102 research outputs found
Surgery of pulmonary aspergillomas in immunocompromised patients
Introduction: Pulmonary aspergillosis is a devastating complication in immunocompromised patients. Timing of surgery is controversial and depends on the patients' general condition
Surgery of pulmonary aspergillomas in immunocompromised patients
Introduction: Pulmonary aspergillosis is a devastating complication in immunocompromised patients. Timing of surgery is controversial and depends on the patients' general condition
Current problems in serologically based diagnostic algorithm of HIV 1/2: The re-evaluation of immunodot blot assays in HIV 1/2 verification in Turkey
Miz1 Is a Critical Repressor of cdkn1a during Skin Tumorigenesis
The transcription factor Miz1 forms repressive DNA-binding complexes with the Myc, Gfi-1 and Bcl-6 oncoproteins. Known target genes of these complexes encode the cyclin-dependent kinase inhibitors (CKIs) cdkn2b (p15Ink4), cdkn1a (p21Cip1), and cdkn1c (p57Kip2). Whether Miz1-mediated repression is important for control of cell proliferation in vivo and for tumor formation is unknown. Here we show that deletion of the Miz1 POZ domain, which is critical for Miz1 function, restrains the development of skin tumors in a model of chemically-induced, Ras-dependent tumorigenesis. While the stem cell compartment appears unaffected, interfollicular keratinocytes lacking functional Miz1 exhibit a reduced proliferation and an accelerated differentiation of the epidermis in response to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tumorigenesis, proliferation and normal differentiation are restored in animals lacking cdkn1a, but not in those lacking cdkn2b. Our data demonstrate that Miz1-mediated attenuation of cell cycle arrest pathways via repression of cdkn1a has a critical role during tumorigenesis in the skin
Effect of methylimidazole on cellulose/ionic liquid solutions and regenerated material therefrom
Botulinumtoxin versus thorakoskopische Sympathektomie bei Patienten mit palmarer Hyperhidrose
Enzymatic pulp modification: an excellent way to expand the raw material base for Lyocell applications?
Kryptokokkose - eine seltene Differentialdiagnose bei immunkompetentem Patienten. Ein Fallbeispiel
A methodology for the sustainable design and implementation strategy of CO<sub>2</sub> utilization processes
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