77 research outputs found
Orbital Magnetism and Current Distribution of Two-Dimensional Electrons under Confining Potential
The spatial distribution of electric current under magnetic field and the
resultant orbital magnetism have been studied for two-dimensional electrons
under a harmonic confining potential V(\vecvar{r})=m \omega_0^2 r^2/2 in
various regimes of temperature and magnetic field, and the microscopic
conditions for the validity of Landau diamagnetism are clarified. Under a weak
magnetic field (\omega_c\lsim\omega_0, \omega_c being a cyclotron frequency)
and at low temperature (T\lsim\hbar\omega_0), where the orbital magnetic
moment fluctuates as a function of the field, the currents are irregularly
distributed paramagnetically or diamagnetically inside the bulk region. As the
temperature is raised under such a weak field, however, the currents in the
bulk region are immediately reduced and finally there only remains the
diamagnetic current flowing along the edge. At the same time, the usual Landau
diamagnetism results for the total magnetic moment. The origin of this dramatic
temperature dependence is seen to be in the multiple reflection of electron
waves by the boundary confining potential, which becomes important once the
coherence length of electrons gets longer than the system length. Under a
stronger field (\omega_c\gsim\omega_0), on the other hand, the currents in
the bulk region cause de Haas-van Alphen effect at low temperature as
T\lsim\hbar\omega_c. As the temperature gets higher (T\gsim\hbar\omega_c)
under such a strong field, the bulk currents are reduced and the Landau
diamagnetism by the edge current is recovered.Comment: 15 pages, 11 figure
Effect of dephasing on mesoscopic conductance fluctuations in quantum dots with single channel leads
We consider the distribution of conductance fluctuations in disordered
quantum dots with single channel leads. Using a perturbative diagrammatic
approach, valid for continuous level spectra, we describe dephasing due to
processes within the dot by considering two different contributions to the
level broadening, thus satisfying particle number conservation. Instead of a
completely non-Gaussian distribution, which occurs for zero dephasing, we find
for strong dephasing that the distribution is mainly Gaussian with
non-universal variance and non-Gaussian tails.Comment: 11 pages in REVTeX two-column format; 6 eps figures included;
submitted to Phys. Rev.
"Optical conductance fluctuations: diagrammatic analysis in Landauer approach and non-universal effects"
The optical conductance of a multiple scattering medium is the total
transmitted light of a diffuse incoming beam. This quantity, very analogous to
the electronic conductance, exhibits universal conductance fluctuations. We
perform a detailed diagrammatic analysis of these fluctuations. With a
Kadanoff-Baym technique all the leading diagrams are systematically generated.
A cancellation of the short distance divergencies occurs, that yields a well
behaved theory. The analytical form of the fluctuations is calculated and
applied to optical systems. Absorption and internal reflections reduce the
fluctuations significantly.Comment: 25 pages Revtex 3.0, 18 seperate postscript figure
Fano Resonances in Electronic Transport through a Single Electron Transistor
We have observed asymmetric Fano resonances in the conductance of a single
electron transistor resulting from interference between a resonant and a
nonresonant path through the system. The resonant component shows all the
features typical of quantum dots, but the origin of the non-resonant path is
unclear. A unique feature of this experimental system, compared to others that
show Fano line shapes, is that changing the voltages on various gates allows
one to alter the interference between the two paths.Comment: 8 pages, 6 figures. Submitted to PR
Strong localization of electrons in quasi-one-dimensional conductors
We report on the experimental study of electron transport in sub-micron-wide
''wires'' fabricated from Si -doped GaAs. These quasi-one-dimensional
(Q1D) conductors demonstrate the crossover from weak to strong localization
with decreasing the temperature. On the insulating side of the crossover, the
resistance has been measured as a function of temperature, magnetic field, and
applied voltage for different values of the electron concentration, which was
varied by applying the gate voltage. The activation temperature dependence of
the resistance has been observed with the activation energy close to the mean
energy spacing of electron states within the localization domain. The study of
non-linearity of the current-voltage characteristics provides information on
the distance between the critical hops which govern the resistance of Q1D
conductors in the strong localization (SL) regime. We observe the exponentially
strong negative magnetoresistance; this orbital magnetoresistance is due to the
universal magnetic-field dependence of the localization length in Q1D
conductors. The method of measuring of the single-particle density of states
(DoS) in the SL regime has been suggested. Our data indicate that there is a
minimum of DoS at the Fermi level due to the long-range Coulomb interaction.Comment: 12 pages, 11 figures; the final version to appear in Phys. Rev.
Magnetolocalization in disordered quantum wires
The magnetic field dependent localization in a disordered quantum wire is
considered nonperturbatively.
An increase of an averaged localization length with the magnetic field is
found, saturating at twice its value without magnetic field.
The crossover behavior is shown to be governed both in the weak and strong
localization regime by the magnetic diffusion length L_B. This function is
derived analytically in closed form as a function of the ratio of the mean free
path l, the wire thickness W, and the magnetic length l_B for a two-dimensional
wire with specular boundary conditions, as well as for a parabolic wire. The
applicability of the analytical formulas to resistance measurements in the
strong localization regime is discussed. A comparison with recent experimental
results on magnetolocalization is included.Comment: 22 pages, RevTe
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Diagnosis and treatment of viral diseases in recipients of allogeneic hematopoietic stem cell transplantation
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