Hvem holder masken?

Source at https://danskhandicapforbund.dk/da/handicap-nyt/#gsc.tab=0Forfatterne til denne artikel arbejder på UiT-Norges arktiske universitet på instituttet for omsorg. Omsorgsuddannelsen er en særlig norsk helse- og socialfaglig uddannelse, som har fokus på enkelt individers udfordringer og muligheder. Uddannelsen har et humanistisk grundsyn

Reminisensøyeblikket

Frivillig innsats er politisk satsningsområde i eldreomsorgen. I denne artikkelen utforskes betingelser for å oppnå motivasjon hos refleksive frivillige med mål om å beholde de som en viktig ressurs i eldreomsorgen. Det legges spesielt vekt på betydningen av å kartlegge de frivilliges interesser og speile de med personer med demens sine interesser. På den måten kan det legges til rette for at det kan oppstå reminisensøyeblikk, som kan gi særlig motivasjon for videre frivillig innsats. Gjennom innovasjonsmodellen for økt frivillighet fokuseres det på betydningen av kartlegging, planlegging, utførelse, dokumentasjon, evaluering og oppdatering av ulike aktivitetstiltak. Dette gjelder både for refleksive frivillige og beboere på livsgledehjem. Konsekvensen av å ikke arbeide systematisk og målrettet, kan være at gløden hos refleksive frivillige forsvinner, og at de kan miste motivasjon til å fortsette som frivillige. Livsglede for eldre (LFE) har utviklet livsgledesirkelen. Det er en modell som omhandler personsentrert omsorg og hvordan det legges til rette for at den enkelte beboers interesser på sykehjem skal ivaretas. Med basis i denne modellen har vi utviklet innovasjonsmodellen for økt frivillighet, som viser hvordan personsentrert frivillighet kan gi økt livsglede og motivasjon for refleksive frivillige som er knyttet til livsgledehjem.Voluntary efforts are a political focus area in the elderly. This study aims to answer the question of: How to facilitate a moment of reminiscence that can rise and contribute as a motivational factor for voluntary efforts in joy of life homes? In order to achieve inner motivation and be able to retain volunteers in the care sector, it is essential that the interests of the volunteers are mapped out and mirrored with the residents’ interests. When planning for activities based on similarities, a moment of reminiscence can arise. The study’s main findings point to a “win-win” situation between the volunteers and residents through golden reminiscence moments that motivate further voluntary efforts. Through the innovation model for increased volunteering, the focus lies within the importance of mapping, planning, execution, documentation, evaluation and updating of various activity measures, both in relation to the reflective volunteers and residents of life joy homes. The organization Joy of life for the elderly (LFE) has developed the circle of joy of life. This model deals with person-centred care, where arrangements are made for the individual resident`s interests in nursing homes to be safeguarded. Based on this model, we have developed the concept of person-centred volunteering as well as the innovation model for increased volunteering, which deals with what can provide joy of life and motivation for reflective volunteers in joy of life homes

Den standhaftige tinsoldat: om musikk som aktiviserings- og inkluderingsverktøy

Journal home page at https://tidsskriftetspecialpaedagogik.dk/.I denne artikkelen ser forfatterne på, hvordan både musikk- og inkluderingsbegrepet kan forstås i utvidet forstand, og hvordan denne tenkningen kan bidra til å skape gode aktiviserings- og inkluderingsverktøy på en måte som fremmer reell deltakelse for personer i alle aldergrupper og med ulike utfordringer. Forfatterne arbeider som henholdsvis førstelektor og universitetslektor ved det helsevitenskapelige fakultetet ved UiT-Norges arktiske universitet. Begge har gjennom flere år hatt spesiell interesse for å se på hvordan en kan hjelpe mennesker med spesielle behov til å oppleve likeverdighet

The Svalbard Carboniferous to Cenozoic Composite Tectono-Stratigraphic Element

The Svalbard Composite Tectono-Stratigraphic Element is located on the north-western corner of the Barents Shelf and comprises a Carboniferous to Pleistocene sedimentary succession. Due to Cenozoic uplift the succession is subaerially exposed in the Svalbard archipelago. The oldest parts of the succession consist of Carboniferous to Permian mixed siliciclastic, carbonate and evaporite and spiculitic sediments that developed during multiple phases of extension. The majority of the Mesozoic succession is composed of siliciclastic deposits formed in sag basins and continental platforms. Episodes of Late Jurassic and Early Cretaceous contraction are evident in the eastern part of the archipelago and in nearby offshore areas. Differential uplift related to the opening of the Amerasian Basin and the Cretaceous emplacement of the High Arctic Large Igneous Province created a major hiatus spanning from most of the Late Cretaceous and early Danian throughout the Svalbard Composite Tectono-Stratigraphic Element. The West Spitsbergen Fold and Thrust Belt and the associated foreland basin in central Spitsbergen (Central Tertiary Basin) formed as a response to the Eurekan orogeny and the progressive northward opening of the North Atlantic during the Palaeogene. This event was followed by formation of yet another major hiatus spanning the Oligocene to Pliocene. Multiple reservoir and source rock units are exposed in Svalbard providing analogues to the offshore prolific offshore acreages in southwest Barents Sea and are important for de-risking of plays and prospects. However, the archipelago itself is regarded as high-risk acreage for petroleum exploration. This is due to Palaeogene contraction and late Neogene uplift of particularly the western and central parts. In the east there is an absence of mature source rocks, and the entire region is subjected to strict environmental protection

Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia: A comparison among participants between 2 and 53 years

Author´s accepted manuscript.This is the peer reviewed version of the following article: Hope, S., Nærland, T., Høyland, A. L., Torske, T., Malt, E., Abrahamsen, T. G., Nerhus, M., Wedervang-Resell, K., Lonning, V. L. H., Johannessen, J., Steen, N. E., Agartz, I., Stenberg, N., Hundhausen, T. E., Mørkrid, L. & Andreassen, O. A. (2020). Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia : A comparison among participants between 2 and 53 years. The FASEB Journal, 34(6), 8114-8124, which has been published in final form at https://doi.org/10.1096/fj.201900855RRR. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Recent studies suggest that both high and low levels of vitamin B12 (vitB12) may have negative health impacts. We measured VitB12 in patients with the Neurodevelopmental disorders (ND) (n = 222), comprised of Autism Spectrum Disorders, specific Developmental disorders, and Intellectual Disability (aged 2-53 years), schizophrenia (n = 401), and healthy controls (HC) (n = 483). Age-and gender-adjusted vitB12 z-scores were calculated by comparisons with a reference population (n = 76 148). We found higher vitB12 in ND (median 420 pmol/L, mean z-score: 0.30) than in HC (316 pmol/L, z-score: 0.06, P < .01) and schizophrenia (306 pmol/L, z-score: −0.02, P < .001), which was significant after adjusting for age, gender, vitB12 supplement, folate, hemoglobin, leukocytes, liver, and kidney function (P < .02). In ND, 20% (n = 44) had vitB12 above 650 pmol/L, and 1% (n = 3) had below 150 pmol/L (common reference limits). In 6.3% (n = 14) of ND, vitB12 was above 2SD of mean in the age-and gender-adjusted reference population, which was more frequent than in HC (n = 8, 1.6%), OR: 4.0, P = .001. Low vitB12 was equally frequent as in HC, and vitB12 z-scores were equal across the age groups. To conclude, vitB12 was higher in ND than in HC and schizophrenia, suggesting a specific feature of ND, which warrants further studies to investigate the underlying mechanisms.acceptedVersio

Status of the cod along the coast in southern Norway

English: In a report from 2008 an assessment of coastal cod in southern Norway, from the Swedish border to Stad, was presented, together with suggestions to management initiatives. This report shortly summarize the 2008-report, but new knowledge attained the last 10 years is the main part. The cod along the coast in southern Norway are made up of possibly there different components: 1) stationary, local stocks in the fjords, 2) cod from the North Sea along the outer coast, and 3) possibly a more “ migrating cod” along the outer coast. The latter type of coastal cod, if existing, has genetic similarities with the North Sea cod. Much new knowledge indicate that the cod along the coast in southern Norway are exposed to increasing pressure from multiple factors, not at least from recreational fisheries. Local stocks of cod in fjords are the smallest and accordingly most vulnerable stocks of cod. Future regulations should aim at a best possible conservation of the local stocks of cod in the fjords, but also reduce mortality of cod living along the outer parts of the coast. This report also suggest some, possible management initiatives. Norsk:2008 kom en rapport som vurderte status for kysttorsk på strekningen Svenskegrensa-Stad, og som også inkluderte forslag til forvaltningstiltak. Denne rapporten starter med en kort oppsummering av oversikten fra 2008, men bringer i hovedsak ny kunnskap som er kommet til de siste 10 årene. Historisk er det en klar nedgang i fangstene av årets yngel (0-gruppe torsk) i strandnotserien fra Havforskningsinstituttet. De siste ca. 20 årene har nedgangen vært størst. Torskeforekomstene langs kysten ser ut til å være sammensatt av tre komponenter: 1) lokale, stasjonære stammer av fjordtorsk, som særlig forekommer i de indre kystområdene/fjordene, 2) nordsjøtorsk og 3) muligens også en mer vandrende komponent av kysttorsk med genetisk likhetstrekk med nordsjøtorsken, som særlig forekommer i de ytre kystområdene. Det er nå dokumentert at torsken langs kysten både på Vestlandet og Sørlandet er utsatt for økende press fra flere påvirkningsfaktorer, ikke minst et betydelig fritidsfiske. Lokale stammer av fjordtorsk er de klart minste og mest sårbare bestandene langs kysten. Fremtidige reguleringer bør gi best mulig vern for lokale stammer av fjordtorsk, men også redusere fiskedødeligheten for «nordsjøtype» torsk langs den ytre delen av kysten. En rekke forslag til tiltak er oppsummert i rapporten

Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide

Glioblastoma multiforme (GBM) has a poor prognosis with an overall survival of 14–15 months after surgery, radiation and chemotherapy using temozolomide (TMZ). A major problem is that the tumors acquire resistance to therapy. In an effort to improve the therapeutic efficacy of TMZ, we performed a genome‐wide RNA interference (RNAi) synthetic lethality screen to establish a functional gene signature for TMZ sensitivity in human GBM cells. We then queried the Connectivity Map database to search for drugs that would induce corresponding changes in gene expression. By this approach we identified several potential pharmacological sensitizers to TMZ, where the most potent drug was the established antipsychotic agent Thioridazine, which significantly improved TMZ sensitivity while not demonstrating any significant toxicity alone. Mechanistically, we show that the specific chemosensitizing effect of Thioridazine is mediated by impairing autophagy, thereby preventing adaptive metabolic alterations associated with TMZ resistance. Moreover, we demonstrate that Thioridazine inhibits late‐stage autophagy by impairing fusion between autophagosomes and lysosomes. Finally, Thioridazine in combination with TMZ significantly inhibits brain tumor growth in vivo, demonstrating the potential clinical benefits of compounds targeting the autophagy‐lysosome pathway. Our study emphasizes the feasibility of exploiting drug repurposing for the design of novel therapeutic strategies for GBM.</p

Physicians’ engagement in dual practices and the effects on labor supply in public hospitals: results from a register-based study

BACKGROUND: Physician dual practice, a combination of public and private practice, has attracted attention due to fear of reduced work supply and a lack of key personnel in the public system, increase in low priority treatments, and conflicts of interest for physicians who may be competing for their own patients when working for private suppliers. In this article, we analyze both choice of dual practice among hospital physicians and the dual practices’ effect on work supply in public hospitals. METHODS: The sample consisted of 12,399 Norwegian hospital physicians working in public hospitals between 2001 and 2009. We linked hospital registry data on salaries and hospital working hours with data from national income and other registries covering non-hospital income, including income from dual work, cohabiting status, childbirths and socioeconomic characteristics. Our dataset also included hospital variables describing i.e. workload. We estimated odds ratio for choosing dual practice and the effects of dual practice on public working hours using different versions of mixed models. RESULTS: The percentage of physicians engaged in dual practice fell from 35.1% for men and 17.6% for women in 2001 to 25.0% and 14.2%, respectively, in 2009. For both genders, financial debt and interest payments were positively correlated and having a newborn baby was negatively correlated with engaging in dual practice. Larger family size and being cohabitating increased the odds ratio of dual practice among men but reduced it for women. The most significant internal hospital factor for choosing dual practice was high wages for extended working hours, which significantly reduced the odds ratio for dual practice. The total working hours in public hospitals were similar for both those who did and did not engage in dual practice; however, dual practice reduced public working hours in some specialties. CONCLUSION: Economic factors followed by family variables are significant elements influencing dual practice. Although our findings indicate that engagement in dual practice by public hospital physicians in a well-regulated market may increase the total labor supply, this may vary significantly between medical specialties