Different radiation and metamorphic history of the Kainsaz CO 3.2 chondrules

Track and thermoluminescence parameters in chondrules from the Kainsaz CO 3.2 chondrite have been studied. Obtained results elucidate their individual shock-thermal history and the early pre-accretion stage of the meteorite parent body formation

Medico-social rationale for adaptation of regional drug supply systems to personalized pharmaceutical care for persons of different ages

In this study, we identified indicators of the state of personalized pharmaceutical care for target population groups at the regional level, in a model region, with the aim to develop a differentiated approach to such care. The rationale for the choice of Moscow Region as a model region is based on its specific socioeconomic indicators and a comparison of these with respective average Russian values. A need was shown to modernize patient-oriented pharmaceutical care, especially for certain population groups, such as children, women of working age (mothers), and the elderl

Methodological aspects of the use of dry components of chicken eggs for feeding children with phenylketonuria

Currently, one of the most important tasks facing science and production is the creation of functional product technologies for use in different diets of the population in order to preserve and improve health, as well as reduce the risks and consequences of various diseases, including hereditary ones, such as phenylketonuria (PKU). The All-Russian Research Institute of Starch Products develops technologies for the production of low-protein starch-based products/semi-products enriched with functional ingredients and intended for therapeutic nutrition of patients with PKU. As part of the pilot production, the production of these products is organized. Purpose of work:to justify the possibility of using dry components of chicken eggs (melange, protein, yolk) to enrich low-protein starch products (noodles, vermichel, «spider») intended for feeding children over 3 years old with phenylketonuria;evaluate organoleptic properties and efficiency of low-protein starch products enriched in hypophenylalanine diet of patients with phenylketonuria older than 3 years

Preparation of alumina nanoparticle suspensions with narrow particle size distribution

Dynamic light scattering (DLS) was applied to the study of the process of the preparing deaggregated water suspensions of alumina nanopowders with specific surface areas of 20-140 m2/g. Nanopowders were prepared by the electric explosion of wire and laser evaporation and, according to electron microscopy (TEM), consisted of nonagglomerated spherical nanoparticles with lognormal size distribution. According to DLS, nonsedimenting water suspensions of alumina nanoparticles, stabilized by sodium citrate at a 5 mM concentration, contain substantial fraction of aggregates. The dynamics of the change in the mean average size of aggregates under exhaustive ultrasound treatment of suspensions with 10 g/l concentration for 1.5-4 h by two types of ultrasonic processors was studied. It was shown that the mean average size of aggregates exponentially diminishes by 1.5-2 times and the fraction of individual particles in suspension enlarges from 45 to 85%. Sequentially centrifuging the suspension at 18000 g separates the remaining aggregates and results in suspensions of individual alumina nanoparticles. Particle size distributions in these suspensions obtained by TEM and DLS are the same within experimental error. © 2013 Pleiades Publishing, Ltd

Трансформация конституционной идентичности государства в условиях вызовов современности

The subject. This article represents an attempt to research the notion of “constitutional identity”, which has recently emerged as a relevant concept in constitutional law, through the prism of its transformation reacting the world’s challenges.The purpose of the research is to confirm or disprove hypothesis that both typical and extraordinary factors may influence differently on the transformation of constitutional identity.The methodology. The article is based on the dialectical method, as well as on the logical, historical, systemic methods. A comparative method was applied to study the features of the constitutional identity of States. Authors pay attention to the interaction of international and national policies.The main results, scope of application. Within the doctrine of constitutional identity it is presented a discussion with respect to terms and definitions of constitutional, state or national identity, constitutional identity of citizens. Moreover, such two notions as “individuality” and “identity” form a curious couple since “identity” may contravene “individuality”. Different factors which can influence on transformation of the constitutional identity, are listed (globalization (antiglobalism), universalization of constitutional values, COVID-19 pandemic, migration, etc.). In particular, different countries choose different models of reflecting the processes of globalization in their domestic constitutional legislation: from striving for unification to systematic confrontation. In this regard, it seems necessary to assess these factors, taking into account the experience of different states. Besides, the activities of international bodies can give rise to the universalization of constitutional values. For example, supranational bodies (in particular, the European Court of Justice) develop generalcial common culture. Another example is the current epidemiological crisis. The coronavirus infection has made its own adjustments to the constitutional identity of states. Examples of such transformation are full border closures or partial closures with individual states; amendments to the national legislation, according to which the issues of measures permissible for implementation by the state are being revised in order to ensure the life and health of the population.Conclusions. Definition the constitutional identity is an important strategic framework for national policy. However, there is no certain fixed constitutional identity of the state. On contrary, the identity of the state tends to be changeable. Transformation can be regarded as voluntary, forced or consciously responsive, expected or not. Voluntary transformation usually becomes a response to the evolutionary development of society, scientific and technological advances and discoveries. Forced transformation is likely to be a reaction to economic, epidemiological, political crises. Therefore, in order to determine the constitutional identity of certain state it is necessary to understand the cultural, historical, social and political contexts of its formation and current development in the conditions of the contemporary world.Рассматривается доктрина трансформации конституционной идентичности и ее проявление в правоотношениях, складывающихся в условиях вызовов современности: глобализация и антиглобализм, пандемия коронавируса COVID-19, научные достижения, универсализация конституционных ценностей – эти и другие разнообразные факторы предопределяют необходимость трансформации конституционной идентичности или стимулируют ее. Ставится цель провести анализ терминов и понятий, используемых в доктрине конституционной идентичности, наработок ученых разных стран для определения ее конституционно-правовой природы, выявления факторов, обусловливающих изменчивость идентичности. Уделяется внимание взаимодействию международной и национальной политики. Делаются выводы о видах и современных практиках трансформации идентичности различных государств

ProtChemSI: a network of protein–chemical structural interactions

Progress in structure determination methods means that the set of experimentally determined 3D structures of proteins in complex with small molecules is growing exponentially. ProtChemSI exploits and extends this useful set of structures by both collecting and annotating the existing data as well as providing models of potential complexes inferred by protein or chemical structure similarity. The database currently includes 7704 proteins from 1803 organisms, 11 324 chemical compounds and 202 289 complexes including 178 974 predicted. It is publicly available at http://pcidb.russelllab.org

Phosphorylation of 3,4-dichloro-5-hydroxy-2(5H)-furanone with tributylphosphine

The reaction of 3,4-dichloro-5-hydroxy-2(5H)-furanone with 2 mol of tributylphosphine involves substitution of both chlorine atoms to form an unstable diphosphonium salt. The latter undergoes partial hydrolysis with cleavage of one of the P-C bonds, yielding finally a monophosphorylation product. A probable reaction pathway is considered in terms of quantum chemistry

SOCIO-ECONOMIC DAMAGE BY ACUTE CORONARY SYNDROME IN RUSSIAN FEDERATION

Aim. To estimate the economic damage by acute coronary syndrome (ACS) in Russia in 2006-2009. Material and Methods. Direct costs and economic losses associated with ACS were estimated. The structure of direct costs includes the costs of hospitalization, medical emergencies, out-patient visits, high-tech medical care, as well as drug therapy in outpatient treatment. Losses in the economy associated with ACS include loss of gross domestic product due to death in working-age, temporary disability and payments of disability benefits. Estimation of economic damage by cardio-vascular diseases was based on analysis of Russian Ministry of Health official statistics. Results. Approximately 520,000 cases of ACS are registered annually (36,4% - myocardial infarction, 63,6% - unstable angina). Trend to increased mortality from myocardial infarction, especially among women, was found during the analyzed period. From 2000 to 2009 this index rose from 34.9 to 41.1 per 100,000 of population among women, and from 52.3 to 55.9 per 100,000 of population among men. Total direct costs of health care for patients with ACS in 2009 amounted to almost 21 billion rubles, and indirect – 53.5 billion rubles. The total economic damage by ACS in Russia in 2008-2009 exceeded 70 billion rubles per year. Conclusion. ACS in Russia is connected with significant social and economic damage. Most part of this damage is indirect losses in economy due to premature mortality of working aged men

The theoretical and experimental investigation of the halogencyclenes' phosphorylation

The phosphorylation reactions of the oxygen- and nitrogen-containing halocyclenes - 3,4-dichloro-5-hydroxyfuranone, 3,4-dichloro-5-substituted pyrrolinon-2-ones and N-phenyl-4,5 dichloropyridazin-2-one by σ3-phosphorus compounds - trialkylphoshphites, triphenylphosphine, and some P-functionalized derivatives of the trivalent phosphorus are studied. The reactions' mechanisms are discussed; the possible and preferable reactions' routes and the relative thermodynamic stabilities of the products and intermediates are estimated via the quantum-chemical methods