Student independent education activities that develop their leadership qualities

Today’s world and society is changing. Young generation is becoming more independent, creative and initiative. The aim of education is to provide students with all the skills necessary to become a successful personality. That’s why developing students’ leadership skills and abilities is a very important issue of today

Application of bent crystals at IHEP 70-GeV accelerator to enhance the efficiency of its usage

Bent crystal was extracting 70-GeV protons with average intensity 4*10^11 (as measured in external beamline) per spill of 1.6 s duration, in parallel to the simultaneous work of two internal targets in the accelerator ring. An additional crystal, placed in the external beamline, was deflecting a small part of the extracted beam with intensity 10^7 protons toward another physics experiment. Crystal-extracted beam had a typical size of 4 mm by 4 mm fwhm at the end of the external beamline. Measurements for the extraction efficiency and other characteristics at the simultaneous work of four experimental set-ups are presented. With crystal working in the above-said regime during one month, no degradation of channeling was observed. The studies of extraction efficiency have been continued with new crystals.Comment: 6pp. Presented at EPAC 200

Multidisciplinary approach in the treatment of spin diseases

The article discusses the method of multidisciplinary treatment of patients with a diagnosis of M54.5 "Low back pain" based on the combined use of physiotherapy, kinesitherapy and correction of anxious depression. It was established that treatment of patients with lower back pain based on the proposed method reduces the level of subjective assessment of pain according to the VAS scale by 28 ± 3% reduces the clinical manifestations of pain and by 21 ± 4% the level of depression according to A. Beck's psychometric table compared to the control group

Роль и место «Национального плана развития науки и технологий в авиастроении на период до 2025 года и последующую перспективу» в документах стратегического планирования

A brief overview of the strategic planning documents in the aviation industry, defined the legal status of the developed "National Plan for Science and Technology in the aircraft industry for the period up to 2025 and the subsequent prospect" assesses its role and place in the strategic planning documents, the relationship with the main documents. Disclosed structure of the National Plan and the goal of scientific and technological potential, defined by the National Plan.В статье проведен краткий обзор документов стратегического планирования в области авиастроения, определён нормативно-правовой статус разрабатываемого «Национального плана развития науки и технологий в авиастроении на период до 2025 года и последующую перспективу», дана оценка его роли и места в документах стратегического планирования, показана взаимосвязь с основными документами. Раскрыта структура Национального плана, а также цели создания научно-технического задела, определяемые Национальным планом

Baikal-GVD: status and prospects

Baikal-GVD is a next generation, kilometer-scale neutrino telescope under construction in Lake Baikal. It is designed to detect astrophysical neutrino fluxes at energies from a few TeV up to 100 PeV. GVD is formed by multi-megaton subarrays (clusters). The array construction started in 2015 by deployment of a reduced-size demonstration cluster named "Dubna". The first cluster in its baseline configuration was deployed in 2016, the second in 2017 and the third in 2018. The full scale GVD will be an array of ~10000 light sensors with an instrumented volume of about 2 cubic km. The first phase (GVD-1) is planned to be completed by 2020-2021. It will comprise 8 clusters with 2304 light sensors in total. We describe the design of Baikal-GVD and present selected results obtained in 2015-2017.Comment: 9 pages, 8 figures. Conference proceedings for QUARKS201

Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.

Anti-obesity drugs in the amphetamine (AMPH) class act in the brain to reduce appetite and increase locomotion. They are also characterized by adverse cardiovascular effects with origin that, despite absence of any in vivo evidence, is attributed to a direct sympathomimetic action in the heart. Here, we show that the cardiac side effects of AMPH originate from the brain and can be circumvented by PEGylation (PEGyAMPH) to exclude its central action. PEGyAMPH does not enter the brain and facilitates SNS activity via theβ2-adrenoceptor, protecting mice against obesity by increasing lipolysis and thermogenesis, coupled to higher heat dissipation, which acts as an energy sink to increase energy expenditure without altering food intake or locomotor activity. Thus, we provide proof-of-principle for a novel class of exclusively peripheral anti-obesity sympathofacilitators that are devoid of any cardiovascular and brain-related side effects

Orally available Mn porphyrins with superoxide dismutase and catalase activities

Superoxide dismutase/catalase mimetics, such as salen Mn complexes and certain metalloporphyrins, catalytically neutralize reactive oxygen and nitrogen species, which have been implicated in the pathogenesis of many serious diseases. Both classes of mimetic are protective in animal models of oxidative stress. However, only AEOL11207 and EUK-418, two uncharged Mn porphyrins, have been shown to be orally bioavailable. In this study, EUK-418 and several new analogs (the EUK-400 series) were synthesized and shown to exhibit superoxide dismutase, catalase, and peroxidase activities in vitro. Some also protected PC12 cells against staurosporine-induced cell death. All EUK-400 compounds were stable in simulated gastric fluid, and most were substantially more lipophilic than the salen Mn complexes EUK-189 and EUK-207, which lack oral activity. Pharmacokinetics studies demonstrate the presence of all EUK-400 series compounds in the plasma of rats after oral administration. These EUK-400 series compounds are potential oral therapeutic agents for cellular damage caused by oxidative stress