Erweiterung einer Komponentenplattform zur Unterstützung multimodaler Anwendungen mit föderierten Endgeräten

Zur Erledigung einer Aufgabe kann der Benutzer mit verschiedenen Endgeräten interagieren, welche unterschiedliche Interaktionsarten (Modalitäten) anbieten. Dabei gibt es jedoch kein Endgerät, welches alle erdenkbaren Modalitäten unterstützt. Aus diesem Grund wird eine komponentenbasierte Integrationsschicht auf Basis einer Komponentenplattform entwickelt, die dem Nutzer die gewünschte Freiheit bei der Wahl der Endgeräte und somit der Modalitäten ermöglicht. Als Ausgangsbasis dafür dient das W3C Multimodal Interaction Framework. Mit Hilfe der Integrationsschicht kann der Nutzer beispielsweise Endgeräteföderationen erzeugen, die einzeln oder gemeinsam zur Interaktion verwendet werden können. Die Integrationsschicht besitzt verschiedene Konzepte, um z.B. Geschäftslogik zur Laufzeit zu verteilen, Komponentenausfälle zu behandeln und die auf verschiedene Endgeräte verteilte Nutzerschnittstelle zu synchronisieren. Die entwickelten Konzepte wurden prototypisch implementiert, validiert und auf Performanz untersucht

Open- vs. closed-chest pig models of donation after circulatory death.

BACKGROUND During donation after circulatory death (DCD), cardiac grafts are exposed to potentially damaging conditions that can impact their quality and post-transplantation outcomes. In a clinical DCD setting, patients have closed chests in most cases, while many experimental models have used open-chest conditions. We therefore aimed to investigate and characterize differences in open- vs. closed-chest porcine models. METHODS Withdrawal of life-sustaining therapy (WLST) was simulated in anesthetized juvenile male pigs by stopping mechanical ventilation following the administration of a neuromuscular block. Functional warm ischemic time (fWIT) was defined to start when systolic arterial pressure was <50 mmHg. Hemodynamic changes and blood chemistry were analyzed. Two experimental groups were compared: (i) an open-chest group with sternotomy prior to WLST and (ii) a closed-chest group with sternotomy after fWIT. RESULTS Hemodynamic changes during the progression from WLST to fWIT were initiated by a rapid decline in blood oxygen saturation and a subsequent cardiovascular hyperdynamic (HD) period characterized by temporary elevations in heart rates and arterial pressures in both groups. Subsequently, heart rate and systolic arterial pressure decreased until fWIT was reached. Pigs in the open-chest group displayed a more rapid transition to the HD phase after WLST, with peak heart rate and peak rate-pressure product occurring significantly earlier. Furthermore, the HD phase duration tended to be shorter and less intense (lower peak rate-pressure product) in the open-chest group than in the closed-chest group. DISCUSSION Progression from WLST to fWIT was more rapid, and the hemodynamic changes tended to be less pronounced in the open-chest group than in the closed-chest group. Our findings support clear differences between open- and closed-chest models of DCD. Therefore, recommendations for clinical DCD protocols based on findings in open-chest models must be interpreted with care

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Erweiterung einer Komponentenplattform zur Unterstützung multimodaler Anwendungen mit föderierten Endgeräten

Zur Erledigung einer Aufgabe kann der Benutzer mit verschiedenen Endgeräten interagieren, welche unterschiedliche Interaktionsarten (Modalitäten) anbieten. Dabei gibt es jedoch kein Endgerät, welches alle erdenkbaren Modalitäten unterstützt. Aus diesem Grund wird eine komponentenbasierte Integrationsschicht auf Basis einer Komponentenplattform entwickelt, die dem Nutzer die gewünschte Freiheit bei der Wahl der Endgeräte und somit der Modalitäten ermöglicht. Als Ausgangsbasis dafür dient das W3C Multimodal Interaction Framework. Mit Hilfe der Integrationsschicht kann der Nutzer beispielsweise Endgeräteföderationen erzeugen, die einzeln oder gemeinsam zur Interaktion verwendet werden können. Die Integrationsschicht besitzt verschiedene Konzepte, um z.B. Geschäftslogik zur Laufzeit zu verteilen, Komponentenausfälle zu behandeln und die auf verschiedene Endgeräte verteilte Nutzerschnittstelle zu synchronisieren. Die entwickelten Konzepte wurden prototypisch implementiert, validiert und auf Performanz untersucht

Applied Service Engineering for Single Services and Corresponding Service Landscapes

Building reusable and autonomous services that possess the proper degree of granularity is critical for the success of a service-oriented architecture (SOA), especially for large and heterogeneous application landscapes. While there are a number of approaches to service engineering, most of these approaches are designed with a special purpose or project context in mind. This paper presents a pragmatic approach to service engineering that can be applied in scenarios where it is particularly necessary to identify service interfaces with the right granularity. The approach is based on a comparison of service engineering methodologies with special regard for their ability to connect different levels of an SOA. We apply concepts from this approach to build single services and their service landscapes. We also suggest the utilization of service inventory techniques to evaluate and assess the outcome of the proposed service engineering methodology

Case studies

Case studies play an important role for validations in general. In particular, they are the first step to a comprehensive validation of USDL, because they can create feedback regarding usability, feasibility, completeness etc. of certain aspects of USDL. This chapter contains the findings of executing four different case studies: Services in the energy domain, services for mobile users, manual services for insurances, and services for B2B integration. Each case study originates from a different company and provides its own conclusion. In general, the case studies show that USDL can be used to realize the described scenarios. However, they identify also room for improvement: The scope of USDL should be limited (don't try to be "universal"), semantic technologies should be used, and a simple API is necessary