THYROIDAL STATUS IN CHILDREN WITH VARIOUS DEGREE OF INCREASE OF THYROID GLAND WHO LIVE IN ECOLOGICALLY UNFAVORABLE AREA OF TRANSBAIKALIA

We performed the research of thyroidal status in children with endemic goiter who live in ecologically unfavorable area of Transbaikalia. Frequency distribution of endemic goiter was analyzed, depending on a sex and ag

Role of radiological methods of diagnostics at simultaneous pancreas-kidney transplantation

Aim of investigation. To characterize radiological methods of diagnostics of surgical complications after simultateous pankreas-kidney transplantation (SPKT).Material and methods. From January, 2008 to June, 2014 overall 40 patients with the type 1 diabetes mellitus complicated by terminal diabetic nephropathy, underwent SPKT, including 17 cases (42,5%) — of intraperitoneal transplantation and 23 (57,5%) — of retroperitoneal transplantation. Mean age of patients was 35,7±6,36 year. Of all recipients 19 were women (47,5%) and 21 — men (52,5%). Results. Of 15 patients after SPKT 21 surgical complications were diagnosed, overwhelming majority of them have been corrected successfully. Only in one case the pancreatic transplant was lost due to postoperative surgical complications.Conclusions. Duly diagnostics and the proven choice of miniinvasive techniques for treatment of surgical complications became possible due to wide and urgent application of the whole spectrum of available radiological methods

Selective laser melting–enabled electrospinning: Introducing complexity within electrospun membranes

Additive manufacturing technologies enable the creation of very precise and well-defined structures that can mimic hierarchical features of natural tissues. In this article, we describe the development of a manufacturing technology platform to produce innovative biodegradable membranes that are enhanced with controlled microenvironments produced via a combination of selective laser melting techniques and conventional electrospinning. This work underpins the manufacture of a new generation of biomaterial devices that have significant potential for use as both basic research tools and components of therapeutic implants. The membranes were successfully manufactured and a total of three microenvironment designs (niches) were chosen for thorough characterisation. Scanning electron microscopy analysis demonstrated differences in fibre diameters within different areas of the niche structures as well as differences in fibre density. We also showed the potential of using the microfabricated membranes for supporting mesenchymal stromal cell culture and proliferation. We demonstrated that mesenchymal stromal cells grow and populate the membranes penetrating within the niche-like structures. These findings demonstrate the creation of a very versatile tool that can be used in a variety of tissue regeneration applications including bone healing

Acceleration of a Positron Bunch in a Hollow Channel Plasma

Plasmas are a compelling medium for particle acceleration owing to their natural ability to sustain electric fields that are orders of magnitude larger than those available in conventional radio-frequency accelerators. Plasmas are also unique amongst accelerator technologies in that they respond differently to beams of opposite charge. The asymmetric response of a plasma to highly-relativistic electron and positron beams arises from the fact that plasmas are composed of light, mobile electrons and heavy, stationary ions. Hollow channel plasma acceleration is a technique for symmetrizing the response of the plasma, such that it works equally well for high-energy electron and positron beams. In the experiment described here, we demonstrate the generation of a positron beam-driven wake in an extended, annular plasma channel, and acceleration of a second trailing witness positron bunch by the wake. The leading bunch excites the plasma wakefield and loses energy to the plasma, while the witness bunch experiences an accelerating field and gains energy, thus providing a proof-of-concept for hollow channel acceleration of positron beams. At a bunch separation of 330 um, the accelerating gradient is 70 MV/m, the transformer ratio is 0.55, and the energy transfer efficiency is 18% for a drive-to-witness beam charge ratio of 5:1

Quality of glycemic control in type 2 diabetes mellitus (T2DM) and its association with markers of coagulation and inhibitors of fibrinolysis: A case–control study in the upper west region, Ghana

Background and Aims: Type 2 diabetes mellitus (T2DM) individuals are at a higher risk of developing diabetes complications, with approximately 80% complication-related mortality. The increased morbidity and mortality among T2DM patients are partly due to dysregulated hemostasis. This study determined the quality of glycemic control in T2DM and its association with markers of coagulation and inhibitors of fibrinolysis. Methods: This case–control study recruited 90 participants involving: 30 T2DM patients with good glycemic control, 30 with poor glycemic control, and 30 nondiabetic subjects as controls at a Municipal Hospital in Ghana. Fasting blood glucose, glycated hemoglobin, activated partial thromboplastin time (APTT), prothrombin time (PT), calculated international normalized ratio (INR), and full blood count (FBC) were determined for each respondent. Plasma levels of plasminogen activator inhibitor-1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI) were determined using the solid-phase sandwich enzyme-linked immunosorbent assay method. Data were analyzed using R language software. Results: Plasma PAI-1 antigen levels were significantly higher in the participants with poor glycemic control as compared to participants with good glycemic control (p \u3c 0.0001). There was no significant difference in plasma TAFI levels between the participants with poor glycemic control as compared to participants with good glycemic control (p = 0.900). T2DM patients had significantly shorter APTT, PT, and INR than controls (p \u3c 0.05). At a cut-off of ≥ 161.70 pg/μL, PAI was independently associated with increasing odds (adjusted odds ratio = 13.71, 95% confidence interval: 3.67–51.26, p \u3c 0.0001) of poor glycemic control and showed the best diagnostic accuracy for poor glycemic control (area under the curve = 0.85, p \u3c 0.0001). Conclusion: PAI-1 levels were significantly increased in T2DM with poor glycemic control and emerged as the best predictor for poor glycemic control. Good glycemic management to control the plasma levels of PAI-1 is required to prevent hypercoagulability and thrombotic disorders

Demonstration of a positron beam-driven hollow channel plasma wakefield accelerator

International audiencePlasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that may disrupt the beam quality. Hollow plasma channels have been proposed as a technique for generating accelerating fields without transverse forces. Here we demonstrate a method for creating an extended hollow plasma channel and measure the wakefields created by an ultrarelativistic positron beam as it propagates through the channel. The plasma channel is created by directing a high-intensity laser pulse with a spatially modulated profile into lithium vapour, which results in an annular region of ionization. A peak decelerating field of 230 MeV/m is inferred from changes in the beam energy spectrum, in good agreement with theory and particle-in-cell simulations

Radio selection of the most distant galaxy clusters

We show that the most distant X-ray detected cluster known to date, ClJ1001 at z=2.506, hosts a strong overdensity of radio sources. Six of them are individually detected (within 10") in deep 0.75" resolution VLA 3GHz imaging, with S(3GHz)>8uJy. Of the six, AGN likely affects the radio emission in two galaxies while star formation is the dominant source powering the remaining four. We searched for cluster candidates over the full COSMOS 2-square degree field using radio-detected 3GHz sources and looking for peaks in Sigma5 density maps. ClJ1001 is the strongest overdensity by far with >10sigma, with a simple z_phot>1.5 preselection. A cruder photometric rejection of z2.5. Samples of hundreds such high-redshift clusters could potentially constrain cosmological parameters and test cluster and galaxy formation models

Coagulation factors and natural anticoagulants as surrogate markers of preeclampsia and its subtypes: A case-control study in a Ghanaian population

Preeclampsia (PE) is associated with endothelial injury and hemostatic abnormalities. However, the diagnostic role of coagulation parameters and natural anticoagulants in predicting PE has not been explored in Ghana. This study assessed plasma levels of these factors as surrogate markers of PE and its subtypes. This case-control study included 90 women with PE (cases) and 90 normotensive pregnant women (controls). Blood samples were drawn for the estimation of complete blood count and coagulation tests. The prothrombin time (PT), activated partial thromboplastin time (APTT), and the calculation of the international normalized ratio (INR) were determined by an ACL elite coagulometer while the levels of protein C (PC), protein S (PS), antithrombin III (ATIII), and D-dimers were also measured using the solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. All statistical analyses were performed using the R Language for Statistical Computing. Results showed significantly (p \u3c .05) shortened APTT (28.25 s) and higher D-dimer levels (1219.00 ng/mL) among PE women, as well as low levels of PC (1.02 g/mL), PS (6.58 g/mL), and ATIII (3.99 ng/mL). No significant difference was found in terms of PT and INR. From the receiver operating characteristic analysis, PC, PS, and ATIII could significantly predict PE and its subtypes at certain cutoffs with high accuracies (area under the curve [AUC] ≥ 0.70). Most women with PE are in a hypercoagulable state with lower natural anticoagulants. PC, PS, and ATIII are good predictive and diagnostic markers of PE and its subtypes (early-onset PE [EO-PE] and late-onset PE [LO-PE]) and should be explored in future studies

Development of a synoptic MRI report for primary rectal cancer

<p>Abstract</p> <p>Background</p> <p>Although magnetic resonance imaging (MRI) is an important imaging modality for pre-operative staging and surgical planning of rectal cancer, to date there has been little investigation on the completeness and overall quality of MRI reports. This is important because optimal patient care depends on the quality of the MRI report and clear communication of these reports to treating physicians. Previous work has shown that the use of synoptic pathology reports improves the quality of pathology reports and communication between physicians.</p> <p>Methods</p> <p>The aims of this project are to develop a synoptic MRI report for rectal cancer and determine the enablers and barriers toward the implementation of a synoptic MRI report for rectal cancer in the clinical setting. A three-step Delphi process with an expert panel will extract the key criteria for the MRI report to guide pre-operative chemoradiation and surgical planning following a review of the literature, and a synoptic template will be developed. Furthermore, standardized qualitative research methods will be used to conduct interviews with radiologists to determine the enablers and barriers to the implementation and sustainability of the synoptic MRI report in the clinic setting.</p> <p>Conclusion</p> <p>Synoptic MRI reports for rectal cancer are currently not used in North America and may improve the overall quality of MRI report and communication between physicians. This may, in turn, lead to improved patient care and outcomes for rectal cancer patients.</p