The Crab Optical/X/gamma-ray polarisation processes

published_or_final_versio

A three-dimensional model for the high-energy emissions from the Crab pulsar

We apply a three-dimensional outer gap accelerator model to the Crab pulsar for examining the light curve, phase-resolved spectrum and polarization. The curvature radiation process of the high-energy particles in the gap is calculated with an assumed three-dimensional structure of the accelerating electric field. We calculate the synchrotron self-inverse Compton process from the secondary pairs, which will be the observed emissions in optical to γ-ray regions. We compute radiation transfer for each radiated beam in three-dimensional geometry. © 2007 American Institute of Physics.published_or_final_versionThe 1st Glast Symposium, Stanford, CA., 5-8 February 2007. In AIP Conference Proceedings, 2007, v. 921, p. 423-42

Overlap of convex polytopes under rigid motion

We present an algorithm to compute a rigid motion that approximately maximizes the volume of the intersection of two convex polytopes P-1 and P-2 in R-3. For all epsilon is an element of (0, 1/2] and for all n >= 1/epsilon, our algorithm runs in O(epsilon(-3) n log(3.5) n) time with probability 1 - n(-O(1)). The volume of the intersection guaranteed by the output rigid motion is a (1 - epsilon)-approximation of the optimum, provided that the optimum is at least lambda . max{vertical bar P-1 vertical bar . vertical bar P-2 vertical bar} for some given constant lambda is an element of (0, 1]. (C) 2013 Elsevier B.V. All rights reserved.X1155Ysciescopu

Authors' reply

published_or_final_versio

Could the compact remnant of SN 1987A be a quark star?

The standard model for Type II supernovae explosions, confirmed by the detection of neutrinos emitted during the supernova explosion, predicts the formation of a compact object, usually assumed to be a neutron star. However, the lack of detection of a neutron star or pulsar formed in the SN 1987A still remains an unsolved mystery. In this paper, we suggest that the newly formed neutron star at the center of SN 1987A may undergo a phase transition after the neutrino trapping timescale (∼10 s). Consequently the compact remnant of SN 1987A may be a strange quark star, which has a softer equation of state than that of neutron star matter. Such a phase transition can induce stellar collapse and result in large amplitude stellar oscillations.We use a three-dimensional Newtonian hydrodynamic code to study the time evolution of the temperature and density at the neutrinosphere. Extremely intense pulsating neutrino fluxes, with submillisecond period and with neutrino energy (greater than 30 MeV), can be emitted because the oscillations of the temperature and density are out of phase almost 180◦. If this is true we predict that the current X-ray emission from the compact remnant of SN 1987A will be lower than 1034 erg s−1, and it should be a thermal bremsstrahlung spectrum for a bare strange star with a surface temperature of around ∼107 K.published_or_final_versio

Phosphorylation of the androgen receptor is associated with reduced survival in hormonerefractory prostate cancer patients

Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed to investigate the expression and phosphorylation status of Akt and AR in matched hormone-sensitive and -refractory prostate cancer tumours from 68 patients. In the hormone-refractory tissue, only phosphorylated AR (pAR) was associated with shorter time to death from relapse (<i>P</i>=0.003). However, when an increase in expression in the transition from hormone-sensitive to -refractory prostate cancer was investigated, an increase in expression of PI3K was associated with decreased time to biochemical relapse (<i>P</i>=0.014), and an increase in expression of pAkt<sup>473</sup> and pAR<sup>210</sup> were associated with decreased disease-specific survival (<i>P</i>=0.0019 and 0.0015, respectively). Protein expression of pAkt<sup>473</sup> and pAR<sup>210</sup> also strongly correlated (<i>P</i><0.001, c.c.=0.711) in the hormone-refractory prostate tumours. These results provide evidence using clinical specimens, that upregulation of the PI3K/Akt pathway is associated with phosphorylation of the AR during development of HRPC, suggesting that this pathway could be a potential therapeutic target

Induced Self-Assembly of Alkynylplatinum(II) Complexes by Variations of Solvent Compositions and Addition of Polyelectrolytes

Poster Presentation: S9- Supramolecular Chemistry and Self-Assembly: no. S9.P6published_or_final_versio

Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study.

This first-in-human study of AGN1 LOEP demonstrated that this minimally-invasive treatment durably increased aBMD in femurs of osteoporotic postmenopausal women. AGN1 resorption was coupled with new bone formation by 12 weeks and that new bone was maintained for at least 5-7 years resulting in substantially increased FEA-estimated femoral strength.IntroductionThis first-in-human study evaluated feasibility, safety, and in vivo response to treating proximal femurs of postmenopausal osteoporotic women with a minimally-invasive local osteo-enhancement procedure (LOEP) to inject a resorbable triphasic osteoconductive implant material (AGN1).MethodsThis prospective cohort study enrolled 12 postmenopausal osteoporotic (femoral neck T-score ≤ - 2.5) women aged 56 to 89 years. AGN1 LOEP was performed on left femurs; right femurs were untreated controls. Subjects were followed-up for 5-7 years. Outcomes included adverse events, proximal femur areal bone mineral density (aBMD), AGN1 resorption, and replacement with bone by X-ray and CT, and finite element analysis (FEA) estimated hip strength.ResultsBaseline treated and control femoral neck aBMD was equivalent. Treated femoral neck aBMD increased by 68 ± 22%, 59 ± 24%, and 58 ± 27% over control at 12 and 24 weeks and 5-7 years, respectively (p < 0.001, all time points). Using conservative assumptions, FEA-estimated femoral strength increased by 41%, 37%, and 22% at 12 and 24 weeks and 5-7 years, respectively (p < 0.01, all time points). Qualitative analysis of X-ray and CT scans demonstrated that AGN1 resorption and replacement with bone was nearly complete by 24 weeks. By 5-7 years, AGN1 appeared to be fully resorbed and replaced with bone integrated with surrounding trabecular and cortical bone. No procedure- or device-related serious adverse events (SAEs) occurred.ConclusionsTreating femurs of postmenopausal osteoporotic women with AGN1 LOEP results in a rapid, durable increase in aBMD and femoral strength. These results support the use and further clinical study of this approach in osteoporotic patients at high risk of hip fracture

Goldstini Can Give the Higgs a Boost

Supersymmetric collider phenomenology depends crucially on whether the lightest observable-sector supersymmetric particle (LOSP) decays, and if so, what the LOSP decay products are. For instance, in SUSY models where the gravitino is lighter than the LOSP, the LOSP decays to its superpartner and a longitudinal gravitino via supercurrent couplings. In this paper, we show that LOSP decays can be substantially modified when there are multiple sectors that break supersymmetry, where in addition to the gravitino there are light uneaten goldstini. As a particularly striking example, a bino-like LOSP can have a near 100% branching fraction to a higgs boson and an uneaten goldstino, even if the LOSP has negligible higgsino fraction. This occurs because the uneaten goldstino is unconstrained by the supercurrent, allowing additional operators to mediate LOSP decay. These operators can be enhanced in the presence of an R symmetry, leading to copious boosted higgs production in SUSY cascade decays.Comment: 30 pages, 12 figures; v2: title change, clarifications added, version to appear in JHE

Are we training our novices towards quality 2D profiles for 3D models?

In the history-based, feature-based, parametric CAD approach, 2D profile sketches are the basis for 3D models. Fully-constraining profiles is mandatory to create robust profiles. At present, neither CAD applications nor Model Quality Testing Tools usually check whether 2D profiles contain redundant constraints. Besides, our experience shows that novices tend to introduce redundant constraints. We hypothesize that 2D profiles over-constrained with redundant relations are more difficult to edit than those that avoid redundancies. In the present work―and as a first step to demonstrate this hypothesis―an experiment was conducted. Students of the subject “Graphics engineering” were taught on the creation of constrained 2D profiles. Then, they were asked two questions. On the one hand, novices had to identify and reason whether a simple given profile was fully-constrained, over-constrained or under-constrained. On the other hand, they had to identify and point out the types of the constraints. The results showed that in spite that novices received a specific training, roughly half of them failed to say if the 2D profile sketch was fully-constrained and which type of constraints it contained. Furthermore, the results of the second question revealed that more than the half of students did not recognize perpendicularity as a geometric constraint. As future work, we will try to demonstrate whether a reinforced training through simple exercises and a quick and effective feedback, will allow novices to improve the identification and removal of redundant 2D constraints when drawing 2D profile sketches (thus helping to produce robust profiles)