Сравнительная оценка экспрессии молекул главного комплекса гистосовместимости в тканях пародонта и периферической крови больных генерализованным пародонтитом

Проведено порівняльні клініко-іммунологічні аналізи стану адгезивних молекул HLA-A, B, C і HLA-DR головного комплексу гістосумісності на місцевому рівні - в тканинах пародонта і периферичної крові хворих на ГП і відповідних антигенів моноклональних антитіл T і В-лімфоцитів. Не виявлено прямого кореляційного зв’язку між клінічним проявом запалення пародонту і загальносоматичним імунним статусом, що розкриває механізми локальних Т-клітинних характеристик імунних змін і зумовлює корекцію місцевої терапії.A comparative clinical and immunological analysis of adhesion molecules HLA-A, B, C and HLA-DR major histocompatibility complex at the local level - in periodontal tissues and peripheral blood of patients with SE and related antigen antibody monoklialnyh T and B lymphocytes. There were no direct connection between korellyatsionnoy clinical manifestation of periodontal inflammation and the immune status of the somatic, that reveals the mechanisms of local T-cell characteristics of the immune changes and determines the correction of local therapy

Identifying Advantages and Disadvantages of Variable Rate Irrigation – An Updated Review

Variable rate irrigation (VRI) sprinklers on mechanical move irrigation systems (center pivot or lateral move) have been commercially available since 2004. Although the number of VRI, zone or individual sprinkler, systems adopted to date is lower than expected there is a continued interest to harness this technology, especially when climate variability, regulatory nutrient management, water conservation policies, and declining water for agriculture compound the challenges involved for irrigated crop production. This article reviews the potential advantages and potential disadvantages of VRI technology for moving sprinklers, provides updated examples on such aspects, suggests a protocol for designing and implementing VRI technology and reports on the recent advancements. The advantages of VRI technology are demonstrated in the areas of agronomic improvement, greater economic returns, environmental protection and risk management, while the main drawbacks to VRI technology include the complexity to successfully implement the technology and the lack of evidence that it assures better performance in net profit or water savings. Although advances have been made in VRI technologies, its penetration into the market will continue to depend on tangible and perceived benefits by producers

Enhancing Water Sustainability in North Africa: Literature Review and Synthesis of Current Knowledge Gaps in Sudan

This study delves into the critical role of groundwater in addressing global water challenges, with a focus on the Nubian Sandstone Aquifer System (NSAS) in North Africa. Groundwater constitutes a source of potable water, irrigation, and industrial use, especially in arid regions where surface water is limited. We analyzed the status of water quantity, withdrawals, recharge, and geological characteristics in the NSAS, specifically in Sudan, Egypt, Libya, and Chad. Though the NSAS is largely an untapped resource, we evaluated various scenarios to determine the quantity of cropland that can be sustainably irrigated. The NSAS is located in an arid region, so local recharge does not exceed 10 mm/year. The primary source of recharge comes from the River Nile. The annual recharge is the following: Sudan Platform: 1.44 ± 0.42 km3/yr, Dakhla: 0.135 km3/yr, Kufra: 0.78 ± 0.49 km3/yr. Withdrawal rates are as follows: Egypt: 1.029 km3/yr; Libya: 0.851 km3/yr; Sudan: 0.406 km3/yr; and Chad: 0.001 km3/yr. The amount of water in the (NSAS) in North Africa is estimated at approximately 150,000 km3. This volume is equivalent to about 500 years\u27 worth of the Nile River\u27s discharge. The NSAS is the most extensive fossil aquifer complex globally underlying an area of 2,200,000 km2. The findings contribute valuable insights for policymakers, researchers, and communities grappling with the challenges of groundwater resources to face climate change and water demands

Flow and transport experiments for a streambank seep originating from a preferential flow pathway

Streambank seeps commonly originate from localized heterogeneity or preferential flow pathways (PFPs) in riparian floodplains. However, limited field data have been reported on ground water seep flows and solute transport to seeps from PFPs. The objective of this research was to build upon previous floodplain-scale investigations of PFPs by analyzing seep discharge and transport characteristics through a single PFP. An important research question was whether this PFP could be conceptualized as a homogeneous, one-dimensional flow path. Streambank seep discharge measurements were obtained by inducing a hydraulic head in a trench injection system. Also, co-injection of Rhodamine WT (RhWT) and a potassium chloride (KCl) tracer over a 60-min period was used to investigate transport dynamics. Seep discharge and breakthrough curves for electrical conductivity (EC) and RhWT were measured at the streambank using a lateral flow collection device. The breakthrough curves were fit to one-dimensional convective-dispersion equations (CDEs) to inversely estimate solute transport parameters. The PFP from which the seep originated was clean, coarse gravel (6% by mass less than 2.0 mm) surrounded by gravel with finer particles (20% by mass less than 2.0 mm). Located approximately 2 m from the trench, the seep (50 cm by 10 cm area) required at least 40 cm of hydraulic head for flow to emerge at the streambank. At a higher hydraulic head of 125 cm, seep discharge peaked at 3.5 L/min. This research verified that localized PFPs can result in the rapid transport of water (hydraulic conductivity on the order of 400 m/d) and solutes once reaching a sufficient near-bank hydraulic head. A one-dimensional equilibrium CDE was capable of simulating the EC (R2 = 0.94) and RhWT (R2 = 0.91) breakthrough curves with minimal RhWT sorption (distribution coefficient, Kd, equal to 0.1 cm3/g). Therefore, the PFP could be conceptualized as a one-dimensional, homogenous flow and transport pathway. These results are consistent with previous research observing larger-scale phosphorus transport

Feed for Milk-Eggs Pork

The biggest service that farmers can give to the nation in war is greater production of meat, milk and eggs. Uncle Sam is calling upon South Dakota farmers for greater production of these products throughout this winter and for next year. In many years of the past, it would not be possible for our state to provide this greater production but now it is different – we now have the greatest feed supply in our history, thanks to the bountifulness of nature last year. To use our vast feed supplies most efficiently- to get the maximum amount of human feed from them-stricter attention to proper winter feeding methods must be given. It will require the utmost cooperation and teamwork between farmers, U. S. Department of Agriculture Neighborhood Leaders, county extension agents and experiment stations to see that not a bit of feed is wasted; that it all goes to make every bit of human food possible

The hydraulic conductivity structure of gravel-dominated vadose zones within alluvial floodplains

The floodplains of many gravel-bed streams have a general stratigraphy that consists of a layer of topsoil covering gravel-dominated subsoil. Previous research has demonstrated that this stratigraphy can facilitate preferential groundwater flow through focused linear features, such as paleochannels, or gravelly regions within the vadose zone. These areas within the floodplain vadose zone may provide a route for interactions between the floodplain surface and alluvial groundwater, effectively extending the hyporheic zone across the floodplain during high stream stage. The objective of this research was to assess the structure and scale of texture heterogeneity within the vadose zone within the gravel subsoils of alluvial floodplains using resistivity data combined with hydraulic testing and sediment sampling of the vadose zone. Point-scale and broad-scale methodologies in combination can help us understand spatial heterogeneity in hydraulic conductivity without the need for a large number of invasive hydraulic tests. The evaluated sites in the Ozark region of the United States were selected due to previous investigations indicating that significant high conductivity flow zones existed in a matrix which include almost no clay content. Data indicated that resistivity corresponded with the fine content in the vadose zone and subsequently corresponds to the saturated hydraulic conductivity. Statistical analysis of resistivity data, and supported by data from the soil sampling and permeameter hydraulic testing, identified isolated high flow regions and zones that can be characterized as broad-scale high hydraulic conductivity features with potentially significant consequences for the migration of water and solutes and therefore are of biogeochemical and ecological significance

Feeding in Winter

In this circular, created by the Agriculture Extension Service at South Dakota State College, the information provided includes feeding techniques during the winter months. This information is provided through the guidance of the Agriculture Department during the year 1943

Comparison of stationary and mobile canopy sensing systems for irrigation management of maize and soybean in Nebraska

Accurate knowledge of plant and field characteristics is crucial for irrigation management. Irrigation can potentially be better managed by utilizing data collected from various sensors installed on different platforms. The accuracy and repeatability of each data source are important considerations when selecting a sensing system suitable for irrigation management. The objective of this study was to compare data from multispectral (red and near-infrared bands) and thermal (long wave thermal infrared band) sensors mounted on different platforms to investigate their comparative usability and accuracy. The different sensor platforms included stationary posts fixed on the ground, the lateral of a center pivot irrigation system, unmanned aircraft systems (UAS), and Planet (PlanetScope multispectral imager, Planet Labs, Inc., San Francisco, Calif.) satellites. The surface reflectance data from multispectral (MS) sensors were used to compute the Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI). The experimental plots were managed with rainfed and irrigated treatments. Irrigation was applied according to a spatial evapotranspiration model informed with Planet satellite imagery. The NDVI and SAVI curves computed from the different sensing systems exhibited similar patterns and were able to capture differences between the rainfed and irrigated treatments when the crops were approaching senescence. Strong correlations were observed for canopy temperature measurements between the stationary and pivot-mounted infrared thermometer (IRT) sensors (p-value of less than 0.01 for the correlations) when canopy were scanned with no irrigation application (dry scans). The best correlation was obtained for the irrigated maize, which yielded r2 of 0.99, RMSE of 0.4°C, and MAE of 0.3°C. The correlation for the canopy temperature data collected during dry scan between UAS and pivot-mounted thermal sensors was weak with r2 = 0.26 to 0.28, larger RMSE values of 3.7°C and MAE values of 3.4°C. Secondary analysis between thermal data from stationary and pivot-mounted IRTs collected during wet scans (during an irrigation event) demonstrated reduced canopy temperature from pivot-mounted IRTs by approximately 2°C for irrigated soybean due to wetting of the canopy by the irrigation. Understanding the performance of these sensor systems is valuable in configuring practical design and operational considerations when using sensor feedback for irrigation management

Low Density Lipoprotein Receptor-Related Protein 1 Dependent Endosomal Trapping and Recycling of Apolipoprotein E

BACKGROUND: Lipoprotein receptors from the low density lipoprotein (LDL) receptor family are multifunctional membrane proteins which can efficiently mediate endocytosis and thereby facilitate lipoprotein clearance from the plasma. The biggest member of this family, the LDL receptor-related protein 1 (LRP1), facilitates the hepatic uptake of triglyceride-rich lipoproteins (TRL) via interaction with apolipoprotein E (apoE). In contrast to the classical LDL degradation pathway, TRL disintegrate in peripheral endosomes, and core lipids and apoB are targeted along the endocytic pathway for lysosomal degradation. Notably, TRL-derived apoE remains within recycling endosomes and is then mobilized by high density lipoproteins (HDL) for re-secretion. The aim of this study is to investigate the involvement of LRP1 in the regulation of apoE recycling. PRINCIPAL FINDINGS: Immunofluorescence studies indicate the LRP1-dependent trapping of apoE in EEA1-positive endosomes in human hepatoma cells. This processing is distinct from other LRP1 ligands such as RAP which is efficiently targeted to lysosomal compartments. Upon stimulation of HDL-induced recycling, apoE is released from LRP1-positive endosomes but is targeted to another, distinct population of early endosomes that contain HDL, but not LRP1. For subsequent analysis of the recycling capacity, we expressed the full-length human LRP1 and used an RNA interference approach to manipulate the expression levels of LRP1. In support of LRP1 determining the intracellular fate of apoE, overexpression of LRP1 significantly stimulated HDL-induced apoE recycling. Vice versa LRP1 knockdown in HEK293 cells and primary hepatocytes strongly reduced the efficiency of HDL to stimulate apoE secretion. CONCLUSION: We conclude that LRP1 enables apoE to accumulate in an early endosomal recycling compartment that serves as a pool for the intracellular formation and subsequent re-secretion of apoE-enriched HDL particles