Influence of environmental factors during seed development and after full-ripeness on pre-harvest sprouting in wheat

Results on environmental and genotypic factors influencing preharvest sprouting of wheat are summarized. Other possible areas where additional research is needed is suggested

Assessment of Cognitive Strain in Digital Logistics Work: Background, Analysis and Implications

Digital logistics processes are not only a technological challenge. In addition, the question of human cognitive strain and human-computer interaction are important success factors for digital logistics work concepts. After a background introduction, conceptual and an analytical frameworks for identifying cognitive strain in digital logistics work are presented and applied to specific logistics activities. Characteristic features are the speed and density of work tasks, the requirement for teamwork and inter-organizational cooperation as well as the important role of motivation in the “people business” of logistics. Further research is warranted regarding the specific characteristics of digital logistics work and the impact on cognitive workload of human workers

Advances and visions in large-scale hydrological modelling: findings from the 11th Workshop on Large-Scale Hydrological Modelling

Large-scale hydrological modelling has become increasingly wide-spread during the last decade. An annual workshop series on large-scale hydrological modelling has provided, since 1997, a forum to the German-speaking community for discussing recent developments and achievements in this research area. In this paper we present the findings from the 2007 workshop which focused on advances and visions in large-scale hydrological modelling. We identify the state of the art, difficulties and research perspectives with respect to the themes "sensitivity of model results", "integrated modelling" and "coupling of processes in hydrosphere, atmosphere and biosphere". Some achievements in large-scale hydrological modelling during the last ten years are presented together with a selection of remaining challenges for the future

Violation and persistence of the K-quantum number in warm rotating nuclei

The validity of the K-quantum number in rapidly rotating warm nuclei is investigated as a function of thermal excitation energy U and angular momentum I, for the rare-earth nucleus 163Er. The quantal eigenstates are described with a shell model which combines a cranked Nilsson mean-field and a residual two-body interaction, together with a term which takes into account the angular momentum carried by the K-quantum number in an approximate way. K-mixing is produced by the interplay of the Coriolis interaction and the residual interaction; it is weak in the region of the discrete rotational bands (U \lesim 1MeV), but it gradually increases until the limit of complete violation of the K-quantum number is approached around U \sim 2 - 2.5 MeV. The calculated matrix elements between bands having different K-quantum numbers decrease exponentially as a function of $\Delta K$, in qualitative agreement with recent data.Comment: 29 pages, 7 figure

Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).

The gene responsible for X-linked agammaglobulinemia (XLA) has been recently identified to code for a cytoplasmic tyrosine kinase (Bruton's agammaglobulinemia tyrosine kinase, BTK), required for normal B cell development. BTK, like many other cytoplasmic tyrosine kinases, contains Src homology domains (SH2 and SH3), and catalytic kinase domain. SH3 domains are important for the targeting of signaling molecules to specific subcellular locations. We have identified a family with XLA whose affected members have a point mutation (g-->a) at the 5' splice site of intron 8, resulting in the skipping of coding exon 8 and loss of 21 amino acids forming the COOH-terminal portion of the BTK SH3 domain. The study of three generations within this kinship, using restriction fragment length polymorphism and DNA analysis, allowed identification of the mutant X chromosome responsible for XLA and the carrier status in this family. BTK mRNA was present in normal amounts in Epstein-Barr virus-induced B lymphoblastoid cell lines established from affected family members. Although the SH3 deletion did not alter BTK protein stability and kinase activity of the truncated BTK protein was normal, the affected patients nevertheless have a severe B cell defect characteristic for XLA. The mutant protein was modeled using the normal BTK SH3 domain. The deletion results in loss of two COOH-terminal beta strands containing several residues critical for the formation of the putative SH3 ligand-binding pocket. We predict that, as a result, one or more crucial SH3 binding proteins fail to interact with BTK, interrupting the cytoplasmic signal transduction process required for B cell differentiation

Open access to scholarly communications, an introduction

published_or_final_versionJULAC, eIFL.net, SpringerLink, HUCOM, Hong Kong Library Associatio