Intracapsular development and dispersal polymorphism in the predatory gastropod Ocenebra erinaceus (Linnaeus 1758)

This is the author accepted manuscript. The final version is available from Springer Verlag via the DOI in this record.Intraspecific polymorphism during development, such as poecilogony or dispersal polymorphism, has rarely been observed in the marine environment. The ecological advantages of this bet-hedging strategy, whereby the offspring from one species exhibit multiple developmental modes, include the potential for rapid colonization of new habitats while simultaneously achieving a degree of gene flow between populations. The muricid gastropod, Ocenebra erinaceus, is a common, shallow-water marine predator found across England and France. Historically, O. erinaceus caused significant damage to shellfisheries, but more recently it has been impacted by TBT-induced imposex. Despite the previous attention given to this species, little is known about its encapsulated development. Studying O. erinaceus egg capsules from the Solent, UK, we describe intracapsular development at 15 °C, the in situ temperature at time of oviposition. Within each capsule, all embryos developed; no nurse eggs were present. Development was categorized into eight ontogenetic stages, although not all individuals displayed every stage; embryos hatched as either swimming late-pediveliger larvae or crawling juveniles after 59–69 days, indicating dispersal polymorphism to occur in this species. Swimming late-pediveliger larvae completed metamorphosis within 72 h of hatching. As O. erinaceus continues to recover from TBT pollution, dispersal polymorphism may facilitate a rapid expansion in both population size and range. If this occurs, O. erinaceus has the potential to, once again, become a serious problem for shellfisheries around Europe.We thank the skipper and crew of RV Callista for their help with sample collection. This work was supported by a grant from the Malacological Society to KES. AJR was supported by a Natural Environment Research Council PhD studentship

Analysis and Implementation of an Ultra-Wide Tuning Range CMOS Ring-VCO With Inductor Peaking

A novel ring voltage controlled oscillator (VCO) topology is proposed which uses monolithic inductors as a peaking load. Four design examples have been fabricated and tested to verify the proposed circuit structure. The highest measured oscillation frequency is 25.07 GHz, with a tuning range of more than four octaves, and the active area is 0.0085 mm2. The design has the highest combined frequency and tuning range with the best figure of merit (≈ 195) comparable to previously published work

The Effects of Recovery Duration on Physiological and Perceptual Responses of Trained Runners during four Self-Paced HIIT Sessions

Objectives This study aimed to examine the effects of different recovery durations on self-selected running velocities, physiological responses, and ratings of perceived exertion (RPE) in a commonly used high intensity interval training (HIIT) protocol. Design & Methods Twelve trained runners performed an incremental treadmill exercise test to determine maximal oxygen uptake (V̇O2max) and heart rate (HRmax). In four subsequent visits, participants performed a HIIT session comprising six 4-min work intervals, in which the recovery duration between work intervals equalled either a fixed (1MIN, 2MIN, 3MIN) or a self-selected duration (ssMIN). HIIT sessions were run on a non-motorized treadmill, and were performed under isoeffort conditions. Results Mean running velocity was significantly higher in 3MIN compared with all other protocols, and higher in ssMIN compared with 2MIN. No significant differences in time spent≥90% and 95% V̇O2max, or ≥ 90% and 95% HRmax were evident between the four protocols. RPE responses were similar across and within the protocols showing a gradual increase with each progressive interval. Discussion In a self-paced HIIT session of six 4-min work intervals, the length of recovery durations had a limited effect on the total physiological strain endured in the training. However, running velocities were higher when participants received the longest recovery period (3MIN). Conclusion Longer recovery durations may facilitate a higher external training load (faster running), whilst maintaining a similar internal training load (physiological stimulus), and may therefore allow for greater training adaptations

Analysis and implementation of an ultra-wide tuning range CMOS ring-VCO with inductor peaking

A novel ring voltage controlled oscillator (VCO) topology is proposed which uses monolithic inductors as a peaking load. Four design examples have been fabricated and tested to verify the proposed circuit structure. The highest measured oscillation frequency is 25.07 GHz, with a tuning range of more than four octaves, and the active area is 0.0085 mm². The design has the highest combined frequency and tuning range with the best figure of merit (~ 195) comparable to previously published work

A 30 Gb/s CMOS driver integrated with silicon photonics MZM

A voltage mode modulator driver is proposed in the TSMC 65nm low power CMOS process. In the electrical testing, the driver itself can achieve a bit rate of 40Gb/s with the single-ended output swing of 1.65V. Unlike equivalent CML modulator drivers, when the proposed driver is integrated with the silicon photonic MZM, it does not require an additional biasing network. The integrated electro-optic transmitter can achieve 30Gb/s with an extinction ratio of 4.05dB, with the power consumption of main driver being 323mW

Bound States in Time-Dependent Quantum Transport: Oscillations and Memory Effects in Current and Density

The presence of bound states in a nanoscale electronic system attached to two biased, macroscopic electrodes is shown to give rise to persistent, non-decaying, localized current oscillations which can be much larger than the steady part of the current. The amplitude of these oscillations depends on the entire history of the applied potential. The bound-state contribution to the {\em static} density is history-dependent as well. Moreover, the time-dependent formulation leads to a natural definition of the bound-state occupations out of equilibrium.Comment: 4 pages, 3 figure

Recent breakthroughs in carrier depletion based silicon optical modulators

The majority of the most successful optical modulators in silicon demonstrated in recent years operate via the plasma dispersion effect and are more specifically based upon free carrier depletion in a silicon rib waveguide. In this work we overview the different types of free carrier depletion type optical modulators in silicon. A summary of some recent example devices for each configuration is then presented together with the performance that they have achieved. Finally an insight into some current research trends involving silicon based optical modulators is provided including integration, operation in the mid-infrared wavelength range and application in short and long haul data transmission link

Analysis and Implementation of an Ultra-Wide Tuning Range CMOS Ring-VCO With Inductor Peaking

A novel ring voltage controlled oscillator (VCO) topology is proposed which uses monolithic inductors as a peaking load. Four design examples have been fabricated and tested to verify the proposed circuit structure. The highest measured oscillation frequency is 25.07 GHz, with a tuning range of more than four octaves, and the active area is 0.0085 mm2. The design has the highest combined frequency and tuning range with the best figure of merit (≈ 195) comparable to previously published work

Silicon photonic Mach Zehnder modulators for next-generation short-reach optical communication networks

Communication traffic grows relentlessly in today’s networks, and with ever more machines connected to the network, this trend is set to continue for the foreseeable future. It is widely accepted that increasingly faster communications are required at the point of the end users, and consequently optical transmission plays a progressively greater role even in short- and medium-reach networks. Silicon photonic technologies are becoming increasingly attractive for such networks, due to their potential for low cost, energetically efficient, high-speed optical components. A representative example is the silicon-based optical modulator, which has been actively studied. Researchers have demonstrated silicon modulators in different types of structures, such as ring resonators or slow light based devices. These approaches have shown remarkably good performance in terms of modulation efficiency, however their operation could be severely affected by temperature drifts or fabrication errors. Mach-Zehnder modulators (MZM), on the other hand, show good performance and resilience to different environmental conditions. In this paper we present a CMOS-compatible compact silicon MZM. We study the application of the modulator to short-reach interconnects by realizing data modulation using some relevant advanced modulation formats, such as 4-level Pulse Amplitude Modulation (PAM-4) and Discrete Multi-Tone (DMT) modulation and compare the performance of the different systems in transmission

Pathogenesis of aerosolized Eastern Equine Encephalitis virus infection in guinea pigs

Mice and guinea pigs were experimentally exposed to aerosols containing regionally-distinct strains (NJ1959 or ArgM) of eastern equine encephalitis virus (EEEV) at two exclusive particle size distributions. Mice were more susceptible to either strain of aerosolized EEEV than were guinea pigs; however, clinical signs indicating encephalitis were more readily observed in the guinea pigs. Lower lethality was observed in both species when EEEV was presented at the larger aerosol distribution (> 6 μm), although the differences in the median lethal dose (LD50) were not significant. Virus isolation and immunohistochemistry indicated that virus invaded the brains of guinea pigs within one day postexposure, regardless of viral strain or particle size distribution. Immunohistochemistry further demonstrated that neuroinvasion occurred through the olfactory system, followed by transneuronal spread to all regions of the brain. Olfactory bipolar neurons and neurons throughout the brain were the key viral targets. The main microscopic lesions in infected guinea pigs were neuronal necrosis, inflammation of the meninges and neuropil of the brain, and vasculitis in the brain. These results indicate that guinea pigs experimentally infected by aerosolized EEEV recapitulate several key features of fatal human infection and thus should serve as a suitable animal model for aerosol exposure to EEEV