Analytical modeling of HSUPA-enabled UMTS networks for capacity planning

In recent years, mobile communication networks have experienced significant evolution. The 3G mobile communication system, UMTS, employs WCDMA as the air interface standard, which leads to quite different mobile network planning and dimensioning processes compared with 2G systems. The UMTS system capacity is limited by the received interference at NodeBs due to the unique features of WCDMA, which is denoted as `soft capacity'. Consequently, the key challenge in UMTS radio network planning has been shifted from channel allocation in the channelized 2G systems to blocking and outage probabilities computation under the `cell breathing' effects which are due to the relationship between network coverage and capacity. The interference characterization, especially for the other-cell interference, is one of the most important components in 3G mobile networks planning. This monograph firstly investigates the system behavior in the operation of UMTS uplink, and develops the analytic techniques to model interference and system load as fully-characterized random variables, which can be directly applicable to the performance modeling of such networks. When the analysis progresses from single-cell scenario to multi-cell scenario, as the target SIR oriented power control mechanism is employed for maximum capacity, more sophisticated system operation, `feedback behavior', has emerged, as the interference levels at different cells depend on each other. Such behaviors are also captured into the constructed interference model by iterative and approximation approaches. The models are then extended to cater for the features of the newly introduced HSUPA, which provides enhanced dedicated channels for the packet switched data services such that much higher bandwidth can be achieved for best-effort elastic traffic, which allows network operators to cope with the coexistence of both circuit-switched and packet-switched traffic and guarantee the QoS requirements. During the derivation, we consider various propagation models, traffic models, resource allocation schemes for many possible scenarios, each of which may lead to different analytical models. All the suggested models are validated with either Monte-Carlo simulations or discrete event simulations, where excellent matches between results are always achieved. Furthermore, this monograph studies the optimization-based resource allocation strategies in the UMTS uplink with integrated QoS/best-effort traffic. Optimization techniques, both linear-programming based and non-linear-programming based, are used to determine how much resource should be assigned to each enhanced uplink user in the multi-cell environment where each NodeB possesses full knowledge of the whole network. The system performance under such resource allocation schemes are analyzed and compared via Monte-Carlo simulations, which verifies that the proposed framework may serve as a good estimation and optimal reference to study how systems perform for network operators

Increased cocaine self-administration in rats lacking the serotonin transporter : a role for glutamatergic signaling in the habenula

Serotonin (5-HT) and the habenula (Hb) contribute to motivational and emotional states such as depression and drug abuse. The dorsal raphe nucleus, where 5-HT neurons originate, and the Hb are anatomically and reciprocally interconnected. Evidence exists that 5-HT influences Hb glutamatergic transmission. Using serotonin transporter knockout (SERT-/- ) rats, which show depression-like behavior and increased cocaine intake, we investigated the effect of SERT reduction on expression of genes involved in glutamate neurotransmission under both baseline conditions as well as after short-access or long-access cocaine (ShA and LgA, respectively) intake. In cocaine-na\uefve animals, SERT removal led to reduced baseline Hb mRNA levels of critical determinants of glutamate transmission, such as SLC1A2, the main glutamate transporter and N-methyl-D-aspartate (Grin1, Grin2A and Grin2B) as well as \u3b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (Gria1 and Gria2) receptor subunits, with no changes in the scaffolding protein Dlg4. In response to ShA and LgA cocaine intake, SLC1A2 and Grin1 mRNA levels decreased in SERT+/+ rats to levels equal of those of SERT-/- rats. Our data reveal that increased extracellular levels of 5-HT modulate glutamate neurotransmission in the Hb, serving as critical neurobiological substrate for vulnerability to cocaine addiction

Патопсихологические особенности и закономерности развития органических психических расстройств при болезни Паркинсона

Проанализированы особенности эмоционально−потребностной сферы, выраженность личностных особенностей, типы отношения к болезни у пациентов с болезнью Паркинсона (БП) и психическими расстройствами. Выявлены патопсихологические факторы формирования органического депрессивного расстройства (F06.36), органического тревожного расстройства (F06.4), органического эмоционально−лабильного расстройства (F06.6), описаны механизмы их патогенеза. Относительно деменции (F02.3) у больных БП единого патопсихологического механизма ее формирования не обнаружено, основная роль в ее патогенезе принадлежит органическому поражению головного мозга.Проаналізовано особливості емоційно−потребової сфери, виразність особистісних особливостей, типи ставлення до хвороби у пацієнтів із хворобою Паркінсона (ХП) та психічними розладами. Виявлено патопсихологічні фактори формування органічного депресивного розладу (F06.36), органічного тривожного розладу (F06.4), органічного емоційно−лабільного розладу (F06.6), описано механізми їх патогенезу. Щодо деменції (F02.3) у хворих на ХП єдиного патопсихологічного механізму її формування не виявлено, основна роль в її патогенезі належить органічному ураженню головного мозку.The peculiarities of emotion−need sphere, degree of personality peculiarities, types of attitude to the disease were analyzed in patients with Parkinson's disease (PD) and mental disorders. Pathopsychological factors of forming organic depressive disorder (F06.36), organic anxiety disorder (F06.4), organic emotional−labile disorder (F06.6) were revealed. The mechanisms of their pathogenesis were described. As for dementia (F02.3), uniform pathopsychological mechanism of its formation was not revealed in patients with PD. Main role in its pathogenesis is played by organic brain lesions

Peripheral serotonin deficiency affects anxiety-like behavior and the molecular response to an acute challenge in rats

Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. While the TPH2 isoform is responsible for the production of serotonin in the brain, TPH1 is expressed in peripheral organs. Interestingly, despite its peripheral localization, alterations of the gene coding for TPH1 have been related to stress sensitivity and an increased susceptibility for psychiatric pathologies. On these bases, we took advantage of newly generated TPH1(-/-)rats, and we evaluated the impact of the lack of peripheral serotonin on the behavior and expression of brain plasticity-related genes under basal conditions and in response to stress. At a behavioral level, TPH1(-/-) rats displayed reduced anxiety-like behavior. Moreover, we found that neuronal activation, quantified by the expression of (Bdnf) and the immediate early gene (Arc) and transcription of glucocorticoid responsive genes after 1 h of acute restraint stress, was blunted in TPH1(-/-) rats in comparison to TPH1 animals(+/+). Overall, we provided evidence for the influence of peripheral serotonin levels in modulating brain functions under basal and dynamic situations

Portfolio of compositions

My Masters research has been to the aim of my development as a composer of original music with an individual voice that is nonetheless informed by the musical and aesthetic currents alive in our contemporary society. This paper is an exegesis on my portfolio of compositions, written during my Masters candidature from 2006-08, in which I pursue a generally-consistent language towards a music that situates itself across a number of dualities with the aim to resolve their opposing strands, while exploring a wide range of thematic and philosophical concerns. The musical analyses contained within demonstrate my compositional technical apparatus which bridges between microstructural cellular detail and an organically unified whole, and promotes a consideration of metaphorical issues that arise through further aesthetic contemplation