Bipolar resistive switching properties of microcrystalline TiO2 thin films deposited by pulsed laser deposition

TiO2 thin films were deposited on ITO (indium-tin-oxide)-buffered glass by pulsed laser deposition. Bipolar resistive switching behaviors of Ag/microcrystalline TiO2/ITO stacked structures were systematically investigated. Dependence of switching voltag

Reversible resistance switching properties in Ti-doped polycrystalline Ta2O5 thin films

Unipolar reversible resistance switching effects were found in 5 at% Ti-doped polycrystalline Ta 2O 5 films with the device structure of Pt/Ti-Ta 2O 5/Pt. Results suggest that the recovery/rupture of the conductive filaments which are involved in the participation of oxygen vacancies and electrons leads to the resistance switching process. Tidoped Ta 2O 5 thin films possess higher resistance whether in low-resistance state or high-resistance state and higher resistance switching ratio than Ta 2O 5 thin films, where Ti addition plays an important role in the resistance switching process by suppressing the migration of oxygen vacancies via forming an electrically inactive Ti/O-vacancy complex. Excellent retention properties of the high and low resistances under constant stress of applied voltage were obtained

Temporal and Spatial Expression Patterns of Bone Morphogenetic Protein 3 in Developing Zebrafish

Bone morphogenetic proteins (BMPs) are important elements in bone biology. We herein report the expression profiles of zebrafish bmp3 (zbmp3) as demonstrated by real-time PCR and in situ hybridization. The expression of zbmp3 was highly detectable by real-time PCR from 1 day post-fertilization (1 dpf) to 2 weeks post-fertilization (2 wpf) and peaked at 1 wpf. For in situ hybridization experiments, zbmp3 was expressed in the otic vesicle at 1 dpf, 2 dpf, 3 dpf, and 5 dpf. It was also expressed in the pharyngeal arches, including the opercle, branchiostegal ray, and pectoral fins, at 2 dpf. Our results suggest that zbmp3 may play an important role in the skeletal biology of developing zebrafish

Realization of rectifying and resistive switching behaviors of TiO2 nanorod arrays for nonvolatile memory

Both the rectifying and resistive switching behaviors are reported in single-crystalline TiO2 nanorod arrays (NRAs). The transition from rectifying to bipolar resistive switching behavior can be controlled by a forming process. The surface of TiO2 nanorods and the Pt/TiO2 NRAs interface play crucial roles on resistive switching. In low resistance state, the dependence of resistance on cell area indicates that filaments form on each individual nanorod, which contributes to the narrow distribution of resistive switching parameters. These results suggest that single-crystalline TiO2 NRAs could be used as nanowire-based switch element and memory cell for next-generation nonvolatile memory

Spatial Information Enhances Myoelectric Control Performance with Only Two Channels

© 2018 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes,creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Automatic gesture recognition (AGR) is investigated as an effortless human-machine interaction method, potentially applied in many industrial sectors. When using surface electromyogram (sEMG) for AGR, i.e. myoelectric control, a minimum of four EMG channels are required. However, in practical applications, fewer number of electrodes is always preferred, particularly for mobile and wearable applications. No published research focused on how to improve the performance of a myoelectric system with only two sEMG channels. In this study, we presented a systematic investigation to fill this gap. Specifically, we demonstrated that through spatial filtering and electrode position optimization, the myoelectric control performance was significantly improved (p < 0.05) and similar to that with four electrodes. Further, we found a significant correlation between offline and online performance metrics in the two-channel system, indicating that offline performance was transferable to online performance, highly relevant for algorithm development for sEMG-based AGR applications.Natural Sciences and Engineering Research Council of Canada || (Discovery Grant 072169) National Natural Science Foundation of China || (Grant 51620105002 and 91748119) State Key Lab of Railway Control and Safety Open Topics Fund of China || (Grant RCS2017K008)

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that mutant embryos and mutant cells in culture experienced genome instability, as do cells in FA patients. In wild-type zebrafish, meiotic cells expressed brca2; and, unexpectedly, transcripts in oocytes localized asymmetrically to the animal pole. In juvenile brca2 mutants, oocytes failed to progress through meiosis, leading to female-to-male sex reversal. Adult mutants became sterile males due to the meiotic arrest of spermatocytes, which then died by apoptosis, followed by neoplastic proliferation of gonad somatic cells that was similar to neoplasia observed in ageing dead end (dnd)-knockdown males, which lack germ cells. The construction of animals doubly mutant for brca2 and the apoptotic gene tp53 (p53) rescued brca2-dependent sex reversal. Double mutants developed oocytes and became sterile females that produced only aberrant embryos and showed elevated risk for invasive ovarian tumors. Oocytes in double-mutant females showed normal localization of brca2 and pou5f1 transcripts to the animal pole and vasa transcripts to the vegetal pole, but had a polarized rather than symmetrical nucleus with the distribution of nucleoli and chromosomes to opposite nuclear poles; this result revealed a novel role for Brca2 in establishing or maintaining oocyte nuclear architecture. Mutating tp53 did not rescue the infertility phenotype in brca2 mutant males, suggesting that brca2 plays an essential role in zebrafish spermatogenesis. Overall, this work verified zebrafish as a model for the role of Brca2 in human disease and uncovered a novel function of Brca2 in vertebrate oocyte nuclear architecture

Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy: Implications for Optical Neuroimaging

Functional near-infrared spectroscopy (fNIRS) is an established optical neuroimaging method for measuring functional hemodynamic responses to infer neural activation. However, the impact of individual anatomy on the sensitivity of fNIRS measuring hemodynamics within cortical gray matter is still unknown. By means of Monte Carlo simulations and structural MRI of 23 healthy subjects (mean age: years), we characterized the individual distribution of tissue-specific NIR-light absorption underneath 24 prefrontal fNIRS channels. We, thereby, investigated the impact of scalp-cortex distance (SCD), frontal sinus volume as well as sulcal morphology on gray matter volumes () traversed by NIR-light, i.e. anatomy-dependent fNIRS sensitivity. The NIR-light absorption between optodes was distributed describing a rotational ellipsoid with a mean penetration depth of considering the deepest of light. Of the detected photon packages scalp and bone absorbed and absorbed of the energy. The mean volume was negatively correlated () with the SCD and frontal sinus volume () and was reduced by in subjects with relatively large compared to small frontal sinus. Head circumference was significantly positively correlated with the mean SCD () and the traversed frontal sinus volume (). Sulcal morphology had no significant impact on . Our findings suggest to consider individual SCD and frontal sinus volume as anatomical factors impacting fNIRS sensitivity. Head circumference may represent a practical measure to partly control for these sources of error variance

Adenovirus-mediated Expression of Aquaporin-5 in Epithelial Cells

A recombinant adenovirus coding for rat aquaporin-5 was constructed and plaque purified. The recombinant adenovirus (AdrAQP5) mediated the expression of aquaporin-5 in rat and human salivary cell lines and in dog kidney cells in vitro as demonstrated by Northern blot and Western blot analyses, and by confocal microscopy after immunofluorescent labeling. In kidney cells, expression of the transgene was optimal if cells were infected at their basolateral surface, a phenomenon associated with the distribution of integrin receptors on these cells. The expressed aquaporin-5 protein was functionally active because viral-mediated gene transfer resulted in a significant increase in the osmotically directed net fluid secretion rate across monolayers of kidney cells. AdrAQP5 should provide an efficient and useful means to impart facilitated water permeability to cells lacking such a pathway