Transmission of matter wave solitons through nonlinear traps and barriers

The transmissions of matter wave solitons through linear and nonlinear inhomogeneities induced by the spatial variations of the trap and the scattering length in Bose-Einstein condensates are investigated. New phenomena, such as the enhanced transmission of a soliton through a linear trap by a modulation of the scattering length, are exhibited. The theory is based on the perturbed Inverse Scattering Transform for solitons, and we show that radiation effects are important. Numerical simulations of the Gross-Pitaevskii equation confirm the theoretical predictions.Comment: 6 pages, 4 figure

Velocity estimation via model order reduction

A novel approach to full waveform inversion (FWI), based on a data driven reduced order model (ROM) of the wave equation operator is introduced. The unknown medium is probed with pulses and the time domain pressure waveform data is recorded on an active array of sensors. The ROM, a projection of the wave equation operator is constructed from the data via a nonlinear process and is used for efficient velocity estimation. While the conventional FWI via nonlinear least-squares data fitting is challenging without low frequency information, and prone to getting stuck in local minima (cycle skipping), minimization of ROM misfit is behaved much better, even for a poor initial guess. For low-dimensional parametrizations of the unknown velocity the ROM misfit function is close to convex. The proposed approach consistently outperforms conventional FWI in standard synthetic tests.Comment: 5 pages, 3 figures, to be presented at IMAGE 202

Estimating the accuracy of satellite ephemerides using the bootstrap method

International audienceContext: The accuracy of predicted orbital positions depends on the quality of the theorical model and of the observations used to fit the model. During the period of observations, this accuracy can be estimated through comparison with observations. Outside this period, the estimation remains difficult. Many methods have been developed for asteroid ephemerides in order to evaluate this accuracy. Aims: This paper introduces a new method to estimate the accuracy of predicted positions at any time, in particular outside the observation period. Methods: This new method is based upon a bootstrap resampling and allows this estimation with minimal assumptions. Results: The method was applied to two of the main Saturnian satellites, Mimas and Titan, and compared with other methods used previously for asteroids. The bootstrap resampling is a robust and practical method for estimating the accuracy of predicted positions

Conditional score-based diffusion models for Bayesian inference in infinite dimensions

Since their first introduction, score-based diffusion models (SDMs) have been successfully applied to solve a variety of linear inverse problems in finite-dimensional vector spaces due to their ability to efficiently approximate the posterior distribution. However, using SDMs for inverse problems in infinite-dimensional function spaces has only been addressed recently and by learning the unconditional score. While this approach has some advantages, depending on the specific inverse problem at hand, in order to sample from the conditional distribution it needs to incorporate the information from the observed data with a proximal optimization step, solving an optimization problem numerous times. This may not be feasible in inverse problems with computationally costly forward operators. To address these limitations, in this work we propose a method to learn the posterior distribution in infinite-dimensional Bayesian linear inverse problems using amortized conditional SDMs. In particular, we prove that the conditional denoising estimator is a consistent estimator of the conditional score in infinite dimensions. We show that the extension of SDMs to the conditional setting requires some care because the conditional score typically blows up for small times contrarily to the unconditional score. We also discuss the robustness of the learned distribution against perturbations of the observations. We conclude by presenting numerical examples that validate our approach and provide additional insights

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

The intricate and multifactorial nature of Alzheimer's disease (AD) requires the development of compounds able to hit different pathophysiological targets, such as cholinergic dysfunction, deposits of amyloid beta (A beta) peptide and metal dyshomeostasis. In order to continue the search for new anti-AD drugs, a design strategy was once more followed based on repositioning donepezil (DNP) drug, by ortho-attaching a benzylpiperidine mimetic of DNP moiety to a hydroxyphenyl-benzimidazole (BIM) chelating unit (compound 1). Herein, compound 1 and a positional isomer 2 are compared in terms of their potential multiple properties: both present good acetylcholinesterase (AChE) inhibition (low mu molar range) and are moderate/good inhibitors of A beta self- and Cu-mediated aggregation, the inhibition process being mainly due to ligand intercalation between the p-sheets of the fibrils; compound 1 has a higher chelating capacity towards Cu2+ and Zn2+ (pCu = 14.3, pZn = 6.4, pH 7.4, C-I/C-M = 10, C-M = 10(-6) M) than 2 (pCu = 10.7, pZn = 6.3), attributed to its ability to establish a tridentate (N,O,O) coordination to the metal ion. Both compounds are eligible as drug candidates for oral administration but compound 1 shows improved neuroprotective role by completely preventing Ali-induced cell toxicity

Prévenir les troubles musculosquelettiques chez les soignants : connaître les expositions et étude des outils d’aide à la manutention

ObjectifsDans le cadre de la Caisse nationale de retaite des agents des collectivités locales (CNRACL), la démarche d’évaluation et de prévention des risques vise à conduire à une démarche spécifique au milieu hospitalier et à construire des outils d’évaluation des risques dans le réseau des CHU français. Les études menées sur la prévention des troubles musculosquelettiques (TMS) associent principalement les compétences en ergonomie, épidémiologie et médecine du travail des CHU d’Angers et de Grenoble. Méthode Une première étude épidémiologique a permis d’identifier les facteurs de risque de TMS et de lombalgie en milieu hospitalier ; une seconde s’est intéressée à l’évaluation des outils d’aide à la manutention des patients en milieu de soins sous un angle ergonomique. Résultats Les salariés du secteur santé sont en moyenne exposés à 2,4 facteurs de risque des 19 répertoriés (3,5 pour le reste du réseau) et ne souffrent pas plus de TMS des membres supérieurs que les autres salariés de la région des Pays-de-la-Loire. En revanche, les expositions aux manutentions manuelles de charges lourdes liées aux soins aux patients sont plus fréquentes. Les aides techniques pour la manutention étudiées ne répondent pas aux critères de dépendance du patient ou aux conditions organisationnelles du service. Du point de vue psychologique, le rapport du patient au matériel ainsi que l’usage du corps du soignant dans la relation aux soins doivent être pris en compte. Conclusion L’approche biomécanique a fait l’objet de cette première investigation. Il s’agit d’une démarche de prévention pluridisciplinaire intégrée dans la politique d’établissement

HV 11423: The Coolest Supergiant in the SMC

We call attention to the fact that one of the brightest red supergiants in the SMC has recently changed its spectral type from K0-1 I (December 2004) to M4 I (December 2005) and back to K0-1 I (September 2006). An archival spectrum from the Very Large Telescope reveals that the star was even cooler (M4.5-M5 I) in December 2001. By contrast, the star was observed to be an M0 I in both October 1978 and October 1979. The M4-5 I spectral types is by far the latest type seen for an SMC supergiant, and its temperature in that state places it well beyond the Hayashi limit into a region of the H-R diagram where the star should not be in hydrostatic equilibrium. The star is variable by nearly 2 mag in V, but essentially constant in K. Our modeling of its spectral energy distribution shows that the visual extinction has varied during this time, but that the star has remained essentially constant in bolometric luminosity. We suggest that the star is currently undergoing a period of intense instability, with its effective temperature changing from 4300 K to 3300 K on the time-scale of months. It has one of the highest 12-micron fluxes of any RSG in the SMC, and we suggest that the variability at V is due primarily to changes in effective temperature, and secondly, due to changes in the local extinction due to creation and dissipation of circumstellar dust. We speculate that the star may be nearing the end of its life.Comment: Accepted by the Astrophysical Journa

Enhanced statistical stability in coherent interferometric imaging

http://iopscience.iop.org/0266-5611/International audienc

The chemical composition of the circumstellar envelopes around yellow hypergiant stars

The yellow hypergiant stars (YHGs) are extremely luminous and massive objects whose general properties are poorly known. Only two of this kind of star show massive circumstellar envelopes, IRC+10420 and AFGL2343. We aim to study the chemistry of the circumstellar envelopes around these two sources, by comparison with well known AGB stars and protoplanetary nebulae. We also estimate the abundances of the observed molecular species. We have performed single-dish observations of different transitions for twelve molecular species. We have compared the ratio of the intensities of the molecular transitions and of the estimated abundances in AFGL2343 and IRC+10420 with those in O-rich and C-rich AGB stars and protoplanetary nebulae. Both YHGs, AFGL2343, and IRC+10420, have been found to have an O-rich chemistry similar to that in O-rich AGB stars, though for AFGL2343 the emission of most molecules compared with 13CO lines is relatively weak. Clear differences with the other evolved sources appear when we compare the line intensity corrected for distance and the profile widths which are, respectively, very intense and very wide in YHGs. The abundances obtained for IRC+10420 agree with those found in AGB stars, but in general those found in AFGL2343, except for 13CO, are too low. This apparently low molecular abundance in AFGL2343 could be due to the fact that these molecules are present only in an inner region of the shell where the mass is relatively low.Comment: 14 pages, 12 figure

Targeted Greybox Fuzzing with Static Lookahead Analysis

Automatic test generation typically aims to generate inputs that explore new paths in the program under test in order to find bugs. Existing work has, therefore, focused on guiding the exploration toward program parts that are more likely to contain bugs by using an offline static analysis. In this paper, we introduce a novel technique for targeted greybox fuzzing using an online static analysis that guides the fuzzer toward a set of target locations, for instance, located in recently modified parts of the program. This is achieved by first semantically analyzing each program path that is explored by an input in the fuzzer's test suite. The results of this analysis are then used to control the fuzzer's specialized power schedule, which determines how often to fuzz inputs from the test suite. We implemented our technique by extending a state-of-the-art, industrial fuzzer for Ethereum smart contracts and evaluate its effectiveness on 27 real-world benchmarks. Using an online analysis is particularly suitable for the domain of smart contracts since it does not require any code instrumentation---instrumentation to contracts changes their semantics. Our experiments show that targeted fuzzing significantly outperforms standard greybox fuzzing for reaching 83% of the challenging target locations (up to 14x of median speed-up)