127 research outputs found

    Solar radiation forecasting using ad-hoc time series preprocessing and neural networks

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    In this paper, we present an application of neural networks in the renewable energy domain. We have developed a methodology for the daily prediction of global solar radiation on a horizontal surface. We use an ad-hoc time series preprocessing and a Multi-Layer Perceptron (MLP) in order to predict solar radiation at daily horizon. First results are promising with nRMSE < 21% and RMSE < 998 Wh/m2. Our optimized MLP presents prediction similar to or even better than conventional methods such as ARIMA techniques, Bayesian inference, Markov chains and k-Nearest-Neighbors approximators. Moreover we found that our data preprocessing approach can reduce significantly forecasting errors.Comment: 14 pages, 8 figures, 2009 International Conference on Intelligent Computin

    Correlation between sunshine hours and climatic parameters at four locations in Uganda

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    One of the most important factors in solar energy production is related to the predictability of sunshine hours. The objective of this study is to assess the correlation between sunshine hours and relative humidity, cloud cover, maximum and minimum temperature, for the purpose of identifying the most appropriate parameter(s) for the prediction of sunshine hours in Uganda. Climatic data for the meteorological stations of Entebbe, Mbarara, Tororo and Makerere, extending over a period of 15 years (1990-2005) was collected from the Department of Meteorology, Kampala. The data set included maximum temperature, minimum temperature, relative humidity at 6 am and at 12 noon, Cloud cover at 6 am and at 12 noon and Sunshine hours. A multiple regression technique was used to assess the correlation between sunshine hours and maximum and minimum temperatures, cloud cover at 6 am and at 12 noon and relative humidity at 6 am and at 12 noon. Results have shown that the availability of sunshine hours can be predicted by the use of maximum and minimum temperatures, relative humidity at 6 am and 12 noon and cloud cover at 6 am and at 12 noon in Uganda, but, principal components and factoraAnalysis have indicated that two parameters, especially relative humidity at noon or 6 am and Maximum temperature are enough to capture the variability of sunshine hours in Uganda

    Climatic trends, risk perceptions and coping strategies of smallholder farmers in rural Uganda

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    Smallholder farmers in Uganda face a wide range of agricultural production risks, with climate change and variability presenting new risks and vulnerabilities. Climate related risks such as prolonged dry seasons have become more frequent and intense with negative impacts on agricultural livelihoods and food security. This paper assesses farmers’ perceptions of climate change and variability and analyses historical trends in temperature and rainfall in two rural districts of Uganda in order to determine the major climate-related risks affecting crop and livestock production and to identify existing innovative strategies for coping with and adapting to climate-related risks, with potential for up-scaling in rural districts. The traditional coping strategies that have been developed by these communities overtime provide a foundation for designing effective adaptation strategies. Drought, disease and pest epidemics, decreasing water sources, lack of pasture, bush fires, hailstorms, changes in crop flowering and fruiting times were the major climate-related risks reported across the two districts. Farmers use a wide range of agricultural technologies and strategies to cope with climate change and climate variability. Mulching, intercropping and planting of food security crops were among the most common practices used. Other strategies included water harvesting for domestic consumption, other soil and water conservation technologies and on-farm diversification. Farmers often use a combination of these technologies and practices to enhance agricultural productivity. The average maximum temperatures increased across the two districts. Trends in average annual rainfall showed mixed results with a general decline in one district and a relatively stable trend in the other district. Perceived changes in climate included erratic rainfall onset and cessation, which were either early or late, poor seasonal distribution of rainfall and little rainfall. Farmers also reported variations in temperatures. Farmers’ perception of changing rainfall characteristics and increasing temperatures were consistent with the observed historical climatic trends from meteorological data

    Comparison of different cardiovascular risk tools used in HIV patient cohorts in sub-Saharan Africa; do we need to include laboratory tests?

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    INTRODUCTION: Cardiovascular disease (CVD) is the leading cause of death globally, representing 31% of all global deaths. HIV and long term anti-retroviral therapy (ART) are risk factors for development of CVD in populations of people living with HIV (PLHIV). CVD risk assessment tools are currently being applied to SSA populations, but there are questions about accuracy as well as implementation challenges of these tools in lower resource setting populations. We aimed to assess the level of agreement between the various cardiovascular screening tools (Data collection on Adverse effects of anti-HIV Drugs (D:A:D), Framingham risk score, WHO risk score and The Atherosclerotic Cardiovascular Disease Score) when applied to an HIV ART experienced population in Sub-Saharan Africa. METHODS: This study was undertaken in an Anti-Retroviral Long Term (ALT) Cohort of 1000 PLHIV in care who have been on ART for at least 10 years in urban Uganda. A systematic review was undertaken to find the most frequently used screening tools from SSA PLHIV populations; these were applied to the ALT cohort. Levels of agreement between the resulting scores (those including lipids and non-lipids based, as well as HIV-specific and non-HIV specific) as applied to our cohort were compared. Prevalence Bias Adjusted Kappa was used to evaluate agreement between tools. RESULTS: Overall, PLHIV in ALT cohort had a median score of 1.1-1.4% risk of a CVD event over 5 years and 1.7-2.5% risk of a CVD event over 10 years. There was no statistical difference in the risk scores obtained for this population when comparing the different tools, including comparisons of those with lipids and non-lipids, and HIV specific vs non-HIV specific. CONCLUSION: The various tools yielded similar results, but those not including lipids are more feasible to apply in our setting. Long-term cohorts of PLHIV in SSA should in future provide longitudinal data to evaluate existing CVD risk prediction tools for these populations. Inclusion of HIV and ART history factors to existing scoring systems may improve accuracy without adding the expense and technical difficulty of lipid testing

    Half versus full vacuum suction drainage after modified radical mastectomy for breast cancer- a prospective randomized clinical trial[ISRCTN24484328]

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    BACKGROUND: Suction drains are routinely used after modified radical mastectomy and are an important factor contributing to increased hospital stay as the patients are often discharged only after their removal. Amongst various factors that influence the amount of postoperative drainage, the negative suction pressure applied to the drain has been reported to be of great significance. While a high negative suction pressure is expected to drain the collection and reduce the dead space promptly, it may also prevent the leaking lymphatics from closing and lead to increased drainage from the wound. Against this background a prospective randomized clinical study was conducted to compare the amount and duration of drainage between a half negative suction and full vacuum suction drainage in patients following modified radical mastectomy. The associated postoperative morbidity was also compared between the two groups. METHODS: 85 FNAC (fine needle aspiration cytology) proven cases of locally advanced breast cancer were randomized. (Using randomly ordered sealed envelops, which were opened immediately before the closure of the wound) in to 50 patients with full vacuum suction (pressure = 700 g/m2) and 35 cases in to half vacuum suction drainage (pressure = 350 g/m2) groups. The two groups were comparable in respect of age, weight, and technique of operation and extent of axillary dissection. Surgery was performed by the same surgical team comprising of five surgeons (two senior and three resident surgeons) using a standardized technique with electrocautery. External compression dressing was provided over the axilla for first 48 hrs and following that patients were encouraged to do active and passive shoulder exercises. The outcomes measured were postoperative morbidity and the length of hospital stay. Statistical methods used: Descriptive studies were performed with SPSS version 10 and group characteristics were compared using student t-test. RESULTS: Half vacuum suction drains were removed earlier than the full suction vacuum suction drains. There was no significant difference in the incidence of seroma formation in the two groups and there was a significant reduction in the total hospital stay in patients with half vacuum suction drainage systems as compared to the full suction drainage group (p < 0.001) without any added morbidity. CONCLUSIONS: Half negative suction drains provide an effective compromise between no suction and full or high suction drainage after modified radical mastectomy by reducing the hospital stay and the post operative morbidity including post operative seromas

    Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.

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    BACKGROUND: Malaria is one of the most serious infectious diseases in the world. The malaria burden is greatly affected by human immunity, and immune responses vary between populations. Genetic diversity in KIR and HLA-C genes, which are important in immunity to infectious diseases, is likely to play a role in this heterogeneity. Several studies have shown that KIR and HLA-C genes influence the immune response to viral infections, but few studies have examined the role of KIR and HLA-C in malaria infection, and these have used low-resolution genotyping. The aim of this study was to determine whether genetic variation in KIR and their HLA-C ligands differ in Ugandan populations with historically varied malaria transmission intensity using more comprehensive genotyping approaches. METHODS: High throughput multiplex quantitative real-time PCR method was used to genotype KIR genetic variants and copy number variation and a high-throughput real-time PCR method was developed to genotype HLA-C1 and C2 allotypes for 1344 participants, aged 6 months to 10 years, enrolled from Ugandan populations with historically high (Tororo District), medium (Jinja District) and low (Kanungu District) malaria transmission intensity. RESULTS: The prevalence of KIR3DS1, KIR2DL5, KIR2DS5, and KIR2DS1 genes was significantly lower in populations from Kanungu compared to Tororo (7.6 vs 13.2%: p = 0.006, 57.2 vs 66.4%: p = 0.005, 33.2 vs 46.6%: p < 0.001, and 19.7 vs 26.7%: p = 0.014, respectively) or Jinja (7.6 vs 18.1%: p < 0.001, 57.2 vs 63.8%: p = 0.048, 33.2 vs 43.5%: p = 0.002, and 19.7 vs 30.4%: p < 0.001, respectively). The prevalence of homozygous HLA-C2 was significantly higher in populations from Kanungu (31.6%) compared to Jinja (21.4%), p = 0.043, with no significant difference between Kanungu and Tororo (26.7%), p = 0.296. CONCLUSIONS: The KIR3DS1, KIR2DL5, KIR2DS5 and KIR2DS1 genes may partly explain differences in transmission intensity of malaria since these genes have been positively selected for in places with historically high malaria transmission intensity. The high-throughput, multiplex, real-time HLA-C genotyping PCR method developed will be useful in disease-association studies involving large cohorts

    Integrated community case management in a peri-urban setting: a qualitative evaluation in Wakiso District, Uganda.

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    Integrated community case management (iCCM) strategies aim to reach poor communities by providing timely access to treatment for malaria, pneumonia and diarrhoea for children under 5 years of age. Community health workers, known as Village Health Teams (VHTs) in Uganda, have been shown to be effective in hard-to-reach, underserved areas, but there is little evidence to support iCCM as an appropriate strategy in non-rural contexts. This study aimed to inform future iCCM implementation by exploring caregiver and VHT member perceptions of the value and effectiveness of iCCM in peri-urban settings in Uganda.A qualitative evaluation was conducted in seven villages in Wakiso district, a rapidly urbanising area in central Uganda. Villages were purposively selected, spanning a range of peri-urban settlements experiencing rapid population change. In each village, rapid appraisal activities were undertaken separately with purposively selected caregivers (n = 85) and all iCCM-trained VHT members (n = 14), providing platforms for group discussions. Fifteen key informant interviews were also conducted with community leaders and VHT members. Thematic analysis was based on the 'Health Access Livelihoods Framework'.iCCM was perceived to facilitate timely treatment access and improve child health in peri-urban settings, often supplanting private clinics and traditional healers as first point of care. Relative to other health service providers, caregivers valued VHTs' free, proximal services, caring attitudes, perceived treatment quality, perceived competency and protocol use, and follow-up and referral services. VHT effectiveness was perceived to be restricted by inadequate diagnostics, limited newborn care, drug stockouts and VHT member absence - factors which drove utilisation of alternative providers. Low community engagement in VHT selection, lack of referral transport and poor availability of referral services also diminished perceived effectiveness. The iCCM strategy was widely perceived to result in economic savings and other livelihood benefits.In peri-urban areas, iCCM was perceived as an effective, well-utilised strategy, reflecting both VHT attributes and gaps in existing health services. Depending on health system resources and organisation, iCCM may be a useful transitional service delivery approach. Implementation in peri-urban areas should consider tailored community engagement strategies, adapted selection criteria, and assessment of population density to ensure sufficient coverage
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