How Iridium Satellite Tracker Model 9602-LP Asset affects span of Control in High Altitidue Balloning

The Irdium Satelitte Network has greatly increased safety in the ballooning field by enabling a greater span of control in flight awarness and termination. This enhanced awareness stems from accurate high interval GPS coordinates that can be integrated into ground station tracking software. The Iridium Network creates the ability to send activation commands remotely with high reliabilty using emails. Additionally this feature has the ability to use local rf transmiters and recievers to increase the flexibilty of cutdown designs. The Iridium Modems provides significant coverage regardless of altitude and loss of ground communication. It is marketed at econmical price point which allows the feasibilty to integrate on a large scale. Server based data can be pulled from any internet capable device to increases the ease of access. Reliabilty plays a significant role, exspecially where low power Radio and Wifi communications come up short. Lastly the Iridium serves a valuable tool in recovery and aquistion of assets post flight

Ground Station Tracking System

One of the Eclipse Ballooning Project’s main goals was to stream live video of the eclipse to the internet. To accomplish this task a tracking antenna was built to follow the balloon payload. As an added challenge, the task had to be completed on a budget. The “ground station” is the center for communication between the payload and user. This system utilizes GPS position reports from the payload via the iridium network to determine the balloons position. The computer algorithm takes in additional GPS and IMU data from the ground station to determine a relative heading to orientate the antenna to point at the balloon payload. The heading and pitch are controlled with independent servos. These subsystems all jointly interact to keep the antenna pointed at the balloon to within a few degrees or the communication would be lost

Preclinical and clinical biomarker studies of CT1812:A novel approach to Alzheimer's disease modification

INTRODUCTION: Amyloid beta (Aβ) oligomers are one of the most toxic structural forms of the Aβ protein and are hypothesized to cause synaptotoxicity and memory failure as they build up in Alzheimer’s disease (AD) patients’ brain tissue. We previously demonstrated that antagonists of the sigma-2 receptor complex effectively block Aβ oligomer toxicity. CT1812 is an orally bioavailable, brain penetrant small molecule antagonist of the sigma-2 receptor complex that appears safe and well tolerated in healthy elderly volunteers. We tested CT1812’s effect on Aβ oligomer pathobiology in preclinical AD models and evaluated CT1812’s impact on cerebrospinal fluid (CSF) protein biomarkers in mild to moderate AD patients in a clinical trial (ClinicalTrials.gov NCT02907567). METHODS: Experiments were performed to measure the impact of CT1812 versus vehicle on Aβ oligomer binding to synapses in vitro, to human AD patient post mortem brain tissue ex vivo, and in living APP(Swe)/PS1dE9 transgenic mice in vivo. Additional experiments were performed to measure the impact of CT1812 versus vehicle on Aβ oligomer-induced deficits in membrane trafficking rate, synapse number, and protein expression in mature hippocampal/cortical neurons in vitro. The impact of CT1812 on cognitive function was measured in transgenic Thy1 huAPP(Swe/Lnd+) and wild-type littermates. A multicenter, double-blind, placebo-controlled parallel group trial was performed to evaluate the safety, tolerability, and impact on protein biomarker expression of CT1812 or placebo given once daily for 28 days to AD patients (Mini-Mental State Examination 18–26). CSF protein expression was measured by liquid chromatography with tandem mass spectrometry or enzyme-linked immunosorbent assay in samples drawn prior to dosing (Day 0) and at end of dosing (Day 28) and compared within each patient and between pooled treated versus placebo-treated dosing groups. RESULTS: CT1812 significantly and dose-dependently displaced Aβ oligomers bound to synaptic receptors in three independent preclinical models of AD, facilitated oligomer clearance into the CSF, increased synaptic number and protein expression in neurons, and improved cognitive performance in transgenic mice. CT1812 significantly increased CSF concentrations of Aβ oligomers in AD patient CSF, reduced concentrations of synaptic proteins and phosphorylated tau fragments, and reversed expression of many AD-related proteins dysregulated in CSF. DISCUSSION: These preclinical studies demonstrate the novel disease-modifying mechanism of action of CT1812 against AD and Aβ oligomers. The clinical results are consistent with preclinical data and provide evidence of target engagement and impact on fundamental disease-related signaling pathways in AD patients, supporting further development of CT1812

How Iridium Satellite Tracker Model 9602-LP Asset affects span of Control in High Altitidue Balloning

The Irdium Satelitte Network has greatly increased safety in the ballooning field by enabling a greater span of control in flight awarness and termination. This enhanced awareness stems from accurate high interval GPS coordinates that can be integrated into ground station tracking software. The Iridium Network creates the ability to send activation commands remotely with high reliabilty using emails. Additionally this feature has the ability to use local rf transmiters and recievers to increase the flexibilty of cutdown designs. The Iridium Modems provides significant coverage regardless of altitude and loss of ground communication. It is marketed at econmical price point which allows the feasibilty to integrate on a large scale. Server based data can be pulled from any internet capable device to increases the ease of access. Reliabilty plays a significant role, exspecially where low power Radio and Wifi communications come up short. Lastly the Iridium serves a valuable tool in recovery and aquistion of assets post flight

Ground Station Tracking System

One of the Eclipse Ballooning Project’s main goals was to stream live video of the eclipse to the internet. To accomplish this task a tracking antenna was built to follow the balloon payload. As an added challenge, the task had to be completed on a budget. The “ground station” is the center for communication between the payload and user. This system utilizes GPS position reports from the payload via the iridium network to determine the balloons position. The computer algorithm takes in additional GPS and IMU data from the ground station to determine a relative heading to orientate the antenna to point at the balloon payload. The heading and pitch are controlled with independent servos. These subsystems all jointly interact to keep the antenna pointed at the balloon to within a few degrees or the communication would be lost

White House publicity operations during the Korean War, June 1950 – June 1951

Truman was the first modern president to face the challenge of selling a limited war. Based on a wide range of primary sources, this article explores the impact that the Korean War had on Truman’s publicity operations. Whereas all wars place important new demands on presidents to speak out more frequently and forcefully, limited wars place significant constraints on what presidents can say and do. During the Korean War, Truman refused to go public at key moments, often employed rhetoric that was more restrained than at earlier moments of the Cold War, and shied away from creating new structures to coordinate the official message. Such actions also had important consequences. In 1950-51, they hampered the task of effective presidential communication, and contributed to the war’s growing unpopularity. For the longer term, they demonstrated the difficulties of selling a limited war, and hence place into sharper context the problems that beset Truman’s successors during the subsequent conflict in Vietnam