Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries

Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries. This paper discusses the use of shape-similarity methods to identify ring systems that are structurally similar to, and aligned with, a user-defined target ring system. These systems can be used as alternative scaffolds for the construction of a combinatorial library

Corrigendum: Initiating Change of People With Criminal Justice Involvement Through Participation in a Drama Project: An Exploratory Study

Author proofs are not yet ready for revisio

Culture or communicative conflict? : The analysis of equivocation in broadcast Japanese political interviews

The focus of this article is on equivocation in Japanese televised interviews, broadcast over a 14-month period in 2012-2013 (before and after the general election of December 16, 2012). An analysis was conducted of responses to questions by three different groups (national politicians, local politicians, and nonpoliticians). Results showed a striking level of equivocation by both national and local politicians, who together equivocated significantly more than nonpoliticians. Furthermore, national level Diet members equivocated significantly more than local politicians, and both coalition groupings when in power were significantly more likely to equivocate than when in opposition. The results were interpreted in terms of the situational theory of communicative conflict and also in terms of cultural norms characteristic of Japanese politics and society. The failure to consider the role of such norms, it is proposed, represents an important omission in the original theory of equivocation

Memory in Interaction: An Analysis of Repeat Calls to a Home Birth Helpline

Drawing on a corpus of 80 calls to a Home Birth helpline, we use conversation analysis to analyze how callers and call takers display to one another that they are talking for a second or subsequent time. We focus in particular on the role of memory in these interactions. We show how caller and call taker are oriented to remembering at the beginning of calls as displayed in what we call the recognition-solicit pre-sequence, how participants are oriented to issues of forgetting and remembering during the course of repeat calls, and how remembering and forgetting are made manifest in interaction. Our analysis shows how the human capacity to remember and propensity to forget have reverberating implications in calling for help

What explains the uneven take-up of ISO 14001 at the global level?: a panel-data analysis

Since its release in the mid-1990s, close to 37 000 facilities have been certified to ISO 14001, the international voluntary standard for environmental management systems. Yet, despite claims that the standard can be readily adapted to very different corporate and geographic settings, its take-up has been highly geographically variable. This paper contributes to a growing body of work concerned with explaining the uneven diffusion of ISO 14001 at the global level. Drawing from the existing theoretical and empirical literature we develop a series of hypotheses about how various economic, market, and regulatory factors influence the national count of ISO 14001 certifications. These hypotheses are then tested using econometric estimation techniques with data for a panel of 142 developed and developing countries. We find that per capita ISO 14001 counts are positively correlated with income per capita, stock of foreign direct investment, exports of goods and services to Europe and Japan, and pressure from civil society. Conversely, productivity and levels of state intervention are negatively correlated. The paper finishes by offering a number of recommendations to policymakers concerned with accelerating the diffusion of voluntary environmental standards

Paraphrases and summaries: A means of clarification or a vehicle for articulating a preferred version of student accounts?

The use of group discussions as a means to facilitate learning from experiences is well documented in adventure education literature. Priest and Naismith (1993) assert that the use of the circular discussion method, where the leader poses questions to the participants, is the most common form of facilitation in adventure education. This paper draws on transcripts of facilitation sessions to argue that the widely advocated practice of leader summaries or paraphrases of student responses in these sessions functions as a potential mechanism to control and sponsor particular knowledge(s). Using transcripts from recorded facilitation sessions the analysis focuses on how the leader paraphrases the students’ responses and how these paraphrases or ‘formulations’ function to modify or exclude particular aspects of the students’ responses. I assert that paraphrasing is not simply a neutral activity that merely functions to clarify a student response, it is a subtle means by which the leader of the session can, often inadvertently or unknowingly, alter the student’s reply with the consequence of favouring particular knowledge(s). Revealing the subtle work that leader paraphrases perform is of importance for educators who claim to provide genuine opportunities for students to learn from their experience

Vorticity alignment results for the three-dimensional Euler and Navier-Stokes equations

We address the problem in Navier-Stokes isotropic turbulence of why the vorticity accumulates on thin sets such as quasi-one-dimensional tubes and quasi-two-dimensional sheets. Taking our motivation from the work of Ashurst, Kerstein, Kerr and Gibson, who observed that the vorticity vector {\boldmath\omega} aligns with the intermediate eigenvector of the strain matrix $S$, we study this problem in the context of both the three-dimensional Euler and Navier-Stokes equations using the variables \alpha = \hat{{\boldmath\xi}}\cdot S\hat{{\boldmath\xi}} and {\boldmath\chi} = \hat{{\boldmath\xi}}\times S\hat{{\boldmath\xi}} where \hat{{\boldmath\xi}} = {\boldmath\omega}/\omega. This introduces the dynamic angle $\phi (x,t) = \arctan(\frac{\chi}{\alpha})$, which lies between {\boldmath\omega} and S{\boldmath\omega}. For the Euler equations a closed set of differential equations for $\alpha$ and {\boldmath\chi} is derived in terms of the Hessian matrix of the pressure $P = \{p_{,ij}\}$. For the Navier-Stokes equations, the Burgers vortex and shear layer solutions turn out to be the Lagrangian fixed point solutions of the equivalent (\alpha,{\boldmath\chi}) equations with a corresponding angle $\phi = 0$. Under certain assumptions for more general flows it is shown that there is an attracting fixed point of the (\alpha,\bchi) equations which corresponds to positive vortex stretching and for which the cosine of the corresponding angle is close to unity. This indicates that near alignment is an attracting state of the system and is consistent with the formation of Burgers-like structures.Comment: To appear in Nonlinearity Nov. 199