- Pariona-Javier Marcos
- Park Kyong Soo
- Patel Keyur
- Patel Sudhirkumar
- Patocchi Cristian
- Paul Vincent
- Pei Dee
- Peng Yongde
- Perepelytsya Mykhaylo
- Perez Luis
- Pertseva Tetyana
- Pesic Milica
- Petit Catherine
- Petrie John
- Petrosyan Olena
- Petrulioniene Zaneta
- PeĂąaherrera-PatiĂąo Carlos
- Pfeffer Marc A.
- Phillips Lawrence
- Piatti Piermarco
- Pieber Thomas
- Piechatzek Richard
- Ping Lin
- Pintilei Ella
- Pinto Miguel
- Pirags Valdis
- Pitts Thomas
- Podoleanu Cristian
- Ponikowski Piotr
- Pontiroli Antonio
- Ponzani Paola
- Pop Lavinia
- Popa Bogdan
- Potthoff Sergio
- Pouleur Anne-Catherine
- Pozzilli Paolo
- Prabhu Mukhya
- Prieto Francisco
- Probstfield Jeffrey L.
- Prohaska Martin
- Pulka Grazyna
- Puttnam Rachel
- PĂŠrez Manghi Federico
- Quadros Alexandre
- Quyyumi Arshed
- Raccah Denis
- Raduan Roberto
- Raev Dimitar
- Rafalskiy Vladimir
- Raffo Carlos
- Rajesh Vinutha
- Ramos Hugo
- Ramos null
- Randhawa Preet
- Ranetti Aurelian Emil
- Rasmussen Soeren
- Rayman Gerry
- Reis Gilmar
- Rekosz Jerzy
- Rendell Marc
- Rey Nannette
- Reyes Eduardo
- Reyes Eliana
- Rha Seungwoon
- Rhie Francis
- Ribeiro Filho Fernando
- Riddle Matthew C.
- Rim Sejoong
- Rinke Andrea
- Rivellese Angela
- Roberts James
- Robinson Anthony
- Robinson Jerome
- Robinson Michael
- Rodier Michel
- Rodionova Tatiana
- Rodrigues Elisabete
- Rodriguez Edgar
- Rodriguez Ignacio
- Rodriguez Jaime
- Rolandi Florencia
- Roldan Yudy
- Rollin Guilherme
- Rooney Desmond
- Rosenthal Svea
- Rossi Paulo
- Rosu Doina
- Rouleau Jean
- Rubino John
- Rudenko Leonid
- Rungby Jørgen
- Ryan Eugene
- Rønne Henning
- Saa Zarandon Raquel
- Saathoff Steven
- Saavedra Silvia Salome
- Saavedra Victor
- Sachmechi Isaac
- Sahay Rakesh
- Sahin Mahmut
- Saifi Ali
- Sainsbury Chris
- Saito Tomiyoshi
- Sakalyte Gintare
- Salacata Abraham
- Samitin Vasily
- Sanchez Vallejo Gregorio
- Sanders Robyn
- Sangla Kunwarjit
- Sanhueza Patricio
- Sanson Jodi
- Santos Elizabete
- Saravanan Ponnusamy
- Satoh Yasuhiro
- Savin Virginia
- Saygili Fusun
- Scarpa Aldo
- Schabauer Alex
- Schattner Mark
- Schellenberg Detlev
- Schiavi Lilia
- Schmedtje John
- Schokotov Vladimir
- Schwartz Alan
- Schygiel Pablo
- Scott Cranford
- Sebastian Peter John
- Seferovic Petar
- Selagamsetty Munni
- Sepulveda Pablo
- Sethuraman Selvamani
- Sgarbi Jose
- Shah Navneet
- Shakher Jayadave
- Shamanna Paramesh
- Shannon Michael
- Shaw Sylvia
- Shelbaya Salah
- Shi Yongquan
- Shilkina Nataliya
- Shin Sung-Hee
- Shogenov Zaur
- Shumkova Rositsa
- Shustov Sergey
- Shvarts Yuri
- Shyu Kou-Gi
- Siebert Mirna
- Sime Iveta
- Singal Dinesh
- Singh Baldev
- Singh K. Singh
- Singh Paminder
- Sjoberg Robert
- Skagen Knud
- Skudlarski Dariusz
- Slimane Hedia
- Smith Kenneth
- Sobolev Konstantin
- Sofley Carl
- Sokolova Jelena
- Solis Carmen Lia
- Solomon Scott D.
- Somasekharan Arun
- Sonn Anthony
- Sorof Suzanne
- Soroka Eugene
- Soto Alfonso
- Soto Nestor
- Souza Juliana
- Souza Maria Regina
- Spellman C. W.
- Sreenivasamurthy Lakshminarayanappa
- Stankovic Goran
- Steinhoff Jeffrey
- Stern Naftali
- Stobschinski De Alba Carlos Alejandro
- Stryuk Raisa
- Su Guohai
- Sudzhaeva Svetlana
- Sulit Dennis Jose
- Supe Pravin
- Suplotova Ludmila
- Suresh Damodhar
- Svensson Karl-Axel
- Sy Rosa Allyn
- Syan Gurcharan
- Syan Rajinder
- Sychov Oleg
- Synenko Volodymyr
- Szymkowiak Katarzyna
- Tahir Mohammad
- Takahashi Akihiko
- Takahashi Junichiro
- Takase Hiroyuki
- Takase Shinichi
- Tanenberg Robert
- Tang Baopeng
- Tardif Jean-Claude
- Tase Adrian
- Tesloianu Dan Nicolae
- Thawani Hemant
- Thomsen Kristian Korsgaard
- Thomson Stephen
- Thrasher James
- Timonera Miriam
- Todua Fridon
- Tokmakova Mariya
- Torp-Pedersen Christian
- Torres Claudia
- Torstensson Ingemar
- Toursarkissian Nicole
- Trachtenbarg David
- Trivi Marcelo
- Trotta Michael
- Tseluyko Vira
- Tsoukas George
- Tsuboko Yusuke
- Tsujimoto Mitsuru
- Tsujino Motoyoshi
- Tsuzuki Masahiro
- Tuan Weiming
- Tuomilehto Jaakko
- Turcios Erick
- Turgeman Yoav
- Turner Jeremy
- Twahirwa Marcel
- Tzekova Maria
- Ueng Kwo-Chang
- Ulla Maria
- Umpierrez Guillermo
- Urboniene Audrone
- Urdiales Pedro
- Uribe Marittza
- Vaid Brij
- Vallejos Julio
- Van Gaal William
- Van Zyl Louis
- Vance Carl
- Vasko Peter
- Vazir Ali
- Vazquez-Garcia Abraham
- Velasco-Sanchez Raul
- Venter Tjaart
- Vico Marisa
- Vida Manuel
- Vides Hella
- Vidrio Maricela
- Viktorova Inna
- Villalobos Renato
- Vinereanu Dragos
- Vinhas Margarida
- Vishnevsky Alexander
- Vorokhobina Natalia
- Wainstein Julio
- Waisman Florencia
- Wang Thomas
- Wang Tzung-Dau
- Warner Alberta
- Warnica James Wayne
- Watanabe Shuichi
- Watson Henry
- Weber Sandra
- Webster Brian
- Weindorff Kathleen
- Weinrauch Larry
- Welch Michelle
- Welker James
- Westerberg Bernhard
- White Anthony
- White Lindsey
- Whitelaw Donald
- Wilczewski Przemyslaw
- Wilding John
- Wiles Philip
- Williams Marcus
- Wu Wen-Chih
- Wu Yujun
- Wynne Alan
- Wyss Fernando
- Xu Biao
- Yakusevich Vladimir
- Yakushin Sergey
- Yamada Takahisa
- Yang Jiefu
- Yang Jinkui
- Yang Yanmin
- YaĂąez Mario
- Yeap Bu
- Yigit Zerrin
- Yocono Mark
- Yordanov Viktor
- Yuen Kevin
- Yupanqui Hernan
- Zadionchenko Vladimir
- Zalevskaya Alsu
- Zalevsky Grigory
- Zarankiene Rima
- Zateyshchikova Anna
- Zavala Alejandro
- Zhuravleva Larisa
- Zidi Borni
- Zorkun Cafer
- Zubiate Carlos
- Zuraw Bruce L.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND:
Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagon-like peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated.
METHODS:
ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallel-group, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy.
RESULTS:
Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean Âą SD age was 60.3 Âą 9.7 years, body mass index was 30.2 Âą 5.7 kg/m(2), and duration of T2DM was 9.3 Âą 8.2 years. The qualifying ACS was a myocardial infarction in 83% and unstable angina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events.
CONCLUSION:
ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres IĂąiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
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- Diego Alejandro Besada
- Diego Felipe Martinez
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- Dinesh Gupta
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- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
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- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- AndrĂĄssy PĂŠter
- AngerĂĽs Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
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- Baracioli Luciano
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- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
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- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
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- Chen Jersey
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- Chen Zhih-Cherng
- Chernyavsky Alexander
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- Feldman Robert
- FernĂĄndez Portales Francisco J
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- Ferrolino Arthur
- Figueiredo Estevao
- Figueroa Christian
- Fil Wojciech
- Fillat Angel C
- Fischer Sabine
- Fischer Stuart
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- GarcĂa LledĂł JosĂŠ A
- GarcĂa Celso
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- Goodfellow Ross
- Gordon Paul
- Gosparini Diego M
- Gossard Denis
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- Goto Shinya
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- Lee Denny
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- Lee Mu-Jang
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- Lehman Ronald
- Leichter Steven
- Leiter Lawrence A
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- Ramos LĂłpez Gabriel A
- Randeva Harpal S.
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- Sivak Vladimir
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- Trenk Dietmar
- Treshkur Tatiana
- Tresukosol Damras
- Tresukosol Damras
- Trevisan Roberto
- Trokis Julien
- Truong Binh
- Tsang Chiu C
- Tse Hung F
- Tseluyko Vira
- Tseng Wei-Kung
- Tsujimoto Mitsuru
- Tsyba Larisa
- Turi Tibor
- Turner Traci
- Turturo Maurizio
- Ueda Osamu
- Uehara Hiroki
- Ueng Kwo-Chang
- Ueno Hideki
- Uguccioni Massimo
- Umpierrez Guillermo
- Urbach Dorothea
- Urban Miroslav
- Urbano Rafael H
- Urbinati Stefano
- Uretsky Barry
- Utsu Noriaki
- Uzunow Anna
- Vaca Carlos
- Vakaliuk Igor
- Valle Timo
- Vallejo Gregorio S
- van de Wal Ruud
- van den Heuvel Christian
- van der Zwaan Coen
- van Eck Martijn
- van Kesteren Henricus
- van Zyl Louis
- Varbella Ferdinando
- Varleta Paola
- Vasconcellos Eduardo
- Vasilyeva Larisa
- Vatova Ralitsa
- Vega Damaris
- Velichko Nataliia
- Vera TomĂĄs R
- Vervoort Geert
- Verwerft Jan
- Viktorova Inna
- Vilamajo Oscar G
- Villablanca Alex
- Vinanska Daniela
- Vinereanu Dragos
- Vinereanu Dragos
- Vishneva Elena
- Vishnevsky Alexander
- Viswanathan Girish
- Vizel Saul
- ViĂąas Jaime A
- Vlastaris Anthony
- von Engelhardt Charlotte
- von MĂźnchhausen Candy
- Vora Kishor
- Voyce Steven
- Vrolix Mathias
- Vykoukalova Tatiana
- Wang Hao
- Wang Ji-Hung
- Wang Yi-Chih
- Weiderman Ann-Charlotte
- Weigmann Ingo
- Weirick Troy
- Weiss Melvin
- Welch Michelle
- Welter Ryan
- Werner Henri
- Westendorp Iris
- Whelan Alan
- WidimskĂ˝ Petr
- Wierucki Lukasz
- Wilderman Igor
- Wilke Andreas
- Willems Frank
- Willis John
- Wilson Vance
- Wilson William
- Wiseman Alan
- Witek Robert
- Wojcik Ronald
- Wojnowski Lukasz
- Wolzt Michael
- Wong Brian
- Wong Michelle
- Wongvipaporn Chaiyasith
- Woolf Kevin
- Worthley Matthew
- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano GĂłmez JosĂŠ L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- ZĂłlyomi SzilĂĄrd
- Ădes IstvĂĄn
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11â154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3¡3 years (IQR 2¡8â3¡8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7¡3%] of 5558 vs 480 [8¡6%] of 5596; HR 0¡85 [95% CI 0¡74â0¡97], p=0¡013). The same effect was not observed in patients without PCI (p=0¡76, p interaction=0¡16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3¡1%] with ticagrelor vs 183 (3¡3%) with placebo; HR 0¡96 [95% CI 0¡78â1¡18], p=0¡68), as well as all-cause death (282 [5¡1%] vs 323 [5¡8%]; 0¡88 [0¡75â1¡03], p=0¡11). TIMI major bleeding occurred in 111 (2¡0%) of 5536 patients receiving ticagrelor and 62 (1¡1%) of 5564 patients receiving placebo (HR 2¡03 [95% CI 1¡48â2¡76], p<0¡0001), and fatal bleeding in 6 (0¡1%) of 5536 patients with ticagrelor and 6 (0¡1%) of 5564 with placebo (1¡13 [0¡36â3¡50], p=0¡83). Intracranial haemorrhage occurred in 33 (0¡6%) and 31 (0¡6%) patients (1¡21 [0¡74â1¡97], p=0¡45). Ticagrelor improved net clinical benefit: 519/5558 (9¡3%) versus 617/5596 (11¡0%), HR=0¡85, 95% CI 0¡75â0¡95, p=0¡005, in contrast to patients without PCI where it did not, p interaction=0¡012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF
- Author
- Abd El-Aziz Ahmed
- Abdel-Qader Muwafeg
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Abou Seif Seif Kamal
- Abraham Sunitha
- Accogli Michele
- Acikel Sadik
- ACourt Christine
- Adachi Sen
- Adachi Susumu
- Adalberto Di Paola Leonel
- Adam Matthew
- Adriaansen Henk
- Agata Jun
- Ageta Masato
- Agnelli Giancarlo
- Agrawal Amrish
- Aguilar Juan
- Ahmad Shahid
- Ahmed Fayzal
- Ahuad Guerrero Rodolfo Andres
- Ainsworth Paul
- Akahane Kunio
- Akiyama Masahiro
- Akutsu Mitsuyuki
- Al Mahmeed Wael
- Al Naeemi Abdullah
- Alban Fabio
- Alberto Berli Mario
- Alberto Sambadaro Gustavo
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alfredo Fernandez Alberto
- Alfredo Sinisi Victor
- Ali Amar
- Almeida Fernandez Carlos Alexandre
- Alomairi Munther
- Altun Armagan
- Alvarez Garcia Pere
- Alvarez Lopez Humberto
- Alves Costa Fernando Augusto
- Amano Toshio
- Amarenco Pierre
- Ambrosio Giuseppe
- Andersson Agneta
- Andersson Lars
- Ando Hiroshi
- Ando Shinichi
- Angaran Paul
- Angchaisuksiri Pantep
- Anne Wim
- Anno Takafumi
- Anti Roberto S.
- Aoki Kenji
- Aoyama Takuma
- Arai Hidekazu
- Aranha Rosito Guido Bernardo
- Aras Dursun
- Arasaki Osamu
- Arcocha Tones Maria Fe
- Argena Antonio
- Arima Shinichi
- Arino Torn
- Armaganijan Luciana Vidal
- Arriaga Nava Roberto
- Arriagada German
- Arstall Margaret
- Asano Hiroshi
- Ashida Ko
- Astridge Penny
- Astudillo Carlos
- Atar Dan
- Atsuchi Yoshihiko
- Avino Maria D.
- Axthelm Christoph
- Ayala-Paredes Felix
- Aydinlar Ali
- Aylward Martin
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babyesiza Adyeri
- Balthazar Yohan
- Bantwal Ganapathi
- Barbarash Olga
- Barreda Gonzalez Maria
- Barrow Susan
- Bassand Jean-Pierre
- Baszak Jacek
- Baumbach Sylvia
- Bayat Junaid
- Bayo i Llibre Joan
- Bazargani Nooshin
- Bazzoni Ruiz Alberto Esteban
- Beach Scott
- Bearez Etienne
- Beattie Andre
- Beaudry Philippe
- Beer Juerg H.
- Belenky Dmitry
- Ben Frankel Ben Frankel
- Benavides Gonzalez Mario
- Bennett James
- Benson Lars
- Berg-Johansen Jan
- Berge Eivind
- Berlingieri Joseph
- Berneau Jean-Baptiste
- Bernhardt Peter
- Bernsten Fredrik
- Bet-suyaku Tetsuo
- Beutels Michel
- Bhargava Kartikeya
- Biedrzycka Malgorzata
- Bilas Roman
- Bilo Grzegorz
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bisatt John
- Bisne Vikas
- Blankoff Ivan
- Blenkhorn Adam
- Blombery Peter
- Blumberg Edwin
- Boda Zoltan
- Bodanese Luiz
- Boersma L. V. A.
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonnefoy Marc
- Boon Mark
- Boonyapisit Warangkana
- Borger Jan
- Borjesson Ulf
- Botelho Roberto Vieira
- Bothin Claes
- Boussy Tim
- Bowen-Simpkins Emma
- Boyes Jean-Paul
- Bradshaw Colin
- Bramley Matthew
- Brauer Gunter
- Bremmelgaard Arne
- Brodmann Marianne
- Broilo Franca Cesar Cassio
- Bromham Catherine
- Bronisz Marek
- Brotons Cuixart Carles
- Brugnaux Jean Philippe
- Bruun Michael
- Buchner Thomas
- Bugueno Gutierrez Claudio
- Buiks Cees
- Bulla Claudio
- Bunyapipat Thanita
- Burianova Hana
- Burns D.
- Butler Amy
- Butter Keith
- Cabrera Jardines Ricardo
- Cader Cas
- Caimi Teresa Maria
- Cairns John
- Cameron Alex
- Camm A. John
- Canosa Roddy
- Cantu Brito Carlos Gerardo
- Cao Shiping
- Capiau Luc
- Cappelli Roberto
- Capucci Alessandro
- Cardona Munoz Ernesto
- Carmo Borges Ney Carter
- Carroll Patrick
- Cartwright Simon
- Casassus Frederic
- Caspar Andreas
- Catanchin Andrei
- Cebron Jean-Pierre
- Centurion Nestor
- Cesar Ingaramo Adrian
- Cha James
- Cha Tae-Joon
- Chandwani Prakash
- Charme Vilches Gustavo
- Chatlaong Boonsert
- Chattranukulchai Pairoj
- Chauhan Naresh
- Chawanadelert Seksan
- Chawla Kamaldeep
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Moshui
- Chen Ping
- Chen Yingmin
- Cheng Xiaoshu
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- Short Stephanie
- Shozawa Yasunobu
- Shudo Hiroshi
- Sibon Igor
- Siebert Heidi
- Sievers Britta
- Silaruks Songkwan
- Simmons Phil
- Singh Bhuwanendu
- Singh Rupesh
- Sinha Bijoy
- Sircar S.
- Siriwattana Khanchai
- Sirnes Per Anton
- Skjelvan Gunnar
- Skonieczny Grzegorz
- Smith R.
- Sobhy Mohamed
- Sobolev Konstantin
- Sobral Filho Dario Celestino
- Solgaard Jorgen
- Soma Akira
- Sonoda Ryuji
- Spacek Rudolf
- Spinar Jindrich
- Spyropoulos Alex
- Stalby Per
- Stanislavchuk Mykola
- Starmer Greg
- Steffel Jan
- Steffens Andre
- Stepinska Janina
- Stipp Yvette
- Stockins Fernandez Benjamin Aleck Joseh
- Stoddart Helen
- Stokes Michael
- Strieder E.
- Striekwold Harry
- Strohmer Bernhard
- Sucu Murat
- Suefuji Hisakazu
- Suetsugu Tetsuro
- Sugimoto Chikako
- Sugishita Nobuyoshi
- Sumi Hirokuni
- Sumner Jon
- Sung Jung Hoon
- Supinski Wieslaw
- Suryani Shoeb
- Suzuki Kazuo
- Suzuki Shu
- Suzuki Shunji
- Suzuki Susumu
- Suzuki Yasuyuki
- Svard Gunnar
- Svensson Peter
- Svilaas Arne
- Svyshchenko Yevgeniya
- Swiatkowska-Byczynska Lucyna
- Sychov Oleg
- Sygehus Nwstved
- Sykora Josef
- Szalai Gabriella
- Szantai Gabor
- Tabuchi Toshifumi
- Tachibana Hiroki
- Tada Masato
- Taga Kuniaki
- Taguchi Atsushi
- Taguchi Toshifumi
- Taha Nasser
- Takagi Tsutomu
- Takagi Yoichi
- Takai Hiroyuki
- Takamura Ichiro
- Takanaka Chiei
- Take Shunsuke
- Takeda Hiroshi
- Takei Kazuo
- Takenaka Ken
- Takeuchi Motoshi
- Takezawa Hiroto
- Tana Takeshi
- Tanaka Mitsuru
- Taniguchi Toshiya
- Tao Guizhou
- Tawfik Mazen
- Taya Koichi
- Taylor Gary
- Techigawara Masaaki
- Tedeschi Luca
- Teixeira Marcelo Silveira
- Ten Cate Hugo
- Teragawa Hiroki
- Tercedor Sanchez Luis
- Terpstra W.
- Tessitori Maria
- Testa Sophie
- Theodoro Daniel
- Theron Hendrik
- Thoeng John
- Thomas Nicolas
- Thompson Julian
- Thompson R.
- Thomson Philip
- Thorne Katarina
- Thulin Jorgen
- Timberg Ingar
- Tirafern Eros
- Tiyanon Waraporn
- Tohyo Shuichi
- Tomimoto Shinobu
- Tondo Claudio
- Topsakal Ramazan
- Toran Monserrat Pere
- Toru Shuta
- Toyota Fumitoshi
- Tradati Filippo
- Tragen Dawn
- Tranche Iparraguirre Salvador
- Treasure Charles
- Tseluyko Vira
- Tsubokura Toshio
- Tsuchida Keizo
- Tsuchiya Yoshihiro
- Tsuji Tsuyoshi
- Tsunoda Satoru
- Tsuruta Makoto
- Tsuzaki Ken
- Tumelero Rogerio Tadeu
- Turpie Alexander G. G.
- Tykhonova Susanna
- Ubukata Satoshi
- Uchiyama Hirohide
- Ueckermann Veronica
- Ueda Samu
- Ueda Takashi
- Ueyama Yuya
- Unoki Toshihide
- Uriate Jorge Salerno
- Ushakov Alexey
- Ushakov Oleksiy
- van Eickels Martin
- van Gaal William
- van Guldener Coen
- van Zyl Louis
- Vandamme Xavier
- Vandergoten Peter
- Vangel Sandor
- Vazquez Caamano Maria
- Veale Richard
- Velasco Barcena Jose
- Vercammen Jan
- Vercoe Stephen
- Verheugt Freek W. A.
- Verstraete Stefan
- Vertes Andras
- Vervoort Geert
- Vida Gutierrez Manuel
- Viitanen Carmela
- Vijan Vinod Madan
- Vijayaraghavan Govindan
- Villeda Espinosa Efrain
- Vinolas Xavier
- Virgen Carrillo Luis Ramon
- Vishnevsky Alexander
- Vishwanathan Bhaskhar
- Vizel Saul
- Voet Joeri
- Volpe Massimo
- Vormann Reinhold
- Wada Masamichi
- Wadeson Paul
- Wagner Helga
- Wakaki Nobuo
- Wakasa Yutaka
- Wakeman Anne
- Wakiyama Tetsushi
- Walton Steve
- Wang Daowen
- Wang Yong
- Ward Ben
- Warke A.
- Washizuka Takashi
- Wassef Adel
- Wastling Rebecca
- Watanabe Hiroshi
- Watanabe Masayuki
- Webster Jonathan
- Weeks Phil
- Welker James
- West Richard
- Wetherell Simon
- Wildenauer Cosmas
- Wilkinson Justin
- Willcock W.
- Williams Marcus
- Williams Philip
- Wilson Pete
- Wilson Vance
- Winkler Michael
- Wirdby Alexander
- Wiswedel Henning
- Wollaert Bart
- Wong Bennett
- Wong Kelvin
- Wong Mike
- Wong Toh
- Wongcharoen Wanwarang
- Wozakowska-Kaplon Beata
- Wozniak-Skowerska Iwona
- Wu Tongguo
- Xhaet Olivier
- Xiong Longgen
- Xue Li
- Yagensky Andriy
- Yakupov Eduard
- Yamagishi Takashi
- Yamaguchi Hiroshi
- Yamamoto Kenichi
- Yamamoto Kentaro
- Yamamoto Kiichiro
- Yamamoto Kunihiko
- Yamamoto Taku
- Yamasawa Masanori
- Yan Xiaowei
- Yang Ping
- Yang Yuejin
- Yang Zhiming
- Yasui Kiyoshi
- YILMAZ MEHMET BÄ°RHAN
- Yilmaz Ozcan
- Yin Yuehui
- Yokota Naoto
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yousef Ghazi
- Yuyang Tan
- Zaitsu Ryuji
- Zaluska Roman
- Zaman Kashif
- Zapata Gerardo
- Zateyshchikov Dmitry
- Zateyshchikova Anna
- Zauzig Heinz-Dieter
- Zemlianskaia Oksana
- Zhang Huaiqin
- Zhao Ruiping
- Zhao Yusheng
- Zhurba Svitlana
- Zidkova Eva
- Zimny Hans-Hermann
- Zinka Elzbieta
- Zrazhevskiy Konstantin
- Zuber Mathieu
- Zutz Stefan
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/12/2019
- Field of study
BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes