Amphetamine recapitulates developmental programs in the zebrafish

The zebrafish as a model for drug addiction

Is There Anything Wrong With the Slogan “My Body My Choice” When It Comes to Abortion?

Early evidence of induced abortion goes back to the 1500s BC. Aristotle’s work, later, described both chemical and mechanical methods to induce it, and ancient Rome also practiced it as a means of population control. Throughout history, there have also been primarily two opposing views regarding a woman’s right to terminate a pregnancy early: one, called pro-choice, which supports abortion for diverse reasons; and the other, pro-life, which opposes that practice, because to them, it is an attack on the most defenseless and helpless class of individuals, the unborn. The pro-choice group often refers to the slogan “My Body, My Choice” to defend a woman’s right to have an abortion, for if it is her body, they say, then it is her choice. However, one may ask: Is there anything wrong with the rhetoric “My body, my choice” when it comes to abortion? Is a fetus entirely part of a woman’s body? Thus, to address these questions, we first looked at the logic behind the pro-choice rhetoric, then explored what really happens inside the womb during a pregnancy, and finally, studied what Scriptures say about the life of the unborn child in the womb

Dextran sulfate enhances the level of an oxidative DNA damage biomarker, 8-oxo-7,8-dihydro-2 0-deoxyguanosine, in rat colonic mucosa

Dextran sodium sulfate (DSS) given in drinking water can induce colonic Inflammation and produce colorectal tumors in rodents, although it is not directly genotoxic. The hypothesis that DSS can produce free radicals and induce oxidative DNA damage in colonic mucosa has been tested. In rats fed for 2 days with water containing 3% and 6% DSS, colonic Inflammation manifestations were recorded and 8-oxo-7,8-dihydro-2 0-deoxyguanosine (8-oxodGuo), a major biomarker of oxidative DNA damage, was assayed in colonic mucosa. As compared with control rats given pure water, inflammatory manifestations were seen in rats given DSS. At the same time, 8-oxodGuo levels in colonic mucosa were doubled (P , 0:001). These results suggest that formation of oxidative DNA damage in colonic mucosa depends on inflammation and maybe on the production of reactive oxygen species. This study shows that DSS can induce oxidative DNA damage within only 2 days, which could explain in part its carcinogenic properties

Making students sensitive to entrepreneurship

The aim of this paper is to present a {proposal to make students sensitive to entrepreneurship} aiming at familiarizing students to the setting up of new firms and stimulating such a course of action. This {{awareness campaign}} would take place during the student's curriculum and rest on a simulation exercise. This campaign is based on the results of a survey conducted at the Technical University of Cartagena (Spain). This study has identified some students’ aspirations to salaried employment and entrepreneurship. This survey also recognized some specific features that the campaign must integrate, in particular the need to make entrepreneurship compatible with the preparation for salaried employment. The results of this study are completed comparing them with the opinion from entrepreneurs of the same region. This comparison highlights some barriers to entrepreneurship among the students population, making it possible to complete the content of the proposed simulation exercise. This paper also highlights the absence of barriers of a psychological nature usually put forward by the literature, such as a low level of the {need for achievement or the propensity for risk-taking}.career, company, entrepreneurship, making sensitive, student

The primacy of cognition in the manifestations of substance use disorders

Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Cadet, Jean Lud. National Institute On Drug Abuse; Estados Unido

Glial-neuronal ensembles: partners in drug addiction-associated synaptic plasticity

Drug addiction is manifested by a compulsive drive to take licit or illicit substances despite repeated severe adverse consequences (Volkow et al., 2012). Addiction is also accompanied by a vicious cycle of binges, abstinence, and relapses. Almost all drugs of abuse trigger euphoric feelings consequent to a rapid increase of dopamine levels in the mesolimbic system. Even after long periods of abstinence, addicts remain vulnerable to drug craving and/or relapses that can be triggered by stimuli previously associated with drugs (Koob and Volkow, 2010). These features of addiction suggest that drugs might cause a form of persistent neuroplasticity that is acutely responsive to environmental stimuli, with consequent compulsive drug-seeking and taking behaviors.Fil: Cadet, Jean Lud. National Institute on Drug Abuse; Estados UnidosFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentin

La politique commerciale des États-Unis et le régionalisme dans les Amériques

Le continentalisme et le panaméricanisme inspiré de la doctrine Monroe ont toujours été des données fondamentales de la politique étrangère des États-Unis et l’Amérique latine a toujours été perçue comme faisant partie de leur sphère d’influence naturelle. Si les questions économiques n’ont jamais été secondaires, la priorité a cependant toujours été accordée aux questions de sécurité dans les rapports avec le reste du continent.Introduction; 1. La politique commerciale américaine: continuité et particularités; 2. De la redéfinition des intérêts économiques et des questions de sécurité au régionalisme ouvert; 3. Du régionalisme ouvert aux alliances commerciales; Conclusion

Early Middle Paleozoic Intraplate Orogeny in the Ogcheon Belt (South Korea): A new insight on the Paleozoic buildup of east Asia

Laurent Jolivet est Professeur à l'Université d'Orléans depuis le 1er septembre 2009.International audienceThe polycyclic Ogcheon belt of South Korea represents the boundary between two Precambrian blocks. Investigation on the timing and kinematics of the block agglomeration is of considerable bearing on the understanding of the constitution of the Asian continent. We report here structural evidence showing that the earlier tectonic event dates back to early middle Paleozoic (the "Ogcheon tectonism" or "orogeny"). The ductile piling up of nappes of the Ogcheon belt corresponds to an intracontinental orogeny involving the opening and the subsequent closure of an aborted rift and not of a wide oceanic area. The nappes contain unequivocal evidence for ductile shearing with a northwest over southeast sense of movement. Field evidence includes the presence of S1 and S1-2 foliations bearing an extensive stretching lineation perpendicular to the belt, associated with a strongly noncoaxial deformation regime. The F1 isoclinal folds are commonly "A type" and sheath folds whose axes are parallel to the stretching lineation, whereas the southeast facing F2 recumbent folds have subhorizontal axes parallel to the belt. All lines of evidence (unconformity, superposed deformations, age of the metamorphism, etc...) imply that the D1-2 "Ogcheon tectonism" is pre-middle Carboniferous (Late Silurian-Early Devonian). The subsequent Indosinian (Middle Triassic) F3 upright synfolial folds that trend NNE-SSW and later structures clearly overprint the middle Paleozoic ductile thrusts and isoclinal folds. The early Paleozoic Ogcheon Supergroup is formed of a thick volcanosedimentary pile deposited above an early platform sequence in a rift basin. On the basis of the geochemical characteristics of the metavolcanics, it appears that oceanization did not occur and Ogcheon rift aborted soon after it was formed. We suggest that middle Paleozoic ductile nappe structures have been formed by the structural inversion of the rift extensional features. During the ductile stacking episode, the early formed foliation and isoclinal folds have been folded in a continuum during the same tectonic event. Middle Carboniferous terrigenous formations have been deposited unconformably upon folded and thrust older rocks. A tentative correlation with early Paleozoic Imjingang, Qinling and Cathaysian belts within the Asian continent reveals that Ogcheon rift was emplaced within the South China plate and that Imjingang belt should represent the limit between North and South China blocks in the Korean peninsula

Référentiels et activité : un rapport complexe à améliorer

Que ferions-nous sans référentiels ? Aujourd’hui, en France et dans bien d’autres pays comparables, les référentiels sont devenus tellement omniprésents dans les sphères de la formation, de la certification et de la gestion qu’on peine à imaginer un monde et un fonctionnement social qui en seraient totalement dépourvus. Ces documents visent à formaliser « ce qui fait référence », c’est-à-dire des repères ou des normes, pour des situations de travail, des emplois ou des métiers donnés. Ils pro..

L’avenir appartient à ceux qui savent anticiper

       Il est de bon ton d’afficher une ambition prospective dans le champ de la relation formation-emploi-travail. Depuis l’époque de la planification, l’Etat n’a cessé d’initier des travaux visant à prévoir, à anticiper ou à pronostiquer l’avenir quantitatif ou qualitatif des emplois pour tenter d’ajuster l’appareil de formation. Aujourd’hui, il perpétue pleinement cette tradition à travers notamment les travaux du Conseil d’analyse stratégique et de la Direction de l’animation de la reche..