Increased lymph node yield in colorectal cancer is not necessarily associated with a greater number of lymph node positive cancers

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The Spitzer View of Low-Metallicity Star Formation: II. Mrk 996, a Blue Compact Dwarf Galaxy with an Extremely Dense Nucleus

(abridged) We present new Spitzer, UKIRT and MMT observations of the blue compact dwarf galaxy (BCD) Mrk 996, with an oxygen abundance of 12+log(O/H)=8.0. This galaxy has the peculiarity of possessing an extraordinarily dense nuclear star-forming region, with a central density of ~10^6 cm^{-3}. The nuclear region of Mrk 996 is characterized by several unusual properties: a very red color J-K = 1.8, broad and narrow emission-line components, and ionizing radiation as hard as 54.9 eV, as implied by the presence of the OIV 25.89 micron line. The nucleus is located within an exponential disk with colors consistent with a single stellar population of age >1 Gyr. The infrared morphology of Mrk 996 changes with wavelength. The IRS spectrum shows strong narrow Polycyclic Aromatic Hydrocarbon (PAH) emission, with narrow line widths and equivalent widths that are high for the metallicity of Mrk 996. Gaseous nebular fine-structure lines are also seen. A CLOUDY model requires that they originate in two distinct HII regions: a very dense HII region of radius ~580 pc with densities declining from ~10^6 at the center to a few hundreds cm^{-3} at the outer radius, where most of the optical lines arise; and a HII region with a density of ~300 cm^{-3} that is hidden in the optical but seen in the MIR. We suggest that the infrared lines arise mainly in the optically obscured HII region while they are strongly suppressed by collisional deexcitation in the optically visible one. The hard ionizing radiation needed to account for the OIV 25.89 micron line is most likely due to fast radiative shocks propagating in an interstellar medium. A hidden population of Wolf-Rayet stars of type WNE-w or a hidden AGN as sources of hard ionizing radiation are less likely possibilities.Comment: 48 pages, 13 figures, accepted for publication in the Astrophysical Journa

Spin squeezing of high-spin, spatially extended quantum fields

Investigations of spin squeezing in ensembles of quantum particles have been limited primarily to a subspace of spin fluctuations and a single spatial mode in high-spin and spatially extended ensembles. Here, we show that a wider range of spin-squeezing is attainable in ensembles of high-spin atoms, characterized by sub-quantum-limited fluctuations in several independent planes of spin-fluctuation observables. Further, considering the quantum dynamics of an $f=1$ ferromagnetic spinor Bose-Einstein condensate, we demonstrate theoretically that a high degree of spin squeezing is attained in multiple spatial modes of a spatially extended quantum field, and that such squeezing can be extracted from spatially resolved measurements of magnetization and nematicity, i.e.\ the vector and quadrupole magnetic moments, of the quantum gas. Taking into account several experimental limitations, we predict that the variance of the atomic magnetization and nematicity may be reduced as far as 20 dB below the standard quantum limits.Comment: 18 pages, 5 figure

Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior.

The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input from the secondary motor cortex (M2), an area involved in licking, and the parafascicular thalamic nucleus (PF). Using neural recordings, together with optogenetic terminal inhibition, we examine the contribution of M2 and PF projections on medium spiny projection neuron (MSN) activity as mice performed an anticipatory licking task. Each input has a similar contribution to striatal activity. By comparing how suppressing single or multiple projections altered striatal activity, we find that cortical and thalamic input signals modulate MSN gain and that this effect is more pronounced in a temporally specific period of the task following the cue presentation. These results demonstrate that cortical and thalamic inputs synergistically regulate striatal output during reward-conditioned behavior

A Coverage Criterion for Spaced Seeds and its Applications to Support Vector Machine String Kernels and k-Mer Distances

Spaced seeds have been recently shown to not only detect more alignments, but also to give a more accurate measure of phylogenetic distances (Boden et al., 2013, Horwege et al., 2014, Leimeister et al., 2014), and to provide a lower misclassification rate when used with Support Vector Machines (SVMs) (On-odera and Shibuya, 2013), We confirm by independent experiments these two results, and propose in this article to use a coverage criterion (Benson and Mak, 2008, Martin, 2013, Martin and No{\'e}, 2014), to measure the seed efficiency in both cases in order to design better seed patterns. We show first how this coverage criterion can be directly measured by a full automaton-based approach. We then illustrate how this criterion performs when compared with two other criteria frequently used, namely the single-hit and multiple-hit criteria, through correlation coefficients with the correct classification/the true distance. At the end, for alignment-free distances, we propose an extension by adopting the coverage criterion, show how it performs, and indicate how it can be efficiently computed.Comment: http://online.liebertpub.com/doi/abs/10.1089/cmb.2014.017

Muon-Spin Rotation Measurements of an Unusual Vortex-Glass Phase in the Layered Superconductor Bi2.15Sr1.85CaCu2O8+δ

Muon-spin rotation measurements, performed on the mixed state of the classic anisotropic superconductor Bi2.15Sr1.85CaCu2O8+δ, obtain quantities directly related to two- and three-body correlations of vortices in space. A novel phase diagram emerges from such local probe measurements of the bulk, revealing an unusual glassy state at intermediate fields which appears to freeze continuously from the equilibrium vortex liquid but differs both from the lattice and the conventional high-field vortex glass state in its structure.Publisher PDFPeer reviewe

The Trans-Pacific Partnership Agreement: Looking Ahead to the Next Steps

Pressure has been building for the conclusion of the 12-country Trans-Pacific Partnership (TPP) negotiations. Getting the deal done is important, but the TPP is not just another free trade agreement (FTA). It represents the chance to set a trade agenda for the future across a wide range of topics for countries throughout the Asia-Pacific region. This means that the agreement should not be settled in haste. More importantly, it also means that key decisions need to be reached about broader issues related to the institutional structure of the TPP. These decisions must be made now, before the deal is closed, on issues such as how to create the TPP as a living agreement, the formation of a TPP Secretariat, and the clarification of entry conditions for future members such as the People’s Republic of China (PRC). These choices must be made deliberately and carefully even while officials are struggling with reaching closure on the most highly sensitive issues still remaining in the agreement. It will not be easy, but wise decisions are necessary now to ensure the long-term success of the TPP

The SAMI Galaxy Survey: Unveiling the nature of kinematically offset active galactic nuclei

We have observed two kinematically offset active galactic nuclei (AGN), whose ionised gas is at a different line-of-sight velocity to their host galaxies, with the SAMI integral field spectrograph (IFS). One of the galaxies shows gas kinematics very different to the stellar kinematics, indicating a recent merger or accretion event. We demonstrate that the star formation associated with this event was triggered within the last 100 Myr. The other galaxy shows simple disc rotation in both gas and stellar kinematics, aligned with each other, but in the central region has signatures of an outflow driven by the AGN. Other than the outflow, neither galaxy shows any discontinuity in the ionised gas kinematics at the galaxy's centre. We conclude that in these two cases there is no direct evidence of the AGN being in a supermassive black hole binary system. Our study demonstrates that selecting kinematically offset AGN from single-fibre spectroscopy provides, by definition, samples of kinematically peculiar objects, but IFS or other data are required to determine their true nature.Comment: MNRAS accepted. 14 pages, 11 figure

How Low Can You Go? The Photoeccentric Effect for Planets of Various Sizes

It is well-known that the light curve of a transiting planet contains information about the planet's orbital period and size relative to the host star. More recently, it has been demonstrated that a tight constraint on an individual planet's eccentricity can sometimes be derived from the light curve via the "photoeccentric effect," the effect of a planet's eccentricity on the shape and duration of its light curve. This has only been studied for large planets and high signal-to-noise scenarios, raising the question of how well it can be measured for smaller planets or low signal-to-noise cases. We explore the limits of the photoeccentric effect over a wide range of planet parameters. The method hinges upon measuring $g$ directly from the light curve, where $g$ is the ratio of the planet's speed (projected on the plane of the sky) during transit to the speed expected for a circular orbit. We find that when the signal-to-noise in the measurement of $g$ is $< 10$, the ability to measure eccentricity with the photoeccentric effect decreases. We develop a "rule of thumb" that for per-point relative photometric uncertainties $\sigma = \{ 10^{-3}, 10^{-4}, 10^{-5} \}$, the critical values of planet-star radius ratio are $R_p / R_\star \approx \{ 0.1, 0.05, 0.03 \}$ for Kepler-like 30-minute integration times. We demonstrate how to predict the best-case uncertainty in eccentricity that can be found with the photoeccentric effect for any light curve. This clears the path to study eccentricities of individual planets of various sizes in the Kepler sample and future transit surveys

Computation of Kolmogorov's Constant in Magnetohydrodynamic Turbulence

In this paper we calculate Kolmogorov's constant for magnetohydrodynamic turbulence to one loop order in perturbation theory using the direct interaction approximation technique of Kraichnan. We have computed the constants for various $E^u(k)/E^b(k)$, i.e., fluid to magnetic energy ratios when the normalized cross helicity is zero. We find that $K$ increases from 1.47 to 4.12 as we go from fully fluid case $(E^b=0)$ to a situation when $E^u/E^b=0.5$, then it decreases to 3.55 in a fully magnetic limit $(E^u=0)$. When $E^u/E^b=1$, we find that $K=3.43$.Comment: Latex, 10 pages, no figures, To appear in Euro. Phys. Lett., 199