Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability

International audienc

Outcomes of 94 cases of PPROM before 24 WG.

<p>WG: Weeks of Gestation; EPPROM: Early Preterm Premature Rupture Of Membranes; NCIU: Neonatal Intensive Care Unit.</p

Comparison of neonatal complications.

<p>WG: weeks of gestation; A/S: Affected/Survivors; <b>*</b> Inflammatory disease: Periventricular leukomalacia, and/or IVH and/or chronic lung disease and/or necrotizing enterocolitis and/or death.</p

Comparison of neonatal criteria.

<p>SD: standard deviation; WG: weeks of gestation; gr: gram; ^<b>1</b> Difference of means, impact of rupture of membranes on the variable; * non interpretable.</p

Comparison of maternal, pregnancy and labour characteristics.

<p>SD: standard deviation; ^<b>1</b> Repetitive urinary or vaginal infections; ^<b>2</b> Uterus malformation, cervix insufficiency, conisation; ^<b>3</b> Interruption of pregnancy, C section, preterm birth; <b>*</b> non interpretable.</p

Clinician-reported symptomatic adverse events in cancer trials: are they concordant with patient-reported outcomes?

We investigate the concordance, in terms of favoring the same treatment arm, between clinician-reported symptomatic adverse events (AEs) and information obtained via patient-reported outcomes (PRO) measures in cancer randomized controlled trials (RCTs)

Dementia Carers Instrument Development (DECIDE) workstream 1, phase 3: psychometric evaluation

Kings Coll Hosp London, London, EnglandKarolinska Inst, Stockholm, SwedenEge Univ Hosp, Izmir, TurkeyMed Univ Gdansk, Gdansk, PolandHosp Santa Creu & Sant Pau, Barcelona, SpainNagoya City Univ, Grad Sch Med Sci, Nagoya, Aichi, JapanGuangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R ChinaAvicenne Hosp, AP HP, Bobigny, FranceUniv Fed Sao Paulo, Paulista Sch Med, Sao Paulo, BrazilMapi, Lyon, FranceUniv Cincinnati, Cincinnati, OH USAUniv Fed Sao Paulo, Paulista Sch Med, Sao Paulo, BrazilWeb of Scienc

Outcome at Two Years of Very Preterm Infants Born after Rupture of Membranes before Viability

To compare the respiratory and neurological outcomes at two years of age of preterm children born before 33 weeks of gestation (WG) after early preterm premature rupture of membranes (EPPROM) between 14 and 24 WG with preterm children without EPPROM.This single-center case-control retrospective study was conducted at Rouen University Hospital between 1st January 2000 and 31st December 2010. All the cases with EPPROM born from 26WG to 32WG were included. Each newborn was matched by sex, gestational age (GA) and year of birth to two very preterm children, born without EPPROM. At two years of corrected age, motor and cognitive abilities were assessed by routine score based on the Amiel-Tison and Denver developmental scales.Ninety-four cases with EPPROM before 24WG have been included. The 31 children born from 26WG to 32WG were matched with 62 controls. The EPPROM group had poorer clinical evaluation at one year for motor (p = 0.003) and cognitive developmental scores (p = 0.016). Neuromotor rehabilitation was performed more often (p = 0.013). However, there was no difference at 2 years of age. Children born after EPPROM were hospitalized more often for bronchiolitis (p<0.001) during their first 2 years, which correlates with increased incidence of pneumothorax (p = 0.017), pulmonary hypoplasia (p = 0.004) and bronchopulmonary dysplasia (p = 0.005) during neonatal period.At two years, despite an increase in severe bronchiolitis and the need for more neuromotor rehabilitation during the first month of the life after discharge, there was no difference in neurological outcomes in the very preterm children of the EPPROM group compared to those born at a similar GA without EPPROM