QUIJOTE scientific results – IV. A northern sky survey in intensity and polarization at 10–20 GHz with the multifrequency instrument

J. A. Rubiño-Martín et al.We present QUIJOTE intensity and polarization maps in four frequency bands centred around 11, 13, 17, and 19 GHz, and covering approximately 29 000 deg2, including most of the northern sky region. These maps result from 9000 h of observations taken between May 2013 and June 2018 with the first QUIJOTE multifrequency instrument (MFI), and have angular resolutions of around 1°, and sensitivities in polarization within the range 35–40 µK per 1° beam, being a factor ∼2–4 worse in intensity. We discuss the data processing pipeline employed, and the basic characteristics of the maps in terms of real space statistics and angular power spectra. A number of validation tests have been applied to characterize the accuracy of the calibration and the residual level of systematic effects, finding a conservative overall calibration uncertainty of 5 per cent. We also discuss flux densities for four bright celestial sources (Tau A, Cas A, Cyg A, and 3C274), which are often used as calibrators at microwave frequencies. The polarization signal in our maps is dominated by synchrotron emission. The distribution of spectral index values between the 11 GHz and WMAP 23 GHz map peaks at β = −3.09 with a standard deviation of 0.14. The measured BB/EE ratio at scales of ℓ = 80 is 0.26 ± 0.07 for a Galactic cut |b| > 10°. We find a positive TE correlation for 11 GHz at large angular scales (ℓ ≲ 50), while the EB and TB signals are consistent with zero in the multipole range 30 ≲ ℓ ≲ 150. The maps discussed in this paper are publicly available.Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01,AYA2007-68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P, ESP2017-83921-C2-1-R, AYA2017-90675-REDC (co-funded with EU FEDER funds), PGC2018-101814-B-I00, PID2019-110610RB-C21,PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE-3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015-0548 and CEX2019-000920-S, the Maria de Maeztu Program MDM-2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 - Research and Innovation Framework Programme under grant agreement number 687312 (RADIOFOREGROUNDS). FP acknowledges support from the Spanish State Research Agency (AEI) under grant number PID2019-105552RB-C43.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).Peer reviewe

The new multi-frequency instrument (MFI2) for the QUIJOTE facility in Tenerife

Event: SPIE Astronomical Telescopes + Instrumentation, 2022, Montréal, Québec, Canada.et al.The QUIJOTE (Q-U-I joint Tenerife) experiment combines the operation of two radio-telescopes and three instruments working in the microwave bands 10–20 GHz, 26–36 GHz and 35–47 GHz at the Teide Observatory, Tenerife, and has already been presented in previous SPIE meetings (Hoyland, R. J. et al, 2012; Rubi˜no-Mart´ın et al., 2012). The Cosmology group at the IAC have designed a new upgrade to the MFI instrument in the band 10–20 GHz. The aim of the QUIJOTE telescopes is to characterise the polarised emission of the cosmic microwave background (CMB), as well as galactic and extra-galactic sources, at medium and large angular scales. This MFI2 will continue the survey at even higher sensitivity levels. The MFI2 project led by the Instituto de Astrof´ısica de Canarias (IAC) consists of five polarimeters, three of them operating in the sub-band 10–15 GHz, and two in the sub-band 15–20 GHz. The MFI2 instrument is expected to be a full two–three times more sensitive than the former MFI. The microwave complex correlator design has been replaced by a simple correlator design with a digital back-end based on the latest Xilinx FPGAs (ZCU111). During the first half of 2019 the manufacture of the new cryostat was completed and since then the opto-mechanical components have been designed and manufactured. It is expected that the cryogenic front-end will be completed by the end of 2022 along with the FPGA acquisition and observing system. This digital system has been employed to be more robust against stray ground-based and satellite interference, having a frequency resolution of 1 MHz.Partial financial support is provided by the Spanish Ministry of Science and Innovation (MICINN), under the projects AYA2017-84185-P, IACA15-BE-3707, EQC2018-004918-P and the FEDER Agreement INSIDE-OOCC (ICTS-2019-03-IAC-12). We also acknowledge financial support of the Severo Ochoa Programs SEV-2015-0548 and CEX2019-000920-S.Peer reviewe

QUIJOTE scientific results - XIII. Intensity and polarization study of the microwave spectra of supernova remnants in the QUIJOTE-MFI wide survey: CTB 80, Cygnus Loop, HB 21, CTA 1, Tycho, and HB 9

We use the new QUIJOTE-MFI wide survey (11, 13, 17, and 19 GHz) to produce spectral energy distributions (SEDs), on an angular scale of 1◦, of the supernova remnants (SNRs) CTB 80, Cygnus Loop, HB 21, CTA 1, Tycho, and HB 9. We provide new measurements of the polarized synchrotron radiation in the microwave range. The intensity and polarization SEDs are obtained and modelled by combining QUIJOTE-MFI maps with ancillary data. In intensity, we confirm the curved spectra of CTB 80 and HB 21 with a break frequency νb at 2.0+1.2−0.5 and 5.0+1.2 −1.0 GHz, respectively; and spectral indices above the break of −0.6+0.04−0.05 and −0.86+0.04−0.05. We provide constraints on the Anomalous Microwave Emission, suggesting that it is negligible towards these SNRs. From a simultaneous intensity and polarization fit, we recover synchrotron spectral indices as flat as −0.24, and the whole sample has a mean and scatter of −0.44 ± 0.12. The polarization fractions have a mean and scatter of 6.1 ± 1.9 per cent. When combining our results with the measurements from other QUIJOTE (Q-U-I JOint TEnerife CMB experiment) studies of SNRs, we find that radio spectral indices are flatter for mature SNRs, and particularly flatter for CTB 80 (−0.24+0.07 −0.06) and HB 21 (−0.34+0.04 −0.03). In addition, the evolution of the spectral indices against the SNRs age is modelled with a power-law function, providing an exponent −0.07 ± 0.03 and amplitude −0.49 ± 0.02 (at 10 kyr), which are conservative with respect to previous studies of our Galaxy and the Large Magellanic Cloud.Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007-68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P, ESP2017-83921-C2-1-R, PID2019-110610RB-C21, PID2020-120514GB-I00, PID2019-110614GB-C21, IACA13-3E-2336, IACA15-BE-3707, EQC2018-004918-P, the Severo Ochoa Programmes SEV-2015-0548 and CEX2019-000920-S, the Maria de Maeztu Programme MDM-2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias, and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 687312 (RADIOFOREGROUNDS).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).Peer reviewe

QUIJOTE scientific results - V. The microwave intensity and polarization spectra of the Galactic regions W49, W51 and IC443

We present new intensity and polarization maps obtained with the QUIJOTE experiment towards the Galactic regions W49, W51 and IC443, covering the frequency range from 10 to 20 GHz at ∼ 1 deg angular resolution, with a sensitivity in the range 35–79 μK beam−1 for total intensity and 13–23 μK beam−1 for polarization. For each region, we combine QUIJOTE maps with ancillary data at frequencies ranging from 0.4 to 3000 GHz, reconstruct the spectral energy distribution and model it with a combination of known foregrounds. We detect anomalous microwave emission (AME) in total intensity towards W49 at 4.7σ and W51 at 4.0σ with peak frequencies νAME = (20.0 ± 1.4) GHz and νAME = (17.7 ± 3.6) GHz, respectively; this is the first detection of AME towards W51. The contamination from ultracompact H II regions to the residual AME flux density is estimated at 10 per cent in W49 and 5 per cent in W51, and does not rule out the AME detection. The polarized SEDs reveal a synchrotron contribution with spectral indices αs = −0.67 ± 0.10 in W49 and αs = −0.51 ± 0.07 in W51, ascribed to the diffuse Galactic emission and to the local supernova remnant, respectively. Towards IC443 in total intensity we measure a broken power-law synchrotron spectrum with cut-off frequency ν0,s = (114 ± 73) GHz, in agreement with previous studies; our analysis, however, rules out any AME contribution which had been previously claimed towards IC443. No evidence of polarized AME emission is detected in this study.Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007-68058-C03-02, AYA2010-21766-C03-01,AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P,ESP2017-83921-C2-1-R,AYA2017-90675-REDC (co-funded with EU FEDER funds), PGC2018-101814-B-I00, PID2019-110610RB-C21, PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE-3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015-0548 and CEX2019-000920-S, the Maria de Maeztu Program MDM-2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement number 687312 (RADIOFOREGROUNDS). DT acknowledges the support from the Chinese Academy of Sciences (CAS) President’s International Fellowship Initiative (PIFI) with Grant N. 2020PM0042; DT also acknowledges the support from the South African Claude Leon Foundation, that partially funded this work. EdlH acknowledges partial financial support from the Concepción Arenal Programme of the Universidad de Cantabria. FG acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 101001897). FP acknowledges the European Commission under the Marie Sklodowska-Curie Actions within the European Union’s Horizon 2020 research and innovation programme under Grant Agreement number 658499 (PolAME). FP acknowledges support from the Spanish State Research Agency (AEI) under grant numbers PID2019-105552RB-C43. BR-G acknowledges ASI-INFN Agreement 2014-037-R.0.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).Peer reviewe

QUIJOTE Scientific Results – XVII. Studying the anomalous microwave emission in the Andromeda Galaxy with QUIJOTE-MFI

The Andromeda Galaxy (M31) is the Local Group galaxy that is most similar to the Milky Way (MW). The similarities between the two galaxies make M31 useful for studying integrated properties common to spiral galaxies. We use the data from the recent QUIJOTE-MFI Wide Survey, together with new raster observations focused on M31, to study its integrated emission. The addition of raster data improves the sensitivity of QUIJOTE-MFI maps by almost a factor 3. Our main interest is to confirm if anomalous microwave emission (AME) is present in M31, as previous studies have suggested. To do so, we built the integrated spectral energy distribution of M31 between 0.408 and 3000 GHz. We then performed a component separation analysis taking into account synchrotron, free–free, AME, and thermal dust components. AME in M31 is modelled as a lognormal distribution with maximum amplitude, AAME, equal to 1.03 ± 0.32 Jy. It peaks at νAME = 17.2 ± 3.2 GHz with a width of WAME = 0.58 ± 0.16. Both the Akaike and Bayesian information criteria find the model without AME to be less than 1 per cent as probable as the one taking AME into consideration. We find that the AME emissivity per 100 μm intensity in M31 is 28.4 GHz AME = 9.6 ± 3.1 μK MJy−1 sr, similar to that of the MW. We also provide the first upper limits for the AME polarization fraction in an extragalactic object. M31 remains the only galaxy where an AME measurement has been made of its integrated spectrum.Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007-68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P,ESP2017-83921-C2-1-R, PID2019-110610RB-C21, PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE-3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015-0548 and CEX2019-000920-S, the Maria de Maeztu Program MDM-2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). We acknowledge support from the ACIISI, Consejeria de Economia, Conocimiento y Empleo del Gobierno de Canarias, and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement number 687312 (RADIOFOREGROUNDS). MFT acknowledges support from the Spanish Agencia Estatal de Investigación (AEI) of the Ministerio de Ciencia, Innovación y Universidades (MCIU) and the European Social Fund (ESF) under grant with reference PRE-C-2018-0067. CA-T acknowledges support from the Millennium Nucleus on Young Exoplanets and their Moons (YEMS). FP acknowledges support from the Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) under the European FEDER (Fondo Europeo de Desarrollo Regional) de Canarias 2014–2020 grant No. PROID2021010078.With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).Peer reviewe

QUIJOTE scientific results – IX. Radio sources in the QUIJOTE-MFI wide survey maps

We present the catalogue of Q-U-I JOint TEnerife (QUIJOTE) Wide Survey radio sources extracted from the maps of the Multi-Frequency Instrument compiled between 2012 and 2018. The catalogue contains 786 sources observed in intensity and polarization, and is divided into two separate sub-catalogues: one containing 47 bright sources previously studied by the Planck collaboration and an extended catalogue of 739 sources either selected from the Planck Second Catalogue of Compact Sources or found through a blind search carried out with a Mexican Hat 2 wavelet. A significant fraction of the sources in our catalogue (38.7 per cent) are within the |b| ≤ 20° region of the Galactic plane. We determine statistical properties for those sources that are likely to be extragalactic. We find that these statistical properties are compatible with currently available models, with a ∼1.8 Jy completeness limit at 11 GHz. We provide the polarimetric properties of (38, 33, 31, 23) sources with P detected above the significance level at (11, 13, 17, 19) GHz respectively. Median polarization fractions are in the 2.8–4.7 per cent range in the 11–19 GHz frequency interval. We do not distinguish between Galactic and extragalactic sources here. The results presented here are consistent with those reported in the literature for flat- and steep-spectrum radio sources.Partial financial support was provided by the Spanish Ministry of Science and Innovation under the projects AYA2007-68058-C03-01, AYA2007-68058-C03-02, AYA2010-21766-C03-01, AYA2010-21766-C03-02, AYA2014-60438-P, ESP2015-70646-C2-1-R, AYA2017-84185-P, ESP2017-83921-C2-1-R, AYA2017-90675-REDC (co-funded with EU FEDER funds), PGC2018-101814-B-I00, PID2019-110610RB-C21, PID2020-120514GB-I00, IACA13-3E-2336, IACA15-BE-3707, EQC2018-004918-P, the Severo Ochoa Programs SEV-2015-0548 and CEX2019-000920-S, the María de Maeztu Program MDM-2017-0765, and by the Consolider-Ingenio project CSD2010-00064 (EPI: Exploring the Physics of Inflation). DT acknowledges the support from the Chinese Academy of Sciences (CAS) President’s International Fellowship Initiative (PIFI) with Grant N. 2020PM0042. FP acknowledges support from the Spanish State Research Agency (AEI) under grant number PID2019-105552RB-C43. We acknowledge support from the ACIISI, Consejería de Economía, Conocimiento y Empleo del Gobierno de Canarias, and the European Regional Development Fund (ERDF) under grant with reference ProID2020010108. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement number 687312 (RADIOFOREGROUNDS).With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2019-000920-S).Peer reviewe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation

Outcomes of elective liver surgery worldwide: a global, prospective, multicenter, cross-sectional study

Background: The outcomes of liver surgery worldwide remain unknown. The true population-based outcomes are likely different to those vastly reported that reflect the activity of highly specialized academic centers. The aim of this study was to measure the true worldwide practice of liver surgery and associated outcomes by recruiting from centers across the globe. The geographic distribution of liver surgery activity and complexity was also evaluated to further understand variations in outcomes. Methods: LiverGroup.org was an international, prospective, multicenter, cross-sectional study following the Global Surgery Collaborative Snapshot Research approach with a 3-month prospective, consecutive patient enrollment within January–December 2019. Each patient was followed up for 90 days postoperatively. All patients undergoing liver surgery at their respective centers were eligible for study inclusion. Basic demographics, patient and operation characteristics were collected. Morbidity was recorded according to the Clavien–Dindo Classification of Surgical Complications. Country-based and hospital-based data were collected, including the Human Development Index (HDI). (NCT03768141). Results: A total of 2159 patients were included from six continents. Surgery was performed for cancer in 1785 (83%) patients. Of all patients, 912 (42%) experienced a postoperative complication of any severity, while the major complication rate was 16% (341/2159). The overall 90-day mortality rate after liver surgery was 3.8% (82/2,159). The overall failure to rescue rate was 11% (82/ 722) ranging from 5 to 35% among the higher and lower HDI groups, respectively. Conclusions: This is the first to our knowledge global surgery study specifically designed and conducted for specialized liver surgery. The authors identified failure to rescue as a significant potentially modifiable factor for mortality after liver surgery, mostly related to lower Human Development Index countries. Members of the LiverGroup.org network could now work together to develop quality improvement collaboratives