Fractals as triggers exploratory statistical analysis of clinical pharmacological data

Proposed and tested an algorithm of using principles of Cantor, von Koch sets for exploratory fractals clinical pharmacological data analysis. The algorithm is based on the grouping data, formation of categorical variabilities in the form of subgroups as iteration process as for receiving Cantor, von Koch sets. It boils down to: selection of informative numerical dependent variabilities; transformation these informative numerical dependent variabilities to new categorical variabilities; formation categorical variabilities in the form of subgroups as a result of an iterative process as for Cantor, von Koch sets; statistical analysis of the data; determination of the distribution of variabilities; transformations that may be normalize from non-normal data; ANOVA - analysis of variance parametric data or nonparametric equivalent of ANOVA - Kruskal-Wallis testing; formulation of the conclusion. Our algorithm of using Cantor, von Koch sets principles for Exploratory Fractals Data Analysis of clinical pharmacological data will help maximize insight, uncover underlying structure, extract important variables, develop models and determine optimal factor settings

Moebius Strip Like Pathology: Mechanisms, Diagnosis, Treatment Correction

Proposed and tested an algorithm for diagnosis of Moebius strip like pathology, as prerequisite for treatment correction. The algorithm is reduced to initialization of study objects as a Moebius strip, in particular symptoms, syndromes, diseases, multimorbid states; clarification of investigation objects as non-orientable two-dimensional surface; cutting a Moebius strip like clinical data, variability to form two disjoint Moebius strips; clarification of chirality Moebius strip turn; the determination of Moebius strip like constituents as the object of research and their 3D representation; clarification of Moebius strips turn chiralities of constituents; the adoption of diagnostic and therapeutic solutions based on geometry of the pathogenetic and sanogenetic mechanisms. Thus, our algorithm may be basis for making diagnosis and treatment decisio

Psychological and stress characteristics of patients with coronary heart disease as prerequisite for individual psychotherapy

Background: Stress and ischemia play a leading role in the occurrence and progression of coronary heart disease (CHD). The aim of the study was to determine psychological characteristics and stress sensitivity in the patients with CHD as prerequisite to improving of diagnosis and treatment. Objects and methods: The study involved 22 patients with CHD. Psychological research was conducted by the method of “constructive human pattern of geometric figures”, stressful sensitivity - by the psychoemotional Stroop test. Statistical analysis included parametric and nonparametric correlation analysis. Results: The predominance of triangles in figures of psycho-graphics test in patients with coronary heart disease leads to higher levels of pulse arterial pressure, heart rate in compare with diastolic arterial pressure during the psycho-emotional Stroop test. The predominance of the squares is characterized by an increasing ratio of diastolic arterial pressure to heart rate. The prevalence of triangles or squares in the drawings of psycho-graphics test leads to prolongation of reading time. Conclusion: The investigation results of CHD patients by psycho-graphic, psycho-emotional tests may be a prerequisite for inclusion different methods of meditation, psychotherapy to reduce the sensitivity to stress, myocardial ischemi

Синтез і дослідження вазоактивних властивостей нових фосфорильованих пептидоміметиків

The paper presents the synthesis of new phosphorylated peptidomimetics and their action on the isolated rat aorta. It has been shown that derivatives of diethyl 5-amino-2-phthalimidoalkyl-1,3-oxazol-4-ylphosphonates can be employed in the synthesis of phosphorylated peptidomimetics containing a phosphonoglycine residue. For this purpose derivatives of 1,3-oxazol-4-ylphosphonates were decomposed hydrolytically in the acidic medium. The reaction of diethyl 5-alkylamino-2-aminoalkyl-1,3-oxazol-4-ylphosphonates with unsaturated azlactones was used to obtain phosphorylated peptidomimetics with dehydroamino acid groups. The method developed is very convenient and preparative because reactions proceed in mild conditions without formation of undesirable byproducts. Peptidomimetics are isolated with high yields and their separation does not require chromatography. Biological research has revealed the vasodilating activity of new derivatives of phosphorylated peptidomimetics depending on their chemical structure when acting on the rat’s isolated aorta. The possible molecular mechanisms of this activity with participation of the plasma membrane Ca2+-channels of vascular smooth muscle cells are discussed. The data of impact of an inhibitor of voltage-dependent Ca2+-channels of L-type of nitrendipine on the vascular tone are reported. It has been found that the concentration dependences of the vasodilating activity of the diethyl esters of 5-alkylamino-2-{N-[N-benzoyl-(4-methylbenzylidene)glycyl]aminomethyl}-1,3-oxazol- 4-ylphosphonates synthesized and nitrendipine are similar. It can testify about the indirect detection of the vasodilatory effect of these compounds associated with inhibition of the calcium signal system. The study shows a direct effect of the compounds synthesized on the muscle cells of blood vessels.В данной работе представлен синтез новых фосфорилированных пептидомиметиков и проведена оценка биологической активности синтезированных соединений. Показана возможность использования производных диэтиловых эфиров 5-амино-2-фталимидоалкил-1,3-оксазол-4-илфосфоновых кислот для синтеза фосфорилированных пептидомиметиков, которые содержат в середине пептидной цепи остаток фосфоноглицина. С этой целью подобраны оптимальные условия расщепления оксазольного кольца в кислой среде. Взаимодействием диэтиловых эфиров 2-аминоалкил-5-алкиламино-1,3-оксазол- 4-илфосфоновых кислот с ненасыщенными азлактонами синтезированы фосфорилированные пептидомиметики, содержащие фрагменты дегидроаминокислот. Разработанный метод синтеза является удобным и препаративным, так как превращения происходят в мягких условиях, что позволяет избежать образования нежелательных побочных продуктов, пептидомиметики выделены с высокими выходами без применения хроматографических колонок. Биологические исследования обнаружили вазодилатирующую активность новых производных фосфорилированных пептидомиметиков в зависимости от их химической структуры при действии на изолированную аорту крыс. В статье обсуждаются возможные молекулярные механизмы их биологической активности с участием Ca2+-каналов плазматических мембран гладкомышечных клеток сосудов. Приведены данные влияния на тонус сосудов ингибитора потенциал-зависимых Ca2+-каналов L-типа нитрендипина, установлено, что концентрационные зависимости вазодилатирующей ативности синтезированных нами диэтиловых эфиров 5-алкиламино-2-{N-[N-бензоил-(4 метилбензилиден)глицил]аминометил}-1,3-оксазол-4-илфосфоновых кислот и нитрендипина похожи, что может свидетельствовать о косвенном обнаружении вазодилатирующего эффекта данных соединений, связанного подавлением кальцевой системы сигнализации. Исследования свидетельствуют о непосредственном влиянии синтезированных соединений на мышечные клетки сосудов.В роботі представлений синтез нових фосфорильованих пептидоміметиків та проведена оцінка біологічної активності синтезованих сполук. Показана можливість використання похідних діетилових естерів 5-аміно-2-фталімідо-1,3-оксазол-4-ілфосфонових кислот для синтезу фосфорильованих пептидоміметиків, які містять всередині пептидного ланцюга залишок фосфоногліцину. З цією метою підібрані оптимальні умови розщеплення оксазольного кільця у кислому середовищі. Взаємодією діетилових естерів 2-аміноалкіл-5-алкіламіно-1,3-оксазол-4-ілфосфонових кислот з ненасиченими азлактонами синтезовані фосфорильовані пептидоміметики, які містять фрагменти дегідроамінокислот. Розроблений метод синтезу є зручним та препаративним, оскільки перетворення проходять у м’яких умовах, що дозволяє уникнути утворення небажаних побічних продуктів, а пептидоміметики отримують із високими виходами без застосування хроматографічних колонок. Біологічні дослідження виявили вазодилатуючу активність нових похідних фосфорильованих пептидоміметиків у залежності від їх хімічної структури при дії на ізольовану аорту щурів. У статті обговорюються можливі молекулярні механізми їх біологічної активності за участі Ca2+-каналів плазматичних мембран гладеньком’язових клітин судин. Наведені дані впливу на тонус судин інгібітора потенціал-залежних Са2+‑каналів L-типу нітрендипіну, встановлено, що концентраційні залежності вазодилатуючої активності синтезованих нами діетилових естерів 5-алкіламіно-2-{N-[N-бензоїл-(4-метилбензиліден)гліцил]амінометил}-1,3-оксазол- 4-ілфосфонових кислот і нітрендипіну схожі, що може свідчити про зв’язок виявленого вазодилатуючого ефекту даних сполук з пригніченням кальцієвої системи сигналізації. Дослідження свідчать про безпосередній вплив синтезованих сполук на м’язові клітини судин

Differentiatial Diagnosis of Dermatoglyphic Peculiarities in the Patients with Coronary Heart Disease and Chronic Kidney Disease

Prediction genetically predisposed people to heart and kidney failure is an actual problem. Dermatoglyphics can be one of the basic research in this area. The purpose of the study was to determine the features of dermatoglyphics in the patients with coronary heart disease and chronic kidney disease with chronic renal failure for making differential diagnosis. The object of the study were 25 patients (45-77 y.o.) with chronic coronary heart disease and 20 patients (42,65 ± 0,71 y.o.) with chronic kidney disease. Investigation and treatment of the patients was carried out in accordance with the standards. Dermatoglyphic study was conducted by the method of fingerprinting surfaces phalanges, using paint. Statistical methods of evaluation findings included parametric and non-parametric statistical methods. Results. The prevalence of ulnar loops on fingers of right hand was typical feature for patients with chronic kidney disease and radial loops on fingers of right hand for patients with coronary heart disease. The predominance of racemates from ulnar loops scallops on the left and right hands was a distinctive sign for the patients with chronic kidney disease in compare to the patients with coronary heart disease. Dissymmetry of scallops in the patients with coronary heart disease was characterized by predominance of radial loops on fingers of right hand in compare with left; predominance of ulnar loops on fingers of left hand in compare with right. Thus, quantity of different types of scallops, their dissymmetry or racemates on fingers of the left and right hands are basis for differential diagnosis between patients with coronary heart disease and chronic kidney disease

First Operational Experience from the LHCb Silicon Tracker

The LHCb Silicon Tracker is a silicon micro-strip detector covering a sensitive area of 12 m2 with a total of 272k readout channels. The installation of the detector is complete and commissioning is making excellent progress. The detector has recorded first beam-induced events during LHC synchronization tests in August 2008 and in June 2009. These events have allowed the performance to be studied, and adjustments to the operational parameters to be made. In this contribution, we will draw first lessons from the in-situ commissioning of the Silicon Tracker, and present results from the reconstruction of data collected during the LHC synchronization tests

Performance of the LHCb Silicon Tracker with first data

The LHCb Silicon Tracker consists of two sub-detectors the Tracker Turicensis and Inner Tracker that are constructed from silicon microstrip technology. Performance studies of both sub-detectors using data taken during the LHC synchronization tests are described

Commissioning of the LHCb Silicon Tracker using data from the LHC injection tests

LHCb is a single-arm forward spectrometer dedicated to the study of the CP-violation and rare decays in the b-quark sector. An efficient and high precision tracking system is a key requirement of the experiment. The LHCb Silicon Tracker Project consists of two sub-detectors that make use of silicon micro-strip technology: the Tracker Turicensis located upstream of the spectrometer magnet and the Inner Tracker which covers the innermost part of the tracking stations after the magnet. In total an area of 12 m^2 is covered by silicon. In September 2008 and June 2009, injection tests from the SPS to the LHC were performed. Bunches of order 5x10^9 protons were dumped onto a beam stopper (TED) located upstream of LHCb. This produced a spray of ~10 GeV muons in the LHCb detector. Though the occupancy in this environment is relatively large, these TED runs have allowed a first space and time alignment of the tracking system. Results of these studies together and the overall detector performance obtained in the TED running will be discussed

Radiation Monitoring System for the LHCb Inner Tracker

The performance requirements and the design of the Radiation Monitoring System (RMS) for the LHCb Inner Tracker are presented. Details of the Metal Foil Detector technology employed for the RMS are described, along with results from tests of RMS prototypes