Tanaka-Tagoshi Parametrization of post-1PN Spin-Free Gravitational Wave Chirps: Equispaced and Cardinal Interpolated Lattices For First Generation Interferometric Antennas

The spin-free binary-inspiral parameter-space introduced by Tanaka and Tagoshi to construct a uniformly-spaced lattice of templates at (and possibly beyond) $2.5PN$ order is shown to work for all first generation interferometric gravitational wave antennas. This allows to extend the minimum-redundant cardinal interpolation techniques of the correlator bank developed by the Authors to the highest available order PN templates. The total number of 2PN templates to be computed for a minimal match $\Gamma=0.97$ is reduced by a factor 4, as in the 1PN case.Comment: 9 pages, 8 figures, 3 tables, accepted for publication in Phys. Rev.

P-248 Futility and utility of two-stage hepatectomy

Meeting abstract in the European-Society-for-Medical-Oncology (ESMO) 21st World Congress on Gastrointestinal Cancer.info:eu-repo/semantics/publishedVersio

A new species of killifish (Pisces, Cyprinodontidae) from the chilean Altiplano

Ce travail décrit #Orestia chungarensis n. sp., un poisson Cyprinodontidae du lac Chungara (Altiplano chilien). #O. chungarensis n. sp. est élancé à flancs gris et ventre blanc avec des bandes verticales marron sombre. Il est caractérisé par ses grands yeux, sa bouche petite et protactile, ses mandibules dirigées vers le haut et ses nageoires pectorales petites comportant peu de rayons. Il vit dans les herbiers de #Myriophyllumelatinoides des zones littorales peu profondes de la partie ouest du lac. Il se nourrit principalement d'Amphipodes et de Chironomidae. Par ses caractéristiques morphologiques, #O. chungarensis ressemble à #O. gracilis$. (Résumé d'auteur

Metabolic and vascular effect of the mediterranean diet

Several studies indicated how dietary patterns that were obtained from nutritional cluster analysis can predict disease risk or mortality. Low-grade chronic inflammation represents a background pathogenetic mechanism linking metabolic risk factors to increased risk of chronic degenerative diseases. A Mediterranean diet (MeDi) style has been reported as associated with a lower degree of inflammation biomarkers and with a protective role on cardiovascular and cerebrovascular events. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. Recently, it has been reported a novel positive association between baseline plasma ceramide concentrations and cardiovascular events and how adherence to a Mediterranean Diet-style may influence the potential negative relationship between elevated plasma ceramide concentrations and cardiovascular diseases (CVD). Several randomized controlled trials (RCTs) showed the positive effects of the MeDi diet style on several cardiovascular risk factors, such as body mass index, waist circumference, blood lipids, blood pressure, inflammatory markers and adhesion molecules, and diabetes and how these advantages of the MeDi are maintained in comparison of a low-fat diet. Some studies reported a positive effect of adherence to a Mediterranean Diet and heart failure incidence, whereas some recent studies, such as the PREDIMED study, showed that the incidence of major cardiovascular events was lower among those assigned to MeDi supplemented with extra-virgin olive oil or nuts than among those assigned to a reduced-fat diet. New studies are needed to better understand the molecular mechanisms, whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases, but also discussing other related diseases. We review MedDiet composition and assessment as well as the latest advances in the genomic, epigenomic (DNA methylation, histone modifications, microRNAs, and other emerging regulators), transcriptomic (selected genes and whole transcriptome), and metabolomic and metagenomic aspects of the MedDiet effects (as a whole and for its most typical food components). We also present a review of the clinical effects of this dietary style underlying the biochemical and molecular effects of the Mediterranean diet. Our purpose is to review the main features of the Mediterranean diet in particular its benefits on human health, underling the anti-inflammatory, anti-oxidant and anti-atherosclerotic effects to which new knowledge about epigenetic and gut-microbiota relationship is recently added

Evaluation of the ability of powdered milk to produce mini-tablets containing paracetamol

Poster presented at the 1st European Conference on Pharmaceutics. 13-14 April 2015, Reims, France"In recent years the development of medicines for paediatric use have gained increase interest. Small, flexible solid dosage forms, such as mini-tablets, are an attractive choice when developing new medicines for children. Excipients, though innocuous in adults, may pose a threat to the different paediatric age groups and, therefore, milk, a complete, universally accepted food, used in children’s diet since birth, seems to be an innovative and attractive excipient when formulating for the aforementioned population. In this study a full factorial design was employed to identify the variables (both formulation and manufacturing) and their interactions with significant impact on selected properties of mini-tablets, containing paracetamol and powdered milk, produced by direct compression."Fundação para a Ciência e a Tecnologia (PTDC/DTP-FTO/1057/2012

Development of casein micellar pediatric formulations

Poster presented at the 1st European Conference on Pharmaceutics. 13-14 April 2015, Reims, France."The current need for medicines specifically designed for children, which consider ease of administration, dose flexibility, palatability, safety of excipients, stability and therapeutic equivalency of pediatric dosage forms, has driven the development of pediatric drug formulations. In the present work casein (CN) based micellar formulations are evaluated as vehicles for the oral delivery of pediatric drugs, since caseins are nontoxic, biodegradable, GRAS materials and nanoencapsulation of drugs can improve their bioavailability. Chemical crosslinking of casein by carbodiimide (EDC) has been studied as an approach to improve the stability of the CN micelles and to tailor drug release."Fundação para a Ciência e a Tecnologia, Portugal (Research grant PTDC/DTPFTO/1057/2012

Understanding chemical evolution in resolved galaxies -- I The local star fraction-metallicity relation

This work studies the relation between gas-phase oxygen abundance and stellar-to-gas fraction in nearby galaxies. We first derive the theoretical prediction, and argue that this relation is fundamental, in the sense that it must be verified regardless of the details of the gas accretion and star formation histories. Moreover, it should hold on "local" scales, i.e. in regions of the order of 1 kpc. These predictions are then compared with a set of spectroscopic observations, including both integrated and resolved data. Although the results depend somewhat on the adopted metallicity calibration, observed galaxies are consistent with the predicted relation, imposing tight constraints on the mass-loading factor of (enriched) galactic winds. The proposed parametrization of the star fraction-metallicity relation is able to describe the observed dependence of the oxygen abundance on gas mass at fixed stellar mass. However, the "local" mass-metallicity relation also depends on the relation between stellar and gas surface densities.Comment: 10 pages, 4 figures. Matches accepted version (significant typo corrected