a combined top-down and bottom-up approach

The thesis focuses on the interoperability of autonomous legacy databases with the idea of meeting the actual requirements of an organization. The interoperability is resolved by combining the topdown and bottom-up strategies. The legacy objects are extracted from the existing databases through a database reverse engineering process. The business objects are defined by both the organization requirements and the integration of the legacy objects

P/2010 A2 LINEAR II: dynamical dust modelling

P/2010 A2 is an object on an asteroidal orbit that was observed to have an extended tail or debris trail in January 2010. In this work, we fit the outburst of P/2010 A2 with a conical burst model, and verify previous suspicions that this was a one--time collisional event rather than an sustained cometary outburst, implying that P/2010 A2 is not a new Main Belt Comet driven by ice sublimation. We find that the best--fit cone opening angle is about 40 to 50 degrees, in agreement with numerical and laboratory simulations of cratering events. Mapping debris orbits to sky positions suggests that the distinctive arc features in the debris correspond to the same debris cone inferred from the extended dust. From the velocity of the debris, and from the presence of a velocity maximum at around 15 cm/s, we infer that the surface of A2 probably has a very low strength (<1 kPa), comparable to lunar regolith.Comment: 14 pages, 25 figures; accepted by Astronomy and Astrophysic

Temperature sensitivity for conformation is an intrinsic property of wild-type p53.

The tumour-suppressor protein p53 is a metal-binding transcription factor with sequence-specific DNA-binding capacity. In cancer, mutation of p53 disrupts protein conformation with consequent loss of DNA binding and associated tumour-suppressor function. In vitro, the conformation and DNA-binding activity of wild-type p53 are subject to redox modulation and are abrogated by exposure to metal chelators. In the present study, we have used the chelator 1, 10-phenanthroline (OP) to probe the effect of temperature on the conformational stability of p53 translated in vitro. Whereas low temperature (30 degrees C) stabilised wild-type p53 conformation and protected against chelation, high temperature (41 degrees C) promoted destabilisation and enhanced chelation, indicating that temperature influences the folding of wild-type p53. Destabilisation of p53 tertiary structure induced protein aggregation through hydrophobic interactions, consistent with the notion that wild-type p53 contains a hydrophobic core which may become exposed by metal chelation. These results indicate that temperature sensitivity for conformation is an intrinsic property of wild-type p53 and suggests that small changes in temperature may directly affect p53 function

The Calibration of the HST Kuiper Belt Object Search: Setting the Record Straight

The limiting magnitude of the HST data set used by Cochran et al. (1995) to detect small objects in the Kuiper belt is reevaluated, and the methods used are described in detail. It is shown, by implanting artificial objects in the original HST images, and re-reducing the images using our original algorithm, that the limiting magnitude of our images (as defined by the 50% detectability limit) is $V=28.4$. This value is statistically the same as the value found in the original analysis. We find that $\sim50$ of the moving Kuiper belt objects with $V=27.9$ are detected when trailing losses are included. In the same data in which these faint objects are detected, we find that the number of false detections brighter than $V=28.8$ is less than one per WFPC2 image. We show that, primarily due to a zero-point calibration error, but partly due to inadequacies in modeling the HST'S data noise characteristics and Cochran et al.'s reduction techniques, Brown et al. 1997 underestimate the SNR of objects in the HST dataset by over a factor of 2, and their conclusions are therefore invalid.Comment: Accepted to ApJ Letters; 10 pages plus 3 figures, LaTe

Database Engineering Processes with DB-MAIN

Software engineering needs more and more to be supported by CASE tools. Since databases are at the heart of information systems, they deserve a particular attention. More and more CASE tools allow method engineers to implement their own methodology and they allow users to record all their actions, with their rationales, in order to improve the quality of the design and the quality of the documentation of the design. DBMAIN is such a database oriented tool with a method description and a documentation generation facilities. But it has its particularities like its procedural non-deterministic Method Description Language, its well integrated multilevel histories and its userfriendly methodological engine

Plausible home stars of the interstellar object 'Oumuamua found in Gaia DR2

The first detected interstellar object 'Oumuamua that passed within 0.25au of the Sun on 2017 September 9 was presumably ejected from a stellar system. We use its newly determined non-Keplerian trajectory together with the reconstructed Galactic orbits of 7 million stars from Gaia DR2 to identify past close encounters. Such an "encounter" could reveal the home system from which 'Oumuamua was ejected. The closest encounter, at 0.60pc (0.53-0.67pc, 90% confidence interval), was with the M2.5 dwarf HIP 3757 at a relative velocity of 24.7km/s, 1Myr ago. A more distant encounter (1.6pc) but with a lower encounter (ejection) velocity of 10.7km/s was with the G5 dwarf HD 292249, 3.8Myr ago. Two more stars have encounter distances and velocities intermediate to these. The encounter parameters are similar across six different non-gravitational trajectories for 'Oumuamua. Ejection of 'Oumuamua by scattering from a giant planet in one of the systems is plausible, but requires a rather unlikely configuration to achieve the high velocities found. A binary star system is more likely to produce the observed velocities. None of the four home candidates have published exoplanets or are known to be binaries. Given that the 7 million stars in Gaia DR2 with 6D phase space information is just a small fraction of all stars for which we can eventually reconstruct orbits, it is a priori unlikely that our current search would find 'Oumuamua's home star system. As 'Oumuamua is expected to pass within 1pc of about 20 stars and brown dwarfs every Myr, the plausibility of a home system depends also on an appropriate (low) encounter velocity.Comment: Accepted to The Astronomical Journa

Isotopic ratios in outbursting comet C/2015 ER61

Isotopic ratios in comets are critical to understanding the origin of cometary material and the physical and chemical conditions in the early solar nebula. Comet C/2015 ER61 (PANSTARRS) underwent an outburst with a total brightness increase of 2 magnitudes on the night of 2017 April 4. The sharp increase in brightness offered a rare opportunity to measure the isotopic ratios of the light elements in the coma of this comet. We obtained two high-resolution spectra of C/2015 ER61 with UVES/VLT on the nights of 2017 April 13 and 17. At the time of our observations, the comet was fading gradually following the outburst. We measured the nitrogen and carbon isotopic ratios from the CN violet (0,0) band and found that $^{12}$C/$^{13}$C=100 $\pm$ 15, $^{14}$N/$^{15}$N=130 $\pm$ 15. In addition, we determined the $^{14}$N/$^{15}$N ratio from four pairs of NH$_2$ isotopolog lines and measured $^{14}$N/$^{15}$N=140 $\pm$ 28. The measured isotopic ratios of C/2015 ER61 do not deviate significantly from those of other comets.Comment: 4 pages, 4 figures, accepted to be published by A&