Short-lived solar burst spectral component at f approximately 100 GHz

A new kind of burst emission component was discovered, exhibiting fast and distinct pulses (approx. 60 ms durations), with spectral peak emission at f approx. 100 GHz, and onset time coincident to hard X-rays to within approx. 128 ms. These features pose serious constraints for the interpretation using current models. One suggestion assumes the f approx. 100 GHz pulses emission by synchrotron mechanism of electrons accelerated to ultrarelativistic energies. The hard X-rays originate from inverse Compton scattering of the electrons on the synchrotron photons. Several crucial observational tests are needed for the understanding of the phenomenon, requiring high sensitivity and high time resolution (approx. 1 ms) simultaneous to high spatial resolution (0.1 arcsec) at f approx. 110 GHz and hard X-rays

The possible importance of synchrotron/inverse Compton losses to explain fast mm-wave and hard X-ray emission of a solar event

The solar burst of 21 May 1984, presented a number of unique features. The time profile consisted of seven major structures (seconds), with a turnover frequency of greater than or approximately 90 GHz, well correlated in time to hard X-ray emission. Each structure consisted of multiple fast pulses (0.1 seconds), which were analyzed in detail. A proportionality between the repetition rate of the pulses and the burst fluxes at 90 GHz and greater than or approximately 100 keV hard X-rays, and an inverse proportionality between repetition rates and hard X-ray power law indices were found. A synchrotron/inverse Compton model was applied to explain the emission of the fast burst structures, which appear to be possible for the first three or four structures

Inhibitory effect on ovarian cancer ALDH+ stem-like cells by Disulfiram and Copper treatment through ALDH and ROS modulation

BACKGROUND: Disulfiram (DSF) is a drug used for treatment of alcoholism that has also displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity of aldehyde dehydrogenase (ALDH) isoforms. METHODS: MTT assay, spheroid formation, clonogenicity assay, qRT-PCR, and ALDH enzyme activity analysis were performed using ovarian cancer cell lines IGROV1, SKOV3 and SKOV3IP1. Cell cycle analyses and measurement of intracellular reactive oxygen species (ROS) were carried out by flow cytometry. ALDH+ and ALDH- cells were isolated by FACS sorting. RESULTS: ALDH activity was inhibited in ovarian cancer stem cells (the proportion of ALDH+ cells was reduced from 21.7% to 0.391%, 8.4% to 0%, 6.88% to 0.05% in cell lines IGROV1, SKOV3, and SKOV3IP1, respectively). DSF with or without the cofactor copper (Cu2+) exhibited cytotoxicity dose- and time-dependent and enhanced cisplatin-induced apoptosis. DSF + Cu2+ increased intracellular ROS levels triggering apoptosis of ovarian cancer stem cells (CSC). Significantly more colony and spheroid formation was observed in ALDH+ compared with ALDH- cells (P < 0.01). Moreover, ALDH+ cells were more resistant to cisplatin treatment compared with ALDH-cells (P < 0.05) and also exhibited a lower basal level of ROS. However, no significant difference in ROS accumulation nor in cellular viability was observed in ALDH + cells in comparison to ALDH- cells after pre-treatment with DSF (0.08 μM). CONCLUSION: Our findings provide evidence that DSF might be employed as a novel adjuvant chemotherapeutic agent in combination with cisplatin for treatment of ovarian cancer

The possible importance of synchrotron/inverse Compton losses to explain fast MM-wave and hard X-ray emission of a solar event

The solar burst of 21 May 1984 presented a number of unique features. The time profile consisted of seven major structures (seconds), with a turnover frequency or approx. 90 GHz, well correlated in time to hard X-ray emission. Each structure consisted of multiple fast pulses (.1 seconds), which were analyzed in detail. A proportionality between the repetition rate of the pulses and the burst fluxes at 90 GHz and or approx. 100 keV hard X-rays, and an inverse proportionality between repetition rates and hard X-rays power law indices have been found. A synchrotron/inverse Compton model has been applied to explain the emission of the fast burst structures, which appear to be possible for the first three or four structures

A new class of solar burst with MM-wave emission but only at the highest frequency (90 GHz)

High sensitivity and high time resolution solar observations at 90 GHz (lambda = 3.3 mm) have identified a unique impulsive burst on May 21, 1984 with emission that was more intense at this frequency than at lower frequencies. The first major time structure of the burst was over 10 times more intense at 90 GHz than at 30 GHz, 7 GHz, or 2.8 GHz.Only 6 seconds later, the 30 GHz impulsive structures started to be observed but still with lower intensity than at 90 GHz. Hard X-ray time structures at energies above 25 keV were almost identical to the 90 GHZ structures (to better than one second). All 90 GHz major time structures consisted of trains of multiple subsecond pulses with rise times as short as 0.03 sec and amplitudes large compared to the mean flux. When detectable, the 30 GHz subsecond pulses had smaller relative amplitude and were in phase with the corresponding 90 GHz pulses

Infinite-Randomness Fixed Points for Chains of Non-Abelian Quasiparticles

One-dimensional chains of non-Abelian quasiparticles described by $SU(2)_k$ Chern-Simons-Witten theory can enter random singlet phases analogous to that of a random chain of ordinary spin-1/2 particles (corresponding to $k \to \infty$). For $k=2$ this phase provides a random singlet description of the infinite randomness fixed point of the critical transverse field Ising model. The entanglement entropy of a region of size $L$ in these phases scales as $S_L \simeq \frac{\ln d}{3} \log_2 L$ for large $L$, where $d$ is the quantum dimension of the particles.Comment: 4 pages, 4 figure

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Context: Soft-tissue injuries are commonly treated with ice or menthol gels. Few studies have compared the effects of these treatments on blood flow and muscle strength. Objective: To compare blood flow and muscle strength in the forearm after an application of ice or menthol gel or no treatment. Design: Repeated measures design in which blood-flow and muscle-strength data were collected from subjects under 3 treatment conditions. Setting: Exercise physiology laboratory. Participants: 17 healthy adults with no impediment to the blood flow or strength in their right arm, recruited through word of mouth. Intervention: Three separate treatment conditions were randomly applied topically to the right forearm: no treatment, 0.5 kg of ice, or 3.5 mL of 3.5% menthol gel. To avoid injury ice was only applied for 20 min. Main Outcome Measures: At each data-collection session blood flow (mL/min) of the right radial artery was determined at baseline before any treatment and then at 5, 10, 15, and 20 min after treatment using Doppler ultrasound. Muscle strength was assessed as maximum isokinetic flexion and extension of the wrist at 30°/s 20, 25, and 30 min after treatment. Results: The menthol gel reduced (–42%, P \u3c .05) blood flow in the radial artery 5 min after application but not at 10, 15, or 20 min after application. Ice reduced (–48%, P \u3c .05) blood flow in the radial artery only after 20 min of application. After 15 min of the control condition blood flow increased (83%, P \u3c .05) from baseline measures. After the removal of ice, wrist-extension strength did not increase per repeated strength assessment as it did during the control condition (9–11%, P \u3c .05) and menthol-gel intervention (8%, P \u3c .05). Conclusions: Menthol has a fast-acting, short-lived effect of reducing blood flow. Ice reduces blood flow after a prolonged duration. Muscle strength appears to be inhibited after ice application

Association of mid-infrared solar plages with Calcium K line emissions and magnetic structures

Solar mid-IR observations in the 8-15 micrometer band continuum with moderate angular resolution (18 arcseconds) reveal the presence of bright structures surrounding sunspots. These plage-like features present good association with calcium CaII K1v plages and active region magnetograms. We describe a new optical setup with reflecting mirrors to produce solar images on the focal plane array of uncooled bolometers of a commercial camera preceded by germanium optics. First observations of a sunspot on September 11, 2006 show a mid-IR continuum plage exhibiting spatial distribution closely associated with CaII K1v line plage and magnetogram structures. The mid-IR continuum bright plage is about 140 K hotter than the neighboring photospheric regions, consistent with hot plasma confined by the magnetic spatial structures in and above the active regionComment: 5 pages, 4 figures. Accepted by PAS