The Reform Scheme and the All-India Muslim League: An Evaluation of Its Performance (1907-1909)

In many ways, the advent of twentieth century was much significant for the Muslims of South Asia as a number of epoch-making events took place during this period that not only changed the Muslim political culture but also the whole political scenario of the subcontinent. This century was marked by a political awakening of the Muslims to the real or perceived idea that the British policies in the subcontinent were hostile towards their interests. Therefore, even those stalwarts of Aligarh who had been preaching their coreligionists to keep aloof from politics, now turned to advise the students of Aligarh College (in March 1903) to participate in politics. This change took place because of a host of issues such as the attack on Urdu (1900), the partition of Bengal (1905) and the Hindu reaction to that, the victory of the pro-Hindu Labour Party in the U.K., an end of Curzon era and start of Minto’s viceroyalty attempting to win over the lost confidence of the Indian public opinion which had emboldened the Indian National Congress (hereafter Congress) and multiplied the Muslim sufferings. The crux of the Muslim collective response to the situation was the formation of the Reform Scheme of Government, the formation of the Muslim Deputation and finally the founding of the All-India Muslim League (hereafter AIML). With these developments began the struggle of Muslims in bracing the abovementioned challenges. This voyage started from Dacca in 1906 and culminated in 1909 at Amritsa

Trade Shocks and Labour Adjustment: Evidence from Pakistan’s Manufacturing Industries

The present study is an attempt to explore the impact of trade liberalisation on employment and wages of production and non-production workers in large scale manufacturing industries of Pakistan. We use a sample of 18 industrial establishments with a time series data covering a period 1970-71 to 2005-06. In order to account for endogeniety problem, this study uses the Generalised Method of Moments (GMM). The study comes up with the findings that trade liberalisation has significantly negative impact on employment of both production and non-production workers. On the other hand, trade liberalisation has a significantly positive impact on wages of production workers, but it has no significant impact on wages of non-production workers. The negative impact of trade is attributed to the high protection given to most of the inefficient industries in the post liberalisation period. On the other hand, reduction in non-production worker employment is not unexpected as in case of developing country like Pakistan, trade liberalisation is supposed to displace capital intensive industries that employ most of the non-production (skilled) workers. Keywords: Production Worker, Non-production Workers, Trade, Employment, Wage

Role of radiosurgery In arteriovenous malformations

Background: Intracranial arteriovenous malformations (AVMs) consist of an abnormal nidus of blood vessels that shunt blood directly from an artery to a vein and thereby bypass an intervening capillary bed. AVMs may be found as an incidental finding. They may be associated with intracranial haemorrhage, seizures, headaches or neurological deficits. There are different treatment options for AVM. These include observation, microsurgery, Stereotactic radio surgery (SRS), endovascular embolization and intensity modulated radiotherapy (IMRT).Methods: Data was collected using searching engines like Pubmed, Google scholar, Embase, Cinahl and Medline. MeSH and Non-MeSH terms were used like Arterio-venous malformations, microsurgery, endovascular embolization.Results: Multiple interventional radiosurgical techniques have been introduced in recent years. The most effective and least risk-associated methods are Stereotactic radiosurgery, Microsurgery, Embolization and Intensity modulated radiotherapy (IMRT). However, the outcome of such treatment modalities depends upon Site of malformation, grade of AVM, patient\u27s age/gender, dose and volume of radiosurgery. Digital substraction angiography (DSA) and MR angiography (MRA) are most suitable methods for the follow-up of AVMs.Conclusions: Stereotactic radiosurgery is the most suitable technique for AVMs considering the good prognosis and the risks associated with this procedure. However, large AVMs require multidisciplinary approach for better results

Epidemiology of Onychomycosis in Gujranwala Division-Pakistan

Onychomycosis is a common fungal infection of nails. It is usually further divided into four types which are Distal and lateral subungual onychomycosis (DLSO), white superficial onychomycosis (WSO), proximal subungual onychomycosis (PSO) and candidal onychomycosis (CO). The main causative agents of onychomycosis are three fungal forms: dermatophytes, yeasts, and non-dermatophytes molds. In current study, occurrence frequency of various types of onychomycosis was observed in a selected region of Pakistan. Collected data were statistically analyzed at 0.001% significance level by using single factor ANOVA for comparative examination on the basis of gender, age and onychomycosis types. Results indicated that males suffer more than females, adults are more prone to get onychomycosis attack and DLSO is frequently occurring than other forms. The root causes of this epidemiological trend were lack of personal hygiene and health care awareness among masses and knowledge about symptoms and effects of onychomycosis meanwhile poverty was also found as a leading indirect reason for the spread of this nail disorder. Future researchers should find out cost effect local alternatives for treatment and control of onychomycosis along with some general public awareness program

Incidence and etiology of omphalitis in Pakistan: a community-based cohort study

Introduction: Although omphalitis (umbilical infections) among newborns is common and a major cause of neonatal deaths in developing countries, information on its burden and etiology from community settings is lacking. This study aimed to determine the incidence and etiology of omphalitis in newborns in high neonatal mortality settings in Karachi, Pakistan. Methodology: Trained community health workers surveyed all new births in three low-income areas from September 2004 to August 2007. Pus samples from the umbilical stumps were obtained from babies with pre-defined signs of illness and subjected to culture and antimicrobial susceptibility testing. Results: Among 6904 births, 1501 (21.7%) newborns were diagnosed with omphalitis. Of these, 325 (21.6%) were classified as mild, 1042 (69.4%) as moderate, and 134 (8.9%) as severe, 141 (9.3%) were associated with clinical signs of sepsis. The incidence of omphalitis was 217.4/1000 live births, moderate-severe omphalitis 170.3 per 1000 live births, and associated with sepsis 20.4 per 1000 live births. Of 853 infants with purulent umbilical discharge, 64% yielded 583 isolates. The most common pathogens were Staphylococcus aureus, of which 291 (95.7%) were methicillin-susceptible Staphylococcus aureus (MSSA) and 13 (4.2%) methicillin-resistant S. aureus (MRSA), Streptococcus pyogenes 105 (18%), Group B beta-hemolytic streptococci 59 (10 %), Pseudomonas spp., 52 (8.9 %), Aeromonas spp. 19 (3.2%), and Klebsiella spp. 12 (2%). Conclusions: A high burden of omphalitis can be associated with sepsis among newborns in low-income communities in Pakistan. S. aureus is the most common pathogen isolated from umbilical pus. Appropriate low-cost prevention strategies need to be implemented

Potential of Indigenous Plants for Skin Healing and Care

The outer protective layer of body is skin which not only guards it from external fluctuations and effects but also performs its thermoregulation. Its functioning may get affected due to several factors like dermal wounds, injuries, aging and many other disorders. These dermal ailments can be cured with the help of indigenous flora to get economical pharamcognosal benefits with no side effects which is a serious concern of synthetic drugs now days. Furthermore, research efforts are necessary for their proper dose optimization and administration to achieve low cost and side effects free pharamcognosal skin cure and care gains

Model farm services centers in Khyber Pakhtunkhwa: Evaluation and the way forward

The sub-national Government of Khyber Pakhtunkhwa in Pakistan enacted Farm Services Centers Act, 2014, to establish Model Farm Services Centers (MFSCs) and Farm Services Centers as “one stop-shop” based on public-private partnership principle to strengthen extension system. The aim of these Centers is to empower small farmers at a platform to enhance their knowledge and skills and availability of quality agricultural inputs as stipulated in Section 4(g) of the Act, 2014, that each FSC shall “purchase certified seed, fertilizers, animal husbandry services, quality veterinary heath care services and medicines, farm machinery, expertise and technology for provision to the members who are registered with the Centre on affordable rates in comparison to open market rates”. The objective is to improve rural livelihoods, and development of the rural economy

Developing local guidelines for management of sepsis in adults: sepsis guidelines for Pakistan (SGP)

Background: The purpose of developing ‘Sepsis Guidelines for Pakistan’ (SGP) is to provide clinicians practicing in local hospitals with a framework to aid timely recognition and management of adult patients in sepsis by adopting evidence-based recommendations of Surviving Sepsis Campaign (SSC) tailored to available resources. These recommendations are not meant to replace the SSC Guidelines. Methodology: SGP is an initiative of Pakistan Society of Critical Care Medicine (PSCCM). Four key decision points to be addressed in the guidelines were identified by a thirteen member multidisciplinary committee i.e., grading the hospitals in the country, recognition of sepsis and associated organ dysfunction, essential interventions to manage sepsis, and general measures for provision of a comprehensive care to patients in sepsis according to the level of education and training of healthcare providers and facilities and resources available in different levels of hospitals. The draft was presented at the 3rd Sepsis Symposium held on 13th September, 2014 in Karachi. The final document was approved by a panel of experts from across the country, representatives of relevant societies and Global Sepsis Alliance (GSA). Recommendations: Hospitals are divided into basic, intermediate and tertiary depending on the availability of diagnostic facilities and training of the medical personnel. Modified definitions of sepsis, severe sepsis, and septic shock are used given the lack of facilities to diagnose sepsis according to international definitionsand criteria in Pakistan. Essential interventions include fluid resuscitation, vasopressors to support the circulation, maintaining oxygen saturation ≥ 90% with oxygen, non-invasive ventilation or mechanical ventilation with lung protective strategies, prompt administration of antibiotics as recommended by the Medical Microbiology & Infectious Diseases Society of Pakistan (MMIDSP) and early source control. It is recommended to avoid starvation, keep an upper blood glucose ≤180 mg/dL, use daily pharmacoprophylaxis against venous thromboembolism (VTE), use stress ulcer prophylaxis, target haemoglobin of 7-9 g/dl in the absence of ischaemic heart disease, avoid sodium bicarbonate therapy as long as pH \u3e 7.20, avoid fresh frozen plasma in the absence of bleeding, transfuse platelets if indicated, not use intravenous immunoglobulins and avoid neuromuscular blocking agents (NMBAs) in the absence of ARDS, target specific titration endpoints when continuous or intermittent sedation is required in mechanically ventilated patients and use continuous renal replacement therapy (CRRT) to facilitate management of fluid balance in hemodynamically unstable septic patients in tertiary care centers. In addition a comprehensive, meticulous and multidisciplinary general care is required to improve outcome of sepsis by reinforcing hand hygiene and other infection control measures, adequate monitoring and documentation tailored to the available resources. Goals of care and prognosis should be discussed with patients and families early and either shifting the patient to a hospital with better facilities or limiting or withdrawing therapy in case of poor prognosis should be considered

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.Peer reviewe

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy