Multi - mechanism coalescence design and matrix expression of logic action sequences of the over-turn nursing robot Part I: Functions and coalescence design

In order to effectively solve the problem in over-turn of a bedridden person with the assistance of external force, a double bed face- three embedded leave over-turn nursing robot with the flexible compensation was put forward, with the abstraction of the bedridden person as an organism. This robot, on the basis of concept gesture of the person in bed and the state of the robot supporting and proving the gesture with the actions and combination of the two bed faces, held the complete function of over-turn nursing with 7 states corresponding to 5 gestures of the bedridden person obeying the fundamental requirements of safety, rapidity, and comport. The design method of "PS-MM-KD" was proposed for multi-mechanism coalescent system with related specific tasks induced from the original problems with Systems Engineering. Mechanics and Mechanisms, then applied in the concrete sub-system design followed by analysis and verification of both the scheme and the sub-systems in the design, using the Kinematics and Dynamics, implementing the gears, chain wheel, slewing mechanism, screw nut and mortise and tenon joint type clutch mechanism design successfully. Based on those above, a "two-bed face/three-leaf embedded flexible compensation nursing robot" was designed adopting to all ages, people of various kinds of body geometry. PLC, sensor and logic algorithm were used to carry out the control and operation of 7 state-5 posture sequences for realization of the automation and intelligent over-turning in safety, comfort, and convenience

Multi - mechanism coalescence design and matrix expression of logic action sequences of the over-turn nursing robot Part II: Gesture-state in sets and matrix

As is expressed in Part I, Functions and coalescence design of the over-turn nursing robot, the performance and requirements have been put forward with systematic design of several mechanisms. Here, in order to control and function well the over-turn nursing robot, the three-dimensional and five-dimensional Euclidean space with the real number were adopted in terms of sets for gesture of the bedridden person and the corresponding state of the robot, respectively. The matrix method was employed to define and describe the gestures-robot performance and its transition path. The gesture-state sequence matrix not only accurately and clearly expressed the gesture series, state sequence and their corresponding relations, but also laid a theoretical and technical foundation for the path planning from the current gesture to the target one. The control and operation of 7 states and 5 gestures were done to realize the automation and intelligent over-turning safely, comfortably and conveniently

Efficient universal quantum computation with auxiliary Hilbert space

We propose a scheme to construct the efficient universal quantum circuit for qubit systems with the assistance of possibly available auxiliary Hilbert spaces. An elementary two-ququart gate, termed the controlled-double-NOT gate, is proposed first in ququart (four-level) systems, and its physical implementation is illustrated in the four-dimensional Hilbert spaces built by the path and polarization states of photons. Then an efficient universal quantum circuit for ququart systems is constructed using the gate and the quantum Shannon decomposition method. By introducing auxiliary two-dimensional Hilbert spaces, the universal quantum circuit for qubit systems is finally achieved using the result obtained in ququart systems with the lowest complexity

D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth

Cancer-associated isocitrate dehydrogenase (IDH) 1 and 2 mutations gain a new activity of reducing α-KG to produce D-2-hydroxyglutarate (D-2-HG), which is proposed to function as an oncometabolite by inhibiting α-KG dependent dioxygenases. We investigated the function of D-2-HG in tumorigenesis using IDH1 and IDH2 mutant cancer cell lines. Inhibition of D-2-HG production either by specific deletion of the mutant IDH1-R132C allele or overexpression of D-2-hydroxyglutarate dehydrogenase (D2HGDH) increases α-KG and related metabolites, restores the activity of some α-KG-dependent dioxygenases, and selectively alters gene expression. Ablation of D-2-HG production has no significant effect on cell proliferation and migration, but strongly inhibits anchorage independent growth in vitro and tumor growth in xenografted mouse models. Our study identifies a new activity of oncometabolite D-2-HG in promoting tumorigenesis

An atlas of DNA methylomes in porcine adipose and muscle tissues

It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose and two distinct skeletal muscle tissues from three pig breeds living within comparable environments but displaying distinct fat level. We generate 1,381 Gb of sequence data from 180 methylated DNA immunoprecipitation libraries, and provide a genome-wide DNA methylation map as well as a gene expression map for adipose and muscle studies. The analysis shows global similarity and difference among breeds, sexes and anatomic locations, and identifies the differentially methylated regions. The differentially methylated regions in promoters are highly associated with obesity development via expression repression of both known obesity-related genes and novel genes. This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth

Tunable Coupling Architectures with Capacitively Connecting Pads for Large-Scale Superconducting Multi-Qubit Processors

We have proposed and experimentally verified a tunable inter-qubit coupling scheme for large-scale integration of superconducting qubits. The key feature of the scheme is the insertion of connecting pads between qubit and tunable coupling element. In such a way, the distance between two qubits can be increased considerably to a few millimeters, leaving enough space for arranging control lines, readout resonators and other necessary structures. The increased inter-qubit distance provides more wiring space for flip-chip process and reduces crosstalk between qubits and from control lines to qubits. We use the term Tunable Coupler with Capacitively Connecting Pad (TCCP) to name the tunable coupling part that consists of a transmon coupler and capacitively connecting pads. With the different placement of connecting pads, different TCCP architectures can be realized. We have designed and fabricated a few multi-qubit devices in which TCCP is used for coupling. The measured results show that the performance of the qubits coupled by the TCCP, such as $T_1$ and $T_2$, was similar to that of the traditional transmon qubits without TCCP. Meanwhile, our TCCP also exhibited a wide tunable range of the effective coupling strength and a low residual ZZ interaction between the qubits by properly tuning the parameters on the design. Finally, we successfully implemented an adiabatic CZ gate with TCCP. Furthermore, by introducing TCCP, we also discuss the realization of the flip-chip process and tunable coupling qubits between different chips.Comment: Main text: 7 pages, 6 figure

Study of J/ψ→ppˉJ/\psi\to p\bar{p} and J/ψ→nnˉJ/\psi\to n\bar{n}

The decays $J/\psi\to p\bar{p}$ and $J/\psi\to n\bar{n}$ have been investigated with a sample of 225.2 million $J/\psi$ events collected with the BESIII detector at the BEPCII $e^+e^-$ collider. The branching fractions are determined to be $\mathcal{B}(J/\psi\to p\bar{p})=(2.112\pm0.004\pm0.031)\times10^{-3}$ and $\mathcal{B}(J/\psi\to n\bar{n})=(2.07\pm0.01\pm0.17)\times10^{-3}$. Distributions of the angle $\theta$ between the proton or anti-neutron and the beam direction are well described by the form $1+\alpha\cos^2\theta$, and we find $\alpha=0.595\pm0.012\pm0.015$ for $J/\psi\to p\bar{p}$ and $\alpha=0.50\pm0.04\pm0.21$ for $J/\psi\to n\bar{n}$. Our branching-fraction results suggest a large phase angle between the strong and electromagnetic amplitudes describing the $J/\psi\to N\bar{N}$ decay.Comment: 16 pages, 13 figures, the 2nd version, submitted to PR

First observation of the M1 transition ψ(3686)→γηc(2S)\psi(3686)\to \gamma\eta_c(2S)

Using a sample of 106 million \psi(3686) events collected with the BESIII detector at the BEPCII storage ring, we have made the first measurement of the M1 transition between the radially excited charmonium S-wave spin-triplet and the radially excited S-wave spin-singlet states: \psi(3686)\to\gamma\eta_c(2S). Analyses of the processes \psi(2S)\to \gamma\eta_c(2S) with \eta_c(2S)\to \K_S^0 K\pi and K^+K^-\pi^0 gave an \eta_c(2S) signal with a statistical significance of greater than 10 standard deviations under a wide range of assumptions about the signal and background properties. The data are used to obtain measurements of the \eta_c(2S) mass (M(\eta_c(2S))=3637.6\pm 2.9_\mathrm{stat}\pm 1.6_\mathrm{sys} MeV/c^2), width (\Gamma(\eta_c(2S))=16.9\pm 6.4_\mathrm{stat}\pm 4.8_\mathrm{sys} MeV), and the product branching fraction (\BR(\psi(3686)\to \gamma\eta_c(2S))\times \BR(\eta_c(2S)\to K\bar K\pi) = (1.30\pm 0.20_\mathrm{stat}\pm 0.30_\mathrm{sys})\times 10^{-5}). Combining our result with a BaBar measurement of \BR(\eta_c(2S)\to K\bar K \pi), we find the branching fraction of the M1 transition to be \BR(\psi(3686)\to\gamma\eta_c(2S)) = (6.8\pm 1.1_\mathrm{stat}\pm 4.5_\mathrm{sys})\times 10^{-4}.Comment: 7 pages, 1 figure, 1 tabl