'I just want to feel like I'm part of everyone else': How schools unintentionally contribute to the isolation of students who identify as LGBT+

This study explores the experiences of students who identify as LGBT+ in six secondary schools in the south of England. Drawing mainly on data from five student focus groups, one student interview and nine teacher interviews, supplemented by a survey of staff and a review of school policy documents, this study examines how schools unwittingly increase LGBT+ students' sense of isolation. Using a framework that identifies different forms of isolation, this study found that use of gendered spaces, the creation of 'safe' spaces such as support groups and the school curriculum can exacerbate students' feelings of isolation, despite the good intentions of schools. Understanding how schools (unwittingly) contribute to LGBT+ students' sense of isolation potentially provides a means to identify more specific ways schools could address this issue

Sex Differences in Liver Toxicity—Do Female and Male Human Primary Hepatocytes React Differently to Toxicants In Vitro?

There is increasing amount of evidence for sex variation in drug efficiency and toxicity profiles. Women are more susceptible than men to acute liver injury from xenobiotics. In general, this is attributed to sex differences at a physiological level as well as differences in pharmacokinetics and pharmacodynamics, but neither of these can give a sufficient explanation for the diverse responses to xenobiotics. Existing data are mainly based on animal models and limited data exist on in vitro sex differences relevant to humans. To date male and female human hepatocytes have not yet been compared in terms of their responses to toxicants. We investigated whether sex-specific differences in acute hepatotoxicity can be observed in vitro at a cellular level by comparing hepatotoxic drug effects in male and female primary human hepatocytes. Significant sex-related differences were found for particular parameters and individual drugs showing that the tested substances are more toxic to female hepatocytes. Moreover, our work demonstrated that high content screening is feasible with pooled primary human hepatocytes in suspension.JRC.I.5-Systems Toxicolog

Month by month overview of UWE Bristol's Green Capital year

The document provides a month-by-month summary of activities which were undertaken by UWE staff and students in support of Bristol's year as European Green Capital. More detail on these activities can be found in the UWE Green Capital Activities Catalogue and accompanying Portfolio

Perinatal deaths in Australia 1993–2012

Summary The loss of a baby who was either stillborn or died in the first weeks of life is a tragic event that affects around 3,000 families every year in Australia. Perinatal mortality is widely recognised as an important indicator of population health. While Australia is one of the safest places in the world to give birth, almost 1 in 100 pregnancies will end in a perinatal death. Perinatal deaths in Australia 1993–2012 represents the first comprehensive national report on perinatal mortality in Australia and includes a detailed analysis of data relating to stillbirths and neonatal deaths for the period 2011-2012 and an analysis of trends for 1993–2012. The aim of this report is to gain a better understanding of the causes of perinatal deaths at a population level and identify changes in perinatal mortality over time. Data used for this report come from information recorded in jurisdictional perinatal data collections and information collated by state and territory perinatal mortality review committees. For the 2 years 2011 and 2012, just over 6,000 babies died during the perinatal period: a rate of 9.9 deaths per 1,000 births. Approximately three-quarters of those deaths were stillbirths (4,485) with the remaining 1,580 deaths being neonatal deaths. The rate of perinatal mortality varied by the state or territory in which babies were born, with the highest perinatal mortality rate recorded in Victoria (12.2 deaths per 1,000 births) and the lowest in New South Wales (8.3 deaths per 1,000 births). The rates also varied considerably between different subgroups including those based on mothers\u27 level of remoteness, socioeconomic status, age, smoking status, body mass index (BMI) and Indigenous status. The perinatal mortality rate of babies born to mothers who identified as Aboriginal or Torres Strait Islander was almost double that of babies of non-Indigenous mothers (17.1 versus 9.6 deaths per 1,000 births). Similarly, the perinatal mortality rate was almost 50% higher among babies whose mothers smoked compared with those who did not smoke (13.3 versus 8.9 deaths per 1,000 births). The stillbirth rate for babies of teenage mothers and mothers older than 45 was more than double that for mothers aged 30–34 (13.9 and 17.1 versus 6.4 deaths per 1,000 births). Over the 20-year period 1993–2012, the overall perinatal mortality rate was stable at around 10 deaths per 1,000 live births. There was a decrease in the rate of neonatal death (3.2 to 2.4 deaths per 1,000 live births) and an increase in the stillbirth rate (6.4 to 7.2 deaths per 1,000 births). Although remaining high, the report shows a decrease of 20% in the perinatal mortality rate among babies of Aboriginal and Torres Strait Islander mothers. During 2011 and 2012, congenital abnormality was the leading condition in the fetus classified by the PSANZ Perinatal Death Classification as the cause of stillbirths (26.3% of stillbirths) and neonatal deaths (33.1%). An additional PSANZ Neonatal Death Classification of extreme prematurity was the leading condition contributing to deaths in the neonatal period (33.5%). When examined by Indigenous status, however, the leading cause of perinatal death among babies of Aboriginal and Torres Strait Islander mothers was spontaneous pre-term birth (26.8% of stillbirths and 48.0% of neonatal deaths). This report provides insight into the trends in perinatal mortality in Australia, and highlights variations in some of Australia\u27s most vulnerable and disadvantaged population subgroups. This indicates areas that warrant further investigation and attention by clinicians, researchers and health policy makers

Data linkage to monitor hepatitis C-associated end-stage liver disease and hepatocellular carcinoma inpatient stays in England

Persons with chronic hepatitis C (HCV) infection are at increased risk of end-stage liver disease (ESLD) and hepatocellular carcinoma (HCC). The impact of hepatitis treatment scale-up and elimination strategies on ESLD and HCC incidence is a critical measure of progress towards WHO targets. Data from national laboratory surveillance of HCV diagnoses were linked to inpatient care records in Hospital Episode Statistics (HES). For persons first diagnosed with HCV between 1998-2016, we describe the characteristics of those with ESLD and HCC and estimate incidence. Of persons diagnosed with HCV between 1998 and 2016 (104,674), 9.1 % (9,525) had an admission for ESLD and 2.5% (2,610) for HCC. The majority of persons with ESLD and HCC were male (70.7% and 82.7%) and of white ethnicity (89.9% and 82.7%). Crude incidence of ESLD and HCC admission was 10.4 and 3.2 per 1,000 person years respectively. When compared to 2011-2013, incidence of ESLD and HCC admissions in 2014-2017 were lower [ESLD incidence rate ratio (IRR): 0.81; 95% Confidence interval (CI): 0.76-0.86; HCC IRR: 0.90; 95% CI: 0.82-1.00, p=0.045]. Data linkage showed considerable underreporting of HCV in HES coding for ESLD and HCC (16.0% and 11.3% respectively). In conclusion, we found a decline in incidence of ESLD and HCC-related inpatient admissions since 2011-2013. Linked analysis is required for the continued monitoring of ESLD and HCC inpatient incidence. However, HES data quality issues around completeness of identifiers contribute to uncertainty in linkage and may limit our ability to robustly monitor progress towards WHO elimination goals

Comparative Analysis of P2P Architectures for Energy Trading and Sharing

Rising awareness and emergence of smart technologies have inspired new thinking in energy system management. Whilst integration of distributed energy resources in micro-grids (MGs) has become the technique of choice for consumers to generate their energy, it also provides a unique opportunity to explore energy trading and sharing amongst them. This paper investigates peer-to-peer (P2P) communication architectures for prosumers’ energy trading and sharing. The performances of common P2P protocols are evaluated under the stringent communication requirements of energy networks defined in IEEE 1547.3-2007. Simulation results show that the structured P2P protocol exhibits a reliability of 99.997% in peer discovery and message delivery whilst the unstructured P2P protocol yields 98%, both of which are consistent with the requirements of MG applications. These two architectures exhibit high scalability with a latency of 0.5 s at a relatively low bandwidth consumption, thus, showing promising potential in their adoption for prosumer to prosumer communication

Distributed Adaptive Primal Algorithm for P2P-ETS over Unreliable Communication Links

Algorithms for distributed coordination and control are increasingly being used in smart grid applications including peer-to-peer energy trading and sharing to improve reliability and efficiency of the power system. However, for realistic deployment of these algorithms, their designs should take into account the suboptimal conditions of the communication network, in particular the communication links that connect the energy trading entities in the energy network. This study proposes a distributed adaptive primal (DAP) routing algorithm to facilitate communication and coordination among proactive prosumers in an energy network over imperfect communication links. The proposed technique employs a multi-commodity flow optimization scheme in its formulation with the objective to minimize both the communication delay and loss of energy transactional messages due to suboptimal network conditions. Taking into account realistic constraints relating to network delay and communication link capacity between the peers, the DAP routing algorithm is used to evaluate network performance using various figures of merit such as probability of signal loss, message delay, congestion and different network topologies. Further, we address the link communication delay problem by redirecting traffic from congested links to less utilized ones. The results show that the proposed routing algorithm is robust to packet loss on the communication links with a 20% reduction in delay compared with hop-by-hop adaptive link state routing algorith

State-Of-The-Art and Prospects for Peer-To-Peer Transaction-Based Energy System

Transaction-based energy (TE) management and control has become an increasingly relevant topic, attracting considerable attention from industry and the research community alike. As a result, new techniques are emerging for its development and actualization. This paper presents a comprehensive review of TE involving peer-to-peer (P2P) energy trading and also covering the concept, enabling technologies, frameworks, active research efforts and the prospects of TE. The formulation of a common approach for TE management modelling is challenging given the diversity of circumstances of prosumers in terms of capacity, profiles and objectives. This has resulted in divergent opinions in the literature. The idea of this paper is therefore to explore these viewpoints and provide some perspectives on this burgeoning topic on P2P TE systems. This study identified that most of the techniques in the literature exclusively formulate energy trade problems as a game, an optimization problem or a variational inequality problem. It was also observed that none of the existing works has considered a unified messaging framework. This is a potential area for further investigation

Exploring the secondary school experience of LGBT+ youth: an examination of school culture and school climate as understood by teachers and experienced by LGBT+ students

The purpose of this mixed methods study was to examine teacher and LGBT+ student attitudes around school climate and school culture. Participants were 153 teachers and staff from six UK secondary schools who completed electronic surveys, nine of whom were interviewed, and students who participated in focus groups at each school. Results suggest a disconnect between teacher and student viewpoints regarding both school climate and school culture around LGBT+-related matters. Many teachers seemed unaware of the overt discrimination that many LGBT+ students received from their peers and that these students were mostly unhappy with the lack of curricular integration of LGBT+ topics. Findings suggest most staff are taking a reactive rather than proactive stance to LGBT+-related issues, and their ignorance of student concerns means little is likely to change. These findings reflect a heteronormative and cisgendered culture, where those in charge are not questioning cultural norms and the status quo. The study argues for a re-examination of how teachers and other staff interpret lived LGBT+ student experiences in these and other secondary contexts

‘I just want to feel like I’m part of everyone else.’ How schools unintentionally contribute to the isolation of students who identify as LGBT+

This study explores the experiences of students who identify as LGBT+ in six secondary schools in the south of England. Drawing mainly on data from six student focus groups (involving 38 students), as well as nine teacher interviews, a survey of 153 staff and analysis of school policy docu¬ments, this study examines the ways in which schools unwittingly increase LGBT+ students’ sense of isolation. This matters because of the established empirical connection between isolation and poor short- and long-term mental health issues, and the associated negative impacts on young people’s life chance. Using a framework that identifies different forms of isolation, this study found that that gendered spaces can be problematic and isolating for students. Also, ‘safe’ spaces such as support groups, although established with the best intentions, are not considered universally ‘safe’ as, depending on the school and contrary to the literature, they may invite unwant¬ed peer victimisation. Schools differ in whether they have clear poli¬cies related to gendered spaces, but when they do exist, staff are not always aware of such policies. Furthermore, LGBT+ matters are seldom integrated in school curriculums, and when they are, this is often done in a problematic or superficial way, further exacerbating students’ feelings of isolation. Understanding how schools (unwittingly) contribute to LGBT+ students’ sense of isolation potentially provides a means to identify more specific ways schools could address this issue