Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets

The aim was to enhance the dissolution of lornoxicam (LOR) and to produce mini-tablets with an optimised system to provide a rapid-release multi-particulate formulation. LOR systems were prepared through co-evaporation with either polyethylene glycol 6000 or Pluronic® F-68 (PLU) and adsorption onto Neusilin® US2 alone or co-adsorption in the presence of different amounts of polysorbate 80. All systems were characterised by FT-IR, differential scanning calorimetry, X-ray diffraction, flowability and dissolution techniques. Mini-tablets were prepared using the system with the optimum dissolution profile and flowability. Tensile strengths, content uniformity and dissolution profiles of the mini-tablets were evaluated. The effects of different excipients and storage conditions on mini-tablet properties were also studied. The optimised rapid-release LOR mini-tablets were further evaluated for their in vivo pharmacokinetic profile. The co-evaporate of LOR with PLU showed significantly faster dissolution and superior flowability and was evaluated together with three directly compressible excipients (Cellactose® 80, StarLac® (STA) and Emcompress®) for mini-tablet formulation. The formulation with STA provided the optimum results in terms of tensile strength content uniformity and rapid drug release following a 3-month stability study and was selected for further in vivo evaluation. The pharmacokinetic profile indicated the potential of the mini-tablets achieving rapid release and increased absorption of LO

Wind tunnel study of ventilation system entrainment of building exhausts at Coolbaugh Hall, Colorado School of Mines campus: final report (September 9, 1993)

For Mr. Brit Probst, Davis Partnership.CER93-94-DEN-3.CSU contract (i.e. project) no. 53-6801

Wind tunnel modeling for GEP stack height, Island End Cogeneration project: final report (September 1991)

CER91-92DEN-HEB3.For Cabot Power Corporation.Includes bibliographical references (page 20).September 1991

Solving 2D-Poisson equation using modified cubic B-spline differential quadrature method

In this study a modified cubic B-spline differential quadrature method (MCBDQM) is used to solve the two dimensional Poisson equation. Using the cubic B-spline functions, explicit expressions of weighting coefficients for approximation of derivatives are obtained. Examples of two dimensional Poisson equation under Dirichlet and mixed boundary conditions are studied using the method. Comparisons between the results of the method, the results of using Shu's general approach and results of other methods are presented. Good agreement with Shu's general approach and with the other methods is reached in case of Dirichlet boundary condition. The differential quadrature based on modified cubic B-splines is found to be an efficient method to solve the two dimensional Poisson equation. Keywords: Differential quadrature method, Modified cubic B-spline, Shu’s general approach, Two dimensional Poisson equatio

Effectiveness of Adding a Salt Tolerant Crop to the Egyptian Crop Pattern to Adapt with the Water Salinity and Shortage Conditions

The imbalance between the high water demand and the limited water supplies in Egypt makes water resources management a big challenge. The Mediterranean Sea water intrusion is predicted to increase, causing high water salinity at the Nile delta. A future reduction in the Nile’s water supply is also expected to occur leading to further water stress. Such water shortage will increase the re-use of drainage water which leads to further increase in the water’s salinity. This study aims at adding a salt-tolerant crop to the traditional Egyptian crop pattern. Using quinoa is suggested as an alternative for wheat crop in areas with high water salinity, where the wheat’s productivity is negatively affected. The effectiveness of the proposed crop is evaluated by using the agriculture sector model for Egypt (ASME) which estimates the water demand and the agricultural productivity for different cropping patterns. The results show that quinoa is a good substitution that produces a reliable yield in the case of Nile flow reduction. A base case considering the current water supply conditions is first studied. Then, a 10% reduction in the Nile water supply and the population projection in the year 2030 are presented in two scenarios, one of which considers financial incentives for supporting quinoa. The results show that the Nile flow reduction adversely affects most of crops’ yields, and accordingly, decreases the total crops’ water productivity, but quinoa is found to have a potential high yield in case of water shortage. The total yield of both quinoa and wheat together decrease from 8,643 million tons to 8.223 million tons for the scenario of 10% Nile water reduction without economic incentives, while it jumps to 11.474 million tons  under the same conditions but with  incentives that encourage the farmers to cultivate quinoa