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Vitiligo-like manifestations of graft-versus-host disease in a pediatric population
Vitiligo-like changes are an uncommon cutaneous manifestation of graft-versus-host disease (GVHD). We report three cases and review the literature of pediatric patients with vitiligo-like changes associated with GVHD. Improved characterization of this phenomenon may lend insight into the biologic pathways that underlie both vitiligo and GVHD
Variational inference formulation for a model-free simulation of a dynamical system with unknown parameters by a recurrent neural network
We propose a recurrent neural network for a "model-free" simulation of a
dynamical system with unknown parameters without prior knowledge. The deep
learning model aims to jointly learn the nonlinear time marching operator and
the effects of the unknown parameters from a time series dataset. We assume
that the time series data set consists of an ensemble of trajectories for a
range of the parameters. The learning task is formulated as a statistical
inference problem by considering the unknown parameters as random variables. A
latent variable is introduced to model the effects of the unknown parameters,
and a variational inference method is employed to simultaneously train
probabilistic models for the time marching operator and an approximate
posterior distribution for the latent variable. Unlike the classical
variational inference, where a factorized distribution is used to approximate
the posterior, we employ a feedforward neural network supplemented by an
encoder recurrent neural network to develop a more flexible probabilistic
model. The approximate posterior distribution makes an inference on a
trajectory to identify the effects of the unknown parameters. The time marching
operator is approximated by a recurrent neural network, which takes a latent
state sampled from the approximate posterior distribution as one of the input
variables, to compute the time evolution of the probability distribution
conditioned on the latent variable. In the numerical experiments, it is shown
that the proposed variational inference model makes a more accurate simulation
compared to the standard recurrent neural networks. It is found that the
proposed deep learning model is capable of correctly identifying the dimensions
of the random parameters and learning a representation of complex time series
data
IceCube expectations for two high-energy neutrino production models at active galactic nuclei
We have determined the currently allowed regions of the parameter spaces of
two representative models of diffuse neutrino flux from active galactic nuclei
(AGN): one by Koers & Tinyakov (KT) and another by Becker & Biermann (BB). Our
observable has been the number of upgoing muon-neutrinos expected in the
86-string IceCube detector, after 5 years of exposure, in the range 10^5 <
E/GeV < 10^8. We have used the latest estimated discovery potential of the
IceCube-86 array at the 5-sigma level to determine the lower boundary of the
regions, while for the upper boundary we have used either the AMANDA upper
bound on the neutrino flux or the more recent preliminary upper bound given by
the half-completed IceCube-40 array (IC40). We have varied the spectral index
of the proposed power-law fluxes, alpha, and two parameters of the BB model:
the ratio between the boost factors of neutrinos and cosmic rays,
Gamma_nu/Gamma_{CR}, and the maximum redshift of the sources that contribute to
the cosmic-ray flux, zCRmax. For the KT model, we have considered two
scenarios: one in which the number density of AGN does not evolve with redshift
and another in which it evolves strongly, following the star formation rate.
Using the IC40 upper bound, we have found that the models are visible in
IceCube-86 only inside very thin strips of parameter space and that both of
them are discarded at the preferred value of alpha = 2.7 obtained from fits to
cosmic-ray data. Lower values of alpha, notably the values 2.0 and 2.3 proposed
in the literature, fare better. In addition, we have analysed the capacity of
IceCube-86 to discriminate between the models within the small regions of
parameter space where both of them give testable predictions. Within these
regions, discrimination at the 5-sigma level or more is guaranteed.Comment: 24 pages, 6 figures, v2: new IceCube-40 astrophysical neutrino upper
bound and IceCube-86 discovery potential used, explanation of AGN flux models
improved, only upgoing neutrinos used, conclusions strengthened. Accepted for
publication in JCA
Detecting a stochastic gravitational wave background with the Laser Interferometer Space Antenna
The random superposition of many weak sources will produce a stochastic
background of gravitational waves that may dominate the response of the LISA
(Laser Interferometer Space Antenna) gravitational wave observatory. Unless
something can be done to distinguish between a stochastic background and
detector noise, the two will combine to form an effective noise floor for the
detector. Two methods have been proposed to solve this problem. The first is to
cross-correlate the output of two independent interferometers. The second is an
ingenious scheme for monitoring the instrument noise by operating LISA as a
Sagnac interferometer. Here we derive the optimal orbital alignment for
cross-correlating a pair of LISA detectors, and provide the first analytic
derivation of the Sagnac sensitivity curve.Comment: 9 pages, 11 figures. Significant changes to the noise estimate
The Effects of Voluntary Disclosure and Dividend Propensity on Prices Leading Earnings
We investigate the joint effects of dividend propensity (i.e. whether a firm pays cash dividends) and voluntary disclosure on the relationship between current stock returns and future earnings. We examine whether dividend propensity and voluntary disclosure act as substitutes or complements in the financial communication process. We also examine whether the effects of dividend propensity and voluntary disclosure vary between high- and lowgrowth firms. Consistent with prior studies, we find that share price anticipation of earnings improves with increasing levels of annual report narrative disclosure, and that firms that pay dividends exhibit higher levels of share price anticipation of earnings than non-dividend-paying firms. The paper adds to the literature on share price anticipation of earnings in two crucial respects. First we show that the associations of voluntary disclosure and dividend propensity with share price anticipation of earnings are statistically significant for high-growth firms and insignificant for low-growth firms. Second we show that the significant effects we find for dividend propensity and voluntary disclosure in high-growth firms are not perfectly additive
Lateral Distribution of Muons in IceCube Cosmic Ray Events
In cosmic ray air showers, the muon lateral separation from the center of the
shower is a measure of the transverse momentum that the muon parent acquired in
the cosmic ray interaction. IceCube has observed cosmic ray interactions that
produce muons laterally separated by up to 400 m from the shower core, a factor
of 6 larger distance than previous measurements. These muons originate in high
pT (> 2 GeV/c) interactions from the incident cosmic ray, or high-energy
secondary interactions. The separation distribution shows a transition to a
power law at large values, indicating the presence of a hard pT component that
can be described by perturbative quantum chromodynamics. However, the rates and
the zenith angle distributions of these events are not well reproduced with the
cosmic ray models tested here, even those that include charm interactions. This
discrepancy may be explained by a larger fraction of kaons and charmed
particles than is currently incorporated in the simulations
Search for Relativistic Magnetic Monopoles with IceCube
We present the first results in the search for relativistic magnetic
monopoles with the IceCube detector, a subsurface neutrino telescope located in
the South Polar ice cap containing a volume of 1 km. This analysis
searches data taken on the partially completed detector during 2007 when
roughly 0.2 km of ice was instrumented. The lack of candidate events
leads to an upper limit on the flux of relativistic magnetic monopoles of
\Phi_{\mathrm{90%C.L.}}\sim 3\e{-18}\fluxunits for . This is a
factor of 4 improvement over the previous best experimental flux limits up to a
Lorentz boost below . This result is then interpreted for a
wide range of mass and kinetic energy values.Comment: 11 pages, 11 figures. v2 is minor text edits, no changes to resul
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