In memoriam : Christian Ehnholm

Non peer reviewe

Biomass production and feeding value of whole-crop cereal-legume-silages

In eastern Finland, several mixtures of spring wheat, spring barley, spring oats and/or rye with vetches and/or peas were evaluated in field experiments in 2005-2007 for their dry matter procuction, crude protein concentration and digestibility using three different harvesting times

Ear Emergence of Different Grass Species under Finnish Growing Conditions

Timothy is the most commonly cultivated grass species in Finland. Swards cultivated for silage of hay are of pure timothy or timothy is the dominant species of the mixture. Successful timing of harvesting of the primary growth is very critical in Northern latitudes where the stand develops very rapidly at daylengths of above 18 hours with a daily mean temperature close to 20 °C. The primary growth has to be harvested within a very short period to obtain a yield of high and uniform quality. Short harvesting periods require high capacity harvest machinery which lead to high costs. If it would be possible to prolong the harvesting over a longer period of time, it would decrease the risk of bad weather conditions and reduce machine costs through better utilization of harvesting capacity. Sowing different grass species makes it possible to extend the harvesting period. The aim of this study was to investigate timing of ear emergence of different grass species in comparison with timothy. The suitable harvesting time for silage in Finland is closely related to ear emergence of the stand

New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Remarkably good results have been achieved in the treatment of atherosclerotic cardiovascular diseases (CVD) by using statin, ezetimibe, antihypertensive, antithrombotic, and PCSK9 inhibitor therapies and their proper combinations. However, despite this success, the remaining CVD risk is still high. To target this residual risk and to treat patients who are statin-intolerant or have an exceptionally high CVD risk for instance due to familial hypercholesterolemia (FH), new therapies are intensively sought. One pathway of drug development is targeting the circulating triglyceride-rich lipoproteins (TRL) and their lipolytic remnants, which, according to the current view, confer a major CVD risk. Angiopoietin-like protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III) are at present the central molecular targets for therapies designed to reduce TRL, and there are new drugs emerging that suppress their expression or inhibit the function of these two key proteins. The medications targeting these components are biological, either human monoclonal antibodies or antisense oligonucleotides. In this article, we briefly review the mechanisms of action of ANGPTL3 and apoC-III, the reasons why they have been considered promising targets of novel therapies for CVD, as well as the current status and the most important results of their clinical trials. (C) 2018 Elsevier B.V. All rights reserved.Peer reviewe

”Vi vill ta krafttag för att bussen ska fra”:en studie om verbanvändning i Centerpartiets valbroschyr inför Stockholms läns landstingsval 2018

Abstrakt. I min kandidatavhandling har jag forskat i Centerpartiets verbanvändning i partiets valbroschyr, som jag använde som forskningsmaterial, inför Stockholms läns landstingsval 2018. Forskningsmetoden i min avhandling är både kvantitativ och kvalitativ. Med hjälp av grammatik och diskursanalys har jag kunnat forska i verb som använts. Det har också varit viktigt att förstå hur språket över huvud taget används i den politiska kontexten. Huvudresultat, som jag fick, visar att olika verbval huvudsakligen är medvetna för att skribenten kan uppnå sina mål med broschyrens innehåll och budskap. I politiken är målet för olika partier att få tillräcklig med makt för att kunna påverka beslut i samhället. Detta förklarar väl partiets språk- och verbanvändning och dess syfte. I broschyren förekommer till exempel flera imperativa verb eftersom partiet vill uttrycka med sitt budskap vad som måste göras i samhället, enligt sin egen ideologi

Angiopoietin-like protein 3, an emerging cardiometabolic therapy target with systemic and cell-autonomous functions

Angiopoietin like protein 3 (ANGPTL3) is best known for its function as an inhibitor of lipoprotein and endothelial lipases. Due to the capacity of genetic or pharmacologic ANGPTL3 suppression to markedly reduce circulating lipoproteins, and the documented cardioprotection upon such suppression, ANGPTL3 has become an emerging therapy target for which both antibody and antisense oligonucleotide (ASO) therapeutics are being clinically tested. While the antibody is relatively selective for circulating ANGPTL3, the ASO also depletes the intra-hepatocellular protein, and there is emerging evidence for cell-autonomous functions of ANGPTL3 in the liver. These include regulation of hepatocyte glucose and fatty acid uptake, insulin sensitivity, LDL/VLDL remnant uptake, VLDL assembly/secretion, polyunsaturated fatty acid (PUFA) and PUFA-derived lipid mediator content, and gene expression. In this review we elaborate on (i) why ANGPTL3 is considered one of the most promising new cardiometabolic therapy targets, and (ii) the present evidences for its intra-hepatocellular or cell-autonomous functions.Peer reviewe

Own or shared silage feeding place for dairy cows?

We studied behaviour, silage eating and milk production of cows when every animal had an own silage feeding place and when the feeding place was shared with two other cows

Current and future CO2 emissions from drained peatlands in Southeast Asia

Peer reviewe