Vitamin D: beyond bone.

In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extraskeletal effects of vitamin D was first noted with the discovery of the vitamin D receptor (VDR) in tissues and cells that are not involved in maintaining mineral homeostasis and bone health, including skin, placenta, pancreas, breast, prostate and colon cancer cells, and activated T cells. However, the biological significance of the expression of the VDR in different tissues is not fully understood, and the role of vitamin D in extraskeletal health has been a matter of debate. This report summarizes recent research on the roles for vitamin D in cancer, immunity and autoimmune diseases, cardiovascular and respiratory health, pregnancy, obesity, erythropoiesis, diabetes, muscle function, and aging

Overview of Intercalibration of Satellite Instruments

Intercalibration of satellite instruments is critical for detection and quantification of changes in the Earth’s environment, weather forecasting, understanding climate processes, and monitoring climate and land cover change. These applications use data from many satellites; for the data to be interoperable, the instruments must be cross-calibrated. To meet the stringent needs of such applications, instruments must provide reliable, accurate, and consistent measurements over time. Robust techniques are required to ensure that observations from different instruments can be normalized to a common scale that the community agrees on. The long-term reliability of this process needs to be sustained in accordance with established reference standards and best practices. Furthermore, establishing physical meaning to the information through robust Système International d’unités traceable calibration and validation (Cal/Val) is essential to fully understand the parameters under observation. The processes of calibration, correction, stabilitymonitoring, and quality assurance need to be underpinned and evidenced by comparison with “peer instruments” and, ideally, highly calibrated in-orbit reference instruments. Intercalibration between instruments is a central pillar of the Cal/Val strategies of many national and international satellite remote sensing organizations. Intercalibration techniques as outlined in this paper not only provide a practical means of identifying and correcting relative biases in radiometric calibration between instruments but also enable potential data gaps between measurement records in a critical time series to be bridged. Use of a robust set of internationally agreed upon and coordinated intercalibration techniques will lead to significant improvement in the consistency between satellite instruments and facilitate accurate monitoring of the Earth’s climate at uncertainty levels needed to detect and attribute the mechanisms of change. This paper summarizes the state-of-the-art of postlaunch radiometric calibration of remote sensing satellite instruments through intercalibration

Overview of Intercalibration of Satellite Instruments

Intercalibration of satellite instruments is critical for detection and quantification of changes in the Earth’s environment, weather forecasting, understanding climate processes, and monitoring climate and land cover change. These applications use data from many satellites; for the data to be interoperable, the instruments must be cross-calibrated. To meet the stringent needs of such applications, instruments must provide reliable, accurate, and consistent measurements over time. Robust techniques are required to ensure that observations from different instruments can be normalized to a common scale that the community agrees on. The long-term reliability of this process needs to be sustained in accordance with established reference standards and best practices. Furthermore, establishing physical meaning to the information through robust Système International d’unités traceable calibration and validation (Cal/Val) is essential to fully understand the parameters under observation. The processes of calibration, correction, stabilitymonitoring, and quality assurance need to be underpinned and evidenced by comparison with “peer instruments” and, ideally, highly calibrated in-orbit reference instruments. Intercalibration between instruments is a central pillar of the Cal/Val strategies of many national and international satellite remote sensing organizations. Intercalibration techniques as outlined in this paper not only provide a practical means of identifying and correcting relative biases in radiometric calibration between instruments but also enable potential data gaps between measurement records in a critical time series to be bridged. Use of a robust set of internationally agreed upon and coordinated intercalibration techniques will lead to significant improvement in the consistency between satellite instruments and facilitate accurate monitoring of the Earth’s climate at uncertainty levels needed to detect and attribute the mechanisms of change. This paper summarizes the state-of-the-art of postlaunch radiometric calibration of remote sensing satellite instruments through intercalibration

Constellations of identity: place-ma(r)king beyond heritage

This paper will critically consider the different ways in which history and belonging have been treated in artworks situated in the Citadel development in Ayr on the West coast of Scotland. It will focus upon one artwork, Constellation by Stephen Hurrel, as an alternative to the more conventional landscapes of heritage which are adjacent, to examine the relationship between personal history and place history and argue the primacy of participatory process in the creation of place and any artwork therein. Through his artwork, Hurrel has attempted to adopt a material process through which place can be created performatively but, in part due to its non-representational form, proves problematic, aesthetically and longitudinally, in wholly engaging the community. The paper will suggest that through variants of ‘new genre public art’ such as this, personal and place histories can be actively re-created through the redevelopment of contemporary urban landscapes but also highlight the complexities and indeterminacies involved in the relationship between artwork, people and place

The business of cultural heritage tourism: critical success factors

This paper explores critical success factors (CSFs) required for cultural heritage tourism (CHT) operation and how these relate to commercial focus. The literature indicates tension between conservation of authenticity and commercial focus as it is seen to undermine authenticity, potentially degrading its quality and ultimate success as a tourism product. A list of nine key CHT business success factors was devised based on the published literature. Managers and operators of a range of Australian CHT operations were interviewed regarding achievement of CSFs. The operations were broadly categorised according to the level of commercial focus. The level of commercial focus was cross tabulated with the number of CHT business CSFs achieved. While all places in this study had addressed authenticity, CHT places presenting highly commercialised products tended to meet the criteria for achieving a greater number of CSFs than their less commercialised counter-parts. This has implications for sustainable CHT operation practices

Rothamsted Conference RC No 12 : The Place and Management of Sheep in Modern Farming (1932)

RESP-94

Vitamin D and COVID-19: evidence and recommendations for supplementation

Vitamin D is a hormone that acts on many genes expressed by immune cells. Evidence linking vitamin D deficiency with COVID-19 severity is circumstantial but considerable—links with ethnicity, obesity, institutionalization; latitude and ultraviolet exposure; increased lung damage in experimental models; associations with COVID-19 severity in hospitalized patients. Vitamin D deficiency is common but readily preventable by supplementation that is very safe and cheap. A target blood level of at least 50 nmol l−1, as indicated by the US National Academy of Medicine and by the European Food Safety Authority, is supported by evidence. This would require supplementation with 800 IU/day (not 400 IU/day as currently recommended in UK) to bring most people up to target. Randomized placebo-controlled trials of vitamin D in the community are unlikely to complete until spring 2021—although we note the positive results from Spain of a randomized trial of 25-hydroxyvitamin D3 (25(OH)D3 or calcifediol) in hospitalized patients. We urge UK and other governments to recommend vitamin D supplementation at 800–1000 IU/day for all, making it clear that this is to help optimize immune health and not solely for bone and muscle health. This should be mandated for prescription in care homes, prisons and other institutions where people are likely to have been indoors for much of the summer. Adults likely to be deficient should consider taking a higher dose, e.g. 4000 IU/day for the first four weeks before reducing to 800 IU–1000 IU/day. People admitted to the hospital with COVID-19 should have their vitamin D status checked and/or supplemented and consideration should be given to testing high-dose calcifediol in the RECOVERY trial. We feel this should be pursued with great urgency. Vitamin D levels in the UK will be falling from October onwards as we head into winter. There seems nothing to lose and potentially much to gain

Preventing vitamin D deficiency during the COVID-19 pandemic: UK definitions of vitamin D sufficiency and recommended supplement dose are set too low.

There is growing evidence linking vitamin D deficiency with risk of COVID-19. It is therefore distressing that there is major disagreement about the optimal serum level for 25-hydroxyvitamin D (25(OH)D) and appropriate supplement dose. The UK Scientific Advisory Committee for Nutrition has set the lowest level for defining sufficiency (10 ng/ml or 25 nmol/L) of any national advisory body or scientific society and consequently recommends supplementation with 10 micrograms (400 IU) per day. We have searched for published evidence to support this but not found it. There is considerable evidence to support the higher level for sufficiency (20 ng/ml or 50 nmol/L) recommended by the European Food Safety Authority and the American Institute of Medicine and hence greater supplementation (20 micrograms or 800 IU per day). Serum 25(OH)D concentrations in the UK typically fall by around 50% through winter. We believe that governments should urgently recommend supplementation with 20-25 micrograms (800-1,000 IU) per day

Patient perspectives of ‘Watch and Wait’ for chronic haematological cancers : Findings from a qualitative study

Purpose: Chronic blood cancers are incurable, and characterised by unpredictable, remitting-relapsing pathways. Management often involves periods of observation prior to treatment (if required), and post-treatment, in an approach known as 'Watch and Wait'. This study aimed to explore patient experiences of Watch and Wait