Spanish validation of the revised depression attitude questionnaire (R-daq)

Purpose: The aim of the study was to develop and validate a Spanish version of the Revised Depression Attitude Questionnaire (R-DAQ). Methods: The R-DAQ was used as a baseline for the study. It was translated and tested to ensure the instrument was appropriate for the target population. 537 Ecuadorian healthcare professionals completed the revised Spanish version of the R-DAQ (SR-DAQ). Statistical and exploratory factor analyses were performed to examine construct validity, internal consistency, readability and floor and ceiling effects. Results: Three factors were obtained: “Professional confidence in depression care”; “Therapeutic optimism about depression”; and “Generalist perspective about depression occurrence, recognition, and management”. The internal consistency of the SR-DAQ was determined by means of Cronbach’s α coefficient, with values ranging between 0.61–0.8. The correlations with the English version reflected adequate validity. The model explained 39% of the variance. Subsequent analysis with a sample restricted to those who had received training in depression produced a model that explained 42% of the variance. Conclusion: The SR-DAQ meets the psychometric requirements for measuring depression attitude in a Spanish-speaking population and shows adequate internal consistency and validity

Integración de dispositivos de salud personal en la plataforma de telecuidado para diabetes PERSONA

La plataforma de telecuidado PERSONA se ha desarrollado en el marco del CIBER-BBN y tiene por objetivo soportar el autocuidado diario de pacientes con diabetes tipo 1. La plataforma proporciona acceso a herramientas de soporte a la decisión, de procesado automático de la información, de monitorización de las variables que afectan a la enfermedad y facilita la comunicación entre los agentes involucrados en el cuidado del paciente. La integración de dispositivos médicos interoperables es un requisito principal de la plataforma PERSONA. En este trabajo presentamos las soluciones adoptadas en cuanto a la integración de dispositivos médicos y analizamos las características de los protocolos de comunicación inalámbrica de los dispositivos considerados y los recursos necesarios para la comunicación con dispositivos móviles de telefonía

Técnica modificada de postioplastia en toros cebuínos con balanopostitis ulcerativa del trópico mexicano

El objetivo del presente trabajo es mostrar los resultados de toros con postitis que se les practicó Técnica Modificada de Postioplastia como manejo quirúrgico de esta patología. Se realizó un estudio de tipo descriptivo no probabilístico en toros reproductivamente activos que presentaron postitis crónica ulcerativa. Los casos clínico-quirúrgicos se presentaron en diferentes ranchos de la zona sur de Veracruz. Los pacientes fueron 10 toros cebús de los cuales 7 eran de la raza brahmán, 1 indubrasil y 2 Sardo Negro, con buena condición corporal y con postitis crónica ulcerativa. Ninguno de los animales había recibido tratamiento quirúrgico. Se aplicó xilacina al 2 % a la dosis de 0,1 mg/kg de peso vivo como tranquilizante por vía intramuscular. Posteriormente, para la anestesia, se infiltró clorhidrato de lidocaína al 2 % a dosis de 1 ml/cm3 de tejido en la base del prepucio. Una vez tranquilizado el paciente y realizadas las maniobras de derribo, se hizo lavado y evaluación detallada de la lesión. Se realizó una incisión en el limbo mucocutáneo y no en piel para reducir las posibilidades de fimosis cicatrizal. Se ligaron los vasos de gran calibre con puntos de transfixión con material absorbible acidó poliglicólico del calibre 0. Para la hemostasia de los vasos pequeños fue suficiente el pinzamiento y torsión. La divulsión se realiza en 360° hasta conseguir el desprendimiento de todo el tejido afectado incluyendo la mucosa prepucial dañada. Una vez practicada la correcta hermostasis se procedió sujetar la mucosa con pinzas de goma para evitar la retracción, así mismo se le colocaron 4 puntos de forma cardinal con sutura de  nylon monofilico para expandir la mucosa y poder suturarla a la piel, esos mismo puntos de sujeción se fijaron con punto de cirujano y posteriormente se colocaran 4 puntos entre ellos. Los 10 toros operados con la técnica descrita tuvieron recuperación en un período de 90 días posoperatorio en promedio, dos de ellos tuvieron complicación de estenosis cicatrizal.  Se concluye que la técnica quirúrgica empleada en este estudio tuvo resultados favorables. Se considera que si el posoperatorio no se lleva correctamente trasciende seriamente en el éxito o fracaso de esta cirugía

Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis

The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. The aim was to analyse the prognostic value of the phase angle to predict clinically relevant events such as hospitalisation, falls, and mortality in patients with cirrhosis. Outpatients with cirrhosis were consecutively included and the phase angle was determined by electrical bioimpedance. Patients were prospectively followed to determine the incidence of hospitalisations, falls, and mortality. One hundred patients were included. Patients with phase angle ≤ 4.6° (n = 31) showed a higher probability of hospitalisation (35% vs 11%, p = 0.003), falls (41% vs 11%, p = 0.001) and mortality (26% vs 3%, p = 0.001) at 2-year follow-up than patients with PA > 4.6° (n = 69). In the multivariable analysis, the phase angle and MELD-Na were independent predictive factors of hospitalisation and mortality. Phase angle was the only predictive factor for falls. In conclusion, the phase angle showed to be a predictive marker for hospitalisation, falls, and mortality in outpatients with cirrhosis

Differences in Expression of IQSEC2 Transcript Isoforms in Male and Female Cases with Loss of Function Variants and Neurodevelopmental Disorder

Pathogenic hemizygous or heterozygous mutations in the IQSEC2 gene cause X-linked intellectual developmental disorder-1 (XLID1), characterized by a variable phenotype including developmental delay, intellectual disability, epilepsy, hypotonia, autism, microcephaly and stereotypies. It affects both males and females typically through loss of function in males and haploinsufficiency in heterozygous females. Females are generally less affected than males. Two novel unrelated cases, one male and one female, with de novo IQSEC2 variants were detected by trio-based whole exome sequencing. The female case had a previously undescribed frameshift mutation (NM_001111125:c.3300dup; p.Met1101Tyrfs*5), and the male showed an intronic variant in intron 6, with a previously unknown effect (NM_001111125:c.2459+21C>T). IQSEC2 gene expression study revealed that this intronic variant created an alternative donor splicing site and an aberrant product, with the inclusion of 19bp, confirming the pathogenic effect of the intron variant. Moreover, a strong reduction in the expression of the long, but also the short IQSEC2 isoforms, was detected in the male correlating with a more severe phenotype, while the female case showed no decreased expression of the short isoform, and milder effects of the disease. This suggests that the abnormal expression levels of the different IQSEC2 transcripts could be implicated in the severity of disease manifestations.This research was funded by INSTITUTO DE SALUD CARLOS III, institutional project Spain UDP and grant PT20CIII/00009.S