Hydroxyapatite Nanocrystal Deposition on Plasma Modified Titanium Surface

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is materials mainly known for its special ability to contact bone tissue. Nanostructures on implant surfaces, a coating composed of nano-HAp particles on Ti, have aroused increasing research interest in the biomedical field. In this study, we prepared HAp nanocrystal coated Ti surface by plasma surface modification and wet chemical method and then evaluated biological behavior of MC3T3-E1 on the HAp coated on plasma modified Ti surface. Nano-size crystals of sintered HAp were uniformly coated on polyacrylic acid (PAA) deposited Ti surface through the ionic interaction between calcium ions on the HAp nanocrystal and carboxyl groups on the PAA/Ti. In vitro cell tests revealed surface modification of Ti surface with HAp nanocrystal significantly improved the proliferation and growth of the osteoblastic MC3T3-E1 cells and induced them to differentiate at an enhanced level. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3495

e^+e^- Pair Production from γ\gamma A Reactions

We present a calculation of e^+e^- production in $\gamma A$ reactions at MAMI and TJNAF energies within a semi-classical BUU transport model. Dilepton invariant mass spectra for $\gamma$C, $\gamma$Ca and $\gamma$Pb are calculated at 0.8, 1.5 and 2.2 GeV. We focus on observable effects of medium modifications of the $\rho$ and $\omega$ mesons. The in-medium widths of these mesons are taken into account in a dynamical, consistent way. We discuss the transport theoretical treatment of broad resonances.Comment: 42 pages including 16 figure

Distorted magnetic orders and electronic structures of tetragonal FeSe from first-principles

We use the state-of-the-arts density-functional-theory method to study various magnetic orders and their effects on the electronic structures of the FeSe. Our calculated results show that, for the spins of the single Fe layer, the striped antiferromagnetic orders with distortion are more favorable in total energy than the checkerboard antiferromagnetic orders with tetragonal symmetry, which is consistent with known experimental data, and the inter-layer magnetic interaction is very weak. We investigate the electronic structures and magnetic property of the distorted phases. We also present our calculated spin coupling constants and discuss the reduction of the Fe magnetic moment by quantum many-body effects. These results are useful to understand the structural, magnetic, and electronic properties of FeSe, and may have some helpful implications to other FeAs-based materials

Complex and unexpected dynamics in simple genetic regulatory networks

Peer reviewedPublisher PD

Identification of the initial molecular changes in response to circulating angiogenic cells-mediated therapy in critical limb ischemia

BackgroundCritical limb ischemia (CLI) constitutes the most aggressive form of peripheral arterial occlusive disease, characterized by the blockade of arteries supplying blood to the lower extremities, significantly diminishing oxygen and nutrient supply. CLI patients usually undergo amputation of fingers, feet, or extremities, with a high risk of mortality due to associated comorbidities.Circulating angiogenic cells (CACs), also known as early endothelial progenitor cells, constitute promising candidates for cell therapy in CLI due to their assigned vascular regenerative properties. Preclinical and clinical assays with CACs have shown promising results. A better understanding of how these cells participate in vascular regeneration would significantly help to potentiate their role in revascularization.Herein, we analyzed the initial molecular mechanisms triggered by human CACs after being administered to a murine model of CLI, in order to understand how these cells promote angiogenesis within the ischemic tissues.MethodsBalb-c nude mice (n:24) were distributed in four different groups: healthy controls (C, n:4), shams (SH, n:4), and ischemic mice (after femoral ligation) that received either 50 mu l physiological serum (SC, n:8) or 5x10(5) human CACs (SE, n:8). Ischemic mice were sacrificed on days 2 and 4 (n:4/group/day), and immunohistochemistry assays and qPCR amplification of Alu-human-specific sequences were carried out for cell detection and vascular density measurements. Additionally, a label-free MS-based quantitative approach was performed to identify protein changes related.ResultsAdministration of CACs induced in the ischemic tissues an increase in the number of blood vessels as well as the diameter size compared to ischemic, non-treated mice, although the number of CACs decreased within time. The initial protein changes taking place in response to ischemia and more importantly, right after administration of CACs to CLI mice, are shown.ConclusionsOur results indicate that CACs migrate to the injured area; moreover, they trigger protein changes correlated with cell migration, cell death, angiogenesis, and arteriogenesis in the host. These changes indicate that CACs promote from the beginning an increase in the number of vessels as well as the development of an appropriate vascular network.Institute of Health Carlos III, ISCIII; Junta de Andaluci

Study of π0\pi^0 pair production in single-tag two-photon collisions

We report a measurement of the differential cross section of $\pi^0$ pair production in single-tag two-photon collisions, $\gamma^* \gamma \to \pi^0 \pi^0$, in $e^+ e^-$ scattering. The cross section is measured for $Q^2$ up to 30 GeV$^2$, where $Q^2$ is the negative of the invariant mass squared of the tagged photon, in the kinematic range 0.5 GeV < W < 2.1 GeV and $|\cos \theta^*|$ < 1.0 for the total energy and pion scattering angle, respectively, in the $\gamma^* \gamma$ center-of-mass system. The results are based on a data sample of 759 fb$^{-1}$ collected with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. The transition form factor of the $f_0(980)$ and that of the $f_2(1270)$ with the helicity-0, -1, and -2 components separately are measured for the first time and are compared with theoretical calculations.Comment: 36 pages, 37 figures, 11 tables, Belle Preprint 2015-15, KEK Preprint 2015-2

Measurement of the branching ratio of Bˉ→D(∗)τ−νˉτ\bar{B} \to D^{(\ast)} \tau^- \bar{\nu}_\tau relative to Bˉ→D(∗)ℓ−νˉℓ\bar{B} \to D^{(\ast)} \ell^- \bar{\nu}_\ell decays with hadronic tagging at Belle

We report a measurement of the branching fraction ratios R(D(*)) of Bbar -> D(*) tau- nubar_tau relative to Bbar -> D()* l- nubar_l (where l = e or mu) using the full Belle data sample of 772 x 10^6 BBbar pairs collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. The measured values are R(D)= 0.375 +- 0.064(stat.) +- 0.026(syst.) and R(D*) = 0.293 +- 0.038(stat.) +- 0.015(syst.). The analysis uses hadronic reconstruction of the tag-side B meson and purely leptonic tau decays. The results are consistent with earlier measurements and do not show a significant deviation from the standard model prediction.Comment: Accepted for publication in Phys.Rev.