2,935 research outputs found
Psychotherapy and Counseling with Minorities: A Cognitive Approach to Individual and Cultural Differences, by Manuel Ramirez III
La presente investigación tiene el propósito de demostrar cómo a través de una red social conocida como Facebook, mediante su plataforma de fanpage, puede servir como herramienta táctica de convocatoria para que los movimientos sociales generen grandes marchas multitudinarias en la ciudad de Lima durante el año 2017. Siendo un estudio no experimental con diseño transeccional. La población y muestra está formada por los participantes de la red social Facebook dentro de los fanpage. La técnica fue la observación y la entrevista y como instrumentos la ficha de observación y la guÃa de entrevista. Los resultados indican que Se hallaron 349 funciones del lenguaje en todos los estados de los fanpages. Siendo la función apelativa y referencial las más utilizadas por estos movimientos en un 87,11 %; mientras que la metalingüÃstica y la fática no se emplearon en ningún momento. Asimismo, y en menor cantidad se usaron la función expresiva y la función poética teniendo un 11.17 % y 1.72 % respectivamente. Cabe resaltar, que en reiteradas ocasiones los estados de los fanpages contenÃan más de una función del lenguaje, llegando a tener hasta las 4 funciones combinadas en un solo estado. Se concluye que las fanpage son utilizadas como herramienta de convocatoria de movimientos sociales mediante mensajes a través de sus estados, imágenes y videos
Psychotherapy and Counseling with Minorities: A Cognitive Approach to Individual and Cultural Differences, by Manuel Ramirez III
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Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival
The incidence of melanoma continues to dramatically increase in most Western countries with predominantly Caucasian populations. However, only limited therapies for the metastatic stage of the disease are currently available. The main purpose of this study is to determine approaches that can substantially increase radiosensitivity of melanoma cells. The PI3K-AKT, NF-κB and COX-2 pathways, which are involved in the radioprotective response, are highly active in melanoma cells. Pharmacological suppression of COX-2 and PI3K-AKT, or RNAi-mediated knockdown of COX-2, substantially increased levels of G2/M arrest of the cell cycle and decreased clonogenic survival of gamma-irradiated melanomas, predominantly via a necrotic mechanism. On the other hand, resveratrol, a polyphenolic phytoalexin, selectively targets numerous cell signaling pathways, decreasing clonogenic survival primarily via an apoptotic mechanism. In melanoma cells, resveratrol inhibits STAT3 and NF-κB-dependent transcription, culminating in suppression of cFLIP and Bcl-xL expression, while activating the MAPK- and the ATM-Chk2-p53 pathways. Resveratrol also upregulates TRAIL promoter activity and induces TRAIL surface expression in some melanoma cell lines, resulting in a rapid development of apoptosis. Sequential treatment of melanoma cells, first with γ-irradiation to upregulate TRAIL-R surface expression, and then with resveratrol to suppress antiapoptotic proteins cFLIP and Bcl-xL and induce TRAIL surface expression, had dramatic effects on upregulation of apoptosis in some melanoma lines, including SW1 and WM35. However, for melanoma lines exhibiting suppressed translocation of TRAIL to the cell surface, a necrotic mechanism of cell death was primarily involved in radiation response. Hence, surface expression of TRAIL induced by resveratrol appears to be a decisive event, one which determines an apoptotic versus a necrotic response of melanoma cells to sequential treatment
KH 15D: A Spectroscopic Binary
We present the results of a high-resolution spectroscopic monitoring program
of the eclipsing pre-main-sequence star KH 15D that reveal it to be a
single-line spectroscopic binary. We find that the best-fit Keplerian model has
a period P = 48.38 days, which is nearly identical to the photometric period.
Thus, we find the best explanation for the periodic dimming of KH 15D is that
the binary motion carries the currently visible star alternately above and
below the edge of an obscuring cloud. The data are consistent with the models
involving an inclined circumstellar disk, as recently proposed by Winn et al.
(2004) and Chiang & Murray-Clay (2004). We show that the mass ratio expected
from models of PMS evolution, together with the mass constraints for the
visible star, restrict the orbital eccentricity to 0.68 < e < 0.80 and the mass
function to 0.125 < Fm < 0.5 Msun.Comment: 8 pages, 4 figures, 3 tables, accepted for publication in September
AJ. Discussion of rotational velocity deferred to Hamilton, et al. (2004, in
prep). Previously reported vsini value in error; Replaced Table 3 with new
Figure 3; Added new Table 2 showing individual radial velocities w.r.t. each
reference star; Fixed typo in Figure
Precise Measures of Orbital Period, Before and After Nova Eruption for QZ Aurigae
For the ordinary classical nova QZ Aurigae (which erupted in 1964), we report
1317 magnitudes from 1912--2016, including four eclipses detected on archival
photographic plates from long before the eruption. We have accurate and robust
measures of the orbital period both pre-eruption and post-eruption, and we find
that the orbital period decreased, with a fractional change of -290.71+-0.28
parts-per-million across the eruption, with the orbit necessarily getting
smaller. Further, we find that the light curve outside of eclipses and eruption
is flat at near B=17.14 from 1912--1981, whereupon the average light curve
starts fading down to B=17.49 with large variability. QZ Aur is a robust
counter-example against the Hibernation model for the evolution of cataclysmic
variables, where the model requires that all novae have their period increase
across eruptions. Large period decreases across eruptions can easily arise from
mass imbalances in the ejecta, as are commonly seen in asymmetric nova shells.Comment: MNRAS in press, 24 pages, 5 tables, 6 figure
Chemical Analysis of Five Red Giants in the Globular Cluster M10 (NGC 6254)
We have determined Al, , Fe-peak, and neutron capture elemental
abundances for five red giant branch (RGB) stars in the Galactic globular
cluster M10. Abundances were determined using equivalent width analyses of
moderate resolution (R15,000) spectra obtained with the Hydra multifiber
positioner and bench spectrograph on the WIYN telescope. The data sample the
upper RGB from the luminosity level near the horizontal branch to about 0.5 mag
below the RGB tip. We find in agreement with previous studies that M10 is
moderately metal-poor with [Fe/H]=-1.45 (=0.04). All stars appear
enhanced in Al with =+0.33 ($\sigma$=0.19), but no stars have
[Al/Fe]$\ga$+0.55. We find the $\alpha$ elements to be enhanced by +0.20 to
+0.40 dex and the Fe--peak elements to have [el/Fe]$\sim$0, which are
consistent with predictions from type II SN ejecta. Additionally, the cluster
appears to be r-process rich with =+0.41.Comment: 16 Pages; 3 Figures; 3 Tables; Accepted for publication in PAS
A Prograde, Low-Inclination Orbit for the Very Hot Jupiter WASP-3b
We present new spectroscopic and photometric observations of the transiting
exoplanetary system WASP-3. Spectra obtained during two separate transits
exhibit the Rossiter-McLaughlin (RM) effect and allow us to estimate the
sky-projected angle between the planetary orbital axis and the stellar rotation
axis, lambda = 3.3^{+2.5}_{-4.4} degrees. This alignment between the axes
suggests that WASP-3b has a low orbital inclination relative to the equatorial
plane of its parent star. During our first night of spectroscopic measurements,
we observed an unexpected redshift briefly exceeding the expected sum of the
orbital and RM velocities by 140 m/s. This anomaly could represent the
occultation of material erupting from the stellar photosphere, although it is
more likely to be an artifact caused by moonlight scattered into the
spectrograph.Comment: 23 pages, 4 figures, Accepted for publication in The Astrophysical
Journal, Replacement includes revised citation
Enhanced Approaches for Identifying Amadori Products: Application to Peanut Allergens
The dry roasting of peanuts is suggested to influence allergic sensitization as a result of the formation of advanced glycation end products (AGEs) on peanut proteins. Identifying AGEs is technically challenging. The AGEs of a peanut allergen were probed with nano-scale liquid chromatography−electrospray ionization−mass spectrometry (nanoLC−ESI−MS) and tandem mass spectrometry (MS/MS) analyses. Amadori product ions matched to expected peptides and yielded fragments that included a loss of three waters and HCHO. As a result of the paucity of b and y ions in the MS/MS spectrum, standard search algorithms do not perform well. Reactions with isotopically labeled sugars confirmed that the peptides contained Amadori products. An algorithm was developed on the basis of information content (Shannon entropy) and the loss of water and HCHO. Results with test data show that the algorithm finds the correct spectra with high precision, reducing the time needed to manually inspect data. Computational and technical improvements allowed for better identification of the chemical differences between modified and unmodified proteins
Two Jovian-Mass Planets in Earthlike Orbits
We report the discovery of two new planets: a 1.94 M_Jup planet in a 1.8-year
orbit of HD 5319, and a 2.51 M_Jup planet in a 1.1-year orbit of HD 75898. The
measured eccentricities are 0.12 for HD 5319 b and 0.10 for HD 75898 b, and
Markov Chain Monte Carlo simulations based on derived orbital parameters
indicate that the radial velocities of both stars are consistent with circular
planet orbits. With low eccentricity and 1 < a < 2 AU, our new planets have
orbits similar to terrestrial planets in the solar system. The radial velocity
residuals of both stars have significant trends, likely arising from substellar
or low-mass stellar companions.Comment: 32 pages, including 11 figures and 5 tables. Accepted by Ap
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