sj-docx-2-dhj-10.1177_20552076221131141 - Supplemental material for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021

Supplemental material, sj-docx-2-dhj-10.1177_20552076221131141 for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021 by Jie Zhao, Jie Mao and Jing Tan in Digital Health</p

sj-docx-1-dhj-10.1177_20552076221131141 - Supplemental material for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021

Supplemental material, sj-docx-1-dhj-10.1177_20552076221131141 for Global trends and hotspots in research on extended reality in sports: A bibliometric analysis from 2000 to 2021 by Jie Zhao, Jie Mao and Jing Tan in Digital Health</p

DataSheet_1_Cost-Effectiveness of Pembrolizumab for the treatment of Non–Small-Cell lung cancer: A systematic review.doc

IntroductionPembrolizumab, an immune checkpoint inhibitor for treating non-small cell lung cancer (NSCLC), can impose a high financial burden. Several studies have explored the cost-effectiveness of this expensive agent. We conducted a systematic review and pooled analysis to evaluate the quality of the existing pharmacoeconomic studies on pembrolizumab strategies for NSCLC treatment as well as to conclude the cost-effectiveness of such strategies.MethodsEnglish and Chinese databases were searched to collect health economic studies on pembrolizumab therapies (monotherapy or a combination with chemotherapy) compared with chemotherapy for the treatment of NSCLC patients. The reporting quality, modeling methods, and results of incremental cost-effectiveness analysis of the included literature were descriptively analyzed.ResultsA total of 24 studies, 3 in Chinese and 21 in English, were selected. All reports satisfy a median of 31 out of 40 reporting quality assessment items based on a quality checklist for pharmacoeconomic evaluations. 12 studies used the Markov model and 11 used the partitioned survival model. A common problem identified in the modeling methods was the insufficient justification of the choices of model structure and data inputs. Pembrolizumab was found to be cost-effective in the United States and Switzerland, but not in China, France, the UK, or Singapore.ConclusionThe current cost-effectiveness studies on pembrolizumab for the treatment of NSCLC are of moderate quality, and the relevant decision-analytic modeling methods have much scope for improvement. The cost-effectiveness of pembrolizumab strategies for NSCLC varies across countries, warranting the need to pay more attention to the methodologies of pharmacoeconomic research in order to produce correct outcomes in terms of cost-effectiveness for different countries.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021250480</p

Table_1_Impact of ashes from the 2022 Tonga volcanic eruption on satellite ocean color signatures.pdf

A powerful eruption within the Hunga Tonga-Hunga Ha’apai (HTHH) volcano (20.64°S, 175.19°W) in the Kingdom of Tonga, occurred on 15 January 2022. The volcanic blast was enormous, leading many scientists to investigate the full impact and magnitude of this event via satellite observations. In this study, we describe a new ocean color signature from a discolored water patch created by the HTHH eruption using NASA and CMEMS products of satellite-derived biological and optical properties. Elevated surface chlorophyll-a concentration (Chl-a) between 0.15 to 2.7 mg.m-3 was not associated with phytoplankton growth, but to basalt-andesitic ash material expelled by the volcano and into the ocean, which resulted in erroneous Chl-a estimates. Distribution of the patch over time was aligned with CMEMS ocean currents for 19 days. The gradual decrease of light attenuation or diffuse attenuation coefficient for downward irradiance at 490 nm, Kd(490), was interpreted as due to the sinking of ash particles with time. It is suggested that due to high porosity of 30-40%, a density close to that of seawater, ash particles stay suspended in the water column for more than 10 days with sustained high values of satellite-derived Chl-a, Kd(490), and particulate backscattering coefficient at 443 nm. The high attenuation of light due to ash, reducing the penetration depth to less than 10 meters during the first period after the eruption may have had implications on ecological processes and biogeochemical cycles in Tongan waters.</p

Dual-Mode Encoded Magnetic Composite Microsphere Based on Fluorescence Reporters and Raman Probes as Covert Tag for Anticounterfeiting Applications

Utilizing fluorescence reporters and SERS probes as the security labels, a series of dual-mode encoded magnetic composite microspheres with micrometer size was designed and prepared for anticounterfeiting applications. At first, the micro-meter-sized melamine formaldehyde microspheres with different fluorescence molecules (FMF) were prepared by precipitation polymerization, and then the magnetite composite microspheres (FMF/MNPs) were fabricated by direct immobilization of magnetic nanoparticles (MNPs) onto the surface of FMF microspheres. After deposition of Ag nanoparticles (Ag-NPs) onto FMF/MNPs microspheres, the SERS probes were absorbed onto the surface of Ag-NPs, and then a protection layer of silica was coated on the composite microspheres by Stöber method. The combination of different fluorescence reporters and SERS probes greatly increased the encoding complexity and volume for high-level anticounterfeiting. The structure of the dual-encoded FMF/MNPs/Ag-NPs/SiO₂ composite microspheres was characterized by FESEM, TEM, FLS­(fluorescence spectrometer), XRD, VSM, UV–vis and EDS. The embedded magnetic nanoparticles enable the composite microspheres to be quickly isolated from the marked latex paint by magnet at the concentration of as low as 1 ppm, and the covert tag information can be read out even from one composite microsphere. In addition, the covert security information in the marked coating film can be also read out in situ and the existence of the composite microspheres does not influence the visible appearance of the coating film. All the above outstanding properties will make these dual-mode encoded composite microspheres as advanced security tags for next-generation anticounterfeiting applications

Transition-Metal-Free N–O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines

An NH₄I-based reductive system has been explored to promote the oxime N–O bond cleavage and thereby enable a modular synthesis of a broad range of pharmacologically significant fluorinated pyridines. Compared with traditional condensation methods for pyridine assembly, this protocol was found to be highly regio- and chemoselective and presented broad functional group tolerance

Table3_Various Bee Pheromones Binding Affinity, Exclusive Chemosensillar Localization, and Key Amino Acid Sites Reveal the Distinctive Characteristics of Odorant-Binding Protein 11 in the Eastern Honey Bee, Apis cerana.PDF

<p>Odorant-binding proteins (OBPs) are the critical elements responsible for binding and transporting odors and pheromones in the sensitive olfactory system in insects. Honey bees are representative social insects that have complex odorants and pheromone communication systems relative to solitary insects. Here, we first cloned and characterized OBP11 (AcerOBP11), from the worker bees antennae of Eastern honey bee, Apis cerana. Based on sequence and phylogenetic analysis, most sequences homologous to AcerOBP11 belong to the typical OBPs family. The transcriptional expression profiles showed that AcerOBP11 was expressed throughout the developmental stages and highly specifically expressed in adult antennae. Using immunofluorescence localization, AcerOBP11 in worker bee's antennae was only localized in the sensilla basiconica (SB) near the fringe of each segment. Fluorescence ligand-binding assay showed that AcerOBP11 protein had strong binding affinity with the tested various bee pheromones components, including the main queen mandibular pheromones (QMPs), methyl p-hydroxybenzoate (HOB), and (E)-9-oxo-2-decanoic acid (9-ODA), alarm pheromone (n-hexanol), and worker pheromone components. AcerOBP11 also had strong binding affinity to plant volatiles, such as 4-Allylveratrole. Based on the docking and site-directed mutagenesis, two key amino acid residues (Ile97 and Ile140) were involved in the binding of AcerOBP11 to various bee pheromones. Taken together, we identified that AcerOBP11 was localized in a single type of antennal chemosensilla and had complex ligand-binding properties, which confer the dual-role with the primary characteristics of sensing various bee pheromones and secondary characteristics of sensing general odorants. This study not only prompts the theoretical basis of OBPs-mediated bee pheromones recognition of honey bee, but also extends the understanding of differences in pheromone communication between social and solitary insects.</p

MOESM1 of An investigation of fungal contamination on the surface of medicinal herbs in China

Additional file 1: Table S1. Samples collection information and depositing numbers

Table1_Various Bee Pheromones Binding Affinity, Exclusive Chemosensillar Localization, and Key Amino Acid Sites Reveal the Distinctive Characteristics of Odorant-Binding Protein 11 in the Eastern Honey Bee, Apis cerana.PDF

<p>Odorant-binding proteins (OBPs) are the critical elements responsible for binding and transporting odors and pheromones in the sensitive olfactory system in insects. Honey bees are representative social insects that have complex odorants and pheromone communication systems relative to solitary insects. Here, we first cloned and characterized OBP11 (AcerOBP11), from the worker bees antennae of Eastern honey bee, Apis cerana. Based on sequence and phylogenetic analysis, most sequences homologous to AcerOBP11 belong to the typical OBPs family. The transcriptional expression profiles showed that AcerOBP11 was expressed throughout the developmental stages and highly specifically expressed in adult antennae. Using immunofluorescence localization, AcerOBP11 in worker bee's antennae was only localized in the sensilla basiconica (SB) near the fringe of each segment. Fluorescence ligand-binding assay showed that AcerOBP11 protein had strong binding affinity with the tested various bee pheromones components, including the main queen mandibular pheromones (QMPs), methyl p-hydroxybenzoate (HOB), and (E)-9-oxo-2-decanoic acid (9-ODA), alarm pheromone (n-hexanol), and worker pheromone components. AcerOBP11 also had strong binding affinity to plant volatiles, such as 4-Allylveratrole. Based on the docking and site-directed mutagenesis, two key amino acid residues (Ile97 and Ile140) were involved in the binding of AcerOBP11 to various bee pheromones. Taken together, we identified that AcerOBP11 was localized in a single type of antennal chemosensilla and had complex ligand-binding properties, which confer the dual-role with the primary characteristics of sensing various bee pheromones and secondary characteristics of sensing general odorants. This study not only prompts the theoretical basis of OBPs-mediated bee pheromones recognition of honey bee, but also extends the understanding of differences in pheromone communication between social and solitary insects.</p

MOESM1 of An investigation of fungal contamination on the surface of medicinal herbs in China

Additional file 1: Table S1. Samples collection information and depositing numbers