Collaboration for innovation in services

The research was motivated by the importance of inter-firm collaboration within service innovation. Inter-firm collaboration covers a broad range of organizational combinations of various size and motivations in various levels of formal agreements. The book chapter will explore the choice of different partners and knowledge sources for enabling co-operative innovation activities following the approach of loosely-coupled and institutional networks. The empirical results show different collaborative behavior within different service industries. --innovation management,service innovation,collaboration

Street Egohood: An Alternative Perspective of Measuring Neighborhood and Spatial Patterns of Crime

Objectives: The current study proposes an approach that accounts for the importance of streets while at the same time accounting for the overlapping spatial nature of social and physical environments captured by the egohood approach. Our approach utilizes overlapping clusters of streets based on the street network distance, which we term street egohoods. Methods: We used the street segment as a base unit and employed two strategies in clustering the street segments: (1) based on the First Order Queen Contiguity; and (2) based on the street network distance considering physical barriers. We utilized our approaches for measuring ecological factors and estimated crime rates in the Los Angeles metropolitan area. Results: We found that whereas certain socio-demographics, land use, and business employee measures show stronger relationships with crime when measured at the smaller street based unit, a number of them actually exhibited stronger relationships when measured using our larger street egohoods. We compared the results for our three-sized street egohoods to street segments and two sizes of block egohoods proposed by Hipp and Boessen (Criminology 51(2):287–327, 2013) and found that two egohood strategies essentially are not different at the quarter mile egohood level but this similarity appears lower when looking at the half mile egohood level. Also, the street egohood models are a better fit for predicting violent and property crime compared to the block egohood models. Conclusions: A primary contribution of the current study is to develop and propose a new perspective of measuring neighborhood based on urban streets. We empirically demonstrated that whereas certain socio-demographic measures show the strongest relationship with crime when measured at the micro geographic unit of street segments, a number of them actually exhibited the strongest relationship when measured using our larger street egohoods. We hope future research can use egohoods to expand understanding of neighborhoods and crime

Fast and slow change in neighbourhoods: characterization and consequences in Southern California

Due to data limitations, most studies of neighbourhood change within regions assume that change over the years of a decade is relatively constant from year-to-year. We use data on home loan information to construct annual measures of key socio-demographic measures in neighbourhoods (census tracts) in the Southern California region from 2000 to 2010 to test this assumption. We use latent trajectory modelling to describe the extent to which neighbourhood change exhibits temporal nonlinearity, rather than a constant rate of change from year to year. There were four key findings: (1) we detected nonlinear temporal change across all socio-demographic dimensions, as a quadratic function better fit the data than a linear one in the latent trajectories; (2) neighbourhoods experiencing more nonlinear temporality also experienced larger overall changes in percent Asian, percent black, and residential stability during the decade; neighbourhoods experiencing an increase in Latinos or a decrease in whites experienced more temporal nonlinearity in this change; (3) the strongest predictor of racial/ethnic temporal nonlinearity was a larger presence of the group at the beginning of the decade; however, the racial and SES composition of the surrounding area, as well as how this was changing in the prior decade, also affected the degree of temporal nonlinearity for these measures in the current decade; (4) this temporal nonlinearity has consequences for neighbourhoods: greater temporal nonlinear change in percent black or Latino was associated with larger increases in violent and property crime during the decade, and the temporal pattern of residential turnover or changing average income impacted changes in crime. The usual assumption of constant year-to-year change when interpolating neighbourhood measures over intervening years may not be appropriate

Drugs, Crime, Space, and Time: A Spatiotemporal Examination of Drug Activity and Crime Rates

To take stock of the “neighborhood effects” of drug activity, we combined theoretical insights from the drugs and crime and communities and place literatures in examining the longitudinal relationship between drug activity and crime rates at more spatially and temporally precise levels of granularity, with blocks as the spatial units and months as the temporal units. We found that drug activity on a block one month “pushes” assaultive violence into surrounding blocks the next month. Integrating perspectives form social disorganization theory with Zimring and Hawkins’ (1997) contingency causation theory, we also found that the economic resources and residential stability of the “the larger social environment”—that is, the surrounding quarter-mile egohood area—moderate drug activity’s block-level relationship to crime. These results suggest that drug activity increases assaultive violence and serious acquisitive crime rates on structurally advantaged blocks, producing a significant ecological niche redefinition for such blocks relative to others in Miami-Dade County, Florida

Micro-Scale, Meso-Scale, Macro-Scale, and Temporal Scale: Comparing the Relative Importance for Robbery Risk in New York City

We compare the relative importance of four dimensions for explaining the micro location of robberies: 1) the micro spatial scale of street segments; 2) the meso spatial scale surrounding the street segment; 3) the temporal pattern, and 4) the macro-scale of the surrounding 2.5 miles. This study uses crime, business, and land use data from New York City and aggregates it to street segments and hours of the day. Although the measures capturing the micro-scale of the street segment explained the largest amount of unique variance, the measures capturing temporal scale across hours of the day (and weekdays) explained the next largest amount of unique variance. The measures of the characteristics in the 2.5 miles macro scale explained the next largest amount of unique variance, and combined with the measures at the meso-scale explained nearly as much of the variance as the street segment measures

Direct Step & Shoot: a New Module for Prostate Cancer IMRT

Aims & Objectives The aim of this treatment planning study is to compare the techniques of 3D conformal radiotherapy (3DCRT) and IMRT to determine the feasible advantages for prostate cancer patientsof using a new direct step & shoot (DSS) IMRT module. For the optimisation of the IMRT, Nucletron offers as a part of the optimising process their IM-optimisation software or their new module DSS. The earlier IM-optimisation software searches first for the ideal fluence for each beam, and this is then followed by the segmentation. The new DSS module integrates the segmentation into the optimisation process. Materials & Methods Between March 2006 and November 2006, four patients with a mean age of 71 years were enrolled for primary EBRT for localised prostate cancer. Three of these patients received antiandrogen therapy either before or during radiotherapy. All four patients had 3D CT treatment planning with a slice thickness of 5 mm and with immobilisation in a vacuum mattress (BlueBAG BodyFIX, Medical Intelligence). As an initial step, it was planned (using Oncentra MasterPlan) to deliver 60 Gy to the planning target volume (PTV), calculated using data for a Siemens Primus linear accelerator (15 MV photons, with multileaf collimator leaf width of 1cm at the isocentre). The preselected gantry angles were 25, 90, 120, 240, 270 and 335 degrees. The rectal volume and urinary bladder were delineated as organs at risk (OARs). Additional structures were also contoured in order to help (we term them ‘Help Contours’) avoid hot spots in normal tissues surrounding the PTV to a distance of 1cm. The dose-volume objectives were defined by two schemes. After optimisation the plans were re-normalised to the average of PTV, giving 30 fractions with a fractional dose of 2 Gy. The 3DCRT plan used identical gantry angles with the beams weighted by experience. Results Both IMRT optimisation schemes reduced the doses received by the OARs when compared to the 3DCRT plan. Using the Nucletron IM-optimisation software the first weighting scheme of the objectives resulted in satisfactory dose-volume histograms (DVHs) for the OARs, and an obviously 'softened' DVH for the PTV (when compared to the 3DCRT plan). The DSS optimisation produced a steeper DVH for the PTV, but worse results for the OARs when compared to the IM-optimisation. Scheme 2 improved the DVHs for the OARs using the DSS process, to about the same level as the IM-optimisation with scheme 1, the PTV DVH staying nearly unchanged. The IM-optimisation produced the worst DVH for the PTV of the five different plans we considered. In Figure 1 the DVHs are shown of a characteristic 3DCRT plan, the IM plan (Scheme 1) and the DSS plan (Scheme 2). Table 1 presents the mean values, averaged over the four patients, for the PTV and for the two OARs. Conclusions In every case the DSS optimisation resulted in a steeper DVH for the PTV than found using the IM process. The DVHs for the OARs are worse with scheme 1 but improve to about the same level with scheme 2. The patients benefit from IMRT by reduced doses to the OARs, keeping a very steep DVH for the PTV with the DSS optimisation. The user should note that weighting schemes based on the experience with IM-optimisation are not retained for the new DSS optimiation without control

The proteostasis network and its decline in ageing

Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark of many age-related diseases is the dysfunction in protein homeostasis (proteostasis), leading to the accumulation of protein aggregates. In healthy cells, a complex proteostasis network, comprising molecular chaperones and proteolytic machineries and their regulators, operates to ensure the maintenance of proteostasis. These factors coordinate protein synthesis with polypeptide folding, the conservation of protein conformation and protein degradation. However, sustaining proteome balance is a challenging task in the face of various external and endogenous stresses that accumulate during ageing. These stresses lead to the decline of proteostasis network capacity and proteome integrity. The resulting accumulation of misfolded and aggregated proteins affects, in particular, postmitotic cell types such as neurons, manifesting in disease. Recent analyses of proteome-wide changes that occur during ageing inform strategies to improve proteostasis. The possibilities of pharmacological augmentation of the capacity of proteostasis networks hold great promise for delaying the onset of age-related pathologies associated with proteome deterioration and for extending healthspan