CFAR Ship Detection in Polarimetric Synthetic Aperture Radar Images Based on Whitening Filter

Polarimetric whitening filter (PWF) can be used to filter polarimetric synthetic aperture radar (PolSAR) images to improve the contrast between ships and sea clutter background. For this reason, the output of the filter can be used to detect ships. This paper deals with the setting of the threshold over PolSAR images filtered by the PWF. Two parameter-constant false alarm rate (2P-CFAR) is a common detection method used on whitened polarimetric images. It assumes that the probability density function (PDF) of the filtered image intensity is characterized by a log-normal distribution. However, this assumption does not always hold. In this paper, we propose a systemic analytical framework for CFAR algorithms based on PWF or multi-look PWF (MPWF). The framework covers the entire log-cumulants space in terms of the textural distributions in the product model, including the constant, gamma, inverse gamma, Fisher, beta, inverse beta, and generalized gamma distributions (GΓDs). We derive the analytical forms of the PDF for each of the textural distributions and the probability of false alarm (PFA). Finally, the threshold is derived by fixing the false alarm rate (FAR). Experimental results using both the simulated and real data demonstrate that the derived expressions and CFAR algorithms are valid and robust

Cytochrome P450 enzymes in the black-spotted frog (Pelophylax nigromaculatus): molecular characterization and upregulation of expression by sulfamethoxazole

Cytochrome P450 (CYP) enzymes are crucial for the detoxification of xenobiotics, cellular metabolism, and homeostasis. This study investigated the molecular characterization of CYP enzymes in the black-spotted frog, Pelophylax nigromaculatus, and examined the regulation of CYP expression in response to chronic exposure to the antibiotic sulfamethoxazole (SMX) at various environmental concentrations (0, 1, 10, and 100 μg/L). The full-length cDNA of Pn-CYP26B1 was identified. The sequence included open reading frames of 1,536 bp, encoding proteins comprising 511 amino acids. The signature motif, FxxGxxxCxG, was highly conserved when compared with a number of selected animal species. SMX significantly upregulated the expression of the protein CYP26B1 in frog livers at concentrations of 1 and 10 μg/L. SMX showed an affinity for CYP26B1 of −7.6 kcal/mol, indicating a potential mechanism for SMX detoxification or adaptation of the frog. These findings contributed to our understanding of the environmental impact of antibiotics on amphibian species and underscored the importance of CYP enzymes in maintaining biochemical homeostasis under exposure to xenobiotic stress

A Business Model Incorporating Harmonic Control as a Value-added Service for Utility-owned Electricity Retailers

With the deepening of electricity market reform in China, the competition in the electricity retail market becomes increasingly intense. Electricity retailers (ERs) need to explore new business models to enhance their competitiveness in the retail market. Meanwhile, with the improvement of industrial production and people's living standards, more and more nonlinear electrical equipment have been put into use, leading to severe harmonic pollution problems. Harmonic pollution causes loss of electricity, resulting in the economic loss of customers, especially for large industrial customers. In the above contexts, this paper proposes a novel business model that incorporates harmonic control as a value-added service into electricity retail contracts for utility-owned ERs. Both utility-owned ERs and customers can benefit from the designed business model. For customers, it helps them to improve the power quality while saving the electricity cost. For ERs, it helps them to cultivate the customer loyalty and improve the customer satisfaction. A case study is performed to demonstrate the effectiveness of the proposed business model

Benzyl isothiocyanate induces apoptosis and inhibits tumor growth in canine mammary carcinoma via down-regulation of the cyclin B1/Cdk1 pathway

Background: Canine mammary carcinoma is common in female dogs, and its poor prognosis remains a serious clinical challenge, especially in developing countries. Benzyl isothiocyanate (BITC) has attracted great interest because of its inhibitory effect against tumor activity. However, its effect and the underlying mechanisms of action in canine mammary cancer are not well-understood. Here, we show that BITC suppresses mammary tumor growth, both in vivo and in vitro, and reveal some of the potential mechanisms involved. Methods: The effect of BITC on canine mammary cancer was evaluated on CIPp and CMT-7364, canine mammary carcinoma lines. The cell lines were treated with BITC and then subjected to wound healing and invasion assays. Cell cycles and apoptosis were measured using flow cytometry; TUNEL assay; immunohistochemistry (IHC) for caspase 3, caspase 9, and cyclin D1; hematoxylin and eosin (H&E) staining; and/or quantitative polymerase chain reaction (qPCR). Results: BITC showed a strong suppressive effect in both CIPp and CMT-7364 cells by inhibiting cell growth in vitro; these effects were both dose- and time-dependent. BITC also inhibited migration and invasion of CIPp and CMT-7364 cells. BITC induced G2 arrest and apoptosis, decreasing tumor growth in nude mice by downregulation of cyclin B1 and Cdk1 expression. Conclusion: BITC suppressed both invasion and migration of CIPp and CMT-7364 cells and induced apoptosis. BITC inhibited canine mammary tumor growth by suppressing cyclinB1 and Cdk1 expression in nude mice

Performance of fast-ion loss diagnostic on EAST

The scintillator-based detector for fast-ion loss measurements has been installed on EAST. To obtain high temporal resolution for fast-ion loss diagnostics, fast photomultiplier tube systems have been developed which can supply the complementary measurements to the previous image system with good energy and pitch resolution by using a CCD camera. By applying the rotatable platform, the prompt losses of beam-ions can be measured in normal and reverse magnetic field. The thick-target bremsstrahlung occurring in the stainless steel shield with energetic electrons can produce X-rays, which will strike on the scintillator based detector. To understand this interference on fast-ion loss signals, the effects of energetic electrons on the scintillator-based detector are studied, including runaway electrons in the plasma ramping-up phase and fast electrons accelerated by the lower hybrid wave

GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3

The actin-rich cortex plays a fundamental role in many cellular processes. Its architecture and molecular composition vary across cell types and physiological states. The full complement of actin assembly factors driving cortex formation and how their activities are spatiotemporally regulated remain to be fully elucidated. Using Dictyostelium as a model for polarized and rapidly migrating cells, we show that GxcM, a RhoGEF localized specifically in the rear of migrating cells, functions together with F-BAR protein Fbp17, a small GTPase RacC, and the actin nucleation-promoting factor WASP to coordinately promote Arp2/3 complex-mediated cortical actin assembly. Overactivation of this signaling cascade leads to excessive actin polymerization in the rear cortex, whereas its disruption causes defects in cortical integrity and function. Therefore, apart from its well-defined role in the formation of the protrusions at the cell front, the Arp2/3 complex-based actin carries out a previously unappreciated function in building the rear cortical subcompartment in rapidly migrating cells

Research on Evaluation of Power Supply Capability of Active Distribution Network with Distributed Power Supply with High Permeability

With the large number of distributed generation (DG) access to the distribution network, the traditional distribution network with a single-supply radial structure has been transformed into an active distribution system (ADS) with source and bidirectional currents. This transformation makes the calculation of the power supply capacity (PSC) of the ADS face new challenges, and the uncertainty of the DG output increases the difficulty in calculating the PSC. At the same time, the power market transaction check needs to meet the safety constraints of the distribution network operation, and is required to know the PSC information of the ADS more quickly and accurately. Therefore, in order to quickly evaluate the PSC of the ADS, this paper proposes a fast evaluation method of the PSC based on the DG output rolling prediction and the information gap decision theory (IGDT). The method first establishes a rolling prediction model of the DG output, and calculates the PSC of the ADS at the corresponding time. Next, it establishes a risk avoidance model (RAM) and a risk speculation model (RSM) for the PSC of the ADS based on the IGDT. These models further calculate the probability of the range of the PSC at the corresponding time, so as to better evaluate the PSC of the ADS. Finally, the improved IEEE-14 node is used to verify that the model can consider the influence of the DG output uncertainty and quickly calculate the information of PSC