Repair of damaged supraglottic airway devices: A novel method

Damage of laryngeal mask airway and other supraglottic airway devices has always been a matter of concern. Although manufacturer recommends maximum 40 uses of LMA (and its congeners) but damage before 40 uses needs to be evaluated. We hereby, describe a novel method of repair of supraglottic devices when damage occurs at mask inflation line or pilot balloon valve assembly

Efficacy of Manjisthadi Yoga in Paracetamol induced Hepatotoxicity in Wistar Rat

The liver is one of the most essential organs in the body, as it regulates a variety of physiological functions. It plays a role in metabolism, secretion, storage and among other things. It has a high ability for detoxication and the creation of beneficial principles. A nutritious meal is essential for developing tissue and cells, however nowadays people avoid eating healthy meals in favor of fast food to save time and money. This junk food is jam-packed with pollutants like phthalates that are bad for the body, as well as excessive amounts of sugar, salt and trans-fat. Numerous metabolic illnesses and systemic issues like obesity, diabetes and liver disease are caused by them. This type of meal or cuisine is referred to as Viruddha Aahara in Ayurveda. Viruddh Aahara, when consumed in excess, agitates the Doshas at their locations and remains in the body, blocking channels (Strotoavrodha). This block prevents nutrients from reaching the Dhatus (tissue) and many Dhatujanya Vikara develop as a result. As a result, hepatotoxic chemicals' injury to the liver has serious consequences. Toxic substances, excessive alcohol intake, virus infections, medicines such as paracetamol, antibiotics and autoimmune disorders are the main causes of liver damage. Taking the all the above facts in consideration the selection of the study has been done

Enhanced One Dimensional Modeling for Predicting Concentration of BOD in rivers

To maintain the river water quality it is necessary to predict the concentration of biochemical oxygen demand (BOD) in rivers. Various one dimensional models that  are developed so far  are applicable only after complete mixing of the pollutant across the cross-section is over which may take longer time for rivers with large width. Such type of situations is not represented effectively by the existing one dimensional model. Moreover, many of these one dimensional models do not account for the settle able part of BOD that invariably takes place when partially treated/ untreated waste enters these water bodies. A model is developed that is not more complicated than a one dimensional model but rationally predict the transport of BOD causing pollutant in almost 80% of initial period. The presented model can be used in conditions when partially treated/untreated waste is discharged in rivers with large width. Keywords: Mathematical Model, BOD, Water Pollutio

AYURVEDIC MEDICINAL PLANT - SHALA (SHOREA ROBUSTA) (A BIRD'S EYE VIEW)

Since the time immemorial the society always relay on plants not only for the diet  resources but also for medicinal purposes along with ecological balance, so that all the creatures of god starting from birth to death spend their life in a manner of dignity or we may say healthy and disease free life. From Vedic era there is a lot of descriptions regarding plants along with their therapeutic properties were available and gradually the same were added as the time progress till the date. As per Ancient Indian Literatures Shorea robusta is cosidered as a Holy Tree said to be the favourite of Lord Maha vishnu which is commnly known as Indian Dammer. Shorea robusta finds its use in Ayurveda, Unani and tribal systems of medicine. It has many medicinal properties, but the tree is valued mostly for its ability to stop bleeding piles and provide relief to the patient. The bark, leaves, fruit and resin of the Shorea are used in medicinal preparations. The resin is burnt as incense and the fumes thus obtained are said to have good medicinal value. Shorea ointments for skin troubles, breast enhancement and for bleeding piles are available at herbal stores. Some herbal doctors consider the Shorea a natural remedy for diabetes, nervine pain, arthritis, burns, ulcers, jaundice and skin infections. It has anti-bacterial properties too. Plant Shala is a contribution in the area of medicinal plants covering various aspects particularly relating to botanical phytochemical, pharmacological & pharmacognostical studies are very relevant & important in the national context.   Shala has been reviewed from different aspect, starting from Vedic era up to recent books on medicinal plants and entire procured information regarding its therapeutic values, synonyms, vernacular name, classification according to Ayurvedic texts, types, purification, Rasa panchaka, karma and adverse drug reaction and  treatment was compiled.Â

Peri-urbanism in globalizing India: a study of pollution, health and community awareness

This paper examines the intersection between environmental pollution and people's acknowledgements of, and responses to, health issues in Karhera, a former agricultural village situated between the rapidly expanding cities of New Delhi (India's capital) and Ghaziabad (an industrial district in Uttar Pradesh). A relational place-based view is integrated with an interpretive approach, highlighting the significance of place, people's emic experiences, and the creation of meaning through social interactions. Research included surveying 1788 households, in-depth interviews, participatory mapping exercises, and a review of media articles on environment, pollution, and health. Karhera experiences both domestic pollution, through the use of domestic waste water, or gandapani, for vegetable irrigation, and industrial pollution through factories' emissions into both the air and water. The paper shows that there is no uniform articulation of any environment/health threats associated with gandapani. Some people take preventative actions to avoid exposure while others do not acknowledge health implications. By contrast, industrial pollution is widely noted and frequently commented upon, but little collective action addresses this. The paper explores how the characteristics of Karhera, its heterogeneous population, diverse forms of environmental pollution, and broader governance processes, limit the potential for citizen action against pollution

Rational Mutational Analysis of a Multidrug MFS Transporter CaMdr1p of Candida albicans by Employing a Membrane Environment Based Computational Approach

CaMdr1p is a multidrug MFS transporter of pathogenic Candida albicans. An over-expression of the gene encoding this protein is linked to clinically encountered azole resistance. In-depth knowledge of the structure and function of CaMdr1p is necessary for an effective design of modulators or inhibitors of this efflux transporter. Towards this goal, in this study, we have employed a membrane environment based computational approach to predict the functionally critical residues of CaMdr1p. For this, information theoretic scores which are variants of Relative Entropy (Modified Relative Entropy REM) were calculated from Multiple Sequence Alignment (MSA) by separately considering distinct physico-chemical properties of transmembrane (TM) and inter-TM regions. The residues of CaMdr1p with high REM which were predicted to be significantly important were subjected to site-directed mutational analysis. Interestingly, heterologous host Saccharomyces cerevisiae, over-expressing these mutant variants of CaMdr1p wherein these high REM residues were replaced by either alanine or leucine, demonstrated increased susceptibility to tested drugs. The hypersensitivity to drugs was supported by abrogated substrate efflux mediated by mutant variant proteins and was not attributed to their poor expression or surface localization. Additionally, by employing a distance plot from a 3D deduced model of CaMdr1p, we could also predict the role of these functionally critical residues in maintaining apparent inter-helical interactions to provide the desired fold for the proper functioning of CaMdr1p. Residues predicted to be critical for function across the family were also found to be vital from other previously published studies, implying its wider application to other membrane protein families

Enumeration of the Mosses in Amarkantak (Madhya Pradesh), India – I

A total of 21 genera and 28 species of mosses belonging to 12 families were investigated from various localities of Amarkantak (Madhya Pradesh), India. The genera, Entodontopsis leucostega (Brid.) Buck & Ireland, Entodontopsis nitens (Mitt.) Buck & Ireland, Pseudotaxiphyllum elegans (Brid.) Iwats., Erythrodontium julaceum (Schwaegr.) Par., Trachyphyllum inflexum (Harv.) Gepp., Hyophila involuta (Hook.) Jaeg. Were the dominant taxa. The richness of the moss taxa has been recorded in the Kapildhara locality and the epiphytic forms are found to be the most successful taxa in the area. The mosses of Amarkantak have been enumerated for the first time

Relationship among glottal area, static supraglottic compression, and laryngeal function studies in unilateral vocal fold paresis and paralysis

Summary In this study, we evaluated the relationship between laryngeal function measures and glottal gap ratio and normalized measures of supraglottic behaviors in patients with unilateral vocal fold paresis (UVFP). Thirty-one patients were found to have unilateral vocal fold paresis by videoendoscopy and laryngeal electromyography, and 13 controls participated in this study. Patients with UVFP demonstrated significantly larger glottal gap ratios (p=0.016) than control subjects. The nonparalyzed or contralateral vocal fold was associated with significantly more static false vocal fold compression (p=0.03) compared with the paralyzed vocal fold or with the controls. Patients with unilateral vocal fold paresis were divided into subgroups: those with normal or abnormal maximum phonation time, flow, or pressure measures. Smaller glottal gap ratios were identified in patients with normal maximum phonation times and flow measures. Greater false vocal fold activity was identified in unilateral vocal fold paresis patients with normal laryngeal function measures than in unilateral vocal fold paresis patients with abnormal measures. These findings suggest that some patients with documented unilateral paresis and glottal incompetence can compensate for vocal fold weakness such that their acoustic and aerodynamic measures are normal

RETRACTED ARTICLE: A review of 45 candidate genes: Association of single nucleotide polymorphism to schizophrenia Risk

The following article has been retracted from publication in the Taylor & Francis journal New Genetics and Society. I. Priya, S. Sharma, I. Sharma, R. Mahajan and N. Kapoor, A review of 45 candidate genes: association of single nucleotide polymorphism to schizophrenia risk, New Genetics and Society https://doi.org/10.1080/14636778.2018.1481740. Version of Record published online 13 July 2018. The editorial office of the journal inadvertently processed the paper through the online submission system without proper peer review or requisite checks. This has now been remedied and the journal and publishers apologise to the authors that this occurred. Journal processes and checks have now been reviewed and updated so that all best efforts are made to ensure this does not occur again. © Taylor & Francis/Journal owne

Low Flow Venoarterial ECMO Support Management in Postcardiac Surgery Patient

Venoarterial extracorporeal membrane oxygenation (VA ECMO) aims to fully support heart and lung function in postcardiac patients, ensuring end-organ perfusion and allowing time for possible heart recovery. VA ECMO is considered the modified and extended form of cardiopulmonary bypass (CPB), which is used to provide adequate tissue oxygenation. ECMO and the associated management protocols will mechanically support the patient and allow for the optimization of all aspects of care for the period of time necessary for the recovery of native cardiac or respiratory function. Significant technical advancements have been made in the equipment and the clinical management available for short- and long-term ECMO application. There are various parameters that have to be considered to evaluate whether the level of perfusion in patients on VA ECMO is adequate, and the outcomes of patients depend on them