757 research outputs found
Thickness dependence of spin-orbit torques generated by WTe2
We study current-induced torques in WTe2/permalloy bilayers as a function of
WTe2 thickness. We measure the torques using both second-harmonic Hall and
spin-torque ferromagnetic resonance measurements for samples with WTe2
thicknesses that span from 16 nm down to a single monolayer. We confirm the
existence of an out-of-plane antidamping torque, and show directly that the
sign of this torque component is reversed across a monolayer step in the WTe2.
The magnitude of the out-of-plane antidamping torque depends only weakly on
WTe2 thickness, such that even a single-monolayer WTe2 device provides a strong
torque that is comparable to much thicker samples. In contrast, the
out-of-plane field-like torque has a significant dependence on the WTe2
thickness. We demonstrate that this field-like component originates
predominantly from the Oersted field, thereby correcting a previous inference
drawn by our group based on a more limited set of samples.Comment: 8 pages, 8 figure
Learning Mixtures of Gaussians in High Dimensions
Efficiently learning mixture of Gaussians is a fundamental problem in
statistics and learning theory. Given samples coming from a random one out of k
Gaussian distributions in Rn, the learning problem asks to estimate the means
and the covariance matrices of these Gaussians. This learning problem arises in
many areas ranging from the natural sciences to the social sciences, and has
also found many machine learning applications. Unfortunately, learning mixture
of Gaussians is an information theoretically hard problem: in order to learn
the parameters up to a reasonable accuracy, the number of samples required is
exponential in the number of Gaussian components in the worst case. In this
work, we show that provided we are in high enough dimensions, the class of
Gaussian mixtures is learnable in its most general form under a smoothed
analysis framework, where the parameters are randomly perturbed from an
adversarial starting point. In particular, given samples from a mixture of
Gaussians with randomly perturbed parameters, when n > {\Omega}(k^2), we give
an algorithm that learns the parameters with polynomial running time and using
polynomial number of samples. The central algorithmic ideas consist of new ways
to decompose the moment tensor of the Gaussian mixture by exploiting its
structural properties. The symmetries of this tensor are derived from the
combinatorial structure of higher order moments of Gaussian distributions
(sometimes referred to as Isserlis' theorem or Wick's theorem). We also develop
new tools for bounding smallest singular values of structured random matrices,
which could be useful in other smoothed analysis settings
Structure and functional motifs of GCR1, the only plant protein with a GPCR fold?
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G
protein coupled receptors (GPCRs), arises because of their importance in signaling. Within plants, this
is controversial as genome analysis has identified 56 putative GPCRs, including GCR1 which is
reportedly a remote homologue to class A, B and E GPCRs. Of these, GCR2, is not a GPCR; more
recently it has been proposed that none are, not even GCR1. We have addressed this disparity
between genome analysis and biological evidence through a structural bioinformatics study, involving
fold recognition methods, from which only GCR1 emerges as a strong candidate. To further probe
GCR1, we have developed a novel helix alignment method, which has been benchmarked against the
the class A – class B - class F GPCR alignments. In addition, we have presented a mutually consistent
set of alignments of GCR1 homologues to class A, class B and class F GPCRs, and shown that GCR1
is closer to class A and /or class B GPCRs than class A, class B or class F GPCRs are to each other.
To further probe GCR1, we have aligned transmembrane helix 3 of GCR1 to each of the 6 GPCR
classes. Variability comparisons provide additional evidence that GCR1 homologues have the GPCR
fold. From the alignments and a GCR1 comparative model we have identified motifs that are common
to GCR1, class A, B and E GPCRs. We discuss the possibilities that emerge from this controversial
evidence that GCR1 has a GPCR fol
Spin-orbit torques in NbSe/Permalloy bilayers
We present measurements of current-induced spin-orbit torques generated by
NbSe, a fully-metallic transition-metal dichalcogenide material, made using
the spin-torque ferromagnetic resonance (ST-FMR) technique with
NbSe/Permalloy bilayers. In addition to the out-of-plane Oersted torque
expected from current flow in the metallic NbSe layer, we also observe an
in-plane antidamping torque with torque conductivity (m) and indications of a weak field-like
contribution to the out-of-plane torque oriented opposite to the Oersted
torque. Furthermore, in some samples we also measure an in-plane field-like
torque with the form , where is the Permalloy
magnetization direction and is perpendicular to the sample plane. The
size of this component varies strongly between samples and is not correlated
with the NbSe thickness. A torque of this form is not allowed by the bulk
symmetries of NbSe, but is consistent with symmetry breaking by a
uniaxial strain that might result during device fabrication.Comment: 14 pages, 3 figure
NASA Flight Planning Branch Space Shuttle Lessons Learned
Planning products and procedures that allowed the mission Flight Control Teams and the Astronaut crews to plan, train and fly every Space Shuttle mission were developed by the Flight Planning Branch at the NASA Johnson Space Center in Houston, Texas. As the Space Shuttle Program came to a close, lessons learned were collected from each phase of the successful execution of these Space Shuttle missions. Specific examples of how roles and responsibilities of console positions that develop the crew and vehicle attitude timelines have been analyzed and will be discussed. Additionally, the relationships and procedural hurdles experienced through international collaboration have molded operations. These facets will be explored and related to current and future operations with the International Space Station and future vehicles. Along with these important aspects, the evolution of technology and continual improvement of data transfer tools between the Space Shuttle and ground team has also defined specific lessons used in improving the control team s effectiveness. Methodologies to communicate and transmit messages, images, and files from the Mission Control Center to the Orbiter evolved over several years. These lessons were vital in shaping the effectiveness of safe and successful mission planning and have been applied to current mission planning work in addition to being incorporated into future space flight planning. The critical lessons from all aspects of previous plan, train, and fly phases of Space Shuttle flight missions are not only documented in this paper, but are also discussed regarding how they pertain to changes in process and consideration for future space flight planning
High Frequency Peakers: young radio sources or flaring blazars?
We present new, simultaneous, multifrequency observations of 45 out of the 55
candidate High Frequency Peakers (HFP) selected by Dallacasa et al. (2000),
carried out 3 to 4 years after a first set of observations. Our sub-sample
consists of 10 galaxies, 28 stellar objects (``quasars'') and 7 unidentified
sources. Both sets of observations are sensitive enough to allow the detection
of variability at the 10% level or lower. While galaxies do not show
significant variability, most quasars do. Seven of them no longer show the
convex spectrum which is the defining property of Gigahertz Peaked Spectrum
(GPS)/HFP sources and are interpreted as blazars caught by Dallacasa et al.
(2000) during a flare, when a highly self-absorbed component dominated the
emission. In general, the variability properties (amplitude, timescales,
correlation between peak luminosity and peak frequency of the flaring
component) of the quasar sub-sample resemble those of blazars. We thus conclude
that most HFP candidates identified with quasars may well be flaring blazars.Comment: 20 pages, 18 figures, accepted for publication in Astronomy &
Astrophysic
Suppression of Wolbachia-mediated male-killing in the butterfly Hypolimnas bolina involves a single genomic region.
BACKGROUND: Sex ratio distorting agents (maternally inherited symbionts and meiotically-driving sex chromosomes) are common in insects. When these agents rise to high frequencies they create strong population sex ratio bias and selection then favours mutations that act to restore the rare sex. Despite this strong selection pressure, the evolution of mutations that suppress sex ratio distorting elements appears to be constrained in many cases, where sex-biased populations persist for many generations. This scenario has been observed in the butterfly Hypolimnas bolina, where Wolbachia-mediated male killing endured for 800-1,000 generations across multiple populations before the evolution of suppression. Here we test the hypothesis that this evolutionary lag is the result of suppression being a multilocus trait requiring multiple mutations. METHODS: We developed genetic markers, based on conservation of synteny, for each H. bolina chromosome and verified coverage using recombinational mapping. We then used a Wolbachia-infected mapping family to assess each chromosome for the presence of loci required for male survival, as determined by the presence of markers in all surviving sons. RESULTS: Informative markers were obtained for each of the 31 chromosomes in H. bolina. The only marker that cosegregated with suppression was located on chromosome 25. A genomic region necessary for suppression has previously been located on this chromosome. We therefore conclude that a single genomic region of the H. bolina genome is necessary for male-killing suppression. DISCUSSION: The evolutionary lag observed in our system is not caused by a need for changes at multiple genomic locations. The findings favour hypotheses in which either multiple mutations are required within a single genomic region, or the suppressor mutation is a singularly rare event
Turbulence Fluctuations and New Universal Realizability Conditions in Modelling
General turbulent mean statistics are shown to be characterized by a
variational principle. The variational functionals, or ``effective actions'',
have experimental consequences for turbulence fluctuations and are subject to
realizability conditions of positivity and convexity. An efficient
Rayleigh-Ritz algorithm is available to calculate approximate effective actions
within PDF closures. Examples are given for Navier-Stokes and for a 3-mode
system of Lorenz. The new realizability conditions succeed at detecting {\em a
priori} the poor predictions of PDF closures even when the classical 2nd-order
moment realizability conditions are satisfied.Comment: 4 pages, LaTeX (Version 2.09), 3 figures, Postscript, Submitted to
Phys. Rev. Let
Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells
HSPG mitigates Aβ1-40-induced mitochondrial and cytosolic ROS production in VSMC under physiological oxygen concentration. To determine if differing levels oxygen impact ROS production in Aβ1-40 treated VSMC, cells were kept in 10 % oxygen (Panel A) or 1 % oxygen (conditions that are considered hypoxic; Panel B) in cell culture incubator with % 5 CO2. Primary human cerebral VSMC were pre-treated with heparin (15 U/mL), heparinase I (HpnI; 5 Sigma U/mL), or heparinase III (HpnIII; 2 Sigma U/mL) for 2 h, washed, loaded with Mitotracker Red CM-H2XRos, washed, and treated with Aβ1-40. In some cases, cells were pre-treated with heat-inactivated (HI) enzyme. Fluorescence was measured after 30 minutes. Results are representative of 3 independent experiments performed in triplicate. *p < 0.05 vs. vehicle-treated control. #p < 0.05 vs. comparison group. (JPEG 70 kb
- …