Hydroxyapatite (Ca10(PO4)6(OH)2, HAp) is materials mainly known for its special ability to contact
bone tissue. Nanostructures on implant surfaces, a coating composed of nano-HAp particles on Ti, have
aroused increasing research interest in the biomedical field. In this study, we prepared HAp nanocrystal
coated Ti surface by plasma surface modification and wet chemical method and then evaluated biological
behavior of MC3T3-E1 on the HAp coated on plasma modified Ti surface. Nano-size crystals of sintered
HAp were uniformly coated on polyacrylic acid (PAA) deposited Ti surface through the ionic interaction between
calcium ions on the HAp nanocrystal and carboxyl groups on the PAA/Ti. In vitro cell tests revealed
surface modification of Ti surface with HAp nanocrystal significantly improved the proliferation and
growth of the osteoblastic MC3T3-E1 cells and induced them to differentiate at an enhanced level.
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