76 research outputs found

    Mind the gap in mindfulness research: A comparative account of the leading schools of thought.

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    The literature on mindfulness has been dominated by the two leading schools of thought: one advanced by Langer and her colleagues the other developed by Kabat-Zinn and his associates. Curiously, the two strands of research have been running in parallel lines for more than 30 years, scarcely addressing each others’ work, and with hardly any attempt to clarify the relationship between them. In view of this gap, this paper aims to systematically compare and contrast the two lines of research. The comparison between the two schools of thought suggests that while there are some similarities in their definitions of mindfulness, they differ in several core aspects: their philosophies, the components of their constructs, their goals, their theoretical scope, their measurement tools, their conceptual focus, their target audiences, the interventions they employ, the mechanisms underlying these interventions, and the outcomes of their interventions. However, the analysis also revealed that self-regulation is a core mechanism in both perspectives, which seems to mediate the impact of their interventions. In view of the differences between the two strands of research, we propose that they would be given different titles that capture their prime features. We suggest ‘creative-mindfulness’ for Langer and her colleagues’ scholarship, and ‘meditative-mindfulness’ for Kabat-Zinn and his associates’ scholarly work

    Untying the text: organizational prosociality and kindness

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    The scholarly field of organizational prosociality is experiencing a renewed interest, yet despite its long track record, researchers still disagree on the definitions of primary concepts. Two umbrella terms, prosocial behaviors and kindness, are particularly baffling, as they are defined similarly, at times used synonymously, yet the differences between them are unclear. Consequently, the field suffers from conceptual ambiguity, which hampers its development. In this brief critical paper, we provide a review of the definitions of prosocial behavior and kindness, in an attempt to semantically untie the text, unpack the context, and discuss the subtext that underlies these concepts. Our analysis suggests that the two concepts overlap in their emphasis on dispositions and actions that aim to promote the welfare of others. However, acts of kindness and prosocial behaviors differ in actors, their target recipients and scale. Acts of kindness are performed by an individual and directed at a person or a small group, while prosocial behaviors can be performed by a person or an organization, and can be directed at a person or a group, but may also be directed at a much larger entity: an organization, community, nation, or society at large

    Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue

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    Rona Barron - ORCID: https://orcid.org/0000-0003-4512-9177Bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt–Jakob disease in humans have previously been shown to be caused by the same strain of transmissible spongiform encephalopathy agent. It is hypothesized that the agent spread to humans following consumption of food products prepared from infected cattle. Despite evidence supporting zoonotic transmission, mouse models expressing human prion protein (HuTg) have consistently shown poor transmission rates when inoculated with cattle BSE. Higher rates of transmission have however been observed when these mice are exposed to BSE that has been experimentally transmitted through sheep or goats, indicating that humans may potentially be more susceptible to BSE from small ruminants. Here we demonstrate that increased transmissibility of small ruminant BSE to HuTg mice was not due to replication of higher levels of infectivity in sheep brain tissue, and is instead due to other specific changes in the infectious agent.https://doi.org/10.1099/vir.0.065730-095pubpub

    Increased susceptibility of transgenic mice expressing human PrP to experimental sheep BSE is not due to increased agent titre in sheep brain tissue

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    Bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt–Jakob disease in humans have previously been shown to be caused by the same strain of transmissible spongiform encephalopathy agent. It is hypothesized that the agent spread to humans following consumption of food products prepared from infected cattle. Despite evidence supporting zoonotic transmission, mouse models expressing human prion protein (HuTg) have consistently shown poor transmission rates when inoculated with cattle BSE. Higher rates of transmission have however been observed when these mice are exposed to BSE that has been experimentally transmitted through sheep or goats, indicating that humans may potentially be more susceptible to BSE from small ruminants. Here we demonstrate that increased transmissibility of small ruminant BSE to HuTg mice was not due to replication of higher levels of infectivity in sheep brain tissue, and is instead due to other specific changes in the infectious agent

    The impact of mindfulness on well-being and performance in the workplace: an inclusive systematic review of the empirical literature

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    Work can be demanding, imposing challenges that can be detrimental to the physical and mental health of workers. Efforts are therefore underway to develop practices and initiatives that may improve occupational well-being. These include interventions based on mindfulness meditation. This paper offers a systematic review of empirical studies featuring analyses of mindfulness in occupational contexts. Databases were reviewed from the start of records to January 2016. Eligibility criteria included experimental and correlative studies of mindfulness conducted in work settings, with a variety of well-being and performance measures. A total of 153 papers met the eligibility criteria and were included in the systematic review, comprising 12,571 participants. Mindfulness was generally associated with positive outcomes in relation to most measures. However, the quality of the studies was inconsistent, so further research is needed, particularly involving high-quality randomized control trials

    The role of host PrP in Transmissible Spongiform Encephalopathies

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    AbstractPrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disease has not been established. To investigate this we have produced by gene targeting a series of inbred lines of transgenic mice expressing different PrP genes. This allows us to study directly the influence of the host PrP gene in TSEs. We have examined the role of glycosylation, point mutations, polymorphisms and PrP from different species on host susceptibility and the disease process both within the murine species and across species barriers

    Host PrP Glycosylation: A Major Factor Determining the Outcome of Prion Infection

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    Rona Barron - ORCID: 0000-0003-4512-9177 https://orcid.org/0000-0003-4512-9177The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host PrP is a major factor influencing TSE infection, we have inoculated gene-targeted transgenic mice that have restricted N-linked glycosylation of PrP with three TSE strains. We have uniquely demonstrated that mice expressing only unglycosylated PrP can sustain a TSE infection, despite altered cellular location of the host PrP. Moreover we have shown that brain material from mice infected with TSE that have only unglycosylated PrPSc is capable of transmitting infection to wild-type mice, demonstrating that glycosylation of PrP is not essential for establishing infection within a host or for transmitting TSE infectivity to a new host. We have further dissected the requirement of each glycosylation site and have shown that different TSE strains have dramatically different requirements for each of the glycosylation sites of host PrP, and moreover, we have shown that the host PrP has a major role in determining the glycosylation state of de novo generated PrPSc.https://doi.org/10.1371/journal.pbio.00601006pubpub

    China Studies Review

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    Our edition begins with Shangsi Zhou’s exploration of the unconventional growth of market capitalism in China’s state-governed economy. Her essay is followed by Sam Boone’s timely review of China’s relationship with the International Criminal Police Organization (Interpol), reflecting on the ways in which China uses international organizations to fulfill domestic goals. The next article is Dominic Chiu’s review of the inefficiency of China’s state sector and the inherent difficulties that exist in reforming state-owned enterprises. The fourth entry is Anna Woods’ examination of China’s growing food insecurity and the ways in which China leverages international organizations and multilateral relationships in attempts to mitigate future shortages. Her work is followed by Brian Hart’s research regarding technological innovation in China in terms of strategic military development, and how this impacts U.S.-China technological competition. Next, Kevin Garrahan examines China’s path to becoming a world leader of innovation, and the challenges presented by China’s current economic structure to this transition. Finally, Michael Sutherland concludes this edition with his review of China’s transition from a “standards taker” to an international “standards maker,” and what this means for international governance organizations

    Host PrP glycosylation: a major factor determining the outcome of prion infection

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    The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host PrP is a major factor influencing TSE infection, we have inoculated gene-targeted transgenic mice that have restricted N-linked glycosylation of PrP with three TSE strains. We have uniquely demonstrated that mice expressing only unglycosylated PrP can sustain a TSE infection, despite altered cellular location of the host PrP. Moreover we have shown that brain material from mice infected with TSE that have only unglycosylated PrP(Sc) is capable of transmitting infection to wild-type mice, demonstrating that glycosylation of PrP is not essential for establishing infection within a host or for transmitting TSE infectivity to a new host. We have further dissected the requirement of each glycosylation site and have shown that different TSE strains have dramatically different requirements for each of the glycosylation sites of host PrP, and moreover, we have shown that the host PrP has a major role in determining the glycosylation state of de novo generated PrP(Sc)

    The impact of mindfulness on well-being and performance in the workplace: an inclusive systematic review of the empirical literature

    Get PDF
    Work can be demanding, imposing challenges that can be detrimental to the physical and mental health of workers. Efforts are therefore underway to develop practices and initiatives that may improve occupational well-being. These include interventions based on mindfulness meditation. This paper offers a systematic review of empirical studies featuring analyses of mindfulness in occupational contexts. Databases were reviewed from the start of records to January 2016. Eligibility criteria included experimental and correlative studies of mindfulness conducted in work settings, with a variety of well-being and performance measures. A total of 153 papers met the eligibility criteria and were included in the systematic review, comprising 12,571 participants. Mindfulness was generally associated with positive outcomes in relation to most measures. However, the quality of the studies was inconsistent, so further research is needed, particularly involving high-quality randomized control trials
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