“It becomes more of an abstract idea, this privacy”—Informing the design for communal privacy experiences in smart homes

In spite of research recognizing the home as a shared space and privacy as inherently social, privacy in smart homes has mainly been researched from an individual angle. Sometimes contrasting and comparing perspectives of multiple individuals, research has rarely focused on how household members might use devices communally to achieve common privacy goals. An investigation of communal use of smart home devices and its relationship with privacy in the home is lacking. The paper presents a grounded analysis based on a synergistic relationship between an ethnomethodologically-informed (EM-informed) study and a grounded theory (GT) approach. The study focuses on household members’ interactions to show that household members’ ability to coordinate the everyday use of their devices depends on appropriate conceptualizations of roles, rules, and privacy that are fundamentally different from those embodied by off-the-shelf products. Privacy is rarely an explicit, actionable, and practical consideration among household members, but rather a consideration wrapped up in everyday concerns. Roles and rules are not used to create social order, but to account for it. To sensitize to this everyday perspective and to reconcile privacy as wrapped up in everyday concerns with the design of smart home systems, the paper presents the social organization of communal use as a descriptive framework. The framework is descriptive in capturing how households navigate the ‘murky waters’ of communal use in practice, where prior research highlighted seemingly irreconcilable differences in interest, attitude, and aptitude between multiple individuals and with other stakeholders. Discussing how households’ use of roles, rules, and privacy in-practice differed from what off-the-shelf products afforded, the framework highlights critical challenges and opportunities for the design of communal privacy experiences

Further Exploring Communal Technology Use in Smart Homes: Social Expectations

Device use in smart homes is becoming increasingly communal, requiring cohabitants to navigate a complex social and technological context. In this paper, we report findings from an exploratory survey grounded in our prior work on communal technology use in the home [4]. The findings highlight the importance of considering qualities of social relationships and technology in understanding expectations and intentions of communal technology use. We propose a design perspective of social expectations, and we suggest existing designs can be expanded using already available information such as location, and considering additional information, such as levels of trust and reliability.Comment: to appear in CHI '20 Extended Abstracts, April 25--30, 2020, Honolulu, HI, US

Epidemiological Methods: About Time

Epidemiological studies often produce false positive results due to use of statistical approaches that either ignore or distort time. The three time-related issues of focus in this discussion are: (1) cross-sectional vs. cohort studies, (2) statistical significance vs. public health significance, and (3), how risk factors “work together” to impact public health significance. The issue of time should be central to all thinking in epidemiology research, affecting sampling, measurement, design, analysis and, perhaps most important, the interpretation of results that might influence clinical and public-health decision-making and subsequent clinical research

“It becomes more of an abstract idea, this privacy” – Informing the design for communal privacy experiences in smart homes

In spite of research recognizing the home as a shared space and privacy as inherently social, privacy in smart homes has mainly been researched from an individual angle. Sometimes contrasting and comparing perspectives of multiple individuals, research has rarely focused on how household members might use devices communally to achieve common privacy goals. An investigation of communal use of smart home devices and its relationship with privacy in the home is lacking. The paper presents a grounded analysis based on a synergistic relationship between an ethnomethodologically-informed (EM-informed) study and a grounded theory (GT) approach. The study focuses on household members’ interactions to show that household members’ ability to coordinate the everyday use of their devices depends on appropriate conceptualizations of roles, rules, and privacy that are fundamentally different from those embodied by off-the-shelf products. Privacy is rarely an explicit, actionable, and practical consideration among household members, but rather a consideration wrapped up in everyday concerns. Roles and rules are not used to create social order, but to account for it. To sensitize to this everyday perspective and to reconcile privacy as wrapped up in everyday concerns with the design of smart home systems, the paper presents the social organization of communal use as a descriptive framework. The framework is descriptive in capturing how households navigate the ‘murky waters’ of communal use in practice, where prior research highlighted seemingly irreconcilable differences in interest, attitude, and aptitude between multiple individuals and with other stakeholders. Discussing how households’ use of roles, rules, and privacy in-practice differed from what off-the-shelf products afforded, the framework highlights critical challenges and opportunities for the design of communal privacy experiences

Toward an understanding of risk factors for binge-eating disorder in black and white women: A community-based case-control study

This study sought to identify in white women risk factors specific to binge-eating disorder (BED) and for psychiatric disorders in general, and to compare black and white women on risk factors for BED.

Cognitive status and behavioral problems in older hospitalized patients

OBJECTIVES: (a) To determine the quantity and quality of behavioral problems in older hospitalized patients on acute care units; (b) to determine the burden of these behaviors on staff; and (c) to identify predictors of behavioral problems. METHODS: Upon admission, patients performed the Mini-Mental State Exam (MMSE), the Geriatric Depression Scale (GDS), and information was obtained on age, ethnicity, level of education, living arrangement, and psychiatric history. Two days post-admission, a clinical staff member caring for each patient, performed the Neuropsychiatric Inventory-Questionnaire (NPI-Q) to assess patients' behavioral problems and staff distress. PARTICIPANTS AND SETTING: Forty-two patients, over 60 years of age, admitted to medical and surgical units of the Veterans Affairs Hospitals in Palo Alto and San Francisco, participated. RESULTS: Twenty-three of 42 (55%) patients exhibited behavioral problems. Anxiety, depression, irritability, and agitation/aggression were the most frequently observed behaviors. The severity of the behavioral problems was significantly correlated with staff distress. Lower performance on the MMSE at admission was significantly associated with higher NPI-Q ratings. Specifically, of those cases with scores less than or equal to 27 on the MMSE, 66% had behavioral problems during hospitalization, compared to only 31% of those with scores greater than 27. CONCLUSION: Behavioral problems in older hospitalized patients appear to occur frequently, are a significant source of distress to staff, and can result in the need for psychiatric consultation. Assessment of the mental status of older adults at admission to hospital may be valuable in identifying individuals at increased risk for behavioral problems during hospitalization

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other mental health disorders. Although ayahuasca ingestion is considered safe, its pharmacokinetics/pharmacodynamics and tolerability profile pose some challenges and may limit the clinical applicability in vulnerable patient populations. While overdosing and the admixture of intolerable plant constituents may explain some of the common adverse reactions, the peroral route of administration may represent another relevant source of gastro-intestinal intolerabilities and unpredictable pharmacokinetics across users. To overcome these challenges, the present work aimed at creating ayahuasca-analogue formulations with improved pharmacokinetics and tolerability profiles. To this end, we developed peroral formulas and compared them with parenteral formulas specifically designed to circumvent the gastro-intestinal tract. In more detail, peroral administration of a capsule (containing purified DMT and harmine) was tested against a combined administration of an oromucosal harmine tablet and an intranasal DMT spray at two dose levels in an open-label within-subject study in 10 healthy male subjects. Pharmacokinetic and pharmacodynamic profiles were assessed by means of continuous blood sampling, vital sign monitoring, and psychometric assessments. Common side effects induced by traditional herbal ayahuasca such as nausea, vomiting, and diarrhea were significantly attenuated by our DMT/harmine formulations. While all preparations were well tolerated, the combined buccal/intranasal administration of harmine and DMT yielded substantially improved pharmacokinetic profiles, indicated by significantly reduced variations in systemic exposure. In conclusion, the combined buccal/intranasal administration of harmine and DMT is an innovative approach that may pave the way towards a safe, rapid-acting, and patient-oriented administration of DMT/harmine for the treatment of affective disorders.Clinical Trial Registration:clinicaltrials.gov, identifier NCT0471633

The development of CHAMP : a checklist for the appraisal of moderators and predictors

BACKGROUND: Personalized healthcare relies on the identification of factors explaining why individuals respond differently to the same intervention. Analyses identifying such factors, so called predictors and moderators, have their own set of assumptions and limitations which, when violated, can result in misleading claims, and incorrect actions. The aim of this study was to develop a checklist for critically appraising the results of predictor and moderator analyses by combining recommendations from published guidelines and experts in the field. METHODS: Candidate criteria for the checklist were retrieved through systematic searches of the literature. These criteria were evaluated for appropriateness using a Delphi procedure. Two Delphi rounds yielded a pilot checklist, which was tested on a set of papers included in a systematic review on reinforced home-based palliative care. The results of the pilot informed a third Delphi round, which served to finalize the checklist. RESULTS: Forty-nine appraisal criteria were identified in the literature. Feedback was obtained from fourteen experts from (bio)statistics, epidemiology and other associated fields elicited via three Delphi rounds. Additional feedback from other researchers was collected in a pilot test. The final version of our checklist included seventeen criteria, covering the design (e.g. a priori plausibility), analysis (e.g. use of interaction tests) and results (e.g. complete reporting) of moderator and predictor analysis, together with the transferability of the results (e.g. clinical importance). There are criteria both for individual papers and for bodies of evidence. CONCLUSIONS: The proposed checklist can be used for critical appraisal of reported moderator and predictor effects, as assessed in randomized or non-randomized studies using individual participant or aggregate data. This checklist is accompanied by a user's guide to facilitate implementation. Its future use across a wide variety of research domains and study types will provide insights about its usability and feasibilit

Evidence, Interpretation, and Qualification From Multiple Reports of Long- Term Outcomes in the Multimodal Treatment Study of Children With ADHD (MTA) Part II: Supporting Details

Objective: To review and provide details about the primary and secondary findings from the Multimodal Treatment study of ADHD (MTA) published during the past decade as three sets of articles. Method: In the second of a two part article, we provide additional background and detail required by the complexity of the MTA to address confusion and controversy about the findings outlined in part I (the Executive Summary). Results: We present details about the gold standard used to produce scientific evidence, the randomized clinical trial (RCT), which we applied to evaluate the long-term effects of two well-established unimodal treatments, Medication Management (MedMGT) and behavior therapy (Beh), the multimodal combination (Comb), and treatment “as usual” in the community (CC). For each of the first three assessment points defined by RCT methods and included in intent-to-treat analyses, we discuss our definition of evidence from the MTA, interpretation of the serial presentations of findings at each assessment point with a different definition of long-term varying from weeks to years, and qualification of the interim conclusions about long-term effects of treatments for ADHD based on many exploratory analyses described in additional published articles. Conclusions: Using a question and answer format, we discuss the possible clinical relevance of the MTA and present some practical suggestions based on current knowledge and uncertainties facing families, clinicians, and investigators regarding the long-term use of stimulant medication and behavioral therapy in the treatment of children with ADHD. (J. of Att. Dis. 2008; 12(1) 15-43