Crossmodal content binding in information-processing architectures

Operating in a physical context, an intelligent robot faces two fundamental problems. First, it needs to combine information from its different sensors to form a representation of the environment that is more complete than any of its sensors on its own could provide. Second, it needs to combine high-level representations (such as those for planning and dialogue) with its sensory information, to ensure that the interpretations of these symbolic representations are grounded in the situated context. Previous approaches to this problem have used techniques such as (low-level) information fusion, ontological reasoning, and (high-level) concept learning. This paper presents a framework in which these, and other approaches, can be combined to form a shared representation of the current state of the robot in relation to its environment and other agents. Preliminary results from an implemented system are presented to illustrate how the framework supports behaviours commonly required of an intelligent robot

Targeting of the Hedgehog Signaling Pathway in Cancer Treatment

The Hedgehog (Hh) signaling pathway is a developmental pathway that is highly conserved evolutionarily. While typically only displaying high activity during embryogenesis, overactivation of the Hh pathway in adults has been linked to multiple forms of cancer including acute myeloid leukemia, myelofibrosis, basal-cell carcinoma, pancreatic ductal adrenal carcinoma, and triple negative breast cancer. The prevalence of Hh activation in many different cancers has made it a prime target for inhibition of these cancers through novel therapies. This literature review sought to assess the current state of cancer treatment through inhibition of Hh signaling. Most current clinical trials involving the pathway use Smoothened (SMO) antagonists to limit GLI1 production and ultimately inhibit Hh signaling. Currently, the FDA has approved the use of the SMO antagonists vismodegib, sonidegib, and glasdegib for cancer treatment. While only these small molecule inhibitors of Hh signaling have been approved for cancer treatment at this point, inhibition of the Hh signaling has shown to be a promising avenue for novel cancer therapies, particularly for future treatment of basal-cell carcinoma

The Sovereign Compulsion Defense in Antitrust Actions and the Role of Statements by Foreign Governments

Large numbers of export cartels and increasing governmental involvement in commerce present the potential for greater conflicts between United States antitrust law and the decrees of foreign governments. Sovereign compulsion as a defense to antitrust complaints is one method for dealing with the contradictory obligations imposed on private parties where such conflicts exist. Sovereign compulsion has been discussed by courts and commentators many times in recent years, yet the limits of the defense and the requirements for its application remain unclear. To demonstrate a sovereign compulsion defense, defendants must show that their actions, although possibly in violation of United States antitrust law, were done in compliance with the directives of a foreign government and, therefore, should not be subject to liability under United States law. A special problem arises in this context when a foreign government submits a statement on behalf of a party that is asserting a sovereign compulsion defense. The response of United States courts to such statements has ranged from deference to disregard

Nonperturbative Vertices in Supersymmetric Quantum Electrodynamics

We derive the complete set of supersymmetric Ward identities involving only two- and three- point proper vertices in supersymmetric QED. We also present the most general form of the proper vertices consistent with both the supersymmetric and U(1) gauge Ward identities. These vertices are the supersymmetric equivalent of the non supersymmetric Ball-Chiu vertices.Comment: seventeen pages late

Systematic Review of Risk and Protective Factors for Externalizing Problems in Children Exposed to Intimate Partner Violence

Intimate partner violence (IPV) is a serious public health issue with innumerable costs to the victims, children, and families affected as well as society at large. The evidence is conclusive regarding a strong association between exposure to IPV and children’s externalizing problems. Moving forward, the next step is to enhance our understanding of risk and protective factors associated with these outcomes in order to tailor treatments to meet the needs of both parents and children. The databases Medline, PubMed, and PsyINFO were searched combining variations of the key words such as parent*, child*, mother, partner abuse, domestic abuse, spousal abuse, interpersonal violence, domestic violence, or intimate partner violence. This search were combined with child externalizing behaviors specifically conduct*, oppositional defiant disorder, externaliz*, aggress*, hyperactivity, and ADHD. A total of 31 studies from all three databases were reviewed following application of inclusion and exclusion criteria. The main findings were that child age and gender, callous–unemotional traits, cognitive appraisals, maternal mental health, and quality of parenting emerged as key mediating and moderating factors of the relationship between IPV exposure and child externalizing problems. These findings suggest that interventions provided to families exposed to IPV need to target both maternal and child risk factors in order to successfully reduce child externalizing problems

Energetic and Environmental Constraints on the Community Structure of Benthic Microbial Mats in Lake Fryxell, Antarctica.

Ecological communities are regulated by the flow of energy through environments. Energy flow is typically limited by access to photosynthetically active radiation (PAR) and oxygen concentration (O2). The microbial mats growing on the bottom of Lake Fryxell, Antarctica, have well-defined environmental gradients in PAR and (O2). We analyzed the metagenomes of layers from these microbial mats to test the extent to which access to oxygen and light controls community structure. We found variation in the diversity and relative abundances of Archaea, Bacteria and Eukaryotes across three (O2) and PAR conditions: high (O2) and maximum PAR, variable (O2) with lower maximum PAR, and low (O2) and maximum PAR. We found distinct communities structured by the optimization of energy use on a millimeter-scale across these conditions. In mat layers where (O2) was saturated, PAR structured the community. In contrast, (O2) positively correlated with diversity and affected the distribution of dominant populations across the three habitats, suggesting that meter-scale diversity is structured by energy availability. Microbial communities changed across covarying gradients of PAR and (O2). The comprehensive metagenomic analysis suggests that the benthic microbial communities in Lake Fryxell are structured by energy flow across both meter- and millimeter-scales

Running coupling and fermion mass in strong coupling QED

Simple toy model is used in order to exhibit the technique of extracting the non-perturbative information about Green's functions in Minkowski space. The effective charge and the dynamical electron mass are calculated in strong coupling 3+1 QED by solving the coupled Dyson-Schwinger equations for electron and photon propagators. The minimal Ball-Chiu vertex was used for simplicity and we impose the Landau gauge fixing on QED action. The solution obtained separately in Euclidean and Minkowski space were compared, the latter one was extracted with the help of spectral technique.Comment: 23 pages, 4 figures, v4: revised and extended version, one introductory section adde

Entometabolomics: applications of modern analytical techniques to insect studies

Metabolomic analyses can reveal associations between an organism's metabolome and further aspects of its phenotypic state, an attractive prospect for many life-sciences researchers. The metabolomic approach has been employed in some, but not many, insect study systems, starting in 1990 with the evaluation of the metabolic effects of parasitism on moth larvae. Metabolomics has now been applied to a variety of aspects of insect biology, including behaviour, infection, temperature stress responses, CO2 sedation, and bacteria–insect symbiosis. From a technical and reporting standpoint, these studies have adopted a range of approaches utilising established experimental methodologies. Here, we review current literature and evaluate the metabolomic approaches typically utilised by entomologists. We suggest that improvements can be made in several areas, including sampling procedures, the reduction in sampling and equipment variation, the use of sample extracts, statistical analyses, confirmation, and metabolite identification. Overall, it is clear that metabolomics can identify correlations between phenotypic states and underlying cellular metabolism that previous, more targeted, approaches are incapable of measuring. The unique combination of untargeted global analyses with high-resolution quantitative analyses results in a tool with great potential for future entomological investigations

Le Lucane cerf-volant Lucanus cervus (Linné, 1758) (Coleoptera: Lucanidae): une étude par capture-recapture dans un jardin résidentiel britannique

In the UK, dead wood present in residential gardens provides a signifi cant resource for stag beetles (Lucanus cervus). Data obtained in a mark-release-recapture study, undertaken from June to August 2006 in one residential garden in the county of Suffolk, using a marking technique developed specifi - cally for use with L. cervus, suggest that dispersal of the insect is very limited. This is a factor which needs to be considered when planning for its conservationAu Royaume-Uni le bois mort présent dans les jardins résidentiels procure une ressource significative au Lucane cerf-volant (Lucanus cervus). Les données obtenues lors d'une étude par capture-recapture d'individus marqués effectuée de juin à août 2006 dans un jardin résidentiel du comté de Suffolk, en utilisant une méthode de marquage mise spécialement au point pour le lucane, suggèrent que la dispersion de cet insecte est très limitée. Ce facteur doit être pris en compte dans les plans de conservation de l'espèce