Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma

Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level. This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs. Proteomic data classified HCC NATs into two subtypes (Subtypes 1 and 2), and Subtype 2 was associated with poor prognosis and high-risk recurrence. The pathway and immune features of these two subtypes were characterized. Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry, revealing the early molecular alterations associated with the progression from healthy livers to NATs. This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice

Edge computing for vehicle battery management:Cloud-based online state estimation

The adoption of electric vehicles (EVs), including battery EVs and hybrid EVs, makes it possible to reduce fossil fuel consumption and greenhouse gas emission. However, an accurate battery model and an effective battery management system should be established to enable this benefit. This paper proposes a novel cloud-assisted online battery management method based on artificial intelligence and edge computing technologies. Integration of cloud computation and big data resources into real-time vehicle battery management is realized by establishing a novel cloud-edge battery management system (CEBMS). A deep learning algorithm-based cloud data mining and battery modeling method is developed to estimate the voltage and energy state of the battery. The accuracy of the established cloud battery model outperforms the onboard battery management system by utilizing multi-sources information from different EVs. Meanwhile, a cloud-assisted battery management method is established at edge nodes in the onboard battery management unit to realize real-time state estimation locally. By using precise battery state estimation provided by the cloud platform, vehicle battery model accuracy can be significantly improved. The performance of the proposed battery management method is verified by a vehicle big data platform and battery pack experimental test bench. Experimental results justify the effectiveness of the proposed method in battery state estimation, which can help the EVs use and manage the battery more effectively.</p

Health-Conscious vehicle battery state estimation based on deep transfer learning

Establishing an accurate mathematical model is fundamental to managing, monitoring, and protecting the battery pack in electric vehicles (EVs). The application of the deep learning algorithm-based state estimation method can significantly improve the accuracy and stability of the battery model but is hindered by the great demand for training data. This paper addresses the challenge of health-conscious battery modeling by utilizing multi-source data based on a novel deep transfer learning method. Firstly, a cloud-based battery management framework is designed, which is able to collect and process battery operation data from various EVs and provide a foundation for deploying the transfer learning method. Battery healthy state information in the collected dataset is labeled by a generic perception model, which can be commonly used to quantify the aging state of different battery packs and facilitate the knowledge transfer process. Additionally, a deep transfer learning method is developed to boost the training process of the battery model, where the operation data from different types of EVs can be used for establishing state estimators. The method is verified by the battery operation data collected from two types of electric buses. With the developed healthy state perception model and transfer learning method, battery model error can be limited to 2.43% and 1.27% in the whole life cycle

Data cleaning and restoring method for vehicle battery big data platform

Battery is one of the most important and costly devices in electric vehicles (EVs). Developing an efficient battery management method is of great significance to enhancing vehicle safety and economy. Recently developed big-data and cloud platform computing technologies bring a bright perspective for efficient utilization and protection of vehicle batteries. However, a reliable data transmission network and a high-quality cloud battery dataset are indispensable to enable this benefit. This paper makes the first effort to systematically solve data quality problems in cloud-based vehicle battery monitoring and management by developing a novel integrated battery data cleaning framework. In the first stage, the outlier samples are detected by analyzing the temporal features in the battery data time series. The outlier data in the dataset can be accurately detected to avoid their impacts on battery monitoring and management. Then, the abnormal samples, including the noise polluted data and missing value, are restored by a novel future fusion data restoring model. The real electric bus operation data collected by a cloud-based battery monitoring and management platform are used to verify the performance of the developed data cleaning method. More than 93.3% of outlier samples can be detected, and the data restoring error can be limited to 2.11%, which validates the effectiveness of the developed methods. The proposed data cleaning method provides an effective data quality assessment tool in cloud-based vehicle battery management, which can further boost the practical application of the vehicle big data platform and Internet of vehicle.</p