Correlation between preoperative CT scan and lung metastases according to surgical approach in patients with colorectal cancer

Introduction: The number of lung metastases (M1) of colorectal carcinoma (CRC) in relation to the findings of computed tomography (CT) is the object of study. Methods: Prospective and multicenter study of the Spanish Group for Surgery of CRC lung metastases (GECMP-CCR). The role of CT in the detection of pulmonary M1 is evaluated in 522 patients who underwent a pulmonary metastasectomy for CRC. We define M1/CT as the ratio between metastatic nodules and those found on preoperative CT. Disease-specific survival (DSS), disease-free survival (DFS), and surgical approach were analyzed using the Kaplan–Meier method. Results: 93 patients were performed by video-assisted surgery (VATS) and 429 by thoracotomy. In 90%, the M1/CT ratio was =1, with no differences between VATS and thoracotomy (94.1% vs 89.7%, p = 0.874). In the remaining 10% there were more M1s than those predicted by CT (M1/CT > 1), with no differences between approaches (8.6% vs 10%, p = 0.874). 51 patients with M1/CT > 1, showed a lower median DSS (35.4 months vs 55.8; p = 0.002) and DFS (14.2 months vs 29.3; p = 0.025) compared to 470 with M1/CT = 1. No differences were observed in DSS and DFS according to VATS or thoracotomy. Conclusions: Our study shows equivalent oncological results in the resection of M1 of CRC using VATS or thoracotomy approach. The group of patients with an M1/CT ratio >1 have a worse DSS and DFS, which may mean a more advanced disease than predicted preoperatively. Introducción El número de metástasis pulmonares (M1) de carcinoma colorrectal (CCR) en relación con los hallazgos de la tomografía computarizada (TC), es objeto de estudio. Métodos Estudio prospectivo y multicéntrico del Grupo Español de Cirugía de las metástasis pulmonares del CCR (GCMP-CCR). Se evalúa el papel de la TC en la detección de M1 pulmonares en 522 pacientes intervenidos de una metastasectomía pulmonar por CCR. Definimos como M1/CT al cociente entre los nódulos metastásicos y los hallados en la TC preoperatoria. Se analizó la supervivencia específica de enfermedad (SEE), la supervivencia libre de enfermedad (SLE) y el abordaje quirúrgico mediante el método de Kaplan-Meier. Resultados En 93 pacientes se utilizó la cirugía videoasistida (VATS) y 429 toracotomías. En un 90% el cociente M1/TC fue =1, sin diferencias entre VATS y toracotomía (94,1 vs. 89,7%; p = 0,874). En el 10% restante existían más M1 que las predichas por la TC (M1/CT > 1), sin diferencias entre abordajes (8,6 vs. 10%; p = 0,874). Cincuenta y un pacientes con M1/CT > 1, mostraron una menor mediana de SEE (35,4 vs. 55,8 meses; p = 0,002) y SLE (14,2 vs. 29,3 meses; p = 0,025) en comparación con 470 con M1/CT = 1. No se observaron diferencias en la SEE y la SLE según VATS o toracotomía. Conclusiones Nuestro estudio muestra unos resultados oncológicos equivalentes en la resección de M1 de CCR mediante abordaje VATS o toracotomía. El grupo de pacientes con un cociente M1/CT > 1 presentan una peor SEE y SLE, pudiendo significar una enfermedad más avanzada de la predicha preoperatoriamente

Spread of the invasive alga Caulerpa racemosa var. cylindracea (Caulerpales, Chlorophyta) along the Mediterranean Coast of the Murcia region (SE Spain)

The aim of this paper was to document the appearance and spread of the green alga Caulerpa racemosa along the coast of Murcia in south–eastern Spain. It was found for the first time in the area in 2005 and over the next two years the number of new sightings increased almost exponentially. In the period 2005–2007 the total surface area colonised by the alga in the region was estimated to be at least 265 ha. Benthic assemblages colonised by the alga were rocky bottoms with photophilic algae, dead P. oceanica rhizomes, infralittoral and circalittoral soft bottoms and maerl beds. No penetration of the alga was observed in P. oceanica meadows, except in one locality. Biometric analysis indicated high vegetative development in the established colonies in comparison to those described in other Mediterranean areas. Rapid spreading dynamics observed in the Murcia region is a potential threat for native benthic communities. Key words: Biological invasions, Caulerpa racemosa var. cylindracea, Colonised surface area, Distribution, Mediterranean Sea, Spain.En el presente trabajo se documenta la aparición y dispersión del alga verde Caulerpa racemosa a lo largo de la costa de Murcia, región situada en el sureste español. El alga fue detectada por primera vez en el año 2005 y durante los dos años consecutivos se observó un crecimiento casi exponencial en el número de áreas colonizadas. La superficie total colonizada por el alga en Murcia durante el periodo 2005–2007 ha sido estimada en 265 ha., siendo las comunidades bentónicas afectadas algas fotófilas sobre sustrato rocoso, "mata muerta" de P. oceanica, fondos blandos infralitorales y circalitorales y fondos con comunidades de maërl. La presencia del alga dentro de praderas de P. oceanica solamente fue detectada en una localidad. Los estudios biométricos realizados muestran un elevado desarrollo vegetativo de las poblaciones de C. racemosa en Murcia en comparación con colonias de otras áreas del Mediterráneo, siendo esta rápida dinámica de expansión una amenaza potencial para las comunidades bentonicas nativas. Palabras clave: Invasiones biológicas, Caulerpa racemosa var. cylindracea, Superficie colonizada, Mar Mediterraneo, España.The aim of this paper was to document the appearance and spread of the green alga Caulerpa racemosa along the coast of Murcia in south–eastern Spain. It was found for the first time in the area in 2005 and over the next two years the number of new sightings increased almost exponentially. In the period 2005–2007 the total surface area colonised by the alga in the region was estimated to be at least 265 ha. Benthic assemblages colonised by the alga were rocky bottoms with photophilic algae, dead P. oceanica rhizomes, infralittoral and circalittoral soft bottoms and maerl beds. No penetration of the alga was observed in P. oceanica meadows, except in one locality. Biometric analysis indicated high vegetative development in the established colonies in comparison to those described in other Mediterranean areas. Rapid spreading dynamics observed in the Murcia region is a potential threat for native benthic communities. Key words: Biological invasions, Caulerpa racemosa var. cylindracea, Colonised surface area, Distribution, Mediterranean Sea, Spain

Monochromatic aberrations of the human eye in a large population

From both a fundamental and a clinical point of view, it is necessary to know the distribution of the eye's aberrations in the normal population and to be able to describe them as efficiently as possible. We used a modified Hartmann-Shack wave-front sensor to measure the monochromatic wave aberration of both eyes for 109 normal human subjects across a 5.7-mm pupil. We analyzed the distribution of the eye's aberrations in the population and found that most Zernike modes are relatively uncorrelated with each other across the population. A principal components analysis was applied to our wave-aberration measurements with the resulting principal components providing only a slightly more compact description of the population data than Zernike modes. This indicates that Zernike modes are efficient basis functions for describing the eye's wave aberration. Even though there appears to be a random variation in the eye's aberrations from subject to subject, many aberrations in the left eye were found to be significantly correlated with their counterparts in the right eye

Density of Superfluid Helium Droplets

The classical integral cross sections of large superfluid 4He_N droplets and the number of atoms in the droplets (N=10^3-10^4) have been measured in molecular beam scattering experiments. These measurements are found to be in good agreement with the cross sections predicted from density functional calculations of the radial density distributions with a 10-90 % surface thickness of 5.7\AA. By using a simple model for the density profile of the droplets a thickness of about 6-8\AA is extracted directly from the data.Comment: 27 pages, REVTeX, 5 postscript figure

Ejercicio interlaboratorio de bioensayos marinos para la evaluación de la calidad ambiental de sedimentos costeros. IV. Ensayo de toxicidad sobre sedimento con crustáceos anfípodos

9 páginas, 2 figuras, 3 tablas.[EN] Interlaboratory variability was studied for the bioassay using crustacean amphipods. Nine series of data were obtained from different laboratories using four different species (Ampelisca brevicornis, Corophium volutator, Corophium multisetosum and Microdeutopus gryllotalpa), all previously used for sediment toxicity assessment in Spain. Results were studied for interlaboratory variability and according to different confounding factors. The coefficients of variation were similar to those previously reported for this bioassay and sample classification was homogeneous among the laboratories that successfully completed the exercise. No significant tendencies related to test species were identified and it seems that the factor most critically affecting test results and the classification of samples is storage time before testing.[ES] Se estudió la precisión interlaboratorio del bioensayo con crustáceos anfípodos. Se recogieron nueve series de datos procedentes de distintos laboratorios europeos y de cuatro especies distintas (Ampelisca brevicornis, Corophium volutator, Corophium multisetosum y Microdeutopus gryllotalpa), todas ellas usadas previamente para la caracterización de la toxicidad de sedimentos en España. Esos resultados se estudiaron para evaluar la variabilidad interlaboratorio de acuerdo a las diferentes especies y los distintos tiempos de almacenamiento de las muestras antes del ensayo. Los resultados mostraron coeficientes de variación similares a los encontrados en estudios previos y permitieron una clasificación homogénea de las muestras entre los laboratorios que completaron el ejercicio con éxito. No se identificaron tendencias significativas debidas al uso de distintas especies y, al parecer, el factor que puede afectar más críticamente la clasificación de las muestras y, por lo tanto, el uso de los resultados para la toma de decisiones, es el tiempo de almacenamiento de los sedimentos previamente al desarrollo del ensayo.This study was carried out under a joint research project between CEDEX and the University of Cádiz. Part of the work was funded by the Spanish Ministry of Science and Technology REN2002_01699/TECNO). The first author was supported by a grant (FPI) from the Spanish Ministry of Education and Science.Peer reviewe

Efficacy of tigecycline for the treatment of complicated intraabdominal infections in real-life clinical practice from five european observational studies

Objectives: Tigecycline is a broad-spectrum antibiotic approved for the treatment of complicated intra-abdominal infections (cIAIs). The efficacy of tigecycline when administered as monotherapy or in combination with other antibacterials in the treatment of cIAIs in routine clinical practice is described. Patients and methods: Individual patient-level data were pooled from five European observational studies (July 2006 to October 2011). Results: A total of 785 cIAI patients who received tigecycline were included (mean age 63.1+14.0 years). Of these, 56.6% were in intensive care units, 65.6% acquired their infection in hospital, 88.1% had at least one comorbidity and 65.7% had secondary peritonitis. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at the beginning of treatment were 16.9+7.6 (n=614) and 7.0+4.2 (n=108), respectively, indicating high disease severity. Escherichia coli (41.8%), Enterococcus faecium (40.1%) and Enterococcus faecalis (21.1%) were the most frequently isolated pathogens; 49.1% of infections were polymicrobial and 17.5% were due to resistant pathogens. Overall, 54.8% (n=430) received tigecycline as monotherapy and 45.2% (n=355) as combination therapy for a mean duration of 10.6 days. Clinical response rates at the end of treatment were 77.4% for all patients (567/733), 80.6% for patients who received tigecycline as monotherapy (329/408), 75.2% for patients with a nosocomial infection (354/471), 75.8% for patients with an APACHE II score .15 (250/330) and 54.2% (32/59) for patients with a SOFA score =7. Conclusions: In these real-life studies, tigecycline, alone and in combination, achieved favourable clinical response rates in patients with cIAI with a high severity of illness

Generalized van der Waals Hamiltonian: Periodic orbits and C

Agraïments: The first author was partially supported by grant number PEII09-0220-0222. The third author was partially supported by Fundación Séneca de la Región de Murcia grant number 12001/PI/0

Completeness in the Mackey topology

Bonet and Cascales [Non-complete Mackey topologies on Banach spaces, Bulletin of the Australian Mathematical Society, 81, 3 (2010), 409-413], answering a question of M. Kunze and W. Arendt, gave an example of a norming norm-closed subspace N of the dual of a Banach space X such that mu(X, N) is not complete,where mu(X, N) denotes the Mackey topology associated with the dual pair aEuroX, NaEuro parts per thousand. We prove in this note that we can decide on the completeness or incompleteness of topologies of this form in a quite general context, thus providing large classes of counterexamples to the aforesaid question. Moreover, our examples use subspaces N of X* that contain a predual P of X (if exists), showing that the phenomenon of noncompleteness that Kunze and Arendt were looking for is not only relatively common but illustrated by "well-located" subspaces of the dual. We discuss also the situation for a typical Banach space without a predual-the space c (0)-and for the James space J.The first author is supported in part by MICINN and FEDER (project no. MTM2008-05396), by Fundacion Seneca (project no. 08848/PI/08), by Generalitat Valenciana (GV/2010/036), and by Universitat Politecnica de Valencia (project no. PAID-06-09-2829). The second author is supported in part by MICINN project no. MTM2011-22417, by Generalitat Valenciana (GV/2010/036), and by Universidad Politecnica de Valencia (project no. PAID-06-09-2829).Guirao Sánchez, AJ.; Montesinos Santalucia, V. (2015). Completeness in the Mackey topology. Functional Analysis and Its Applications. 49(2):97-105. https://doi.org/10.1007/s10688-015-0091-2S97105492J. Bonet and B. Cascales, “Non-complete Mackey topologies on Banach spaces,” Bull. Aust. Math. Soc., 81:3 (2010), 409–413.M. Fabian, P. Habala, P. Hájek, V. Montesinos, and V. Zizler, Banach Space Theory. The Basis for Linear and Nonlinear Analysis, CMS Books in Math., Springer-Verlag, New York, 2011.P. Pérez-Carreras and J. Bonet, Barreled Locally Convex Spaces, North-Holland Mathematical Studies, vol. 131, North-Holland, Amsterdam, 1987.P. Civin and B. Yood, “Quasi-reflexive spaces,” Proc. Amer. Math. Soc., 8:5 (1957), 906–911.J. Diestel, Sequences and Series in Banach Spaces, Graduate Text in Math., vol. 92, Springer-Verlag, New York, 1984.K. Floret, Weakly Compact Sets, Lecture Notes in Math., vol. 801, Springer-Verlag, Berlin, 1980.G. Godefroy, “Boundaries of convex sets and interpolation sets,” Math. Ann., 277:2 (1987), 173–184.R. C. James, “On nonreflexive Banach space isometric with its second conjugate,” Proc. Nat. Acad. Sci. USA, 37 (1951), 174–177.G. Köthe, Topological Vector Spaces I, Springer-Verlag, New York, 1969

A remark on totally smooth renormings

[EN] E. Oja, T. Viil, andD. Werner showed, in Totally smooth renormings, Archiv der Mathematik, 112, 3, (2019), 269-281, that a weakly compactly generated Banach space ( X, center dot) with the property that every linear functional on X has a unique Hahn-Banach extension to the bidual X ** (the so-called Phelps' property U in X **, also known as the Hahn-Banach smoothness property) can be renormed to have the stronger property that for every subspace Y of X, every linear functional on Y has a unique Hahn-Banach extension to X ** (the so-called total smoothness property of the space). We mention here that this result holds in full generality -without any restriction on the space- and in a stronger form, thanks to a result ofM. Raja, On dual locally uniformly rotund norms, Israel Journal of Mathematics 129 (2002), 77-91.Supported by AEI/FEDER (project MTM2017-83262-C2-2-P of Ministerio de Economia y Competitividad), by Fundacion Seneca, Region de Murcia (Grant 19368/PI/14), and Universitat Politecnica de Valencia (A. J. Guirao). Supported by AEI/FEDER (project MTM2017-83262-C2-1-P of Ministerio de Economia y Competitividad) and Universitat Politecnica de Valencia (V. Montesinos). We thank the referees for their work, that neatly improved the original version of this note to its final form.Cobollo, C.; Guirao Sánchez, AJ.; Montesinos Santalucia, V. (2020). A remark on totally smooth renormings. Revista de la Real Academia de Ciencias Exactas Físicas y Naturales Serie A Matemáticas. 114(2):1-4. https://doi.org/10.1007/s13398-020-00831-5S141142Fabian, M., Habala, P., Hájek, P., Montesinos, V., Zizler, V.: Banach space theory: the basis of linear and nonlinear analysis. Springer, New York (2011)Fabian, M., Montesinos, V., Zizler, V.: Smoothness in Banach spaces. Selected problems. Rev. R. Acad. Cien. Ser. A. Mat. RACSAM. 100(1–2), 101–125 (2006)Ferrari, S., Orihuela, J., Raja, M.: Generalized metric properties of spheres and renorming of Banach spaces. Rev. R. Acad. Cienc. Exactas Fis. Natl. Ser. A Math. RACSAM. 113, 2655–2663 (2019)Foguel, S.R.: On a theorem by A. E. Taylor. Proc. Amer. Math. Soc. 9, 325 (1958)Godefroy, G.: Points de Namioka, espaces normants, applications à la théorie isométrique de la dualité. Israel J. Math. 38, 209–220 (1981)Guirao, A.J., Montesinos, V., Zizler, V.: Open Problems in the geometry and analysis of Banach spaces. Springer International Pub, Switzerland (2016)Harmand, P., Werner, D., Werner, W.: M-ideals in Banach spaces and Banach algebras. Lecture notes in math, vol. 1547. Springer, Berlin (1993)Haydon, R.: Locally uniformly rotund norms in Banach spaces and their duals. J. Funct. Anal. 254, 2023–2039 (2008)Oja, E., Viil, T., Werner, D.: Totally smooth renormings. Archiv. der. Mathematik. 112(3), 269–281 (2019)Phelps, R.R.: Uniqueness of Hahn–Banach extensions and unique best approximation. Trans. Amer. Math. Soc. 95, 238–255 (1960)Raja, M.: On dual locally uniformly rotund norms. Israel J. Math. 129, 77–91 (2002)Smith, R.J., Troyanski, S.L.: Renormings of $$C(K)$$ spaces. Rev. R. Acad. Cienc. Exactas Fís. Natl. Ser. A Math. RACSAM 104(2), 375–412 (2010)Sullivan, F.: Geometrical properties determined by the higher duals of a Banach space. Illinois J. Math. 21, 315–331 (1977)Taylor, A.E.: The extension of linear functionals. Duke Math. J. 5, 538–547 (1939

Generic flow profiles induced by a beating cilium

We describe a multipole expansion for the low Reynolds number fluid flows generated by a localized source embedded in a plane with a no-slip boundary condition. It contains 3 independent terms that fall quadratically with the distance and 6 terms that fall with the third power. Within this framework we discuss the flows induced by a beating cilium described in different ways: a small particle circling on an elliptical trajectory, a thin rod and a general ciliary beating pattern. We identify the flow modes present based on the symmetry properties of the ciliary beat.Comment: 12 pages, 6 figures, to appear in EPJ