eGovernment: Processing of Information About Economic Subjects

Tato bakalářská práce se zabývá elektronickou veřejnou správou v ČR, jak po stránce informačních technologií, tak i po stránce legislativní. Popisuje vybrané rejstříky státní správy, zejména informační systém ARES, který je využit v návrhu praktické části práce. Výsledkem práce je aplikace, která získává údaje z více rejstříků. Údaje pak spojuje a vizuálně interpretuje uživateli. Aplikace je vytvořena pomocí knihoven QT v jazyce C++.This bachelor's thesis deals with eGovernment of the Czech Republic, as in terms of information technology, as well as legislative. The thesis describes selected registers of eGovernment of the Czech Republic, especially ARES information system, which is used in proposition of practical part of the thesis. The outcome of the thesis is the aplication that retriever data from multiple registers. Data are combined are visually interpreted to user. The aplication is created with assistance of QT Libraries of language C++.

ANALYSIS OF MECHANICAL PROPERTIES OF HYDROTHERMALLY CURED HIGH STRENGTH CEMENT MATRIX FOR TEXTILE REINFORCED CONCRETE

The main objective of this article is to describe the influence of hydrothermal curing conditions in an autoclave device (different pressure and temperature), which took place at various ages of a fresh mixture (cement matrix – CM, and fibre-reinforced cement matrix – FRCM), on textile reinforced concrete production. The positive influence of autoclaving has been evaluated through the results of physical and mechanical testing – compressive strength, flexural strength, bulk density and dynamic modulus of elasticity, which have been measured on specimens with the following dimensions: 40×40×160mm3. In addition, it has been found that increasing the pressure and temperature resulted in higher values of measured characteristics. The results indicate that the most suitable surrounding conditions are 0.6MPa, and 165 °C at the age of 21 hours; the final compressive strength of cement matrix is 134.3MPa and its flexural strength is 25.9MPa (standard cured samples achieve 114.6MPa and 15.7MPa). Hydrothermal curing is even more effective for cement matrix reinforced by steel fibres (for example, the compressive strength can reach 177.5MPa, while laboratory-cured samples achieve a compressive strength of 108.5MPa)

RESPONSE OF HIGH-PERFORMANCE FIBRE REINFORCED CONCRETE REINFORCED BY TEXTILE REINFORCEMENT TO IMPACT LOADING

Generally, cement composites like high-performance concrete (HPC) are very brittle. The resistance to the impact loading of the HPFRC and the HPFRC reinforced by the textile reinforcement are compared in this article. The samples (0.56 × 0.1 × 0.1 m) were experimentally tested in three-point bending, by using horizontal impact machine. The better resistance of the textile reinforced HPFRC is obvious from the collected data (impact force, acceleration of hammer and acceleration of the tested sample)

CYCLIC TEMPERATURE LOADING RESIDUAL FLEXURAL STRENGHT OF REFRACTORY SLABS

This paper describes the effect of cyclic elevated temperature loading on refractory slabs made from high performance, fibre reinforced cement composite. Slabs were produced from aluminous cement-based composites, reinforced by different dosages of basalt fibres. The composite investigated in this study had self-compacting characteristics. The slabs used were exposed to different thermal loading – 600 °C, 1000 °C, six times applied 600 °C and 1000 °C. Then, flexural strength was investigated in all groups of slabs, including group reference slabs with no thermal loading. The results show that the appropriate combination of aluminous cement, natural basalt aggregate, fine filler and basalt fibres in dosage 1.00% of volume is able to successfully resist to cyclic temperature loading. Tensile strength in bending of these slabs (after cyclic temperature loading at 600 °C) achieved 6.0 MPa. It was demonstrated that it is possible to use this composite for high extensive conditions in real industrial conditions

Response of Refractory Cement Based Composite to Gradual Temperature Loading

This paper deals with the experimental study of the response of refractory concrete mixture to gradual thermal loading, up to 1000 °C. A binding system based on calcium aluminate cement (CAC) modified by the partial replacement of metakaolin was used. Short ceramic fibers were applied in a dose of 4% by volume in the studied mixture. Material transformations due to thermal loading were monitored in terms of residual mechanical, fracture and basic physical properties-compressive strength, flexural strength, fracture energy, dynamic modulus of elasticity, and bulk density in the study. The results obtained corresponded well with the mineral transformations monitored using the thermogravimetric analysis performed on the binder paste. Residual values of compressive and flexural strength were approximately 40% of the initial values after exposure to a temperature of 1000°C; however, the dominant part of the total loss was monitored up to 400°C, due to decomposition of the hydrates. Fiber employment contributed considerably to the resistance against thermal loading up to 400°C, which was demonstrated by the fracture energy results (a loss of 25% was monitored). An additional increase of the temperature load led to micro crack propagation, which was obvious in the results of dynamic modulus of elasticity determination, in which the short fiber incorporation was noticeably limited

EVALUATION OF THE APPLICATION OF A THERMAL INSULATION SYSTEM: INSITU COMPARISSON OF SEASONAL AND DAILY CLIMATIC FLUCTUATIONS

The current outdated state of many institutional and administrative buildings in the EU region poses a significant burden from the energy sustainability point of view. According to the contemporary EU requirements on the energy efficiency of buildings maintenance, an evaluation of performed improvements is essential for the assessment of expended investments. This paper describes the effect of building envelope reconstruction works consisting in the installation of a thermal insulation system. Here, a long-term continuous monitoring is used for the extensive assessment of the seasonal and daily temperature and relative humidity fluctuations. The obtained results include temperature and relative humidity profiles in the wall cross-section as a response to the changing exterior climatic conditions. The analysis of measured data reveals substantial improvements in thermal stability of the analyzed wall during temperature peaks. While the indoor temperatures exceeding 28 °C are recorded during summer before application of the thermal insulation layer, the thermal stability of the indoor environment is distinctly upgraded after performed improvements. Based on the complex long-term monitoring, a relevant experience is gained for the future work on energy sustainability and fulfilment of the EU directives

APPLICABILITY OF CARBON FIBRES IN REFRACTORY CEMENT COMPOSITES

The main objective of this article is to present the influence of high temperatures on mechanical properties of advanced refractory cement composite reinforced with carbon fibres. The presented material is suitable for industrial applications and can withstand elevated temperatures up to 1000 °C. The action of high temperatures was investigated on two temperature levels 600 °C and 1000 °C and was compared to reference specimens dried at 105 °C. The carbon fibres with flexural strength of 4100MPa were applied in dosage 0.50 %, 0.75% and 1.00% of the total volume. The second investigated modification was mutual ratio between aluminous cement and fine ceramic powder. The influence of high temperatures was investigated by measuring the bulk density, compressive and flexural strength, dynamic modulus of elasticity and fracture energy; all measured on prismatic specimens 40 × 40 × 160 mm. The workability of fresh mixture was limited by the maximum dosage of carbon fibres in 1% of the total volume. Based on the workability and evaluation of residual mechanical properties after temperature loading, the best was found to be the combination of carbon fibres in dosage of 0.75% by volume

Thermophysical and mechanical properties of fiber‐reinforced composite material subjected to high temperatures

The bulk density, open porosity, matrix density, tensile strength, bending strength, thermal diffusivity, specific heat capacity, thermal conductivity and linear thermal expansion coefficient of high‐density glass fiber reinforced cement composite are determined as functions of temperature up to 1000 °C. The basic physical parameters and mechanical parameters are found to exhibit the most important changes between the reference state and 600 °C pre‐heating where the increase of porosity is as high as 40% and both the tensile strength and bending strength decrease to about one third of their original values. The measured dependences of thermal diffusivity and thermal conductivity on temperature indicate that the heat transfer in the studied material is accelerated once temperature achieves 500–600 °C but the change in heat storage expressed by the specific heat capacity is less important. The linear thermal expansion coefficient is not found to be affected by high temperatures in a negative way; it is either lower or comparable to its low‐temperature values. Santrauka Tiriama, kaip kinta tankiojo stiklo pluoštu armuoto cementinio kompozito tankis, atvirasis poringumas, matricinis tankis, tempiamasis bei lenkiamasis stipris, terminis laidumas, savitasis šilumos imlumas, savitasis šilumos laidumas ir tiesinis terminio pletimosi koeficientas, kai šia medžiaga veikia temperatūra, kylanti iki 1000 °C. Rasta, kad pagrindiniai fiziniai ir mechaniniai parametrai daugiausia keičiasi temperatūrai kylant nuo pradines iki 600 °C. Šioje temperatūros kilimo atkarpoje poringumas išaugo iki 40 %, o tempiamasis ir lenkiamasis stipriai sumažejo maždaug trečdaliu, palyginti su pradinemis reikšmemis. Išmatuotoji terminio laidumo ir savitojo šilumos laidumo priklausomybe nuo temperatūros rodo, kad šilumos perdavimas tiriamoje medžiagoje pagreiteja temperatūrai pasiekus 500–600 °C, tačiau šilumos kaupimas, išreikštas savituoju šilumos imlumu, yra ne toks svarbus. Nenustatyta, kad tiesinis terminio pletimosi koeficientas būtu neigiamai veikiamas aukštos temperatūros. Šio koeficiento reikšmes yra mažesnes arba maždaug lygios reikšmems, išmatuotoms žemoje temperatūroje. First Published Online: 10 Feb 2011 Reikšminiai žodžiai: stiklo pluoštu stiprinti cemento kompozitai, aukšta temperatūra, tempiamasis stipris, lenkiamasis stipris, terminis laidumas, savitasis šilumos imlumas, savitasis šilumos laidumas, tiesinis terminio pletimosi koeficienta

Physical and Mechanical Properties of Composites Made with Aluminous Cement and Basalt Fibers Developed for High Temperature Application

Present paper deals with the experimental study of the composition of refractory fiber-reinforced aluminous cement based composites and its response to gradual thermal loading. Basalt fibers were applied in doses of 0.25, 0.5, 1.0, 2.0, and 4.0% in volume. Simultaneously, binder system based on the aluminous cement was modified by fine ground ceramic powder originated from the accurate ceramic blocks production. Ceramic powder was dosed as partial replacement of used cement of 5, 10, 15, 20, and 25%. Influence of composition changes was evaluated by the results of physical and mechanical testing; compressive strength, flexural strength, bulk density, and fracture energy were determined on the different levels of temperature loading. Increased dose of basalt fibers allows reaching expected higher values of fracture energy, but with respect to results of compressive and flexural strength determination as an optimal rate of basalt fibers dose was considered 0.25% in volume. Fine ground ceramic powder application led to extensive increase of residual mechanical parameters just up to replacement of 10%. Higher replacement of aluminous cement reduced final values of bulk density but kept mechanical properties on the level of mixtures without aluminous cement replacement

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases. Additionally, NLRP3 gain-of-function point mutations cause systemic periodic fever syndromes that are collectively known as cryopyrin-associated periodic syndrome (CAPS). There is significant interest in the discovery and development of diarylsulfonylurea Cytokine Release Inhibitory Drugs (CRIDs) such as MCC950/CRID3, a potent and selective inhibitor of the NLRP3 inflammasome pathway, for the treatment of CAPS and other diseases. However, drug discovery efforts have been constrained by the lack of insight into the molecular target and mechanism by which these CRIDs inhibit the NLRP3 inflammasome pathway. Here, we show that the NAIP, CIITA, HET-E, and TP1 (NACHT) domain of NLRP3 is the molecular target of diarylsulfonylurea inhibitors. Interestingly, we find photoaffinity labeling (PAL) of the NACHT domain requires an intact (d)ATP-binding pocket and is substantially reduced for most CAPS-associated NLRP3 mutants. In concordance with this finding, MCC950/CRID3 failed to inhibit NLRP3-driven inflammatory pathology in two mouse models of CAPS. Moreover, it abolished circulating levels of interleukin (IL)-1 beta and IL-18 in lipopolysaccharide (LPS)-challenged wild-type mice but not in Nlrp3(L351P) knock-in mice and ex vivo-stimulated mutant macrophages. These results identify wild-type NLRP3 as the molecular target of MCC950/CRID3 and show that CAPS-related NLRP3 mutants escape efficient MCC950/CRID3 inhibition. Collectively, this work suggests that MCC950/CRID3-based therapies may effectively treat inflammation driven by wild-type NLRP3 but not CAPS-associated mutants